product summary
request information :
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Rabbit Polyclonal OXPAT Antibody
catalog :
NB110-60511F
quantity :
0.1 ml
price :
299 USD
clonality :
polyclonal
host :
rabbit
conjugate :
FITC
reactivity :
mouse, cow, human, rat
application :
western blot
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NB110-60511F
Product Name :
Rabbit Polyclonal OXPAT Antibody
List Price :
299 USD
Product Type :
Primary Antibodies
Package Size :
0.1 ml
AltNames :
lipid storage droplet protein 5, LSDA5, LSDP5, MLDP, OXPAT, perilipin 5, perilipin-5
Background :
OXPAT (PLIN5/Perilipin 5) is a novel PAT-1 (Perilipin, ADRP and TIP47) that binds to lipid droplets (LDs) and protects them from lipolytic degradation. The tissue distribution of PAT-1 proteins differs considerably, however, all of them are involved in accumulation and metabolism of lipids in LDs. OXPAT covers LDs in the cytosol and its expression is highest in tissues with a high fat-oxidative capacity, such as heart, oxidative (type I) skeletal muscles and brown adipose tissue wherein the OXPAT contents parallel the LD content. OXPAT overexpression in OP-9 and COS-7 cells increased cellular triglyceride storage in parallel with increases in fatty acid oxidation and induction of gene expression of mitochondrial enzymes involved in oxidative metabolism. OXPAT has the potential of modulating the interaction of the major triacylglycerol lipase ATGL with LD as well as with its co-factor CGI-58 in a well control manner to regulate LD lipolysis. OXPAT expression is up-regulated by PPARalpha, and this regulation appears to be part of an expression program that shifts the metabolism of cells from fatty acid storage to oxidation.
Buffer :
50mM sodium borate
Clonality :
Polyclonal
Concentration :
1.01 mg/ml
Conjugate :
FITC
Application Summary :
Western Blot
Host :
Rabbit
Immunogen :
A synthetic peptide made to a C-terminal region of the mouse OXPAT protein, within residues 400-463. [UniProt# Q8BVZ1]
Preservative :
No Preservative
Purity :
Immunogen affinity purified
CrossReactivity :
Human and mouse. Immunogen sequence has 89% homology to rat and 75% homology to bovine.
Storage :
Store at 4C in the dark.
TMW :
50 kDa
Uses :
This OXPAT antibody is useful for Western blot analysis where a band can be seen at ~50 kDa, representing the OXPAT protein.
Research Area :
Diabetes Research, Lipid and Metabolism, Lipid Droplets
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: USA
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.