| Published Application/Species/Sample/Dilution | Reference |
|---|
- ELISA; human
- western blot; human
| Fukuhara T, Wada M, Nakamura S, Ono C, Shiokawa M, Yamamoto S, et al. Amphipathic α-helices in apolipoproteins are crucial to the formation of infectious hepatitis C virus particles. PLoS Pathog. 2014;10:e1004534 pubmed publisher |
| Lee C, Tse W, Smith J, Landreth G. Apolipoprotein E promotes ?-amyloid trafficking and degradation by modulating microglial cholesterol levels. J Biol Chem. 2012;287:2032-44 pubmed publisher |
- ELISA; mouse
- western blot; mouse
| Hirsch Reinshagen V, Donkin J, Stukas S, Chan J, Wilkinson A, Fan J, et al. LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins. J Lipid Res. 2009;50:885-93 pubmed publisher |
| Fryer J, DeMattos R, McCormick L, O Dell M, Spinner M, Bales K, et al. The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice. J Biol Chem. 2005;280:25754-9 pubmed |
| Krul E, Tikkanen M, Schonfeld G. Heterogeneity of apolipoprotein E epitope expression on human lipoproteins: importance for apolipoprotein E function. J Lipid Res. 1988;29:1309-25 pubmed |
| Ayoubi R, Southern K, Laflamme C. Identification of high-performing antibodies for Apolipoprotein E for use in Western Blot and immunoprecipitation. F1000Res. 2023;12:810 pubmed publisher |
| Watanabe H, Murakami R, Tsumagari K, Morimoto S, Hashimoto T, Imaizumi K, et al. Astrocytic APOE4 genotype-mediated negative impacts on synaptic architecture in human pluripotent stem cell model. Stem Cell Reports. 2023;18:1854-1869 pubmed publisher |
| Wynne M, Ogunbona O, Lane A, Gokhale A, Zlatic S, Xu C, et al. APOE expression and secretion are modulated by mitochondrial dysfunction. elife. 2023;12: pubmed publisher |
| Kessler K, Giannisis A, Bial G, Foquet L, Nielsen H, Raber J. Behavioral and cognitive performance of humanized APOEε3/ε3 liver mice in relation to plasma apolipoprotein E levels. Sci Rep. 2023;13:1728 pubmed publisher |
| Watanabe S, Sudo Y, Makino T, Kimura S, Tomita K, Noguchi M, et al. Skeletal muscle releases extracellular vesicles with distinct protein and microRNA signatures that function in the muscle microenvironment. PNAS Nexus. 2022;1:pgac173 pubmed publisher |
| Fern xe1 ndez Zapata C, Giacomello G, Spruth E, Middeldorp J, Gallaccio G, Dehlinger A, et al. Differential compartmentalization of myeloid cell phenotypes and responses towards the CNS in Alzheimer's disease. Nat Commun. 2022;13:7210 pubmed publisher |
| Zhang H, Shao L, Lin Z, Long Q, Yuan H, Cai L, et al. APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patients. Signal Transduct Target Ther. 2022;7:261 pubmed publisher |
| Jin Y, Li F, Sonoustoun B, Kondru N, Martens Y, Qiao W, et al. APOE4 exacerbates α-synuclein seeding activity and contributes to neurotoxicity in Alzheimer's disease with Lewy body pathology. Acta Neuropathol. 2022;143:641-662 pubmed publisher |
| Wang G, Yin W, Shin H, Tian Q, Lu W, Hou S. Neuronal accumulation of peroxidated lipids promotes demyelination and neurodegeneration through the activation of the microglial NLRP3 inflammasome. Nat Aging. 2021;1:1024-1037 pubmed publisher |
| Shim H, Horner J, Wu C, Li J, Lan Z, Jiang S, et al. Telomerase Reverse Transcriptase Preserves Neuron Survival and Cognition in Alzheimer's Disease Models. Nat Aging. 2021;1:1162-1174 pubmed publisher |
