| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; mouse; loading ...; fig 1b
| Luckett K, Cracchiolo J, Krishnamoorthy G, Leandro García L, Nagarajah J, Saqcena M, et al. Co-inhibition of SMAD and MAPK signaling enhances 124I uptake in BRAF-mutant thyroid cancers. Endocr Relat Cancer. 2021;28:391-402 pubmed publisher |
- western blot; human; fig 4m
| Mota M, Metge B, Hinshaw D, Alsheikh H, Chen D, Samant R, et al. Merlin deficiency alters the redox management program in breast cancer. Mol Oncol. 2021;15:942-956 pubmed publisher |
- western blot; mouse; loading ...; fig s1
- western blot; human; loading ...; fig s7
| Kim Y, Kim J, Gu S, Jo S, Kim S, Young Kim S, et al. Identification of highly potent and selective inhibitor, TIPTP, of the p22phox-Rubicon axis as a therapeutic agent for rheumatoid arthritis. Sci Rep. 2020;10:4570 pubmed publisher |
- western blot; mouse; 1:500; loading ...; fig 3
| Dyikanov D, Vasiluev P, Rysenkova K, Aleksandrushkina N, Tyurin Kuzmin P, Kulebyakin K, et al. Optimization of CRISPR/Cas9 technology to knock-out genes of interest in aneuploid cell lines. Tissue Eng Part C Methods. 2019;: pubmed publisher |
- western blot; rat; loading ...; fig 3f
| Bitar M, Nader J, Al Ali W, Al Madhoun A, Arefanian H, Al Mulla F. Hydrogen Sulfide Donor NaHS Improves Metabolism and Reduces Muscle Atrophy in Type 2 Diabetes: Implication for Understanding Sarcopenic Pathophysiology. Oxid Med Cell Longev. 2018;2018:6825452 pubmed publisher |
- western blot; human; fig 2
- immunohistochemistry - paraffin section; mouse; fig 5
| Sato N, Takasaka N, Yoshida M, Tsubouchi K, Minagawa S, Araya J, et al. Metformin attenuates lung fibrosis development via NOX4 suppression. Respir Res. 2016;17:107 pubmed publisher |
| Lee J, Kim J, Leem J. Efficacy of Trametinib in Alleviating Cisplatin-Induced Acute Kidney Injury: Inhibition of Inflammation, Oxidative Stress, and Tubular Cell Death in a Mouse Model. Molecules. 2024;29: pubmed publisher |
| Bonanni R, Cariati I, Rinaldi A, Marini M, D Arcangelo G, Tarantino U, et al. Trolox and recombinant Irisin as a potential strategy to prevent neuronal damage induced by random positioning machine exposure in differentiated HT22 cells. PLoS ONE. 2024;19:e0300888 pubmed publisher |
| Yang A, Kim K, Kwon H, Leem J, Song J. 6-Shogaol Ameliorates Liver Inflammation and Fibrosis in Mice on a Methionine- and Choline-Deficient Diet by Inhibiting Oxidative Stress, Cell Death, and Endoplasmic Reticulum Stress. Molecules. 2024;29: pubmed publisher |
| Bonanni R, Abbondante L, Cariati I, Gasbarra E, Tarantino U. Metallosis after Hip Arthroplasty Damages Skeletal Muscle: A Case Report. Geriatrics (Basel). 2023;8: pubmed publisher |
| Festa J, Hussain A, Hackney A, Desai U, Sahota T, Singh H, et al. Elderberry extract improves molecular markers of endothelial dysfunction linked to atherosclerosis. Food Sci Nutr. 2023;11:4047-4059 pubmed publisher |
| Pandey J, Larson Casey J, Patil M, Joshi R, Jiang C, Zhou Y, et al. NOX4-TIM23 interaction regulates NOX4 mitochondrial import and metabolic reprogramming. J Biol Chem. 2023;299:104695 pubmed publisher |
