product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
OPA1 Antibody - BSA Free
catalog :
NB110-55290
quantity :
0.1 ml (also 0.025 ml)
price :
399 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
ep190b
reactivity :
human, mouse, rat, chicken, zebrafish
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry knockout validation
more info or order :
citations: 207
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry knockout validation; mouse; 1:100; loading ...; fig s2f
Gómez Valadés A, Pozo M, Varela L, Boudjadja M, Ramirez S, Chivite I, et al. Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis. Cell Metab. 2021;: pubmed publisher
  • western blot; human; 1:500; loading ...; fig 6f
  • western blot; mouse; 1:500; loading ...; fig 5c
Xu L, Humphries F, Delagic N, Wang B, Holland A, Edgar K, et al. ECSIT is a critical limiting factor for cardiac function. JCI Insight. 2021;6: pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 4g
Tan L, Toops K, Lakkaraju A. Protective responses to sublytic complement in the retinal pigment epithelium. Proc Natl Acad Sci U S A. 2016;113:8789-94 pubmed publisher
  • western blot; human; fig s1
Kobayashi K, Araya J, Minagawa S, Hara H, Saito N, Kadota T, et al. Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis. J Immunol. 2016;197:504-16 pubmed publisher
Senthil K, Ranganathan A, Piel S, Hefti M, Reeder R, Kirschen M, et al. Elevated serum neurologic biomarker profiles after cardiac arrest in a porcine model. Resusc Plus. 2024;19:100726 pubmed publisher
Filice M, Gattuso A, Imbrogno S, Mazza R, Amelio D, Caferro A, et al. Functional, structural, and molecular remodelling of the goldfish (Carassius auratus) heart under moderate hypoxia. Fish Physiol Biochem. 2024;50:667-685 pubmed publisher
Faiq M, Sengupta T, Nath M, Velpandian T, Saluja D, Dada R, et al. Ocular manifestations of central insulin resistance. Neural Regen Res. 2023;18:1139-1146 pubmed publisher
Yao J, Takenaga K, Koshikawa N, Kida Y, Lin J, Watanabe T, et al. Anticancer effect of a pyrrole-imidazole polyamide-triphenylphosphonium conjugate selectively targeting a common mitochondrial DNA cancer risk variant in cervical cancer cells. Int J Cancer. 2023;152:962-976 pubmed publisher
Saito E, Warren C, Hanegan C, Larsen J, du Randt J, Cannon M, et al. A Novel Ketone-Supplemented Diet Improves Recognition Memory and Hippocampal Mitochondrial Efficiency in Healthy Adult Mice. Metabolites. 2022;12: pubmed publisher
Wang D, Kuang Y, Wan Z, Li P, Zhao J, Zhu H, et al. Aspartate Alleviates Colonic Epithelial Damage by Regulating Intestinal Stem Cell Proliferation and Differentiation via Mitochondrial Dynamics. Mol Nutr Food Res. 2022;66:e2200168 pubmed publisher
Soundararajan R, Hern xe1 ndez Cuervo H, Stearns T, Griswold A, Patil S, Fukumoto J, et al. A-Kinase Anchor Protein 1 deficiency causes mitochondrial dysfunction in mouse model of hyperoxia induced acute lung injury. Front Pharmacol. 2022;13:980723 pubmed publisher
Trewin A, Silver J, Dillon H, Della Gatta P, Parker L, Hiam D, et al. Long non-coding RNA Tug1 modulates mitochondrial and myogenic responses to exercise in skeletal muscle. BMC Biol. 2022;20:164 pubmed publisher
Wongkitikamjorn W, Hosomichi J, Wada E, Maeda H, Satrawaha S, Hong H, et al. Gestational Intermittent Hypoxia Induces Mitochondrial Impairment in the Geniohyoid Muscle of Offspring Rats. Cureus. 2022;14:e25088 pubmed publisher
