| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunohistochemistry - paraffin section; human
| Khanna A, Rane J, Kivinummi K, Urbanucci A, Helenius M, Tolonen T, et al. CIP2A is a candidate therapeutic target in clinically challenging prostate cancer cell populations. Oncotarget. 2015;6:19661-70 pubmed |
| Jung H, Phillips B, Chan E. miR-375 activates p21 and suppresses telomerase activity by coordinately regulating HPV E6/E7, E6AP, CIP2A, and 14-3-3?. Mol Cancer. 2014;13:80 pubmed publisher |
| Jung H, Patel R, Phillips B, Wang H, Cohen D, Reinhold W, et al. Tumor suppressor miR-375 regulates MYC expression via repression of CIP2A coding sequence through multiple miRNA-mRNA interactions. Mol Biol Cell. 2013;24:1638-48, S1-7 pubmed publisher |
| Lee J, Jeong H, Park E, Hwang J, Huang B, Bae E, et al. CIP2A facilitates apoptotic resistance of fibroblast-like synoviocytes in rheumatoid arthritis independent of c-Myc expression. Rheumatol Int. 2013;33:2241-8 pubmed publisher |
- immunohistochemistry; human
- western blot; human
| Ma L, Wen Z, Liu Z, Hu Z, Ma J, Chen X, et al. Overexpression and small molecule-triggered downregulation of CIP2A in lung cancer. PLoS ONE. 2011;6:e20159 pubmed publisher |
- immunohistochemistry; human
- western blot; human
| Lee J, Park E, Hwang J, Oh J, Kim H, Bae E, et al. CIP2A expression is associated with synovial hyperplasia and invasive function of fibroblast-like synoviocytes in rheumatoid arthritis. Rheumatol Int. 2012;32:2023-30 pubmed publisher |
| Wang J, Li W, Li L, Yu X, Jia J, Chen C. CIP2A is over-expressed in acute myeloid leukaemia and associated with HL60 cells proliferation and differentiation. Int J Lab Hematol. 2011;33:290-8 pubmed publisher |
- immunohistochemistry; human
- western blot; human
| Li W, Ge Z, Liu C, Liu Z, Bjorkholm M, Jia J, et al. CIP2A is overexpressed in gastric cancer and its depletion leads to impaired clonogenicity, senescence, or differentiation of tumor cells. Clin Cancer Res. 2008;14:3722-8 pubmed publisher |
| Chuang H, Pan J, Cai Y, Rupa D, Huang T, Kuo T, et al. Reciprocal regulation of CIP2A and AR expression in prostate cancer cells. Discov Oncol. 2022;13:87 pubmed publisher |
| Singh G, Storey K. MondoA:MLX complex regulates glucose-dependent gene expression and links to circadian rhythm in liver and brain of the freeze-tolerant wood frog, Rana sylvatica. Mol Cell Biochem. 2020;473:203-216 pubmed publisher |
| Ko J, Shin N, Je Oh L, Jung T, Moon C, Kim T, et al. Silica dioxide nanoparticles aggravate airway inflammation in an asthmatic mouse model via NLRP3 inflammasome activation. Regul Toxicol Pharmacol. 2020;112:104618 pubmed publisher |
| Khanna A, Thoms J, Stringer B, Chung S, Ensbey K, Jue T, et al. Constitutive CHK1 Expression Drives a pSTAT3-CIP2A Circuit that Promotes Glioblastoma Cell Survival and Growth. Mol Cancer Res. 2020;18:709-722 pubmed publisher |
| Endicott S, Boynton D, Beckmann L, Miller R. Long-lived mice with reduced growth hormone signaling have a constitutive upregulation of hepatic chaperone-mediated autophagy. Autophagy. 2020;:1-14 pubmed publisher |
| Wei H, Bu R, Yang Q, Jia J, Li T, Wang Q, et al. Exendin-4 Protects against Hyperglycemia-Induced Cardiomyocyte Pyroptosis via the AMPK-TXNIP Pathway. J Diabetes Res. 2019;2019:8905917 pubmed publisher |
| Macer Wright J, Sileikaite I, Rayner B, Hawkins C. 8-Chloroadenosine Alters the Metabolic Profile and Downregulates Antioxidant and DNA Damage Repair Pathways in Macrophages. Chem Res Toxicol. 2020;33:402-413 pubmed publisher |
| Yuan J, Tan J, Rajamani K, Solly E, King E, Lecce L, et al. Fenofibrate Rescues Diabetes-Related Impairment of Ischemia-Mediated Angiogenesis by PPARα-Independent Modulation of Thioredoxin-Interacting Protein. Diabetes. 2019;68:1040-1053 pubmed publisher |
| Li W, Zhang H, Yang L, Wang Y. Cancerous inhibitor of protein phosphatase 2A regulates cisplatin resistance in ovarian cancer. Oncol Lett. 2019;17:1211-1216 pubmed publisher |