| Jiang Z, Wu L, van der Leeden B, van Rossum A, Niessen H, Krijnen P. NOX2 and NOX5 are increased in cardiac microvascular endothelium of deceased COVID-19 patients. Int J Cardiol. 2023;370:454-462 pubmed publisher |
| Milara J, Mart xed nez Exp xf3 sito F, Montero P, Roger I, Bayarri M, Ribera P, et al. N-acetylcysteine Reduces Inflammasome Activation Induced by SARS-CoV-2 Proteins In Vitro. Int J Mol Sci. 2022;23: pubmed publisher |
| Jo J, Kim J, Leem J. Protective Effects of Orexin A in a Murine Model of Cisplatin-Induced Acute Kidney Injury. J Clin Med. 2022;11: pubmed publisher |
| Piao S, Ding J, Lin X, Nan Q, Xuan M, Jiang Y, et al. Inhibition of RIP1-RIP3-mediated necroptosis attenuates renal fibrosis via Wnt3α/β-catenin/GSK-3β signaling in unilateral ureteral obstruction. PLoS ONE. 2022;17:e0274116 pubmed publisher |
| Chen Y, Wu T, Ho C, Yeh T, Sun G, Tseng C, et al. Blocking of SGLT2 to Eliminate NADPH-Induced Oxidative Stress in Lenses of Animals with Fructose-Induced Diabetes Mellitus. Int J Mol Sci. 2022;23: pubmed publisher |
| Baylan U, Korn A, Emmens R, Schalkwijk C, Niessen H, Krijnen P, et al. Liraglutide treatment attenuates inflammation markers in the cardiac, cerebral and renal microvasculature in streptozotocin-induced diabetic rats. Eur J Clin Invest. 2022;52:e13807 pubmed publisher |
| Fukatsu M, Ohkawara H, Wang X, Alkebsi L, Furukawa M, Mori H, et al. The suppressive effects of Mer inhibition on inflammatory responses in the pathogenesis of LPS-induced ALI/ARDS. Sci Signal. 2022;15:eabd2533 pubmed publisher |
| Ding J, Jin J, Na Lei Y, Cui S, Ying Li H, Lan Zheng H, et al. Exogenous pancreatic kininogenase protects against tacrolimus-induced renal injury by inhibiting PI3K/AKT signaling: The role of bradykinin receptors. Int Immunopharmacol. 2022;105:108547 pubmed publisher |
| Xuan M, Piao S, Ding J, Nan Q, Piao M, Jiang Y, et al. Dapagliflozin Alleviates Renal Fibrosis by Inhibiting RIP1-RIP3-MLKL-Mediated Necroinflammation in Unilateral Ureteral Obstruction. Front Pharmacol. 2021;12:798381 pubmed publisher |
| Youn J, Zhang Y, Wu Y, Cannesson M, Cai H. Therapeutic application of estrogen for COVID-19: Attenuation of SARS-CoV-2 spike protein and IL-6 stimulated, ACE2-dependent NOX2 activation, ROS production and MCP-1 upregulation in endothelial cells. Redox Biol. 2021;46:102099 pubmed publisher |
| Chiou J, Shi Y, Lee Y, Wang L, Chen Y, Chang L. Carboxyl group-modified α-lactalbumin induces TNF-α-mediated apoptosis in leukemia and breast cancer cells through the NOX4/p38 MAPK/PP2A axis. Int J Biol Macromol. 2021;187:513-527 pubmed publisher |
| Jaekel C, Thelen S, Oezel L, Wohltmann M, Wille J, Windolf J, et al. Illuminating the effect of beneficial blue light and ROS-modulating enzymes in Dupuytren's disease. PLoS ONE. 2021;16:e0253777 pubmed publisher |
| Lv Y, Li T, Yang M, Su L, Zhu Z, Zhao S, et al. Melatonin Attenuates Chromium (VI)-Induced Spermatogonial Stem Cell/Progenitor Mitophagy by Restoration of METTL3-Mediated RNA N6-Methyladenosine Modification. Front Cell Dev Biol. 2021;9:684398 pubmed publisher |
| Larson Casey J, Gu L, Kang J, Dhyani A, Carter A. NOX4 regulates macrophage apoptosis resistance to induce fibrotic progression. J Biol Chem. 2021;297:100810 pubmed publisher |