L xe9 n xe1 rt K, Bank xf3 C, Ujlaki G, P xf3 liska S, Kis G, Cs x151 sz x, et al. Tissue Transglutaminase Knock-Out Preadipocytes and Beige Cells of Epididymal Fat Origin Possess Decreased Mitochondrial Functions Required for Thermogenesis. Int J Mol Sci. 2022;23: pubmed publisher
Ramasubramanian B, Griffith C, Hanson M, Bunquin L, Reddy A, Hegde V, et al. Protective Effects of Chaya against Mitochondrial and Synaptic Toxicities in the Type 2 Diabetes Mouse Model TallyHO. Cells. 2022;11: pubmed publisher
Chidipi B, Angulo M, Shah S, Rieser M, Ullah G, McDonald T, et al. The dynamin-related protein 1 is decreased and the mitochondrial network is altered in Friedreich's ataxia cardiomyopathy. Int J Biochem Cell Biol. 2022;143:106137 pubmed publisher
Li J, Zhang Z, Wang L, Jiang L, Qin Z, Zhao Y, et al. Maresin 1 Attenuates Lipopolysaccharide-Induced Acute Kidney Injury via Inhibiting NOX4/ROS/NF-κB Pathway. Front Pharmacol. 2021;12:782660 pubmed publisher
Meng Q, Zaharieva E, Sasatani M, Kobayashi J. Possible relationship between mitochondrial changes and oxidative stress under low dose-rate irradiation. Redox Rep. 2021;26:160-169 pubmed publisher
Senthil K, Morgan R, Hefti M, Karlsson M, Lautz A, Mavroudis C, et al. Haemodynamic-directed cardiopulmonary resuscitation promotes mitochondrial fusion and preservation of mitochondrial mass after successful resuscitation in a pediatric porcine model. Resusc Plus. 2021;6:100124 pubmed publisher
Chidipi B, Shah S, Reiser M, Kanithi M, Garces A, Cha B, et al. All-Trans Retinoic Acid Increases DRP1 Levels and Promotes Mitochondrial Fission. Cells. 2021;10: pubmed publisher
Sakiyama H, Li L, Kuwahara Otani S, Nakagawa T, Eguchi H, Yoshihara D, et al. A lack of ChREBP inhibits mitochondrial cristae formation in brown adipose tissue. Mol Cell Biochem. 2021;476:3577-3590 pubmed publisher
Portz P, Lee M. Changes in Drp1 Function and Mitochondrial Morphology Are Associated with the α-Synuclein Pathology in a Transgenic Mouse Model of Parkinson's Disease. Cells. 2021;10: pubmed publisher
Reddy A, Sawant N, Morton H, Kshirsagar S, Bunquin L, Yin X, et al. Selective serotonin reuptake inhibitor citalopram ameliorates cognitive decline and protects against amyloid beta-induced mitochondrial dynamics, biogenesis, autophagy, mitophagy and synaptic toxicities in a mouse model of Alzheimer's disease. Hum Mol Genet. 2021;30:789-810 pubmed publisher
Douida A, Batista F, Boto P, Regdon Z, Robaszkiewicz A, Tar K. Cells Lacking PA200 Adapt to Mitochondrial Dysfunction by Enhancing Glycolysis via Distinct Opa1 Processing. Int J Mol Sci. 2021;22: pubmed publisher
Harper S, Bassler J, Peramsetty S, Yang Y, Roberts L, Drummer D, et al. Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial. Exp Gerontol. 2021;143:111111 pubmed publisher
Li G, Chan Y, Wang B, Saad S, George J, Oliver B, et al. E-cigarettes damage the liver and alter nutrient metabolism in pregnant mice and their offspring. Ann N Y Acad Sci. 2020;1475:64-77 pubmed publisher
Hong K, Hu L, Liu X, Simon J, Ptacek T, Zheng X, et al. USP37 promotes deubiquitination of HIF2α in kidney cancer. Proc Natl Acad Sci U S A. 2020;117:13023-13032 pubmed publisher
Ren Z, Guo C, He H, Zuo Z, Hu Y, Yu S, et al. Effects of deoxynivalenol on mitochondrial dynamics and autophagy in pig spleen lymphocytes. Food Chem Toxicol. 2020;140:111357 pubmed publisher
