product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
TRF-2 Antibody - BSA Free
catalog :
NB110-57130
quantity :
0.1 ml (also 0.025 ml)
price :
469 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
5B12
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, proximity ligation assay, dot blot
more info or order :
citations: 101
Published Application/Species/Sample/DilutionReference
  • chromatin immunoprecipitation; human; loading ...; fig 6f
  • western blot; human; 1:1000; loading ...; fig 6a
Sanchez Vazquez R, Martinez P, Blasco M. AKT-dependent signaling of extracellular cues through telomeres impact on tumorigenesis. PLoS Genet. 2021;17:e1009410 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 2c
  • western blot; human; loading ...; fig 4c
Li P, Meng Y, Wang Y, Li J, Lam M, Wang L, et al. Nuclear localization of Desmoplakin and its involvement in telomere maintenance. Int J Biol Sci. 2019;15:2350-2362 pubmed publisher
  • western blot; human; 1:20,000; loading ...; fig 3i
Benyelles M, Episkopou H, O Donohue M, Kermasson L, Frange P, Poulain F, et al. Impaired telomere integrity and rRNA biogenesis in PARN-deficient patients and knock-out models. EMBO Mol Med. 2019;: pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig s5a
  • immunocytochemistry; human; loading ...; fig s2f
Li J, Miralles Fusté J, Simavorian T, Bartocci C, Tsai J, Karlseder J, et al. TZAP: A telomere-associated protein involved in telomere length control. Science. 2017;355:638-641 pubmed publisher
  • immunocytochemistry; mouse; 1:100; loading ...; fig 4i
Tu Z, Bayazit M, Liu H, Zhang J, Busayavalasa K, Risal S, et al. Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation. Proc Natl Acad Sci U S A. 2017;114:592-597 pubmed publisher
  • immunocytochemistry; human; 1:100; fig 5
Cipressa F, Morciano P, Bosso G, Mannini L, Galati A, Raffa G, et al. A role for Separase in telomere protection. Nat Commun. 2016;7:10405 pubmed publisher
Herrera Moyano E, Porreca R, Ranjha L, Skourti E, Gonzalez Franco R, Stylianakis E, et al. Human SKI component SKIV2L regulates telomeric DNA-RNA hybrids and prevents telomere fragility. iScience. 2024;27:111096 pubmed publisher
Muoio D, Laspata N, Dannenberg R, Curry C, Darkoa Larbi S, Hedglin M, et al. PARP2 promotes Break Induced Replication-mediated telomere fragility in response to replication stress. Nat Commun. 2024;15:2857 pubmed publisher
Bories C, Lejour T, Adolphe F, Kermasson L, Couv xe9 S, Tanguy L, et al. DCLRE1B/Apollo germline mutations associated with renal cell carcinoma impair telomere protection. Biochim Biophys Acta Mol Basis Dis. 2024;1870:167107 pubmed publisher
Ma B, Mart xed nez P, S xe1 nchez V xe1 zquez R, Blasco M. Telomere dynamics in human pluripotent stem cells. Cell Cycle. 2023;22:2505-2521 pubmed publisher
Meng X, Yao D, Imaizumi K, Chen X, Kelley K, Reis N, et al. Assembloid CRISPR screens reveal impact of disease genes in human neurodevelopment. Nature. 2023;622:359-366 pubmed publisher
Sullivan D, Bello F, Silva A, Redding K, Giordano L, Hinchie A, et al. Intact mitochondrial function in the setting of telomere-induced senescence. Aging Cell. 2023;22:e13941 pubmed publisher
Amin A, Morello M, Petrara M, Rizzo B, Argenton F, De Rossi A, et al. Short-Term TERT Inhibition Impairs Cellular Proliferation via a Telomere Length-Independent Mechanism and Can Be Exploited as a Potential Anticancer Approach. Cancers (Basel). 2023;15: pubmed publisher
Zhang T, Rawal Y, Jiang H, Kwon Y, Sung P, Greenberg R. Break-induced replication orchestrates resection-dependent template switching. Nature. 2023;619:201-208 pubmed publisher
Jacome Burbano M, Robin J, Bauwens S, Martin M, Donati E, Mart xed nez L, et al. Non-canonical telomere protection role of FOXO3a of human skeletal muscle cells regulated by the TRF2-redox axis. Commun Biol. 2023;6:561 pubmed publisher