| Chiou J, Huang N, Huang C, Wang L, Lee Y, Shi Y, et al. NOXA-mediated degradation of MCL1 and BCL2L1 causes apoptosis of daunorubicin-treated human acute myeloid leukemia cells. J Cell Physiol. 2021;236:7356-7375 pubmed publisher |
| Chen H, Yan T, Song Z, Ying S, Wu B, Ju X, et al. MD2 blockade prevents modified LDL-induced retinal injury in diabetes by suppressing NADPH oxidase-4 interaction with Toll-like receptor-4. Exp Mol Med. 2021;53:681-694 pubmed publisher |
| Wei X, Lin H, Zhang B, Li M, Chen Y, Huang Y, et al. Phoenixin-20 Prevents ox-LDL-Induced Attachment of Monocytes to Human Aortic Endothelial Cells (HAECs): A Protective Implication in Atherosclerosis. ACS Chem Neurosci. 2021;12:990-997 pubmed publisher |
| Ammon J, Valls D, Eldemerdash M, Patel J, Tran P, Feng L, et al. G protein-coupled receptor kinase 2 modifies the cellular reaction to cisplatin through interactions with NADPH oxidase 4. Mol Cell Biochem. 2021;476:1505-1516 pubmed publisher |
| Li X, Chen X, Liu Y, Zhang P, Zheng Y, Zeng W. The Histone Methyltransferase SETDB1 Modulates Survival of Spermatogonial Stem/Progenitor Cells Through NADPH Oxidase. Front Genet. 2020;11:997 pubmed publisher |
| Huang K, Wang Y, Siu K, Zhang Y, Cai H. Targeting feed-forward signaling of TGFβ/NOX4/DHFR/eNOS uncoupling/TGFβ axis with anti-TGFβ and folic acid attenuates formation of aortic aneurysms: Novel mechanisms and therapeutics. Redox Biol. 2020;38:101757 pubmed publisher |
| Jayachandran I, Sundararajan S, Venkatesan S, Paadukaana S, Balasubramanyam M, Mohan V, et al. Asymmetric dimethylarginine (ADMA) accelerates renal cell fibrosis under high glucose condition through NOX4/ROS/ERK signaling pathway. Sci Rep. 2020;10:16005 pubmed publisher |
| Tsuji S, Nakamura S, Maoka T, Yamada T, Imai T, Ohba T, et al. Antitumour Effects of Astaxanthin and Adonixanthin on Glioblastoma. Mar Drugs. 2020;18: pubmed publisher |
| Pan L, Ren Z, Liu Y, Zhao Y, Li H, Pan X, et al. A novel danshensu derivative ameliorates experimental colitis by modulating NADPH oxidase 4-dependent NLRP3 inflammasome activation. J Cell Mol Med. 2020;: pubmed publisher |
| Jiang J, Huang K, Xu S, Garcia J, Wang C, Cai H. Targeting NOX4 alleviates sepsis-induced acute lung injury via attenuation of redox-sensitive activation of CaMKII/ERK1/2/MLCK and endothelial cell barrier dysfunction. Redox Biol. 2020;36:101638 pubmed publisher |
| Wang C, Chao Y, Xu W, Liu Z, Wang H, Huang K. Myeloid FBW7 deficiency disrupts redox homeostasis and aggravates dietary-induced insulin resistance. Redox Biol. 2020;37:101688 pubmed publisher |
| Kim J, Leem J, Hong H. Protective Effects of SPA0355, a Thiourea Analogue, Against Lipopolysaccharide-Induced Acute Kidney Injury in Mice. Antioxidants (Basel). 2020;9: pubmed publisher |
| Kaushik D, Ashcraft K, Wang H, Shanmugasundaram K, Shah P, Gonzalez G, et al. Nuclear NADPH oxidase-4 associated with disease progression in renal cell carcinoma. Transl Res. 2020;223:1-14 pubmed publisher |
| Yu H, Kim Y, Cho M. Cytoplasm-localized SIRT1 downregulation attenuates apoptosis and cell cycle arrest in cisplatin-resistant lung cancer A549 cells. J Cancer. 2020;11:4495-4509 pubmed publisher |