Raynor J, Liu C, Dhungana Y, Guy C, Chapman N, Shi H, et al. Hippo/Mst signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions. J Exp Med. 2020;217: pubmed publisher
Gkagkalidis K, Kampantais S, Dimitriadis G, Gourvas V, Kapoukranidou D, Mironidou Tzouveleki M. Expression of HIF-2a in clear-cell renal cell carcinoma independently predicts overall survival. Med Mol Morphol. 2020;: pubmed publisher
Zakarya R, Sapkota A, Chan Y, Shah J, Saad S, Bottle S, et al. Nitroxides affect neurological deficits and lesion size induced by a rat model of traumatic brain injury. Nitric Oxide. 2020;97:57-65 pubmed publisher
Strassheim D, Karoor V, Nijmeh H, Weston P, Lapel M, Schaack J, et al. c-Jun, Foxo3a, and c-Myc Transcription Factors are Key Regulators of ATP-Mediated Angiogenic Responses in Pulmonary Artery Vasa Vasorum Endothelial Cells. Cells. 2020;9: pubmed publisher
Persson C, von Stedingk K, Fredlund E, Bexell D, Påhlman S, Wigerup C, et al. ARNT-dependent HIF-2 transcriptional activity is not sufficient to regulate downstream target genes in neuroblastoma. Exp Cell Res. 2020;388:111845 pubmed publisher
Ge Y, Shi X, Boopathy S, McDonald J, Smith A, Chao L. Two forms of Opa1 cooperate to complete fusion of the mitochondrial inner-membrane. elife. 2020;9: pubmed publisher
Chao T, Gómez B, Heard T, Smith B, Dubick M, Burmeister D. Burn-induced reductions in mitochondrial abundance and efficiency are more pronounced with small volumes of colloids in swine. Am J Physiol Cell Physiol. 2019;317:C1229-C1238 pubmed publisher
Bacci L, Aiello A, Ripoli C, Loria R, Pugliese D, Pierconti F, et al. H19-Dependent Transcriptional Regulation of β3 and β4 Integrins Upon Estrogen and Hypoxia Favors Metastatic Potential in Prostate Cancer. Int J Mol Sci. 2019;20: pubmed publisher
Tang K, Yu Y, Zhu L, Xu P, Chen J, Ma J, et al. Hypoxia-reprogrammed tricarboxylic acid cycle promotes the growth of human breast tumorigenic cells. Oncogene. 2019;: pubmed publisher
Das B, Pal B, Bhuyan R, Li H, Sarma A, Gayan S, et al. MYC regulates the HIF-2α stemness pathway via Nanog and Sox2 to maintain self-renewal in cancer stem cells versus non-stem cancer cells. Cancer Res. 2019;: pubmed publisher
Knowles H. The Adenosine A2B Receptor Drives Osteoclast-Mediated Bone Resorption in Hypoxic Microenvironments. Cells. 2019;8: pubmed publisher
Chao T, Burmeister D, Corona B, Greising S. Oxidative pathophysiology following volumetric muscle loss injury in a porcine model. J Appl Physiol (1985). 2019;126:1541-1549 pubmed publisher
Duan L, Fong G. Developmental vascular pruning in neonatal mouse retinas is programmed by the astrocytic oxygen-sensing mechanism. Development. 2019;146: pubmed publisher
Chang J, Chang H, Wu Y, Cheng W, Lin T, Chang H, et al. Mitochondrial transplantation regulates antitumour activity, chemoresistance and mitochondrial dynamics in breast cancer. J Exp Clin Cancer Res. 2019;38:30 pubmed publisher
Sasagawa T, Nagamatsu T, Morita K, Mimura N, Iriyama T, Fujii T, et al. HIF-2α, but not HIF-1α, mediates hypoxia-induced up-regulation of Flt-1 gene expression in placental trophoblasts. Sci Rep. 2018;8:17375 pubmed publisher
Krueger K, Catanese L, Sciesielski L, Kirschner K, Scholz H. Deletion of an intronic HIF-2α binding site suppresses hypoxia-induced WT1 expression. Biochim Biophys Acta Gene Regul Mech. 2018;1862:71-83 pubmed publisher
