product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
TRPA1 Antibody - BSA Free
catalog :
NB110-40763
quantity :
0.1 ml (also 0.025 ml)
price :
469 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
Alexa Fluor 405
clone name :
711-66
reactivity :
human, mouse, rat, zebrafish
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 65
Reference
Hur K, Lee Y, Donio A, Kim S, Lee B, Seo J, et al. Transient receptor potential ankyrin 1 channel modulates the abuse-related mechanisms of methamphetamine through interaction with dopamine transporter. Br J Pharmacol. 2024;181:2794-2809 pubmed publisher
Matsubara M, Muraki Y, Suzuki H, Hatano N, Muraki K. Critical amino acid residues regulating TRPA1 Zn2+ response: A comparative study across species. J Biol Chem. 2024;300:107302 pubmed publisher
Soma C, Hitomi S, Oshima E, Hayashi Y, Soma K, Shibuta I, et al. Involvement of oxidative stress in orofacial mechanical pain hypersensitivity following neonatal maternal separation in rats. Sci Rep. 2023;13:22760 pubmed publisher
Warfield R, Robinson J, Podgorski R, Miller A, Burdo T. Neuroinflammation in the Dorsal Root Ganglia and Dorsal Horn Contributes to Persistence of Nociceptor Sensitization in SIV-Infected Antiretroviral Therapy-Treated Macaques. Am J Pathol. 2023;193:2017-2030 pubmed publisher
Luostarinen S, H xe4 m xe4 l xe4 inen M, Pemmari A, Moilanen E. The regulation of TRPA1 expression and function by Th1 and Th2-type inflammation in human A549 lung epithelial cells. Inflamm Res. 2023;72:1327-1339 pubmed publisher
Wang M, Zhao M, Xu S, Zheng Z, Zhang J, Pan W, et al. TRPA1 deficiency attenuates cardiac fibrosis via regulating GRK5/NFAT signaling in diabetic rats. Biochem Pharmacol. 2023;214:115671 pubmed publisher
Pandey M, Zhang J, Adikaram P, Kittock C, Lue N, Awe A, et al. Specific regulation of mechanical nociception by Gβ5 involves GABA-B receptors. JCI Insight. 2023;8: pubmed publisher
Pereira G, Piton E, Bornholdt J, Dos Santos B, de Almeida A, Dalenogare D, et al. TRPA1 participation in behavioral impairment induced by chronic corticosterone administration. Psychopharmacology (Berl). 2023;240:157-169 pubmed publisher
Yang N, Shao H, Deng J, Yang Y, Tang Z, Wu G, et al. Dictamnine ameliorates chronic itch in DNFB-induced atopic dermatitis mice via inhibiting MrgprA3. Biochem Pharmacol. 2023;208:115368 pubmed publisher
S xe1 nchez J, Mu xf1 oz L, Galindo M xe1 rquez M, Valencia V xe1 squez A, Garc xed a A. Paclitaxel Regulates TRPA1 Function and Expression Through PKA and PKC. Neurochem Res. 2023;48:295-304 pubmed publisher
Ma S, Wang D. Knockout of Trpa1 accelerates age-related cardiac fibrosis and dysfunction. PLoS ONE. 2022;17:e0274618 pubmed publisher
Kusiak A, Jakubowska M, Stopa K, Zhang X, Huang W, Gerasimenko J, et al. Activation of pancreatic stellate cells attenuates intracellular Ca2+ signals due to downregulation of TRPA1 and protects against cell death induced by alcohol metabolites. Cell Death Dis. 2022;13:744 pubmed publisher
Vasavda C, Xu R, Liew J, Kothari R, Dhindsa R, Semenza E, et al. Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain. Sci Adv. 2022;8:eabo5633 pubmed publisher
