product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
BDNF Antibody
catalog :
NB100-98682
quantity :
0.1 ml (also 0.025 ml)
price :
409 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
4H8
reactivity :
human, mouse, rat, zebrafish
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 43
Published Application/Species/Sample/DilutionReference
  • western blot; rat; 1:1000; loading ...; fig 1b
Ding H, Chen J, Su M, Lin Z, Zhan H, Yang F, et al. BDNF promotes activation of astrocytes and microglia contributing to neuroinflammation and mechanical allodynia in cyclophosphamide-induced cystitis. J Neuroinflammation. 2020;17:19 pubmed publisher
Tikhonova M, Shvaikovskaya A, Zhanaeva S, Moysak G, Akopyan A, Rzaev J, et al. Concordance between the In Vivo Content of Neurospecific Proteins (BDNF, NSE, VILIP-1, S100B) in the Hippocampus and Blood in Patients with Epilepsy. Int J Mol Sci. 2023;25: pubmed publisher
Gao Q, Gao Z, Su M, Huang Y, Zhang C, Li C, et al. Umbilical Cord Mesenchymal Stem Cells Overexpressing Heme Oxygenase-1 Promotes Symptoms Recovery in Cystitis Rats by Alleviating Neuroinflammation. Stem Cells Int. 2023;2023:8887091 pubmed publisher
Filimonova E, Pashkov A, Moysak G, Tropynina A, Zhanaeva S, Shvaikovskaya A, et al. Brain but not serum BDNF levels are associated with structural alterations in the hippocampal regions in patients with drug-resistant mesial temporal lobe epilepsy. Front Neurosci. 2023;17:1217702 pubmed publisher
Poon C, Liu Y, Pak S, Zhao R, Aquili L, Tipoe G, et al. Prelimbic Cortical Stimulation with L-methionine Enhances Cognition through Hippocampal DNA Methylation and Neuroplasticity Mechanisms. Aging Dis. 2023;14:112-135 pubmed publisher
Doboszewska U, Soca x142 a K, Pier xf3 g M, Nieoczym D, Sawicki J, Sajn xf3 g A, et al. Dietary Zinc Differentially Regulates the Effects of the GPR39 Receptor Agonist, TC-G 1008, in the Maximal Electroshock Seizure Test and Pentylenetetrazole-Kindling Model of Epilepsy. Cells. 2023;12: pubmed publisher
Staszkiewicz R, G x142 adysz D, Gralewski M, Bry x15b K, Garczarek M, Gadzieli x144 ski M, et al. Usefulness of Detecting Brain-Derived Neurotrophic Factor in Intervertebral Disc Degeneration of the Lumbosacral Spine. Med Sci Monit. 2023;29:e938663 pubmed publisher
Wang M, Wang T, Ji H, Yan J, Wang X, Zhang X, et al. Modulation effect of non-invasive transcranial ultrasound stimulation in an ADHD rat model. J Neural Eng. 2023;20: pubmed publisher
Gao F, Wang J, Yang S, Ji M, Zhu G. Fear extinction induced by activation of PKA ameliorates anxiety-like behavior in PTSD mice. Neuropharmacology. 2023;222:109306 pubmed publisher
Ma W, Wei X, Gu H, Liu D, Luo W, Cao S, et al. Intra-amniotic transplantation of brain-derived neurotrophic factor-modified mesenchymal stem cells treatment for rat fetuses with spina bifida aperta. Stem Cell Res Ther. 2022;13:413 pubmed publisher
Doboszewska U, Sawicki J, Sajn xf3 g A, Szopa A, Serefko A, Soca x142 a K, et al. Alterations of Serum Magnesium Concentration in Animal Models of Seizures and Epilepsy-The Effects of Treatment with a GPR39 Agonist and Knockout of the Gpr39 Gene. Cells. 2022;11: pubmed publisher
Saleem S, Banerjee R, Rajesh Kannan R. Chrysin-Loaded Chitosan Nanoparticle-Mediated Neuroprotection in Aβ1-42-Induced Neurodegenerative Conditions in Zebrafish. ACS Chem Neurosci. 2022;13:2017-2034 pubmed publisher
Fanarioti E, Tsarouchi M, Vasilakopoulou P, Chiou A, Karvelas M, Karathanos V, et al. Brain polar phenol content, behavioural and neurochemical effects of Corinthian currant in a rotenone rat model of Parkinson's disease. Nutr Neurosci. 2022;:1-15 pubmed publisher
Pak M, Park Y, Yang H, Hwang Y, Li W, Go Y. Samhwangsasim-tang attenuates neuronal apoptosis and cognitive decline through BDNF-mediated activation of tyrosin kinase B and p75-neurotrophin receptors. Phytomedicine. 2022;99:153997 pubmed publisher
Gentry N, McMahon T, Yamazaki M, Webb J, Arnold T, Rosi S, et al. Microglia are involved in the protection of memories formed during sleep deprivation. Neurobiol Sleep Circadian Rhythms. 2022;12:100073 pubmed publisher
Wang J, Gao F, Cui S, Yang S, Gao F, Wang X, et al. Utility of 7,8-dihydroxyflavone in preventing astrocytic and synaptic deficits in the hippocampus elicited by PTSD. Pharmacol Res. 2022;176:106079 pubmed publisher
Ferguson L, Giza C, Serpa R, Greco T, Robert H, Folkerts M, et al. Sex Differences in Neurophysiological Changes Following Voluntary Exercise in Adolescent Rats. Front Neurol. 2021;12:685822 pubmed publisher