Liu N, Luo J, Kuang D, Xu S, Duan Y, Xia Y, et al. Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α-mediated tumor progression. J Clin Invest. 2019;129:631-646 pubmed publisher
Han J, Lee J, Kong J, Ji Y, Kim J, Choe S, et al. Hypoxia Restrains Lipid Utilization via Protein Kinase A and Adipose Triglyceride Lipase Downregulation through Hypoxia-Inducible Factor. Mol Cell Biol. 2019;39: pubmed publisher
Sikorski K, Mehta A, Inngjerdingen M, Thakor F, Kling S, Kalina T, et al. A high-throughput pipeline for validation of antibodies. Nat Methods. 2018;15:909-912 pubmed publisher
Chen H, Chan Y, Linnane C, Mao Y, Anwer A, Sapkota A, et al. L-Carnitine and extendin-4 improve outcomes following moderate brain contusion injury. Sci Rep. 2018;8:11201 pubmed publisher
Moreno Roig E, Yaromina A, Houben R, Groot A, Dubois L, Vooijs M. Prognostic Role of Hypoxia-Inducible Factor-2α Tumor Cell Expression in Cancer Patients: A Meta-Analysis. Front Oncol. 2018;8:224 pubmed publisher
Du X, Wen J, Wang Y, Karmaus P, Khatamian A, Tan H, et al. Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells. Nature. 2018;558:141-145 pubmed publisher
Lin Z, Liu F, Shi P, Song A, Huang Z, Zou D, et al. Fatty acid oxidation promotes reprogramming by enhancing oxidative phosphorylation and inhibiting protein kinase C. Stem Cell Res Ther. 2018;9:47 pubmed publisher
Liu Y, Tan X, Liu W, Chen X, Hou X, Shen D, et al. Follistatin-like protein 1 plays a tumor suppressor role in clear-cell renal cell carcinoma. Chin J Cancer. 2018;37:2 pubmed publisher
Chen R, Xu M, Nagati J, Garcia J. Coordinate regulation of stress signaling and epigenetic events by Acss2 and HIF-2 in cancer cells. PLoS ONE. 2017;12:e0190241 pubmed publisher
Carew J, Espitia C, Zhao W, Mita M, Mita A, Nawrocki S. Oncolytic reovirus inhibits angiogenesis through induction of CXCL10/IP-10 and abrogation of HIF activity in soft tissue sarcomas. Oncotarget. 2017;8:86769-86783 pubmed publisher
Sadiku P, Willson J, Dickinson R, Murphy F, Harris A, Lewis A, et al. Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses. J Clin Invest. 2017;127:3407-3420 pubmed publisher
Padró M, Louie R, Lananna B, Krieg A, Timmerman L, Chan D. Genome-independent hypoxic repression of estrogen receptor alpha in breast cancer cells. BMC Cancer. 2017;17:203 pubmed publisher
Liu W, Chen H, Wong N, Haynes W, Baker C, Wang X. Pseudohypoxia induced by miR-126 deactivation promotes migration and therapeutic resistance in renal cell carcinoma. Cancer Lett. 2017;394:65-75 pubmed publisher
Chan Y, Saad S, Al Odat I, Oliver B, Pollock C, Jones N, et al. Maternal L-Carnitine Supplementation Improves Brain Health in Offspring from Cigarette Smoke Exposed Mothers. Front Mol Neurosci. 2017;10:33 pubmed publisher
Shiraishi A, Tachi K, Essid N, Tsuboi I, Nagano M, Kato T, et al. Hypoxia promotes the phenotypic change of aldehyde dehydrogenase activity of breast cancer stem cells. Cancer Sci. 2017;108:362-372 pubmed publisher
Endo H, Okami J, Okuyama H, Nishizawa Y, Imamura F, Inoue M. The induction of MIG6 under hypoxic conditions is critical for dormancy in primary cultured lung cancer cells with activating EGFR mutations. Oncogene. 2017;36:2824-2834 pubmed publisher
Leszczynska K, Dobrynin G, Leslie R, Ient J, Boumelha A, Senra J, et al. Preclinical testing of an Atr inhibitor demonstrates improved response to standard therapies for esophageal cancer. Radiother Oncol. 2016;121:232-238 pubmed publisher