Adwan Shekhidem H, Sharvit L, Huffman D, Manov I, Atzmon G, Shams I. Damage-Free Shortening of Telomeres Is a Potential Strategy Supporting Blind Mole-Rat Longevity. Genes (Basel). 2023;14: pubmed publisher
Fleury H, MacEachern M, Stiefel C, Anand R, Sempeck C, Nebenfuehr B, et al. The APE2 nuclease is essential for DNA double-strand break repair by microhomology-mediated end joining. Mol Cell. 2023;83:1429-1445.e8 pubmed publisher
Rose A, Goncalves T, Cunniffe S, Geiller H, KENT T, Shepherd S, et al. Induction of the alternative lengthening of telomeres pathway by trapping of proteins on DNA. Nucleic Acids Res. 2023;51:6509-6527 pubmed publisher
Jiang H, Kong N, Liu Z, West S, Chan Y. Human Endonuclease ANKLE1 Localizes at the Midbody and Processes Chromatin Bridges to Prevent DNA Damage and cGAS-STING Activation. Adv Sci (Weinh). 2023;10:e2204388 pubmed publisher
Storchova R, Palek M, Palkova N, Veverka P, Brom T, Hofr C, et al. Phosphorylation of TRF2 promotes its interaction with TIN2 and regulates DNA damage response at telomeres. Nucleic Acids Res. 2023;51:1154-1172 pubmed publisher
Romero Zamora D, Hayashi M. A non-catalytic N-terminus domain of WRN prevents mitotic telomere deprotection. Sci Rep. 2023;13:645 pubmed publisher
Dinami R, Pompili L, Petti E, Porru M, D Angelo C, Di Vito S, et al. MiR-182-3p targets TRF2 and impairs tumor growth of triple-negative breast cancer. EMBO Mol Med. 2023;15:e16033 pubmed publisher
Stock A, McDevitt R, Puligilla C, Wang Y, Zhang Y, Wang K, et al. Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes. PLoS Genet. 2022;18:e1010506 pubmed publisher
Mar xed n Gual L, Gonz xe1 lez Rodelas L, M Garcias M, Kratochv xed l L, Valenzuela N, Georges A, et al. Meiotic chromosome dynamics and double strand break formation in reptiles. Front Cell Dev Biol. 2022;10:1009776 pubmed publisher
Iachettini S, Ciccarone F, Maresca C, D Angelo C, Petti E, Di Vito S, et al. The telomeric protein TERF2/TRF2 impairs HMGB1-driven autophagy. Autophagy. 2022;:1-12 pubmed publisher
Kaminski N, Wondisford A, Kwon Y, Lynskey M, Bhargava R, Barroso Gonz xe1 lez J, et al. RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA. Mol Cell. 2022;82:4001-4017.e7 pubmed publisher
Yadav T, Zhang J, Ouyang J, Leung W, Simoneau A, Zou L. TERRA and RAD51AP1 promote alternative lengthening of telomeres through an R- to D-loop switch. Mol Cell. 2022;82:3985-4000.e4 pubmed publisher
Guh C, Shen H, Chen L, Chiu P, Liao I, Lo C, et al. XPF activates break-induced telomere synthesis. Nat Commun. 2022;13:5781 pubmed publisher
Zhang S, Lee E, Lee M, Zhang D. DNA polymerase delta interacting protein 3 facilitates the activation and maintenance of DNA damage checkpoint in response to replication stress. Animal Model Exp Med. 2022;5:461-469 pubmed publisher
Lima M, Freitas M, Hamedani M, Rangel Pozzo A, Zhu X, Mai S. Consecutive Inhibition of Telomerase and Alternative Lengthening Pathway Promotes Hodgkin's Lymphoma Cell Death. Biomedicines. 2022;10: pubmed publisher
Konstantinidou F, Budani M, Marconi G, Gonnella F, Sarra A, Trubiani O, et al. The Aftermath of Long-Term Cigarette Smoking on Telomere Length and Mitochondrial DNA Copy Number in Human Cumulus Cells Prior to In Vitro Fertilization-A Pilot Study. Antioxidants (Basel). 2022;11: pubmed publisher
Silva B, Arora R, Azzalin C. The alternative lengthening of telomeres mechanism jeopardizes telomere integrity if not properly restricted. Proc Natl Acad Sci U S A. 2022;119:e2208669119 pubmed publisher
Xu Q, Mojiri A, Boulahouache L, Morales E, Walther B, Cooke J. Vascular senescence in progeria: role of endothelial dysfunction. Eur Heart J Open. 2022;2:oeac047 pubmed publisher