| Sikorski K, Mehta A, Inngjerdingen M, Thakor F, Kling S, Kalina T, et al. A high-throughput pipeline for validation of antibodies. Nat Methods. 2018;15:909-912 pubmed publisher |
| Liu C, Hsu C, Huang T, Lee C, Chen J, Yang S, et al. ER stress-related ATF6 upregulates CIP2A and contributes to poor prognosis of colon cancer. Mol Oncol. 2018;12:1706-1717 pubmed publisher |
| Zhao S, Gao X, Zang S, Li Y, Feng X, Yuan X. MicroRNA-383-5p acts as a prognostic marker and inhibitor of cell proliferation in lung adenocarcinoma by cancerous inhibitor of protein phosphatase 2A. Oncol Lett. 2017;14:3573-3579 pubmed publisher |
| Wang X, Gao P, Wang M, Liu J, Lin J, Zhang S, et al. Feedback between E2F1 and CIP2A regulated by human papillomavirus E7 in cervical cancer: implications for prognosis. Am J Transl Res. 2017;9:2327-2339 pubmed |
| Zaragoza Campillo M, Moran J. Reactive Oxygen Species Evoked by Potassium Deprivation and Staurosporine Inactivate Akt and Induce the Expression of TXNIP in Cerebellar Granule Neurons. Oxid Med Cell Longev. 2017;2017:8930406 pubmed publisher |
| Chen W, Wang J, Luo Y, Wang T, Li X, Li A, et al. Ginsenoside Rb1 and compound K improve insulin signaling and inhibit ER stress-associated NLRP3 inflammasome activation in adipose tissue. J Ginseng Res. 2016;40:351-358 pubmed |
| Ahrens T, Timme S, Ostendorp J, Bogatyreva L, Hoeppner J, Hopt U, et al. Response of esophageal cancer cells to epigenetic inhibitors is mediated via altered thioredoxin activity. Lab Invest. 2016;96:307-16 pubmed publisher |
| Bronner D, Abuaita B, Chen X, Fitzgerald K, Nuñez G, He Y, et al. Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage. Immunity. 2015;43:451-62 pubmed publisher |
| Wang X, Li R, Wang X, Fu Q, Ma S. Umbelliferone ameliorates cerebral ischemia-reperfusion injury via upregulating the PPAR gamma expression and suppressing TXNIP/NLRP3 inflammasome. Neurosci Lett. 2015;600:182-7 pubmed publisher |
| Li Y, Yang J, Chen M, Wang Q, Qin M, Zhang T, et al. Ilexgenin A inhibits endoplasmic reticulum stress and ameliorates endothelial dysfunction via suppression of TXNIP/NLRP3 inflammasome activation in an AMPK dependent manner. Pharmacol Res. 2015;99:101-15 pubmed publisher |
| Zhao Y, Li Q, Zhao W, Li J, Sun Y, Liu K, et al. Astragaloside IV and cycloastragenol are equally effective in inhibition of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in the endothelium. J Ethnopharmacol. 2015;169:210-8 pubmed publisher |
| Li Y, Li J, Li S, Li Y, Wang X, Liu B, et al. Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK. Toxicol Appl Pharmacol. 2015;286:53-63 pubmed publisher |
| Chao T, Wang C, Chen Y, Lai C, Chang F, Tsai Y, et al. Afatinib induces apoptosis in NSCLC without EGFR mutation through Elk-1-mediated suppression of CIP2A. Oncotarget. 2015;6:2164-79 pubmed |
| Song J, Li J, Hou F, Wang X, Liu B. Mangiferin inhibits endoplasmic reticulum stress-associated thioredoxin-interacting protein/NLRP3 inflammasome activation with regulation of AMPK in endothelial cells. Metabolism. 2015;64:428-37 pubmed publisher |
| Wu J, Xu X, Li Y, Kou J, Huang F, Liu B, et al. Quercetin, luteolin and epigallocatechin gallate alleviate TXNIP and NLRP3-mediated inflammation and apoptosis with regulation of AMPK in endothelial cells. Eur J Pharmacol. 2014;745:59-68 pubmed publisher |
| Joshi S, Wang W, Peck A, Khan S. Activation of the NLRP3 inflammasome in association with calcium oxalate crystal induced reactive oxygen species in kidneys. J Urol. 2015;193:1684-91 pubmed publisher |
| Zhai M, Cong L, Han Y, Tu G. CIP2A is overexpressed in osteosarcoma and regulates cell proliferation and invasion. Tumour Biol. 2014;35:1123-8 pubmed publisher |
| Saxena G, Chen J, Shalev A. Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein. J Biol Chem. 2010;285:3997-4005 pubmed publisher |
| Chen J, Cha Molstad H, Szabo A, Shalev A. Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein. Am J Physiol Endocrinol Metab. 2009;296:E1133-9 pubmed publisher |
