product summary
request information :
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Rabbit Polyclonal Lipin 1 Antibody
catalog :
NB110-57151B
quantity :
0.1 ml
price :
299.00 USD
clonality :
polyclonal
host :
rabbit
conjugate :
biotin
reactivity :
human, mouse, rat
application :
western blot
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NB110-57151B
Product Name :
Rabbit Polyclonal Lipin 1 Antibody
List Price :
299.00 USD
Product Type :
Primary Antibodies
Package Size :
0.1 ml
AltNames :
DKFZp781P1796, EC 3.1.3.18, EC 3.1.3.4, EC 5.4.2.7, KIAA0188phosphatidate phosphatase LPIN1, lipin 1, lipin-1, Lipin-1, PAP1
Background :
The Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2 and Lipin-3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin-1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC-1alpha; target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARalpha. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.
Buffer :
PBS
Clonality :
Polyclonal
Conjugate :
Biotin
Application Summary :
Western Blot
Host :
Rabbit
Immunogen :
A synthetic peptide to an internal region (within residues 500-600) of the human LPIN1 protein. [Swiss-Prot# Q14693]
Localization :
Nuclear
Preservative :
No Preservative
Purity :
Immunogen affinity purified
CrossReactivity :
Mouse and human. Immunogen has 94% homology to primate and 76% homology to rat protein.
Storage :
Store at 4C in the dark.
Swissprot Human :
Q14693
TMW :
97 kDa
Uses :
This LPIN1 antibody is useful for Western blot analysis, where a band is seen at ~97 kDa.
Research Area :
Cell Biology, Cell Cycle and Replication, Cholesterol Metabolism, Diabetes Research, Lipid and Metabolism, Signal Transduction
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: USA
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.