Mendez Bermudez A, Lototska L, Pousse M, Tessier F, Croce O, Latrick C, et al. Selective pericentromeric heterochromatin dismantling caused by TP53 activation during senescence. Nucleic Acids Res. 2022;50:7493-7510 pubmed publisher
Mart xed nez P, S xe1 nchez V xe1 zquez R, Ferrara Romeo I, Serrano R, Flores J, Blasco M. A mouse model for Li-Fraumeni-Like Syndrome with cardiac angiosarcomas associated to POT1 mutations. PLoS Genet. 2022;18:e1010260 pubmed publisher
Choo S, Lorbeer F, Regalado S, Short S, Wu S, Rieser G, et al. Editing TINF2 as a potential therapeutic approach to restore telomere length in dyskeratosis congenita. Blood. 2022;140:608-618 pubmed publisher
Tanno N, Takemoto K, Takada Horisawa Y, Shimada R, Fujimura S, Tani N, et al. FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis. iScience. 2022;25:104008 pubmed publisher
Dinami R, Petti E, Porru M, Rizzo A, Ganci F, Sacconi A, et al. TRF2 cooperates with CTCF for controlling the oncomiR-193b-3p in colorectal cancer. Cancer Lett. 2022;533:215607 pubmed publisher
Barry R, Sacco O, Mameri A, Stojaspal M, Kartsonis W, Shah P, et al. Rap1 regulates TIP60 function during fate transition between two-cell-like and pluripotent states. Genes Dev. 2022;36:313-330 pubmed publisher
Frank L, Rademacher A, M xfc cke N, Tirier S, Koeleman E, Knotz C, et al. ALT-FISH quantifies alternative lengthening of telomeres activity by imaging of single-stranded repeats. Nucleic Acids Res. 2022;50:e61 pubmed publisher
Zhang K, Tarczykowska A, Gupta D, Pendlebury D, Zuckerman C, Nandakumar J, et al. The TERB1 MYB domain suppresses telomere erosion in meiotic prophase I. Cell Rep. 2022;38:110289 pubmed publisher
Jack A, Kim Y, Strom A, Lee D, Williams B, Schaub J, et al. Compartmentalization of telomeres through DNA-scaffolded phase separation. Dev Cell. 2022;57:277-290.e9 pubmed publisher
De Sadeleer L, McDonough J, Schupp J, Yan X, Vanstapel A, Van Herck A, et al. Lung Microenvironments and Disease Progression in Fibrotic Hypersensitivity Pneumonitis. Am J Respir Crit Care Med. 2022;205:60-74 pubmed publisher
Mangosh T, Grabowska M, Taylor D. SLX4IP N-terminus dictates telomeric localization in ALT-like castration-resistant prostate cancer cell lines. Prostate. 2021;81:1235-1251 pubmed publisher
Lezaja A, Panagopoulos A, Wen Y, Carvalho E, Imhof R, Altmeyer M. RPA shields inherited DNA lesions for post-mitotic DNA synthesis. Nat Commun. 2021;12:3827 pubmed publisher
Silva B, Arora R, Bione S, Azzalin C. TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells. Nat Commun. 2021;12:3760 pubmed publisher
Sharma S, Mukherjee A, Roy S, Bagri S, Lier S, Verma M, et al. Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interaction. Cell Rep. 2021;35:109154 pubmed publisher
Bauwens S, Lototska L, Koundrioukoff S, Debatisse M, Ye J, Gilson E, et al. The Telomeric Protein TRF2 Regulates Replication Origin Activity within Pericentromeric Heterochromatin. Life (Basel). 2021;11: pubmed publisher
Kim C, Sung S, Kim J, Lee H, Jung Y, Shin S, et al. Telomeres reforged with non-telomeric sequences in mouse embryonic stem cells. Nat Commun. 2021;12:1097 pubmed publisher
Kosebent E, Ozturk S. The spatiotemporal expression of TERT and telomere repeat binding proteins in the postnatal mouse testes. Andrologia. 2021;53:e13976 pubmed publisher
Zhang J, Genois M, Ouyang J, Lan L, Zou L. Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies. Mol Cell. 2021;81:1027-1042.e4 pubmed publisher
Lamm N, Read M, Nobis M, Van Ly D, Page S, Masamsetti V, et al. Nuclear F-actin counteracts nuclear deformation and promotes fork repair during replication stress. Nat Cell Biol. 2020;22:1460-1470 pubmed publisher