| Zhou S, Li Z, Liu P, Wang S, Zhao J, Zhang G. Donepezil Prevents ox-LDL-Induced Attachment of THP-1 Monocytes to Human Aortic Endothelial Cells (HAECs). Chem Res Toxicol. 2020;33:975-981 pubmed publisher |
| Wang L, Chiou J, Lee Y, Huang C, Shi Y, Chang L. SIRT3, PP2A and TTP protein stability in the presence of TNF-α on vincristine-induced apoptosis of leukaemia cells. J Cell Mol Med. 2020;24:2552-2565 pubmed publisher |
| Li L, Chen B, Zhu R, Li R, Tian Y, Liu C, et al. Fructus Ligustri Lucidi preserves bone quality through the regulation of gut microbiota diversity, oxidative stress, TMAO and Sirt6 levels in aging mice. Aging (Albany NY). 2019;11:9348-9368 pubmed publisher |
| Chen Y, Wu T, Ho C, Yeh T, Sun G, Kung Y, et al. Dapagliflozin Prevents NOX- and SGLT2-Dependent Oxidative Stress in Lens Cells Exposed to Fructose-Induced Diabetes Mellitus. Int J Mol Sci. 2019;20: pubmed publisher |
| Rojas Morales P, Tapia E, León Contreras J, González Reyes S, Jiménez Osorio A, Trujillo J, et al. Mechanisms of Fasting-Mediated Protection against Renal Injury and Fibrosis Development after Ischemic Acute Kidney Injury. Biomolecules. 2019;9: pubmed publisher |
| He C, Larson Casey J, Davis D, Hanumanthu V, Longhini A, Thannickal V, et al. NOX4 modulates macrophage phenotype and mitochondrial biogenesis in asbestosis. JCI Insight. 2019;4: pubmed publisher |
| Wegner A, Campos N, Robbins M, Haddad A, Cunningham H, Yik J, et al. Acute Changes in NADPH Oxidase 4 in Early Post-Traumatic Osteoarthritis. J Orthop Res. 2019;37:2429-2436 pubmed publisher |
| Ikeda S, Matsushima S, Okabe K, Ikeda M, Ishikita A, Tadokoro T, et al. Blockade of L-type Ca2+ channel attenuates doxorubicin-induced cardiomyopathy via suppression of CaMKII-NF-κB pathway. Sci Rep. 2019;9:9850 pubmed publisher |
| Chen Z, Tao S, Li X, Zeng X, Zhang M, Yao Q. Anagliptin protects neuronal cells against endogenous amyloid β (Aβ)-induced cytotoxicity and apoptosis. Artif Cells Nanomed Biotechnol. 2019;47:2213-2220 pubmed publisher |
| Buck T, Hack C, Berg D, Berg U, Kunz L, Mayerhofer A. The NADPH oxidase 4 is a major source of hydrogen peroxide in human granulosa-lutein and granulosa tumor cells. Sci Rep. 2019;9:3585 pubmed publisher |
| Tang P, Dang H, Huang J, Xu T, Yuan P, Hu J, et al. NADPH oxidase NOX4 is a glycolytic regulator through mROS-HIF1α axis in thyroid carcinomas. Sci Rep. 2018;8:15897 pubmed publisher |
| Lanza Jacoby S, Cheng G. 3,3'-Diindolylmethane enhances apoptosis in docetaxel-treated breast cancer cells by generation of reactive oxygen species. Pharm Biol. 2018;56:407-414 pubmed publisher |
| Liu R, Yan X. Sulforaphane protects rabbit corneas against oxidative stress injury in keratoconus through activation of the Nrf-2/HO-1 antioxidant pathway. Int J Mol Med. 2018;42:2315-2328 pubmed publisher |
| Lindquist R, Bayat Sarmadi J, Leben R, Niesner R, Hauser A. NAD(P)H Oxidase Activity in the Small Intestine Is Predominantly Found in Enterocytes, Not Professional Phagocytes. Int J Mol Sci. 2018;19: pubmed publisher |
