product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
YAP1 Antibody - BSA Free
catalog :
NB110-58358
quantity :
0.1 ml (also 0.025 ml)
price :
459 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
FITC
clone name :
6C5cc
reactivity :
human, mouse, dogs, zebrafish
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, ChIP-Seq
more info or order :
citations: 79
Published Application/Species/Sample/DilutionReference
  • chromatin immunoprecipitation; mouse; 1:1000; loading ...; fig 6a
Savorani C, Malinverno M, Seccia R, Maderna C, Giannotta M, Terreran L, et al. A dual role of YAP in driving TGFβ-mediated endothelial-to-mesenchymal transition. J Cell Sci. 2021;134: pubmed publisher
  • ChIP-Seq; mouse; loading ...; fig 5b
Lin C, Yao E, Zhang K, Jiang X, Croll S, Thompson Peer K, et al. YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis. elife. 2017;6: pubmed publisher
Very N, Boulet C, Gheeraert C, Berthier A, Johanns M, Bou Saleh M, et al. O-GlcNAcylation controls pro-fibrotic transcriptional regulatory signaling in myofibroblasts. Cell Death Dis. 2024;15:391 pubmed publisher
Enokido T, Horie M, Yoshino S, Suzuki H, Matsuki R, Brunnstr xf6 m H, et al. Distinct microRNA Signature and Suppression of ZFP36L1 Define ASCL1-Positive Lung Adenocarcinoma. Mol Cancer Res. 2024;22:29-40 pubmed publisher
Sunderland A, Williams J, Andreou T, Rippaus N, Fife C, James F, et al. Biglycan and reduced glycolysis are associated with breast cancer cell dormancy in the brain. Front Oncol. 2023;13:1191980 pubmed publisher
Karatsai O, Lehka L, Wojton D, Grabowska A, Duda M, Lenartowski R, et al. Unconventional myosin VI in the heart: Involvement in cardiac dysfunction progressing with age. Biochim Biophys Acta Mol Basis Dis. 2023;1869:166748 pubmed publisher
Macfarlane E, Cavanagh L, Fong Yee C, Tuckermann J, Chen D, Little C, et al. Deletion of the chondrocyte glucocorticoid receptor attenuates cartilage degradation through suppression of early synovial activation in murine posttraumatic osteoarthritis. Osteoarthritis Cartilage. 2023;31:1189-1201 pubmed publisher
Fetiva M, Liss F, Gertzmann D, Thomas J, Gantert B, Vogl M, et al. Oncogenic YAP mediates changes in chromatin accessibility and activity that drive cell cycle gene expression and cell migration. Nucleic Acids Res. 2023;51:4266-4283 pubmed publisher
Meliambro K, Yang Y, de Cos M, Rodriguez Ballestas E, Malkin C, Haydak J, et al. KIBRA upregulation increases susceptibility to podocyte injury and glomerular disease progression. JCI Insight. 2023;8: pubmed publisher
Banerjee P, Kumaravel S, Roy S, Gaddam N, Odeh J, Bayless K, et al. Conjugated Bile Acids Promote Lymphangiogenesis by Modulation of the Reactive Oxygen Species-p90RSK-Vascular Endothelial Growth Factor Receptor 3 Pathway. Cells. 2023;12: pubmed publisher
McCourt J, Stearns Reider K, Mamsa H, Kannan P, Afsharinia M, Shu C, et al. Multi-omics analysis of sarcospan overexpression in mdx skeletal muscle reveals compensatory remodeling of cytoskeleton-matrix interactions that promote mechanotransduction pathways. Skelet Muscle. 2023;13:1 pubmed publisher
Sakabe M, Thompson M, Chen N, Verba M, Hassan A, Lu R, et al. Inhibition of β1-AR/Gαs signaling promotes cardiomyocyte proliferation in juvenile mice through activation of RhoA-YAP axis. elife. 2022;11: pubmed publisher
Hazra R, Brine L, Garcia L, Benz B, Chirathivat N, Shen M, et al. Platr4 is an early embryonic lncRNA that exerts its function downstream on cardiogenic mesodermal lineage commitment. Dev Cell. 2022;57:2450-2468.e7 pubmed publisher
Zhao X, Tang L, Le T, Nguyen B, Chen W, Zheng M, et al. Yap and Taz promote osteogenesis and prevent chondrogenesis in neural crest cells in vitro and in vivo. Sci Signal. 2022;15:eabn9009 pubmed publisher