Lowin T, Laaser S, Kok C, Bruneau E, Pongratz G. Cannabidiol: Influence on B Cells, Peripheral Blood Mononuclear Cells, and Peripheral Blood Mononuclear Cell/Rheumatoid Arthritis Synovial Fibroblast Cocultures. Cannabis Cannabinoid Res. 2022;: pubmed publisher
Marcotti A, Fern xe1 ndez Trillo J, Gonz xe1 lez A, Vizca xed no Escoto M, Ros Arlanz xf3 n P, Romero L, et al. TRPA1 modulation by Sigma-1 receptor prevents oxaliplatin-induced painful peripheral neuropathy. Brain. 2022;: pubmed publisher
Zhu H, Wang Y, He Y, Yu W. Inflammation-mediated macrophage polarization induces TRPV1/TRPA1 heteromers in endometriosis. Am J Transl Res. 2022;14:3066-3078 pubmed
Chen Y, Lian Y, Chen W, Chang C, Tinkov A, Skalny A, et al. Lycium barbarum Polysaccharides and Capsaicin Inhibit Oxidative Stress, Inflammatory Responses, and Pain Signaling in Rats with Dextran Sulfate Sodium-Induced Colitis. Int J Mol Sci. 2022;23: pubmed publisher
Kiss F, Kormos V, Sz x151 ke x, Kecsk xe9 s A, T xf3 th N, Steib A, et al. Functional Transient Receptor Potential Ankyrin 1 and Vanilloid 1 Ion Channels Are Overexpressed in Human Oral Squamous Cell Carcinoma. Int J Mol Sci. 2022;23: pubmed publisher
Yang X, Ling S, Zhou M, Deng H, Qi M, Liu X, et al. Inhibition of TRPA1 Attenuates Oxidative Stress-induced Damage After Traumatic Brain Injury via the ERK/AKT Signaling Pathway. Neuroscience. 2022;494:51-68 pubmed publisher
Szab xf3 K, Kem xe9 ny x, Bal xe1 zs N, Khanfar E, S xe1 ndor Z, Boldizs xe1 r F, et al. Presence of TRPA1 Modifies CD4+/CD8+ T Lymphocyte Ratio and Activation. Pharmaceuticals (Basel). 2022;15: pubmed publisher
Liu Q, Feng L, Han X, Zhang W, Zhang H, Xu L. The TRPA1 Channel Mediates Mechanical Allodynia and Thermal Hyperalgesia in a Rat Bone Cancer Pain Model. Front Pain Res (Lausanne). 2021;2:638620 pubmed publisher
Chen L, Lee M, Chang C, Liou K, Liu S, Chern C, et al. Suppression of Inflammatory and Fibrotic Signals by Cinnamon (Cinnamomum cassia) and Cinnamaldehyde in Cyclophosphamide-Induced Overactive Bladder in Mice. Evid Based Complement Alternat Med. 2021;2021:5205759 pubmed publisher
Chen C, Huang X, Zhu W, Ding C, Huang P, Li R. TRPA1 triggers hyperalgesia and inflammation after tooth bleaching. Sci Rep. 2021;11:17418 pubmed publisher
Luostarinen S, Hamalainen M, Hatano N, Muraki K, Moilanen E. The inflammatory regulation of TRPA1 expression in human A549 lung epithelial cells. Pulm Pharmacol Ther. 2021;70:102059 pubmed publisher
Chen L, Liu S, Xiao L, Chen K, Tang J, Huang C, et al. An initial assessment of the involvement of transglutaminase2 in eosinophilic bronchitis using a disease model developed in C57BL/6 mice. Sci Rep. 2021;11:11946 pubmed publisher
Guan M, Ying S, Wang Y. Increased expression of transient receptor potential channels and neurogenic factors associates with cough severity in a guinea pig model. BMC Pulm Med. 2021;21:187 pubmed publisher
Wamba B, Ghosh P, Mbaveng A, Bhattacharya S, Debarpan M, Depanwita S, et al. Botanical from Piper capense Fruit Can Help to Combat the Melanoma as Demonstrated by In Vitro and In Vivo Studies. Evid Based Complement Alternat Med. 2021;2021:8810368 pubmed publisher