Kwak J, Lee N, Lee H, Hong I, Nam J. HIF2?/EFEMP1 cascade mediates hypoxic effects on breast cancer stem cell hierarchy. Oncotarget. 2016;7:43518-43533 pubmed publisher
Szendroi A, Szász A, Kardos M, Tokes A, Idan R, Szucs M, et al. Opposite prognostic roles of HIF1? and HIF2? expressions in bone metastatic clear cell renal cell cancer. Oncotarget. 2016;7:42086-42098 pubmed publisher
Nüsken E, Wohlfarth M, Lippach G, Rauh M, Schneider H, Dotsch J, et al. Reduced Perinatal Leptin Availability May Contribute to Adverse Metabolic Programming in a Rat Model of Uteroplacental Insufficiency. Endocrinology. 2016;157:1813-25 pubmed publisher
Espana Agusti J, Zou X, Wong K, Fu B, Yang F, Tuveson D, et al. Generation and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells. PLoS ONE. 2016;11:e0148055 pubmed publisher
Kim Y, Nam H, Lee J, Park D, Kim C, Yu Y, et al. Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis. Nat Commun. 2016;7:10347 pubmed publisher
Lee S, Frattini V, Bansal M, Castano A, Sherman D, Hutchinson K, et al. An ID2-dependent mechanism for VHL inactivation in cancer. Nature. 2016;529:172-7 pubmed publisher
Su J, Li Z, Cui S, Ji L, Geng H, Chai K, et al. The Local HIF-2α/EPO Pathway in the Bone Marrow is Associated with Excessive Erythrocytosis and the Increase in Bone Marrow Microvessel Density in Chronic Mountain Sickness. High Alt Med Biol. 2015;16:318-30 pubmed publisher
Bohovych I, Fernandez M, Rahn J, Stackley K, Bestman J, Anandhan A, et al. Metalloprotease OMA1 Fine-tunes Mitochondrial Bioenergetic Function and Respiratory Supercomplex Stability. Sci Rep. 2015;5:13989 pubmed publisher
Seidl C, Martinez Sanchez A, Murphy C. Derepression of MicroRNA-138 Contributes to Loss of the Human Articular Chondrocyte Phenotype. Arthritis Rheumatol. 2016;68:398-409 pubmed publisher
Espana Agusti J, Tuveson D, Adams D, Matakidou A. A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of renal tubules. Sci Rep. 2015;5:11061 pubmed publisher
Her Y, Nelson Holte M, MAHER L. Oxygen concentration controls epigenetic effects in models of familial paraganglioma. PLoS ONE. 2015;10:e0127471 pubmed publisher
Påhlman S, Lund L, Jögi A. Differential HIF-1α and HIF-2α Expression in Mammary Epithelial Cells during Fat Pad Invasion, Lactation, and Involution. PLoS ONE. 2015;10:e0125771 pubmed publisher
Yue M, Hinkle K, Davies P, Trushina E, Fiesel F, Christenson T, et al. Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice. Neurobiol Dis. 2015;78:172-95 pubmed publisher
Chen R, Xu M, Nagati J, Hogg R, Das A, Gerard R, et al. The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment. PLoS ONE. 2015;10:e0116515 pubmed publisher
Chen T, Zhou G, Zhou Q, Tang H, Ibe J, Cheng H, et al. Loss of microRNA-17∼92 in smooth muscle cells attenuates experimental pulmonary hypertension via induction of PDZ and LIM domain 5. Am J Respir Crit Care Med. 2015;191:678-92 pubmed publisher
Niemi H, Honkonen K, Korpisalo P, Huusko J, Kansanen E, Merentie M, et al. HIF-1α and HIF-2α induce angiogenesis and improve muscle energy recovery. Eur J Clin Invest. 2014;44:989-99 pubmed publisher
Xu M, Nagati J, Xie J, Li J, Walters H, Moon Y, et al. An acetate switch regulates stress erythropoiesis. Nat Med. 2014;20:1018-26 pubmed publisher
Motzer R, Hutson T, Hudes G, Figlin R, Martini J, English P, et al. Investigation of novel circulating proteins, germ line single-nucleotide polymorphisms, and molecular tumor markers as potential efficacy biomarkers of first-line sunitinib therapy for advanced renal cell carcinoma. Cancer Chemother Pharmacol. 2014;74:739-50 pubmed publisher