Kokate S, Ciuba K, Tran V, Kumari R, Tojkander S, Engel U, et al. Caldesmon controls stress fiber force-balance through dynamic cross-linking of myosin II and actin-tropomyosin filaments. Nat Commun. 2022;13:6032 pubmed publisher
De Chiara L, Conte C, Semeraro R, Diaz Bulnes P, Angelotti M, Mazzinghi B, et al. Tubular cell polyploidy protects from lethal acute kidney injury but promotes consequent chronic kidney disease. Nat Commun. 2022;13:5805 pubmed publisher
Moon S, Lee O, Kim B, Park J, Hwang S, Lee S, et al. Estrogen Regulates the Expression and Localization of YAP in the Uterus of Mice. Int J Mol Sci. 2022;23: pubmed publisher
Fang K, Du S, Shen D, Xiong Z, Jiang K, Liang D, et al. SUFU suppresses ferroptosis sensitivity in breast cancer cells via Hippo/YAP pathway. iScience. 2022;25:104618 pubmed publisher
Chen N, Golczer G, Ghose S, Lin B, Langenbucher A, Webb J, et al. YAP1 maintains active chromatin state in head and neck squamous cell carcinomas that promotes tumorigenesis through cooperation with BRD4. Cell Rep. 2022;39:110970 pubmed publisher
Xiao W, Pahlavanneshan M, Eun C, Zhang X, DeKalb C, Mahgoub B, et al. Matrix stiffness mediates pancreatic cancer chemoresistance through induction of exosome hypersecretion in a cancer associated fibroblasts-tumor organoid biomimetic model. Matrix Biol Plus. 2022;14:100111 pubmed publisher
Das A, Adhikary S, Chowdhury A, Barui A. Leveraging Substrate Stiffness to Promote Stem Cell Asymmetric Division via Mechanotransduction-Polarity Protein Axis and Its Bayesian Regression Analysis. Rejuvenation Res. 2022;25:59-69 pubmed publisher
Gu Y, Chen Y, Wei L, Wu S, Shen K, Liu C, et al. ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation. Nat Commun. 2021;12:6711 pubmed publisher
Nacarino Palma A, Gonz xe1 lez Rico F, Rejano Gordillo C, Ordiales Talavero A, Merino J, Fern xe1 ndez Salguero P. The aryl hydrocarbon receptor promotes differentiation during mouse preimplantational embryo development. Stem Cell Reports. 2021;16:2351-2363 pubmed publisher
Zhu M, Peng R, Liang X, Lan Z, Tang M, Hou P, et al. P4HA2-induced prolyl hydroxylation suppresses YAP1-mediated prostate cancer cell migration, invasion, and metastasis. Oncogene. 2021;40:6049-6056 pubmed publisher
Wolfe A, Zhou Q, Toska E, Galeas J, Ku A, Koche R, et al. UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Hicks Berthet J, Ning B, Federico A, Tilston Lunel A, Matschulat A, Ai X, et al. Yap/Taz inhibit goblet cell fate to maintain lung epithelial homeostasis. Cell Rep. 2021;36:109347 pubmed publisher
Chakravarti D, Lee R, Multani A, Santoni A, Keith Z, Hsu W, et al. Telomere dysfunction instigates inflammation in inflammatory bowel disease. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Liu S, Li K, Wagner Florencio L, Tang L, Heallen T, Leach J, et al. Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial infarction. Sci Transl Med. 2021;13: pubmed publisher
Kastan N, Gnedeva K, Alisch T, Petelski A, Huggins D, Chiaravalli J, et al. Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues. Nat Commun. 2021;12:3100 pubmed publisher
Sun X, Malandraki Miller S, Kennedy T, Bassat E, Klaourakis K, Zhao J, et al. The extracellular matrix protein agrin is essential for epicardial epithelial-to-mesenchymal transition during heart development. Development. 2021;148: pubmed publisher
Tang Q, Efe G, Chiarella A, Leung J, Chen M, Yamazoe T, et al. Mutant p53 regulates Survivin to foster lung metastasis. Genes Dev. 2021;35:528-541 pubmed publisher
Li C, Peng Z, Wang Y, Lam G, Nissen N, Tang J, et al. Epithelial Cell Transforming 2 (ECT2) is regulated by Yes-associated protein 1 (YAP1) and mediates pancreatic cancer progression and metastasis. Am J Physiol Gastrointest Liver Physiol. 2021;: pubmed publisher