Huang H, Tay S, Ng W, Ng S, Soong T. Targeting novel human transient receptor potential ankyrin 1 splice variation with splice-switching antisense oligonucleotides. Pain. 2021;162:2097-2109 pubmed publisher
Shi L, Lin Y, Jiao Y, Herr S, Tang J, Rogers E, et al. Acrolein scavenger dimercaprol offers neuroprotection in an animal model of Parkinson's disease: implication of acrolein and TRPA1. Transl Neurodegener. 2021;10:13 pubmed publisher
Chen Y, Wang Z, Yeo M, Zhang Q, López Romero A, Ding H, et al. Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine. Gastroenterology. 2021;161:301-317.e16 pubmed publisher
Hoebart C, Rojas Galvan N, Ciotu C, Aykac I, Reissig L, Weninger W, et al. No functional TRPA1 in cardiomyocytes. Acta Physiol (Oxf). 2021;232:e13659 pubmed publisher
Luostarinen S, H xe4 m xe4 l xe4 inen M, Moilanen E. Transient Receptor Potential Ankyrin 1 (TRPA1)-An Inflammation-Induced Factor in Human HaCaT Keratinocytes. Int J Mol Sci. 2021;22: pubmed publisher
Oguri G, Nakajima T, Kikuchi H, Obi S, Nakamura F, Komuro I. Allyl isothiocyanate (AITC) activates nonselective cation currents in human cardiac fibroblasts: possible involvement of TRPA1. Heliyon. 2021;7:e05816 pubmed publisher
Nummenmaa E, Hamalainen M, Pemmari A, Moilanen L, Tuure L, Nieminen R, et al. Transient Receptor Potential Ankyrin 1 (TRPA1) Is Involved in Upregulating Interleukin-6 Expression in Osteoarthritic Chondrocyte Models. Int J Mol Sci. 2020;22: pubmed publisher
Van Liefferinge E, Van Noten N, Degroote J, Vrolix G, Van Poucke M, Peelman L, et al. Expression of Transient Receptor Potential Ankyrin 1 and Transient Receptor Potential Vanilloid 1 in the Gut of the Peri-Weaning Pig Is Strongly Dependent on Age and Intestinal Site. Animals (Basel). 2020;10: pubmed publisher
Wang S, Qi S, Kogure Y, Kanda H, Tian L, Yamamoto S, et al. The ubiquitin E3 ligase Nedd4-2 relieves mechanical allodynia through the ubiquitination of TRPA1 channel in db/db mice. Eur J Neurosci. 2021;53:1691-1704 pubmed publisher
Chen Z, Luo J, Li J, Kim G, Stewart A, Urban J, et al. Interleukin-33 Promotes Serotonin Release from Enterochromaffin Cells for Intestinal Homeostasis. Immunity. 2021;54:151-163.e6 pubmed publisher
Yoshida M, Yamamiya R, Shimizu Y, Yoshimura K. Transgenic Chlamydomonas Expressing Human Transient Receptor Potential Ankyrin 1 (TRPA1) Channels to Assess the Effect of Agonists and Antagonists. Front Pharmacol. 2020;11:578955 pubmed publisher
Li Q, Ma T, Qiu Y, Cui W, Chen T, Zhang W, et al. Connexin 36 Mediates Orofacial Pain Hypersensitivity Through GluK2 and TRPA1. Neurosci Bull. 2020;36:1484-1499 pubmed publisher
Chen L, Yeh Y, Chen Y, Hsu Y, Wang H, Lin P, et al. Targeting interleukin-20 alleviates paclitaxel-induced peripheral neuropathy. Pain. 2020;161:1237-1254 pubmed publisher
Virk H, Rekas M, Biddle M, Wright A, Sousa J, Weston C, et al. Validation of antibodies for the specific detection of human TRPA1. Sci Rep. 2019;9:18500 pubmed publisher
Sahoo S, Majhi R, Tiwari A, Acharya T, Kumar P, Saha S, et al. Transient receptor potential ankyrin1 channel is endogenously expressed in T cells and is involved in immune functions. Biosci Rep. 2019;39: pubmed publisher