Evans C, Wadoodi A, Humphries J, Lu X, Grover S, Saha P, et al. Local accumulation of hypoxia-inducible factor 2 alpha during venous thrombus resolution. Thromb Res. 2014;134:757-60 pubmed publisher
Wong W, Richardson T, Seykora J, Cotsarelis G, Simon M. Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function. J Invest Dermatol. 2015;135:454-461 pubmed publisher
Peng Y, Yuan G, Khan S, Nanduri J, Makarenko V, Reddy V, et al. Regulation of hypoxia-inducible factor-? isoforms and redox state by carotid body neural activity in rats. J Physiol. 2014;592:3841-58 pubmed publisher
Carrera S, Senra J, Acosta M, Althubiti M, Hammond E, De Verdier P, et al. The role of the HIF-1? transcription factor in increased cell division at physiological oxygen tensions. PLoS ONE. 2014;9:e97938 pubmed publisher
Toyoda H, Hirayama J, Sugimoto Y, Uchida K, Ohishi K, Hirayama M, et al. Polycythemia and paraganglioma with a novel somatic HIF2A mutation in a male. Pediatrics. 2014;133:e1787-91 pubmed publisher
Gregg J, Turner R, Chang G, Joshi D, Zhan Y, Chen L, et al. NADPH oxidase NOX4 supports renal tumorigenesis by promoting the expression and nuclear accumulation of HIF2?. Cancer Res. 2014;74:3501-3511 pubmed publisher
Raspaglio G, Petrillo M, Martinelli E, Li Puma D, Mariani M, De Donato M, et al. Sox9 and Hif-2? regulate TUBB3 gene expression and affect ovarian cancer aggressiveness. Gene. 2014;542:173-81 pubmed publisher
Duan L, Takeda K, Fong G. Hematological, hepatic, and retinal phenotypes in mice deficient for prolyl hydroxylase domain proteins in the liver. Am J Pathol. 2014;184:1240-1250 pubmed publisher
Duan L, Takeda K, Fong G. Hypoxia inducible factor-2? regulates the development of retinal astrocytic network by maintaining adequate supply of astrocyte progenitors. PLoS ONE. 2014;9:e84736 pubmed publisher
Ellinghaus P, Heisler I, Unterschemmann K, Haerter M, Beck H, Greschat S, et al. BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I. Cancer Med. 2013;2:611-24 pubmed publisher
Anderson E, Taylor M, Xue X, Ramakrishnan S, Martin A, Xie L, et al. Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia. Proc Natl Acad Sci U S A. 2013;110:E4922-30 pubmed publisher
Zhang T, Niu X, Liao L, Cho E, Yang H. The contributions of HIF-target genes to tumor growth in RCC. PLoS ONE. 2013;8:e80544 pubmed publisher
Tsang W, Shu Y, Kwok P, Zhang F, Lee K, Tang M, et al. CD146+ human umbilical cord perivascular cells maintain stemness under hypoxia and as a cell source for skeletal regeneration. PLoS ONE. 2013;8:e76153 pubmed publisher
Thompson A, Elks P, Marriott H, Eamsamarng S, Higgins K, Lewis A, et al. Hypoxia-inducible factor 2? regulates key neutrophil functions in humans, mice, and zebrafish. Blood. 2014;123:366-76 pubmed publisher
Klotzsche von Ameln A, Prade I, Grosser M, Kettelhake A, Rezaei M, Chavakis T, et al. PHD4 stimulates tumor angiogenesis in osteosarcoma cells via TGF-?. Mol Cancer Res. 2013;11:1337-48 pubmed publisher
Yeh I, Ogba N, Bensigner H, Welford S, Montano M. HEXIM1 down-regulates hypoxia-inducible factor-1? protein stability. Biochem J. 2013;456:195-204 pubmed publisher
David J, Owens T, Barwe S, Rajasekaran A. Gramicidin A induces metabolic dysfunction and energy depletion leading to cell death in renal cell carcinoma cells. Mol Cancer Ther. 2013;12:2296-307 pubmed publisher
