product summary
request information :
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Mouse Monoclonal BAP1 Antibody
catalog :
NB110-60521B
quantity :
0.1 ml
price :
299.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
biotin
reactivity :
human
application :
western blot
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NB110-60521B
Product Name :
Mouse Monoclonal BAP1 Antibody
List Price :
299.00 USD
Product Type :
Primary Antibodies
Package Size :
0.1 ml
AltNames :
Cerebral protein 6, cerebral protein-13, cerebral protein-6, DKFZp686N04275, EC 3.4.19.12, FLJ35406, FLJ37180, hucep-6, KIAA0272HUCEP-13, ubiquitin carboxyl-terminal hydrolase BAP1, ubiquitin carboxy-terminal hydrolase, UCHL2, BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase), BRCA1-associated protein 1
Background :
Mutations within the BRCA1 gene, localized to chromosome 17q, are believed to account for approximately 45% of families with increased incidence of both early-onset breast cancer and ovarian cancer. The BRCA1 gene is expressed in numerous tissues, including breast and ovary, and encodes a predicted protein of 1863 amino acids. This protein contains a RING domain near the N-terminus and appears to encode a tumor suppressor. BARD1 (BRCA1-associated RING domain protein 1) and BAP1 (BRCA1-associated protein 1) have both been shown to bind to the N-terminus of BRCA1 and are potential mediators of tumor suppression. BARD1 contains an N-terminal RING domain and three tandem ankyrin repeats. The C-terminus of BARD1 contains a region with sequence homology to BRCA1, termed the BRCT domain. BAP1 is a ubiquitin hydrolase and has been shown to enhance BRCA1-mediated cell growth suppression.
Buffer :
PBS
Clonality :
Monoclonal
Clone :
1G8
Conjugate :
Biotin
Application Summary :
Western Blot
Epitope :
Within the UCH domain of BAP1.
Host :
Mouse
Immunogen :
Full-length human BAP1 protein expressed and purified from E.coli. [UniProt# Q92560]
Isotype :
IgG1 Kappa
Localization :
Nuclear
Preservative :
No Preservative
Purity :
Protein G purified
CrossReactivity :
Human
Storage :
Store at 4C in the dark.
Swissprot Human :
Q92560
TMW :
85 kDa
Uses :
This BAP1 antibody is useful for Western blot. In Western blot a band is seen at ~85 kDa, representing the BAP1 protein.
Research Area :
Apoptosis, Cancer, Cell Cycle and Replication, Chromatin Research, DNA Repair, Tumor Suppressors
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: USA
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.