Zhang H, Gui T, Liu R, Tong K, Wu C, Li Z, et al. Sequential targeting of YAP1 and p21 enhances the elimination of senescent cells induced by the BET inhibitor JQ1. Cell Death Dis. 2021;12:121 pubmed publisher
Passaro F, De Martino I, Zambelli F, Di Benedetto G, Barbato M, D Erchia A, et al. YAP contributes to DNA methylation remodeling upon mouse embryonic stem cell differentiation. J Biol Chem. 2020;: pubmed publisher
Yemanyi F, Raghunathan V. Lysophosphatidic Acid and IL-6 Trans-signaling Interact via YAP/TAZ and STAT3 Signaling Pathways in Human Trabecular Meshwork Cells. Invest Ophthalmol Vis Sci. 2020;61:29 pubmed publisher
Imam Aliagan A, Madungwe N, Tombo N, Feng Y, Bopassa J. Chronic GPER1 Activation Protects Against Oxidative Stress-Induced Cardiomyoblast Death via Preservation of Mitochondrial Integrity and Deactivation of Mammalian Sterile-20-Like Kinase/Yes-Associated Protein Pathway. Front Endocrinol (Lausanne). 2020;11:579161 pubmed publisher
Fomicheva M, Macara I. Genome-wide CRISPR screen identifies noncanonical NF-κB signaling as a regulator of density-dependent proliferation. elife. 2020;9: pubmed publisher
Aharonov A, Shakked A, Umansky K, Savidor A, Genzelinakh A, Kain D, et al. ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration. Nat Cell Biol. 2020;22:1346-1356 pubmed publisher
Gao C, Hu W, Liu F, Zeng Z, Zhu Q, Fan J, et al. Aldo-keto reductase family 1 member B induces aortic valve calcification by activating hippo signaling in valvular interstitial cells. J Mol Cell Cardiol. 2020;150:54-64 pubmed publisher
Lorenzo Martín L, Fernández Parejo N, Menacho Márquez M, Rodríguez Fdez S, Robles Valero J, Zumalave S, et al. VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma. Nat Commun. 2020;11:4788 pubmed publisher
Chakravarti D, Hu B, Mao X, Rashid A, Li J, Li J, et al. Telomere dysfunction activates YAP1 to drive tissue inflammation. Nat Commun. 2020;11:4766 pubmed publisher
Yemanyi F, Vranka J, Raghunathan V. Crosslinked Extracellular Matrix Stiffens Human Trabecular Meshwork Cells Via Dysregulating β-catenin and YAP/TAZ Signaling Pathways. Invest Ophthalmol Vis Sci. 2020;61:41 pubmed publisher
Yamashita A, Yoshitomi H, Kihara S, Toguchida J, Tsumaki N. Culture substrate-associated YAP inactivation underlies chondrogenic differentiation of human induced pluripotent stem cells. Stem Cells Transl Med. 2020;: pubmed publisher
Wilson K, Ameen M, Guo H, Abilez O, Tian L, Mumbach M, et al. Endogenous Retrovirus-Derived lncRNA BANCR Promotes Cardiomyocyte Migration in Humans and Non-human Primates. Dev Cell. 2020;54:694-709.e9 pubmed publisher
Zhang X, Liu P, Shang Y, Kerndl H, Kumstel S, Gong P, et al. Metformin and LW6 impairs pancreatic cancer cells and reduces nuclear localization of YAP1. J Cancer. 2020;11:479-487 pubmed publisher
Liu T, Zhou L, Yang K, Iwasawa K, Kadekaro A, Takebe T, et al. The β-catenin/YAP signaling axis is a key regulator of melanoma-associated fibroblasts. Signal Transduct Target Ther. 2019;4:63 pubmed publisher
Lefort S, Tan S, Balani S, Rafn B, Pellacani D, Hirst M, et al. Initiation of human mammary cell tumorigenesis by mutant KRAS requires YAP inactivation. Oncogene. 2020;39:1957-1968 pubmed publisher
St Jean G, Tsoi M, Abedini A, Levasseur A, Rico C, Morin M, et al. Lats1 and Lats2 are required for the maintenance of multipotency in the Müllerian duct mesenchyme. Development. 2019;146: pubmed publisher
Kattan W, Chen W, Ma X, Lan T, van der Hoeven D, van der Hoeven R, et al. Targeting plasma membrane phosphatidylserine content to inhibit oncogenic KRAS function. Life Sci Alliance. 2019;2: pubmed publisher
Pattschull G, Walz S, Gründl M, Schwab M, Rühl E, Baluapuri A, et al. The Myb-MuvB Complex Is Required for YAP-Dependent Transcription of Mitotic Genes. Cell Rep. 2019;27:3533-3546.e7 pubmed publisher