Drosopoulos W, Deng Z, Twayana S, Kosiyatrakul S, Vladimirova O, Lieberman P, et al. TRF2 Mediates Replication Initiation within Human Telomeres to Prevent Telomere Dysfunction. Cell Rep. 2020;33:108379 pubmed publisher
Viceconte N, Loriot A, Lona Abreu P, Scheibe M, Fradera Sola A, Butter F, et al. PAR-TERRA is the main contributor to telomeric repeat-containing RNA transcripts in normal and cancer mouse cells. RNA. 2021;27:106-121 pubmed publisher
Pinzaru A, Kareh M, Lamm N, Lazzerini Denchi E, Cesare A, Sfeir A. Replication stress conferred by POT1 dysfunction promotes telomere relocalization to the nuclear pore. Genes Dev. 2020;34:1619-1636 pubmed publisher
Querido E, Sfeir A, Chartrand P. Imaging of Telomerase RNA by Single-Molecule Inexpensive FISH Combined with Immunofluorescence. STAR Protoc. 2020;1:100104 pubmed publisher
Hoang S, Kaminski N, Bhargava R, Barroso González J, Lynskey M, García Expósito L, et al. Regulation of ALT-associated homology-directed repair by polyADP-ribosylation. Nat Struct Mol Biol. 2020;27:1152-1164 pubmed publisher
Uysal F, Kosebent E, Toru H, Ozturk S. Decreased expression of TERT and telomeric proteins as human ovaries age may cause telomere shortening. J Assist Reprod Genet. 2020;: pubmed publisher
Segura Bayona S, Villamor Payà M, Attolini C, Koenig L, Sanchiz Calvo M, Boulton S, et al. Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres. Cell Rep. 2020;32:107983 pubmed publisher
Awad A, Glousker G, Lamm N, Tawil S, Hourvitz N, Smoom R, et al. Full length RTEL1 is required for the elongation of the single-stranded telomeric overhang by telomerase. Nucleic Acids Res. 2020;48:7239-7251 pubmed publisher
Laprade H, Querido E, Smith M, Guérit D, Crimmins H, Conomos D, et al. Single-Molecule Imaging of Telomerase RNA Reveals a Recruitment-Retention Model for Telomere Elongation. Mol Cell. 2020;79:115-126.e6 pubmed publisher
Loe T, Li J, Zhang Y, Azeroglu B, BODDY M, Denchi E. Telomere length heterogeneity in ALT cells is maintained by PML-dependent localization of the BTR complex to telomeres. Genes Dev. 2020;34:650-662 pubmed publisher
Lototska L, Yue J, Li J, Giraud Panis M, Songyang Z, Royle N, et al. Human RAP1 specifically protects telomeres of senescent cells from DNA damage. EMBO Rep. 2020;21:e49076 pubmed publisher
Porreca R, Herrera Moyano E, Skourti E, Law P, Gonzalez Franco R, Montoya A, et al. TRF1 averts chromatin remodelling, recombination and replication dependent-break induced replication at mouse telomeres. elife. 2020;9: pubmed publisher
Pan X, Chen Y, Biju B, Ahmed N, Kong J, Goldenberg M, et al. FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops. Sci Rep. 2019;9:19110 pubmed publisher
Hua R, Wei H, Liu C, Zhang Y, Liu S, Guo Y, et al. FBXO47 regulates telomere-inner nuclear envelope integration by stabilizing TRF2 during meiosis. Nucleic Acids Res. 2019;47:11755-11770 pubmed publisher
Sarek G, Kotsantis P, Ruis P, Van Ly D, Margalef P, Borel V, et al. CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle. Nature. 2019;: pubmed publisher
Perera O, Sobinoff A, Teber E, Harman A, Maritz M, Yang S, et al. Telomerase promotes formation of a telomere protective complex in cancer cells. Sci Adv. 2019;5:eaav4409 pubmed publisher
Mukherjee A, Sharma S, Bagri S, Kutum R, Kumar P, Hussain A, et al. Telomere repeat-binding factor 2 binds extensively to extra-telomeric G-quadruplexes and regulates the epigenetic status of several gene promoters. J Biol Chem. 2019;294:17709-17722 pubmed publisher
Masamsetti V, Low R, Mak K, O Connor A, Riffkin C, Lamm N, et al. Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection. Nat Commun. 2019;10:4224 pubmed publisher
Kroustallaki P, Lirussi L, Carracedo S, You P, Esbensen Q, Götz A, et al. SMUG1 Promotes Telomere Maintenance through Telomerase RNA Processing. Cell Rep. 2019;28:1690-1702.e10 pubmed publisher