| Konings S, Torres Garcia L, Martinsson I, Gouras G. Astrocytic and Neuronal Apolipoprotein E Isoforms Differentially Affect Neuronal Excitability. Front Neurosci. 2021;15:734001 pubmed publisher |
| Milich L, Choi J, Ryan C, Cerqueira S, Benavides S, Yahn S, et al. Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord. J Exp Med. 2021;218: pubmed publisher |
| Gnanaguru G, Wagschal A, Oh J, Saez Torres K, Li T, Temel R, et al. Targeting of miR-33 ameliorates phenotypes linked to age-related macular degeneration. Mol Ther. 2021;29:2281-2293 pubmed publisher |
| Schmid B, Holst B, Clausen C, Bahnassawy L, Reinhardt P, Bakker M, et al. Generation of a set of isogenic iPSC lines carrying all APOE genetic variants (Ɛ2/Ɛ3/Ɛ4) and knock-out for the study of APOE biology in health and disease. Stem Cell Res. 2021;52:102180 pubmed publisher |
| Xu Y, Li Y, Jadhav K, Pan X, Zhu Y, Hu S, et al. Hepatocyte ATF3 protects against atherosclerosis by regulating HDL and bile acid metabolism. Nat Metab. 2021;3:59-74 pubmed publisher |
| Yamazaki Y, Liu C, Yamazaki A, Shue F, Martens Y, Chen Y, et al. Vascular ApoE4 Impairs Behavior by Modulating Gliovascular Function. Neuron. 2021;109:438-447.e6 pubmed publisher |
| Yang R, Zhao Y, Gu Y, Yang Y, Gao X, Yuan Y, et al. Isocitrate dehydrogenase 1 mutation enhances 24(S)-hydroxycholesterol production and alters cholesterol homeostasis in glioma. Oncogene. 2020;: pubmed publisher |
| Hofmann S, Mai J, Masser S, Groitl P, Herrmann A, Sternsdorf T, et al. ATO (Arsenic Trioxide) Effects on Promyelocytic Leukemia Nuclear Bodies Reveals Antiviral Intervention Capacity. Adv Sci (Weinh). 2020;7:1902130 pubmed publisher |
| Qi F, Meng Q, Hayashi I, Kobayashi J. FXR1 is a novel MRE11-binding partner and participates in oxidative stress responses. J Radiat Res. 2020;61:368-375 pubmed publisher |
| Jeyaram A, Lamichhane T, Wang S, Zou L, Dahal E, Kronstadt S, et al. Enhanced Loading of Functional miRNA Cargo via pH Gradient Modification of Extracellular Vesicles. Mol Ther. 2020;28:975-985 pubmed publisher |
| Pan X, Chen Y, Biju B, Ahmed N, Kong J, Goldenberg M, et al. FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops. Sci Rep. 2019;9:19110 pubmed publisher |
| Mladenov E, Staudt C, Soni A, Murmann Konda T, Siemann Loekes M, Iliakis G. Strong suppression of gene conversion with increasing DNA double-strand break load delimited by 53BP1 and RAD52. Nucleic Acids Res. 2020;48:1905-1924 pubmed publisher |
| Hanlon K, Meltzer J, Buzhdygan T, Cheng M, Sena Esteves M, Bennett R, et al. Selection of an Efficient AAV Vector for Robust CNS Transgene Expression. Mol Ther Methods Clin Dev. 2019;15:320-332 pubmed publisher |
| Scherthan H, Lee J, Maus E, Schumann S, Muhtadi R, Chojowski R, et al. Nanostructure of Clustered DNA Damage in Leukocytes after In-Solution Irradiation with the Alpha Emitter Ra-223. Cancers (Basel). 2019;11: pubmed publisher |
| Fievet A, Bellanger D, Zahed L, Burglen L, Derrien A, Dubois d Enghien C, et al. DNA repair functional analyses of NBN hypomorphic variants associated with NBN-related infertility. Hum Mutat. 2020;41:608-618 pubmed publisher |
| Yamazaki Y, Shinohara M, Yamazaki A, Ren Y, Asmann Y, Kanekiyo T, et al. ApoE (Apolipoprotein E) in Brain Pericytes Regulates Endothelial Function in an Isoform-Dependent Manner by Modulating Basement Membrane Components. Arterioscler Thromb Vasc Biol. 2020;40:128-144 pubmed publisher |
