product summary
request information :
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Rabbit Polyclonal Perilipin-3/TIP47 Antibody
catalog :
NB110-40765B
quantity :
0.1 ml
price :
299.00 USD
clonality :
polyclonal
host :
rabbit
conjugate :
biotin
reactivity :
human, mouse
application :
western blot
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NB110-40765B
Product Name :
Rabbit Polyclonal Perilipin-3/TIP47 Antibody
List Price :
299.00 USD
Product Type :
Primary Antibodies
Package Size :
0.1 ml
AltNames :
M6PRBP1MGC2012, Mannose-6-phosphate receptor-binding protein 1, perilipin 3,47 kDa MPR-binding protein, perilipin-3, Placental protein 17,47 kDa mannose 6-phosphate receptor-binding protein, PP17MGC11117, tail-interacting protein, 47 kD, TIP47mannose-6-phosphate receptor binding protein 1, Cargo selection protein TIP47
Background :
TIP47 has been described as cargo protein involved in the trafficking of the mannose-6-phosphate receptor between endosomes and the Golgi complex. Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. TIP47 has been localized in milk fat globule membranes of human and bovine origin. It has been described as a placental protein, as well. Increased amounts of TIP47 are secreted into circulation of cervix carcinoma patients. Therefore, this protein is probably significant as an oncodevelopmental marker.
Buffer :
PBS
Clonality :
Polyclonal
Conjugate :
Biotin
Application Summary :
Western Blot
Host :
Rabbit
Immunogen :
A synthetic peptide made to a region within the N-terminus (within residues 1-100) of the mouse TIP47 protein. [Swiss-Prot# Q9DBG5]
Localization :
Cytoplasm. Endosome. Membrane associated on endosomes. Detected in the envelope and the core of lipid bodies and in lipid sails.
Preservative :
No Preservative
Purity :
Immunogen affinity purified
CrossReactivity :
Human and mouse.
Storage :
Store at 4C in the dark.
TMW :
47 kDa
Uses :
This TIP47 antibody is useful for Western Blot and Immunocytochemistry/Immunofluorescence. In Western Blot analysis, a band is seen ~47 kDa (isoform B, containing the first 184 residues that isoform A is lacking). In ICC/IF, endosomal staining was observed in U2OS cells.
Research Area :
Golgi Apparatus Markers, Lipid and Metabolism, Lipid Droplets, Signal Transduction
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: USA
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.