Pike A, Strong M, Ouyang J, Greider C. TIN2 Functions with TPP1/POT1 To Stimulate Telomerase Processivity. Mol Cell Biol. 2019;39: pubmed publisher
Episkopou H, Diman A, Claude E, Viceconte N, Decottignies A. TSPYL5 Depletion Induces Specific Death of ALT Cells through USP7-Dependent Proteasomal Degradation of POT1. Mol Cell. 2019;: pubmed publisher
Benyelles M, Episkopou H, O Donohue M, Kermasson L, Frange P, Poulain F, et al. Impaired telomere integrity and rRNA biogenesis in PARN-deficient patients and knock-out models. EMBO Mol Med. 2019;11:e10201 pubmed publisher
Min J, Wright W, Shay J. Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52. Genes Dev. 2019;33:814-827 pubmed publisher
Lu R, O Rourke J, Sobinoff A, Allen J, Nelson C, Tomlinson C, et al. The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT). Nat Commun. 2019;10:2252 pubmed publisher
Fouquerel E, Barnes R, Uttam S, Watkins S, Bruchez M, Opresko P. Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis. Mol Cell. 2019;: pubmed publisher
Wallace H, Rana V, Nguyen H, Bosco G. Condensin II subunit NCAPH2 associates with shelterin protein TRF1 and is required for telomere stability. J Cell Physiol. 2019;: pubmed publisher
Wu Y, Li X, Yu J, Bjorkholm M, Xu D. ASF1a inhibition induces p53-dependent growth arrest and senescence of cancer cells. Cell Death Dis. 2019;10:76 pubmed publisher
Mukherjee A, Sharma S, Sengupta S, Saha D, Kumar P, Hussain T, et al. Telomere length-dependent transcription and epigenetic modifications in promoters remote from telomere ends. PLoS Genet. 2018;14:e1007782 pubmed publisher
Chow T, Shi X, Wei J, Guan J, Stadler G, Huang B, et al. Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection. Nat Commun. 2018;9:3583 pubmed publisher
Van Ly D, Low R, Frölich S, Bartolec T, Kafer G, Pickett H, et al. Telomere Loop Dynamics in Chromosome End Protection. Mol Cell. 2018;71:510-525.e6 pubmed publisher
Gu P, Jia S, Takasugi T, Smith E, Nandakumar J, HENDRICKSON E, et al. CTC1-STN1 coordinates G- and C-strand synthesis to regulate telomere length. Aging Cell. 2018;:e12783 pubmed publisher
Mendez Bermudez A, Lototska L, Bauwens S, Giraud Panis M, Croce O, Jamet K, et al. Genome-wide Control of Heterochromatin Replication by the Telomere Capping Protein TRF2. Mol Cell. 2018;70:449-461.e5 pubmed publisher
Bell W, Meeker A, Rizzo A, Rajpara S, Rosenthal I, Flores Bellver M, et al. A unique telomere DNA expansion phenotype in human retinal rod photoreceptors associated with aging and disease. Brain Pathol. 2019;29:45-52 pubmed publisher
Nelson N, Dodson L, Escudero L, Sukumar A, Williams C, Mihalek I, et al. The C-Terminal Extension Unique to the Long Isoform of the Shelterin Component TIN2 Enhances Its Interaction with TRF2 in a Phosphorylation- and Dyskeratosis Congenita Cluster-Dependent Fashion. Mol Cell Biol. 2018;38: pubmed publisher
Biswas U, Stevense M, Jessberger R. SMC1α Substitutes for Many Meiotic Functions of SMC1β but Cannot Protect Telomeres from Damage. Curr Biol. 2018;28:249-261.e4 pubmed publisher
Wang L, Tu Z, Liu C, Liu H, Kaldis P, Chen Z, et al. Dual roles of TRF1 in tethering telomeres to the nuclear envelope and protecting them from fusion during meiosis. Cell Death Differ. 2018;25:1174-1188 pubmed publisher
Zhang J, Tu Z, Watanabe Y, Shibuya H. Distinct TERB1 Domains Regulate Different Protein Interactions in Meiotic Telomere Movement. Cell Rep. 2017;21:1715-1726 pubmed publisher
Ilić A, Lu S, Bhatia V, Begum F, Klonisch T, Agarwal P, et al. Ubiquitin C-terminal hydrolase isozyme L1 is associated with shelterin complex at interstitial telomeric sites. Epigenetics Chromatin. 2017;10:54 pubmed publisher