Chen P, Zhao D, Li J, Liang X, Li J, Chang A, et al. Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma. Cancer Cell. 2019;35:868-884.e6 pubmed publisher
Rueda E, Hall B, Hill M, Swinton P, Tong X, Martin J, et al. The Hippo Pathway Blocks Mammalian Retinal Müller Glial Cell Reprogramming. Cell Rep. 2019;27:1637-1649.e6 pubmed publisher
He Q, Gao Y, Wang T, Zhou L, Zhou W, Yuan Z. Deficiency of Yes-Associated Protein Induces Cataract in Mice. Aging Dis. 2019;10:293-306 pubmed publisher
Ma R, Ren J, Li P, Zhou Y, Zhou M, Hu Z, et al. Activated YAP causes renal damage of type 2 diabetic nephropathy. Eur Rev Med Pharmacol Sci. 2019;23:755-763 pubmed publisher
Mueller K, Glajch K, Huizenga M, Wilson R, Granucci E, Dios A, et al. Hippo Signaling Pathway Dysregulation in Human Huntington's Disease Brain and Neuronal Stem Cells. Sci Rep. 2018;8:11355 pubmed publisher
Liu M, Jiang K, Lin G, Liu P, Yan Y, Ye T, et al. Ajuba inhibits hepatocellular carcinoma cell growth via targeting of β-catenin and YAP signaling and is regulated by E3 ligase Hakai through neddylation. J Exp Clin Cancer Res. 2018;37:165 pubmed publisher
Frank S, Köllmann C, Luong P, Galli G, Zou L, Bernards A, et al. p190 RhoGAP promotes contact inhibition in epithelial cells by repressing YAP activity. J Cell Biol. 2018;217:3183-3201 pubmed publisher
Cai J, Song X, Wang W, Watnick T, Pei Y, Qian F, et al. A RhoA-YAP-c-Myc signaling axis promotes the development of polycystic kidney disease. Genes Dev. 2018;32:781-793 pubmed publisher
Dehghanian F, Hojati Z, Esmaeili F, Masoudi Nejad A. Network-based expression analyses and experimental validations revealed high co-expression between Yap1 and stem cell markers compared to differentiated cells. Genomics. 2018;: pubmed publisher
Artap S, Manderfield L, Smith C, Poleshko A, Aghajanian H, See K, et al. Endocardial Hippo signaling regulates myocardial growth and cardiogenesis. Dev Biol. 2018;440:22-30 pubmed publisher
Xiao Y, Hill M, Zhang M, Martin T, Morikawa Y, Wang S, et al. Hippo Signaling Plays an Essential Role in Cell State Transitions during Cardiac Fibroblast Development. Dev Cell. 2018;45:153-169.e6 pubmed publisher
Zheng Y, Liu B, Wang L, Lei H, Pulgar Prieto K, Pan D. Homeostatic Control of Hpo/MST Kinase Activity through Autophosphorylation-Dependent Recruitment of the STRIPAK PP2A Phosphatase Complex. Cell Rep. 2017;21:3612-3623 pubmed publisher
Meliambro K, Wong J, Ray J, Calizo R, Towne S, Cole B, et al. The Hippo pathway regulator KIBRA promotes podocyte injury by inhibiting YAP signaling and disrupting actin cytoskeletal dynamics. J Biol Chem. 2017;292:21137-21148 pubmed publisher
Leach J, Heallen T, Zhang M, Rahmani M, Morikawa Y, Hill M, et al. Hippo pathway deficiency reverses systolic heart failure after infarction. Nature. 2017;550:260-264 pubmed publisher
Sarkar S, Bristow C, Dey P, Rai K, Perets R, Ramirez Cardenas A, et al. PRKCI promotes immune suppression in ovarian cancer. Genes Dev. 2017;31:1109-1121 pubmed publisher
Morikawa Y, Heallen T, Leach J, Xiao Y, Martin J. Dystrophin-glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation. Nature. 2017;547:227-231 pubmed publisher
Bassat E, Mutlak Y, Genzelinakh A, Shadrin I, Baruch Umansky K, Yifa O, et al. The extracellular matrix protein agrin promotes heart regeneration in mice. Nature. 2017;547:179-184 pubmed publisher
Kim Y, Kim W, Song Y, Kim J, Cho K, Moon H, et al. Deubiquitinase YOD1 potentiates YAP/TAZ activities through enhancing ITCH stability. Proc Natl Acad Sci U S A. 2017;114:4691-4696 pubmed publisher
Hirata H, Samsonov M, Sokabe M. Actomyosin contractility provokes contact inhibition in E-cadherin-ligated keratinocytes. Sci Rep. 2017;7:46326 pubmed publisher
Nakajima H, Yamamoto K, Agarwala S, Terai K, Fukui H, Fukuhara S, et al. Flow-Dependent Endothelial YAP Regulation Contributes to Vessel Maintenance. Dev Cell. 2017;40:523-536.e6 pubmed publisher