Brandolini L, Castelli V, Aramini A, Giorgio C, Bianchini G, Russo R, et al. DF2726A, a new IL-8 signalling inhibitor, is able to counteract chemotherapy-induced neuropathic pain. Sci Rep. 2019;9:11729 pubmed publisher
Ma S, Zhang Y, He K, Wang P, Wang D. Knockout of TRPA1 exacerbates angiotensin II-induced kidney injury. Am J Physiol Renal Physiol. 2019;317:F623-F631 pubmed publisher
Miao F, Wang R, Cui G, Li X, Wang T, Li X. Engagement of MicroRNA-155 in Exaggerated Oxidative Stress Signal and TRPA1 in the Dorsal Horn of the Spinal Cord and Neuropathic Pain During Chemotherapeutic Oxaliplatin. Neurotox Res. 2019;: pubmed publisher
Kameda T, Zvick J, Vuk M, Sadowska A, Tam W, Leung V, et al. Expression and Activity of TRPA1 and TRPV1 in the Intervertebral Disc: Association with Inflammation and Matrix Remodeling. Int J Mol Sci. 2019;20: pubmed publisher
CONKLIN D, Guo Y, Nystoriak M, Jagatheesan G, Obal D, Kilfoil P, et al. TRPA1 channel contributes to myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2019;316:H889-H899 pubmed publisher
Ma W, Chen X, Cerne R, Syed S, Ficorilli J, Cabrera O, et al. Catechol estrogens stimulate insulin secretion in pancreatic β-cells via activation of the transient receptor potential A1 (TRPA1) channel. J Biol Chem. 2019;294:2935-2946 pubmed publisher
Peixoto Neves D, Soni H, Adebiyi A. CGRPergic Nerve TRPA1 Channels Contribute to Epigallocatechin Gallate-Induced Neurogenic Vasodilation. ACS Chem Neurosci. 2019;10:216-220 pubmed publisher
Wang Z, Xu Y, Wang M, Ye J, Liu J, Jiang H, et al. TRPA1 inhibition ameliorates pressure overload-induced cardiac hypertrophy and fibrosis in mice. EBioMedicine. 2018;36:54-62 pubmed publisher
Takahashi N, Chen H, Harris I, Stover D, Selfors L, Bronson R, et al. Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance. Cancer Cell. 2018;33:985-1003.e7 pubmed publisher
Lowin T, Bleck J, Schneider M, Pongratz G. Selective killing of proinflammatory synovial fibroblasts via activation of transient receptor potential ankyrin (TRPA1). Biochem Pharmacol. 2018;154:293-302 pubmed publisher
De Logu F, Nassini R, Materazzi S, Carvalho Gonçalves M, Nosi D, Rossi Degl Innocenti D, et al. Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice. Nat Commun. 2017;8:1887 pubmed publisher
Matsuda K, Okamoto N, Kondo M, Arkwright P, Karasawa K, Ishizaka S, et al. Mast cell hyperactivity underpins the development of oxygen-induced retinopathy. J Clin Invest. 2017;127:3987-4000 pubmed publisher
Nummenmaa E, Hamalainen M, Moilanen L, Moilanen T, Vuolteenaho K, Moilanen E. TRPA1 expression is downregulated by dexamethasone and aurothiomalate in human chondrocytes: TRPA1 as a novel factor and drug target in arthritis. RMD Open. 2017;3:e000556 pubmed publisher
Chen J, Ping Y, Tseng M, Chang Y, Lee H, Hsieh R, et al. Notch1-promoted TRPA1 expression in erythroleukemic cells suppresses erythroid but enhances megakaryocyte differentiation. Sci Rep. 2017;7:42883 pubmed publisher
Hidaka T, Ogawa E, Kobayashi E, Suzuki T, Funayama R, Nagashima T, et al. The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin. Nat Immunol. 2017;18:64-73 pubmed publisher