Bruells C, Maes K, Rossaint R, Thomas D, Cielen N, Bleilevens C, et al. Prolonged mechanical ventilation alters the expression pattern of angio-neogenetic factors in a pre-clinical rat model. PLoS ONE. 2013;8:e70524 pubmed publisher
Park Y, Park B, Lee S, Choi K, Moon Y, Park H. Hypoxia-inducible factor-2?-dependent hypoxic induction of Wnt10b expression in adipogenic cells. J Biol Chem. 2013;288:26311-22 pubmed publisher
Gottfried E, Lang S, Renner K, Bosserhoff A, Gronwald W, Rehli M, et al. New aspects of an old drug--diclofenac targets MYC and glucose metabolism in tumor cells. PLoS ONE. 2013;8:e66987 pubmed publisher
Nakajima T, Nakajima E, Shearer T, Azuma M. Concerted inhibition of HIF-1? and -2? expression markedly suppresses angiogenesis in cultured RPE cells. Mol Cell Biochem. 2013;383:113-22 pubmed publisher
Jamil S, Cedervall J, Hultman I, Ali R, Margaryan N, Rasmuson A, et al. Neuroblastoma cells injected into experimental mature teratoma reveal a tropism for embryonic loose mesenchyme. Int J Oncol. 2013;43:831-8 pubmed publisher
Adamski J, Price A, Dive C, Makin G. Hypoxia-induced cytotoxic drug resistance in osteosarcoma is independent of HIF-1Alpha. PLoS ONE. 2013;8:e65304 pubmed publisher
Nakayama K. cAMP-response element-binding protein (CREB) and NF-?B transcription factors are activated during prolonged hypoxia and cooperatively regulate the induction of matrix metalloproteinase MMP1. J Biol Chem. 2013;288:22584-95 pubmed publisher
Fukui N, Kageyama Y, Higashi Y, Kihara K, Kizaka Kondoh S, Hiraoka M, et al. Development of a novel interferon-?2b gene construct with a repetitive hypoxia-inducible factor binding site and its suppressive effects on human renal cell carcinoma cell lines in vitro. Int J Clin Oncol. 2014;19:497-504 pubmed publisher
Lee W, Lee J, Lim C, Kim S, Kim S. Structural requirements within protoporphyrin IX in the inhibition of heat shock protein 90. Chem Biol Interact. 2013;204:49-57 pubmed publisher
Kucharzewska P, Christianson H, Welch J, Svensson K, Fredlund E, Ringner M, et al. Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development. Proc Natl Acad Sci U S A. 2013;110:7312-7 pubmed publisher
Onnis B, Fer N, Rapisarda A, Perez V, Melillo G. Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells. J Clin Invest. 2013;123:1615-29 pubmed publisher
Scheuermann T, Li Q, Ma H, Key J, Zhang L, Chen R, et al. Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat Chem Biol. 2013;9:271-6 pubmed publisher
Huang C, Hales B. Effects of exposure to a DNA damaging agent on the hypoxia inducible factors in organogenesis stage mouse limbs. PLoS ONE. 2012;7:e51937 pubmed publisher
Sun H, Xu Y, Yang X, Wang W, Bai H, Shi R, et al. Hypoxia inducible factor 2 alpha inhibits hepatocellular carcinoma growth through the transcription factor dimerization partner 3/ E2F transcription factor 1-dependent apoptotic pathway. Hepatology. 2013;57:1088-97 pubmed publisher
Macaulay I, Thon J, Tijssen M, Steele B, MacDonald B, Meade G, et al. Canonical Wnt signaling in megakaryocytes regulates proplatelet formation. Blood. 2013;121:188-96 pubmed publisher
Havasi A, Haegele J, Gall J, Blackmon S, Ichimura T, Bonegio R, et al. Histone acetyl transferase (HAT) HBO1 and JADE1 in epithelial cell regeneration. Am J Pathol. 2013;182:152-62 pubmed publisher