Plubell D, Wilmarth P, Zhao Y, Fenton A, Minnier J, Reddy A, et al. Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. Mol Cell Proteomics. 2017;16:873-890 pubmed publisher
Tao G, Kahr P, Morikawa Y, Zhang M, Rahmani M, Heallen T, et al. Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury. Nature. 2016;534:119-23 pubmed publisher
Rizvi S, Yamada D, Hirsova P, Bronk S, Werneburg N, Krishnan A, et al. A Hippo and Fibroblast Growth Factor Receptor Autocrine Pathway in Cholangiocarcinoma. J Biol Chem. 2016;291:8031-47 pubmed publisher
Jung K, McCarthy R, Zhou C, Uprety N, Barton M, Beretta L. MicroRNA Regulates Hepatocytic Differentiation of Progenitor Cells by Targeting YAP1. Stem Cells. 2016;34:1284-96 pubmed publisher
Brusgard J, Choe M, Chumsri S, Renoud K, MacKerell A, Sudol M, et al. RUNX2 and TAZ-dependent signaling pathways regulate soluble E-Cadherin levels and tumorsphere formation in breast cancer cells. Oncotarget. 2015;6:28132-50 pubmed publisher
Chen W, Lin H, Tang M. Matrix-Stiffness-Regulated Inverse Expression of Krüppel-Like Factor 5 and Krüppel-Like Factor 4 in the Pathogenesis of Renal Fibrosis. Am J Pathol. 2015;185:2468-81 pubmed publisher
Cai J, Maitra A, Anders R, Taketo M, Pan D. β-Catenin destruction complex-independent regulation of Hippo-YAP signaling by APC in intestinal tumorigenesis. Genes Dev. 2015;29:1493-506 pubmed publisher
Chen Q, Zhang N, Xie R, Wang W, Cai J, Choi K, et al. Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP. Genes Dev. 2015;29:1285-97 pubmed publisher
Karystinou A, Roelofs A, Neve A, Cantatore F, Wackerhage H, De Bari C. Yes-associated protein (YAP) is a negative regulator of chondrogenesis in mesenchymal stem cells. Arthritis Res Ther. 2015;17:147 pubmed publisher
product information
master code :
NB110-58358
SKU :
NB110-58358
product name :
YAP1 Antibody - BSA Free
unit size :
0.1 ml (also 0.025 ml)
description :
The YAP1 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to YAP1. This antibody reacts with canine,human,mouse,rat,zebrafish,fish - danio rerio (zebrafish). The YAP1 Antibody - BSA Free has been validated for the following applications: Western Blot,Immunohistochemistry,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence,Chromatin Immunoprecipitation,Chemotaxis,IF/IHC,IHC-F,Immunoprecipitation,Immunohistochemistry-Paraffin,Knockdown Validated,Immunoblotting,Simple Western,Chromatin Immunoprecipitation (ChIP),Knockout Validated.
target :
YAP1
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
This YAP1 Antibody was developed against a partial recombinant human YAP1 protein expressed in bacteria. [Uniprot: P46937], N-terminal GST fusion protein
isotype :
IgG
purity :
Immunogen affinity purified
species :
Canine,Human,Mouse,Rat,Zebrafish,Fish - Danio rerio (Zebrafish)
specificity :
Expected reactivity based on immunogen homology: Isoform 4 (100%), Isoform 6 (100%)
theoretical molecular weight :
48 kDa
gene symbol :
YAP1
Antibody validation :
Biological Validation
applications :
Immunohistochemistry,Western Blot,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence,Chromatin Immunoprecipitation,Chemotaxis,IF/IHC,IHC-F,Immunoprecipitation,Immunohistochemistry-Paraffin,Knockdown Validated,Immunoblotting,Simple Western,Chromatin Immunoprecipitation (ChIP),Knockout Validated
USD :
459 USD
alt names :
65 kDa Yes-associated protein, COB1, Protein Yorkie Homolog, Transcriptional Coactivator YAP1, YAP, YAP1-2gamma, YAP2, YAP2L, YAP65, YAP65yes-associated protein 2, Yes Associated Protein, Yes-Associated Protein, Yes-associated protein 1, Yes-associated protein 1, 65kDa, yes-associated protein beta, yes-associated protein delta, Yes-Associated Protein YAP65 Homolog, YKI, yorkie homolog
storage :
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.