Lu Y, Piplani H, McAllister S, Hurt C, Gross E. Transient Receptor Potential Ankyrin 1 Activation within the Cardiac Myocyte Limits Ischemia-reperfusion Injury in Rodents. Anesthesiology. 2016;125:1171-1180 pubmed
Nummenmaa E, Hamalainen M, Moilanen L, Paukkeri E, Nieminen R, Moilanen T, et al. Transient receptor potential ankyrin 1 (TRPA1) is functionally expressed in primary human osteoarthritic chondrocytes. Arthritis Res Ther. 2016;18:185 pubmed publisher
Lee K, Lin H, Lee H, Tsai F, Lee T. Loss of Transient Receptor Potential Ankyrin 1 Channel Deregulates Emotion, Learning and Memory, Cognition, and Social Behavior in Mice. Mol Neurobiol. 2017;54:3606-3617 pubmed publisher
Lee K, Lee H, Lin H, Tsay H, Tsai F, Shyue S, et al. Role of transient receptor potential ankyrin 1 channels in Alzheimer's disease. J Neuroinflammation. 2016;13:92 pubmed publisher
Takaya J, Mio K, Shiraishi T, Kurokawa T, Otsuka S, Mori Y, et al. A Potent and Site-Selective Agonist of TRPA1. J Am Chem Soc. 2015;137:15859-64 pubmed publisher
Billeter A, Galbraith N, Walker S, Lawson C, Gardner S, Sarojini H, et al. TRPA1 mediates the effects of hypothermia on the monocyte inflammatory response. Surgery. 2015;158:646-54 pubmed publisher
Weng H, Patel K, Jeske N, Bierbower S, Zou W, Tiwari V, et al. Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain. Neuron. 2015;85:833-46 pubmed publisher
Terada Y, Fujimura M, Nishimura S, Tsubota M, Sekiguchi F, Kawabata A. Roles of Cav3.2 and TRPA1 channels targeted by hydrogen sulfide in pancreatic nociceptive processing in mice with or without acute pancreatitis. J Neurosci Res. 2015;93:361-9 pubmed publisher
product information
master code :
NB110-40763
SKU :
NB110-40763
product name :
TRPA1 Antibody - BSA Free
unit size :
0.1 ml (also 0.025 ml)
description :
The TRPA1 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to TRPA1. This antibody reacts with guinea pig,human,mouse,rat,zebrafish. The TRPA1 Antibody - BSA Free has been validated for the following applications: Western Blot,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence,IF/IHC,ELISA,Flow Cytometry,Immunohistochemistry,Immunohistochemistry-Paraffin,Block/Neutralize,Flow (Intracellular).
target :
TRPA1
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
A synthetic peptide made to a region within the N-terminus (residues 1-100) of the human TRPA1 protein. [Swiss-Prot# O75762]
isotype :
IgG
purity :
Immunogen affinity purified
species :
Guinea Pig,Human,Mouse,Rat,Zebrafish
specificity :
Additional modified form of TRPA1 can also be detected
theoretical molecular weight :
127.5 kDa
gene symbol :
TRPA1
accessionNumbers :
O75762
applications :
Western Blot,Immunocytochemistry/ Immunofluorescence,IF/IHC,ELISA,Flow Cytometry,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Block/Neutralize,Flow (Intracellular)
USD :
469 USD
alt names :
ANKTM1ankyrin-like with transmembrane domains 1, Ankyrin-like with transmembrane domains protein 1, Transformation-sensitive protein p120, transient receptor potential cation channel subfamily A member 1, transient receptor potential cation channel, subfamily A, member 1
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.