| Porebski B, Wild S, Kummer S, Scaglione S, Gaillard P, Gari K. WRNIP1 Protects Reversed DNA Replication Forks from SLX4-Dependent Nucleolytic Cleavage. iScience. 2019;21:31-41 pubmed publisher |
| Bai Y, Wang W, Li S, Zhan J, Li H, Zhao M, et al. C1QBP Promotes Homologous Recombination by Stabilizing MRE11 and Controlling the Assembly and Activation of MRE11/RAD50/NBS1 Complex. Mol Cell. 2019;: pubmed publisher |
| Yoshimura Y. Increased error-free DNA repair gene expression through reprogramming in human iPS cells. Regen Ther. 2019;11:101-105 pubmed publisher |
| Jung J, Volk C, Marga C, Navarrete Santos A, Jung M, Rujescu D, et al. Adipose-Derived Stem/Stromal Cells Recapitulate Aging Biomarkers and Show Reduced Stem Cell Plasticity Affecting Their Adipogenic Differentiation Capacity. Cell Reprogram. 2019;21:187-199 pubmed publisher |
| Velichko A, Petrova N, Luzhin A, Strelkova O, Ovsyannikova N, Kireev I, et al. Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription. Nucleic Acids Res. 2019;: pubmed publisher |
| Zimmerman K, Bentley M, Lever J, Li Z, Crossman D, Song C, et al. Single-Cell RNA Sequencing Identifies Candidate Renal Resident Macrophage Gene Expression Signatures across Species. J Am Soc Nephrol. 2019;30:767-781 pubmed publisher |
| Afzal S, Garg S, Ishida Y, Terao K, Kaul S, Wadhwa R. Rat Glioma Cell-Based Functional Characterization of Anti-Stress and Protein Deaggregation Activities in the Marine Carotenoids, Astaxanthin and Fucoxanthin. Mar Drugs. 2019;17: pubmed publisher |
| Alfano L, Caporaso A, Altieri A, Dell Aquila M, Landi C, Bini L, et al. Depletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation. Nucleic Acids Res. 2019;47:4068-4085 pubmed publisher |
| Li C, Mahon C, Sweeney N, Verschueren E, Kantamani V, Li D, et al. PPARγ Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis. Cell Rep. 2019;26:1333-1343.e7 pubmed publisher |
| Schmid B, Prehn K, Nimsanor N, Garcia B, Poulsen U, Jørring I, et al. Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line. Stem Cell Res. 2019;34:101349 pubmed publisher |
| Jachimowicz R, Beleggia F, Isensee J, Velpula B, Goergens J, Bustos M, et al. UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors. Cell. 2019;176:505-519.e22 pubmed publisher |
| Zhao N, Liu C, Van Ingelgom A, Linares C, Kurti A, Knight J, et al. APOE ε2 is associated with increased tau pathology in primary tauopathy. Nat Commun. 2018;9:4388 pubmed publisher |
| Gustafsson N, Färnegårdh K, Bonagas N, Ninou A, Groth P, Wiita E, et al. Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination. Nat Commun. 2018;9:3872 pubmed publisher |
| Hung P, Johnson B, Chen B, Byrum A, Bredemeyer A, Yewdell W, et al. MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining. Mol Cell. 2018;71:332-342.e8 pubmed publisher |
| Müncheberg S, Hay R, Ip W, Meyer T, Weis C, Brenke J, et al. E1B-55K-Mediated Regulation of RNF4 SUMO-Targeted Ubiquitin Ligase Promotes Human Adenovirus Gene Expression. J Virol. 2018;92: pubmed publisher |
| Vadnais C, Chen R, Fraszczak J, Yu Z, Boulais J, Pinder J, et al. GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1. Nat Commun. 2018;9:1418 pubmed publisher |