| Seo G, Hyun C, Koh D, Park S, Lim Y, Kim Y, et al. A Novel Synthetic Material, BMM, Accelerates Wound Repair by Stimulating Re-Epithelialization and Fibroblast Activation. Int J Mol Sci. 2018;19: pubmed publisher |
| Dai Y, Zhang H, Zhang J, Yan M. Isoquercetin attenuates oxidative stress and neuronal apoptosis after ischemia/reperfusion injury via Nrf2-mediated inhibition of the NOX4/ROS/NF-κB pathway. Chem Biol Interact. 2018;284:32-40 pubmed publisher |
| Moloney J, Jayavelu A, Stanicka J, Roche S, O Brien R, Scholl S, et al. Nuclear membrane-localised NOX4D generates pro-survival ROS in FLT3-ITD-expressing AML. Oncotarget. 2017;8:105440-105457 pubmed publisher |
| Shanmugasundaram K, Nayak B, Friedrichs W, Kaushik D, Rodriguez R, Block K. NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance. Nat Commun. 2017;8:997 pubmed publisher |
| Tsubouchi K, Araya J, Minagawa S, Hara H, Ichikawa A, Saito N, et al. Azithromycin attenuates myofibroblast differentiation and lung fibrosis development through proteasomal degradation of NOX4. Autophagy. 2017;13:1420-1434 pubmed publisher |
| Wang L, Ma R, Guo Y, Sun J, Liu H, Zhu R, et al. Antioxidant Effect of Fructus Ligustri Lucidi Aqueous Extract in Ovariectomized Rats Is Mediated through Nox4-ROS-NF-κB Pathway. Front Pharmacol. 2017;8:266 pubmed publisher |
| Kim Y, Kim S, Tatsunami R, Yamamura H, Fukai T, Ushio Fukai M. ROS-induced ROS release orchestrated by Nox4, Nox2, and mitochondria in VEGF signaling and angiogenesis. Am J Physiol Cell Physiol. 2017;312:C749-C764 pubmed publisher |
| Sigala F, Efentakis P, Karageorgiadi D, Filis K, Zampas P, Iliodromitis E, et al. Reciprocal regulation of eNOS, H2S and CO-synthesizing enzymes in human atheroma: Correlation with plaque stability and effects of simvastatin. Redox Biol. 2017;12:70-81 pubmed publisher |
| Dickson B, Gatie M, Spice D, Kelly G. NOX1 and NOX4 are required for the differentiation of mouse F9 cells into extraembryonic endoderm. PLoS ONE. 2017;12:e0170812 pubmed publisher |
| Sweetwyne M, Pippin J, Eng D, Hudkins K, Chiao Y, Campbell M, et al. The mitochondrial-targeted peptide, SS-31, improves glomerular architecture in mice of advanced age. Kidney Int. 2017;91:1126-1145 pubmed publisher |
| Chen L, Zhao M, Li J, Wang Y, Bao Q, Wu S, et al. Critical role of X-box binding protein 1 in NADPH oxidase 4-triggered cardiac hypertrophy is mediated by receptor interacting protein kinase 1. Cell Cycle. 2017;16:348-359 pubmed publisher |
| Moloney J, Stanicka J, Cotter T. Subcellular localization of the FLT3-ITD oncogene plays a significant role in the production of NOX- and p22phox-derived reactive oxygen species in acute myeloid leukemia. Leuk Res. 2017;52:34-42 pubmed publisher |
| Liu X, Hao B, Ma A, He J, Liu X, Chen J. The Expression of NOX4 in Smooth Muscles of Small Airway Correlates with the Disease Severity of COPD. Biomed Res Int. 2016;2016:2891810 pubmed |
| Dosoki H, Stegemann A, Taha M, Schnittler H, Luger T, Schröder K, et al. Targeting of NADPH oxidase in vitro and in vivo suppresses fibroblast activation and experimental skin fibrosis. Exp Dermatol. 2017;26:73-81 pubmed publisher |