Persano L, Pistollato F, Rampazzo E, Della Puppa A, Abbadi S, Frasson C, et al. BMP2 sensitizes glioblastoma stem-like cells to Temozolomide by affecting HIF-1? stability and MGMT expression. Cell Death Dis. 2012;3:e412 pubmed publisher
Demachi Okamura A, Torikai H, Akatsuka Y, Miyoshi H, Yoshimori T, Kuzushima K. Autophagy creates a CTL epitope that mimics tumor-associated antigens. PLoS ONE. 2012;7:e47126 pubmed publisher
Xue X, Shah Y. Hypoxia-inducible factor-2? is essential in activating the COX2/mPGES-1/PGE2 signaling axis in colon cancer. Carcinogenesis. 2013;34:163-9 pubmed publisher
Vaapil M, Helczynska K, Villadsen R, Petersen O, Johansson E, Beckman S, et al. Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells. PLoS ONE. 2012;7:e46543 pubmed publisher
Thomas S, Harding M, Smith S, Overdevest J, Nitz M, Frierson H, et al. CD24 is an effector of HIF-1-driven primary tumor growth and metastasis. Cancer Res. 2012;72:5600-12 pubmed publisher
Muratsu Ikeda S, Nangaku M, Ikeda Y, Tanaka T, Wada T, Inagi R. Downregulation of miR-205 modulates cell susceptibility to oxidative and endoplasmic reticulum stresses in renal tubular cells. PLoS ONE. 2012;7:e41462 pubmed publisher
Mihaylova S, Killian A, Mayer K, Pullamsetti S, Schermuly R, Rosengarten B. Effects of anti-inflammatory vagus nerve stimulation on the cerebral microcirculation in endotoxinemic rats. J Neuroinflammation. 2012;9:183 pubmed publisher
Chen R, Xu M, Hogg R, Li J, Little B, Gerard R, et al. The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling. J Biol Chem. 2012;287:30800-11 pubmed publisher
Kiss J, Mollenhauer M, Walmsley S, Kirchberg J, Radhakrishnan P, Niemietz T, et al. Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis. J Immunol. 2012;189:1955-65 pubmed publisher
Lim C, Kiriakidis S, Paleolog E, Davies A. The effects of doxycycline and micronized purified flavonoid fraction on human vein wall remodeling are not hypoxia-inducible factor pathway-dependent. J Vasc Surg. 2012;56:1069-77 pubmed publisher
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product information
master code :
NB110-55290
SKU :
NB110-55290
product name :
OPA1 Antibody - BSA Free
unit size :
0.1 ml (also 0.025 ml)
description :
The OPA1 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to OPA1. This antibody reacts with chicken,human,mouse,porcine,rat,zebrafish,fish - danio rerio (zebrafish). The OPA1 Antibody - BSA Free has been validated for the following applications: Western Blot,Immunohistochemistry,Immunocytochemistry/ Immunofluorescence,IF/IHC,Simple Western,Immunohistochemistry-Paraffin,Immunoblotting.
target :
OPA1
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
A synthetic peptide made to an internal region within residues 500-600 of human OPA1. [Swiss-Prot: O60313]
isotype :
IgG
purity :
Immunogen affinity purified
species :
Chicken,Human,Mouse,Porcine,Rat,Zebrafish,Fish - Danio rerio (Zebrafish)
theoretical molecular weight :
111 kDa
gene symbol :
OPA1
applications :
Immunohistochemistry,Western Blot,Immunocytochemistry/ Immunofluorescence,IF/IHC,Simple Western,Immunohistochemistry-Paraffin,Immunoblotting
USD :
399 USD
alt names :
FLJ12460, KIAA0567dynamin-like 120 kDa protein, mitochondrial, MGM1, mitochondrial dynamin-like GTPase, NPGlargeG, NTGmitochondrial dynamin-like 120 kDa protein, optic atrophy 1 (autosomal dominant), Optic atrophy protein 1
storage :
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.