Hussain T, Saha D, Purohit G, Kar A, Kishore Mukherjee A, Sharma S, et al. Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex. Sci Rep. 2017;7:11541 pubmed publisher
Knecht H, Johnson N, Haliotis T, Lichtensztejn D, Mai S. Disruption of direct 3D telomere-TRF2 interaction through two molecularly disparate mechanisms is a hallmark of primary Hodgkin and Reed-Sternberg cells. Lab Invest. 2017;97:772-781 pubmed publisher
Knecht H, Mai S. The Use of 3D Telomere FISH for the Characterization of the Nuclear Architecture in EBV-Positive Hodgkin's Lymphoma. Methods Mol Biol. 2017;1532:93-104 pubmed
Burla R, Carcuro M, Torre M, Fratini F, Crescenzi M, D Apice M, et al. The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence. Open Biol. 2016;6: pubmed publisher
Benhamou Y, Picco V, Raybaud H, Sudaka A, Chamorey E, Brolih S, et al. Telomeric repeat-binding factor 2: a marker for survival and anti-EGFR efficacy in oral carcinoma. Oncotarget. 2016;7:44236-44251 pubmed publisher
Manterola M, Sicinski P, Wolgemuth D. E-type cyclins modulate telomere integrity in mammalian male meiosis. Chromosoma. 2016;125:253-64 pubmed publisher
Sishc B, Nelson C, McKenna M, Battaglia C, Herndon A, Idate R, et al. Telomeres and Telomerase in the Radiation Response: Implications for Instability, Reprograming, and Carcinogenesis. Front Oncol. 2015;5:257 pubmed publisher
Shibuya H, Hernández Hernández A, Morimoto A, Negishi L, Höög C, Watanabe Y. MAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging Telomere Cap. Cell. 2015;163:1252-1266 pubmed publisher
Ci X, Li B, Ma X, Kong F, Zheng C, Björkholm M, et al. Bortezomib-mediated down-regulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells. Oncotarget. 2015;6:38079-92 pubmed publisher
Badie S, Carlos A, Folio C, Okamoto K, Bouwman P, Jonkers J, et al. BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres. EMBO J. 2015;34:410-24 pubmed publisher
Wood A, Rendtlew Danielsen J, Lucas C, Rice E, Scalzo D, Shimi T, et al. TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends. Nat Commun. 2014;5:5467 pubmed publisher
product information
master code :
NB110-57130
SKU :
NB110-57130
product name :
TRF-2 Antibody - BSA Free
unit size :
0.1 ml (also 0.025 ml)
description :
The TRF-2 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to TRF-2. This antibody reacts with chinese hamster,human,mouse,primate,rat. The TRF-2 Antibody - BSA Free has been validated for the following applications: Western Blot,Immunocytochemistry/ Immunofluorescence,Flow (Intracellular),Chemotaxis,Cytometric Bead Assay Standard,FISH,IF/IHC,Knockdown,ELISA,Immunoprecipitation,Proximity Ligation Assay,Chromatin Immunoprecipitation (ChIP),Flow Cytometry,Immunohistochemistry,Immunohistochemistry-Paraffin,Dot Blot,Simple Western,Knockdown Validated.
target :
TRF-2
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
This TRF-2 Antibody was developed against Baculovirus purified TRF2 protein.
isotype :
IgG
purity :
Immunogen affinity purified
species :
Chinese Hamster,Human,Mouse,Primate,Rat
theoretical molecular weight :
59.6 kDa
gene symbol :
TERF2
Antibody validation :
Knockout/Knockdown
applications :
Western Blot,Immunocytochemistry/ Immunofluorescence,Flow (Intracellular),Chemotaxis,Cytometric Bead Assay Standard,FISH,IF/IHC,Knockdown,ELISA,Immunoprecipitation,Proximity Ligation Assay,Chromatin Immunoprecipitation (ChIP),Flow Cytometry,Immunohistochemistry,Immunohistochemistry-Paraffin,Dot Blot,Simple Western,Knockdown Validated
USD :
469 USD
alt names :
Telomeric DNA-binding protein, telomeric repeat binding factor 2, Telomeric repeat binding protein 2, telomeric repeat-binding factor 2, TERF2, TRBF2, TRF2, TTAGGG repeat binding factor 2, TTAGGG repeat-binding factor 2
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.