| Pancholi N, Weitzman M. Serotype-specific restriction of wild-type adenoviruses by the cellular Mre11-Rad50-Nbs1 complex. Virology. 2018;518:221-231 pubmed publisher |
| Liu C, Zhao N, Fu Y, Wang N, Linares C, Tsai C, et al. ApoE4 Accelerates Early Seeding of Amyloid Pathology. Neuron. 2017;96:1024-1032.e3 pubmed publisher |
| Huynh T, Liao F, Francis C, Robinson G, Serrano J, Jiang H, et al. Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis. Neuron. 2017;96:1013-1023.e4 pubmed publisher |
| Zhao N, Liu C, Van Ingelgom A, Martens Y, Linares C, Knight J, et al. Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes. Neuron. 2017;96:115-129.e5 pubmed publisher |
| Zhou H, Kawamura K, Yanagihara H, Kobayashi J, Zhang Akiyama Q. NBS1 is regulated by two kind of mechanisms: ATM-dependent complex formation with MRE11 and RAD50, and cell cycle-dependent degradation of protein. J Radiat Res. 2017;58:487-494 pubmed publisher |
| Morales A, Carrero J, Hung P, Tubbs A, Andrews J, Edelson B, et al. A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages. elife. 2017;6: pubmed publisher |
| Gong Y, Handa N, Kowalczykowski S, de Lange T. PHF11 promotes DSB resection, ATR signaling, and HR. Genes Dev. 2017;31:46-58 pubmed publisher |
| Speiseder T, Hofmann Sieber H, Rodriguez E, Schellenberg A, Akyüz N, Dierlamm J, et al. Efficient Transformation of Primary Human Mesenchymal Stromal Cells by Adenovirus Early Region 1 Oncogenes. J Virol. 2017;91: pubmed publisher |
| Cirilli M, Bereshchenko O, Ermakova O, Nerlov C. Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis. Biochim Biophys Acta Gen Subj. 2017;1861:467-476 pubmed publisher |
| Alvarez P, Genre F, Iglesias M, Augustin J, Tamayo E, Escolà Gil J, et al. Modulation of autoimmune arthritis severity in mice by apolipoprotein E (ApoE) and cholesterol. Clin Exp Immunol. 2016;186:292-303 pubmed publisher |
| Xu Z, Song Z, Li G, Tu H, Liu W, Liu Y, et al. H2B ubiquitination regulates meiotic recombination by promoting chromatin relaxation. Nucleic Acids Res. 2016;44:9681-9697 pubmed |
| Hampp S, Kiessling T, Buechle K, Mansilla S, Thomale J, Rall M, et al. DNA damage tolerance pathway involving DNA polymerase ? and the tumor suppressor p53 regulates DNA replication fork progression. Proc Natl Acad Sci U S A. 2016;113:E4311-9 pubmed publisher |
| Chouinard Watkins R, Pinçon A, Coulombe J, Spencer R, Massenavette L, Plourde M. A Diet Rich in Docosahexaenoic Acid Restores Liver Arachidonic Acid and Docosahexaenoic Acid Concentrations in Mice Homozygous for the Human Apolipoprotein E ?4 Allele. J Nutr. 2016;146:1315-21 pubmed publisher |
| Pinçon A, Coulombe J, Chouinard Watkins R, Plourde M. Human apolipoprotein E allele and docosahexaenoic acid intake modulate peripheral cholesterol homeostasis in mice. J Nutr Biochem. 2016;34:83-8 pubmed publisher |
| Jung B, Kim H, Park G, Luo G, Chang K. Roles of human apolipoprotein E in the infectivity and replication of hepatitis C virus genotype 2a. J Microbiol. 2016;54:451-8 pubmed publisher |
| Sódar B, Kittel A, Pálóczi K, Vukman K, Osteikoetxea X, Szabó Taylor K, et al. Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection. Sci Rep. 2016;6:24316 pubmed publisher |