| Maraldi T, Resca E, Nicoli A, Beretti F, Zavatti M, Capodanno F, et al. NADPH oxidase-4 and MATER expressions in granulosa cells: Relationships with ovarian aging. Life Sci. 2016;162:108-14 pubmed publisher |
| Min H, Cha J, Kim K, Kim J, Ghee J, Kim H, et al. Renoprotective Effects of a Highly Selective A3 Adenosine Receptor Antagonist in a Mouse Model of Adriamycin-induced Nephropathy. J Korean Med Sci. 2016;31:1403-12 pubmed publisher |
| Avin K, Chen N, Organ J, Zarse C, O Neill K, Conway R, et al. Skeletal Muscle Regeneration and Oxidative Stress Are Altered in Chronic Kidney Disease. PLoS ONE. 2016;11:e0159411 pubmed publisher |
| Dushpanova A, Agostini S, Ciofini E, Cabiati M, Casieri V, Matteucci M, et al. Gene silencing of endothelial von Willebrand Factor attenuates angiotensin II-induced endothelin-1 expression in porcine aortic endothelial cells. Sci Rep. 2016;6:30048 pubmed publisher |
| Dalal S, Zha Q, Singh M, Singh K. Osteopontin-stimulated apoptosis in cardiac myocytes involves oxidative stress and mitochondrial death pathway: role of a pro-apoptotic protein BIK. Mol Cell Biochem. 2016;418:1-11 pubmed publisher |
| Tyurin Kuzmin P, Zhdanovskaya N, Sukhova A, Sagaradze G, Albert E, Ageeva L, et al. Nox4 and Duox1/2 Mediate Redox Activation of Mesenchymal Cell Migration by PDGF. PLoS ONE. 2016;11:e0154157 pubmed publisher |
| Rajamanickam S, Panneerdoss S, Gorthi A, Timilsina S, Onyeagucha B, Kovalskyy D, et al. Inhibition of FoxM1-Mediated DNA Repair by Imipramine Blue Suppresses Breast Cancer Growth and Metastasis. Clin Cancer Res. 2016;22:3524-36 pubmed publisher |
| Shi Y, Sun X, Sun Y, Hou L, Yao M, Lian K, et al. Elevation of cortical C26:0 due to the decline of peroxisomal β-oxidation potentiates amyloid β generation and spatial memory deficits via oxidative stress in diabetic rats. Neuroscience. 2016;315:125-35 pubmed publisher |
| Austin S, Santhanam A, d Uscio L, Katusic Z. Regional Heterogeneity of Cerebral Microvessels and Brain Susceptibility to Oxidative Stress. PLoS ONE. 2015;10:e0144062 pubmed publisher |
| Cheng G, Lanza Jacoby S. Metformin decreases growth of pancreatic cancer cells by decreasing reactive oxygen species: Role of NOX4. Biochem Biophys Res Commun. 2015;465:41-6 pubmed publisher |
| Youn J, Zhou J, Cai H. Bone Morphogenic Protein 4 Mediates NOX1-Dependent eNOS Uncoupling, Endothelial Dysfunction, and COX2 Induction in Type 2 Diabetes Mellitus. Mol Endocrinol. 2015;29:1123-33 pubmed publisher |
| Yu C, Luo X, Duquette N, Thorin Trescases N, Thorin E. Knockdown of angiopoietin like-2 protects against angiotensin II-induced cerebral endothelial dysfunction in mice. Am J Physiol Heart Circ Physiol. 2015;308:H386-97 pubmed publisher |
| Sanders Y, Liu H, Liu G, Thannickal V. Epigenetic mechanisms regulate NADPH oxidase-4 expression in cellular senescence. Free Radic Biol Med. 2015;79:197-205 pubmed publisher |
| Milara J, Peiró T, Serrano A, Artigues E, Aparicio J, Tenor H, et al. Simvastatin Increases the Ability of Roflumilast N-oxide to Inhibit Cigarette Smoke-Induced Epithelial to Mesenchymal Transition in Well-differentiated Human Bronchial Epithelial Cells in vitro. COPD. 2015;12:320-31 pubmed publisher |