| Choi Y, Meghani K, Brault M, Leclerc L, He Y, Day T, et al. Platinum and PARP Inhibitor Resistance Due to Overexpression of MicroRNA-622 in BRCA1-Mutant Ovarian Cancer. Cell Rep. 2016;14:429-439 pubmed publisher |
| Mayer A, Baran V, Sakakibara Y, Brzakova A, Ferencova I, Motlik J, et al. DNA damage response during mouse oocyte maturation. Cell Cycle. 2016;15:546-58 pubmed publisher |
| Obermeier K, Sachsenweger J, Friedl T, Pospiech H, Winqvist R, Wiesmüller L. Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients. Oncogene. 2016;35:3796-806 pubmed publisher |
| Tambini M, Pera M, Kanter E, Yang H, Guardia Laguarta C, Holtzman D, et al. ApoE4 upregulates the activity of mitochondria-associated ER membranes. EMBO Rep. 2016;17:27-36 pubmed publisher |
| Bürck C, Mund A, Berscheminski J, Kieweg L, Müncheberg S, Dobner T, et al. KAP1 Is a Host Restriction Factor That Promotes Human Adenovirus E1B-55K SUMO Modification. J Virol. 2016;90:930-46 pubmed publisher |
| Liu X, Chandramouly G, Rass E, Guan Y, Wang G, Hobbs R, et al. LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair. Nat Commun. 2015;6:8325 pubmed publisher |
| Iannascoli C, Palermo V, Murfuni I, Franchitto A, Pichierri P. The WRN exonuclease domain protects nascent strands from pathological MRE11/EXO1-dependent degradation. Nucleic Acids Res. 2015;43:9788-803 pubmed publisher |
| Kijas A, Lim Y, Bolderson E, Cerosaletti K, Gatei M, Jakob B, et al. ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1. Nucleic Acids Res. 2015;43:8352-67 pubmed publisher |
| Lee K, Im J, Shibata E, Park J, Handa N, Kowalczykowski S, et al. MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex. Nat Commun. 2015;6:7744 pubmed publisher |
| Muraki K, Han L, Miller D, Murnane J. Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks. Nucleic Acids Res. 2015;43:7911-30 pubmed publisher |
| Xu Y, Wu X, Her C. hMSH5 Facilitates the Repair of Camptothecin-induced Double-strand Breaks through an Interaction with FANCJ. J Biol Chem. 2015;290:18545-58 pubmed publisher |
| Kobayashi J, Saito Y, Okui M, Miwa N, Komatsu K. Increased oxidative stress in AOA3 cells disturbs ATM-dependent DNA damage responses. Mutat Res Genet Toxicol Environ Mutagen. 2015;782:42-50 pubmed publisher |
| Wimmer P, Berscheminski J, Blanchette P, Groitl P, Branton P, Hay R, et al. PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53. Oncogene. 2016;35:69-82 pubmed publisher |
| Thangavel S, Berti M, Levikova M, Pinto C, Gomathinayagam S, Vujanovic M, et al. DNA2 drives processing and restart of reversed replication forks in human cells. J Cell Biol. 2015;208:545-62 pubmed publisher |
| Patel J, Puck J, Srinivasan R, Brown C, Sunderam U, Kundu K, et al. Nijmegen breakage syndrome detected by newborn screening for T cell receptor excision circles (TRECs). J Clin Immunol. 2015;35:227-33 pubmed publisher |
| Kondratova A, Watanabe T, Marotta M, Cannon M, Segall A, Serre D, et al. Replication fork integrity and intra-S phase checkpoint suppress gene amplification. Nucleic Acids Res. 2015;43:2678-90 pubmed publisher |
| Parameswaran B, Chiang H, Lu Y, Coates J, Deng C, Baer R, et al. Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection. Cell Cycle. 2015;14:437-48 pubmed publisher |
| Badie S, Carlos A, Folio C, Okamoto K, Bouwman P, Jonkers J, et al. BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres. EMBO J. 2015;34:410-24 pubmed publisher |