Topal A, Özdemir S, Arslan H, Comaklı S. How does elevated water temperature affect fish brain? (A neurophysiological and experimental study: Assessment of brain derived neurotrophic factor, cFOS, apoptotic genes, heat shock genes, ER-stress genes and oxidative stress genes). Fish Shellfish Immunol. 2021;115:198-204 pubmed publisher
Jung D, Ahn S, Pak M, Lee H, Jung Y, Kim K, et al. Therapeutic effects of anodal transcranial direct current stimulation in a rat model of ADHD. elife. 2020;9: pubmed publisher
Wang X, Xu W, Chen H, Li W, Li W, Zhu G. Astragaloside IV prevents Aβ1-42 oligomers-induced memory impairment and hippocampal cell apoptosis by promoting PPARγ/BDNF signaling pathway. Brain Res. 2020;1747:147041 pubmed publisher
Celik H, Kucukler S, Özdemir S, Comaklı S, Gur C, Kandemir F, et al. Lycopene protects against central and peripheral neuropathy by inhibiting oxaliplatin-induced ATF-6 pathway, apoptosis, inflammation and oxidative stress in brains and sciatic tissues of rats. Neurotoxicology. 2020;80:29-40 pubmed publisher
Song Z, Shen F, Zhang Z, Wu S, Zhu G. Calpain inhibition ameliorates depression-like behaviors by reducing inflammation and promoting synaptic protein expression in the hippocampus. Neuropharmacology. 2020;174:108175 pubmed publisher
Appanah R, Lones E, Aiello U, Libri D, De Piccoli G. Sen1 Is Recruited to Replication Forks via Ctf4 and Mrc1 and Promotes Genome Stability. Cell Rep. 2020;30:2094-2105.e9 pubmed publisher
Paldino E, Balducci C, La Vitola P, Artioli L, D Angelo V, Giampà C, et al. Neuroprotective Effects of Doxycycline in the R6/2 Mouse Model of Huntington's Disease. Mol Neurobiol. 2020;57:1889-1903 pubmed publisher
Pak M, Ahn S, Jung D, Lee H, Ha K, Shin H, et al. Electroacupuncture Therapy Ameliorates Motor Dysfunction via Brain-Derived Neurotrophic Factor and Glial Cell Line-Derived Neurotrophic Factor in a Mouse Model of Parkinson's Disease. J Gerontol A Biol Sci Med Sci. 2020;75:712-721 pubmed publisher
Eng J, Thibault G, Luoh S, Gray J, Chang Y, Chin K. Cyclic Multiplexed-Immunofluorescence (cmIF), a Highly Multiplexed Method for Single-Cell Analysis. Methods Mol Biol. 2020;2055:521-562 pubmed publisher
Comaklı S, Köktürk M, Topal A, Ozkaraca M, Ceyhun S. Immunofluorescence/fluorescence assessment of brain-derived neurotrophic factor, c-Fos activation, and apoptosis in the brain of zebrafish (Danio rerio) larvae exposed to glufosinate. Neurotoxicology. 2018;69:60-67 pubmed publisher
Kim Y, Park B, Kim Y, Shim I, Kang I, Lee M. Antidepressant Effect of Fraxinus rhynchophylla Hance Extract in a Mouse Model of Chronic Stress-Induced Depression. Biomed Res Int. 2018;2018:8249563 pubmed publisher
Park B, Kim Y, Kim Y, Yang C, Seo C, Jung I, et al. Antidepressant-Like Effects of Gyejibokryeong-hwan in a Mouse Model of Reserpine-Induced Depression. Biomed Res Int. 2018;2018:5845491 pubmed publisher
Lin J, Izar B, Wang S, Yapp C, Mei S, Shah P, et al. Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes. elife. 2018;7: pubmed publisher
Kim Y, Ahn S, Pak M, Lee H, Jung D, Shin Y, et al. Potential benefits of mesenchymal stem cells and electroacupuncture on the trophic factors associated with neurogenesis in mice with ischemic stroke. Sci Rep. 2018;8:2044 pubmed publisher
Pak M, Jung D, Lee H, Shin M, Kim S, Shin Y, et al. Combined therapy involving electroacupuncture and treadmill exercise attenuates demyelination in the corpus callosum by stimulating oligodendrogenesis in a rat model of neonatal hypoxia-ischemia. Exp Neurol. 2018;300:222-231 pubmed publisher
Tang Y, Liu L, Xu D, Zhang W, Zhang Y, Zhou J, et al. Interaction between astrocytic colony stimulating factor and its receptor on microglia mediates central sensitization and behavioral hypersensitivity in chronic post ischemic pain model. Brain Behav Immun. 2018;68:248-260 pubmed publisher
Nam S, Kim J, Kwon H, Yoo D, Jung H, Kim D, et al. Differential Effects of Low- and High-dose Zinc Supplementation on Synaptic Plasticity and Neurogenesis in the Hippocampus of Control and High-fat Diet-fed Mice. Neurochem Res. 2017;42:3149-3159 pubmed publisher
Lee H, Lee S, Kim N, Park K, Choi B, Shin Y, et al. Low-level light emitting diode therapy promotes long-term functional recovery after experimental stroke in mice. J Biophotonics. 2017;10:1761-1771 pubmed publisher
Atasoy İ, Dursun E, Gezen Ak D, Metin Armağan D, Ozturk M, Yilmazer S. Both secreted and the cellular levels of BDNF attenuated due to tau hyperphosphorylation in primary cultures of cortical neurons. J Chem Neuroanat. 2017;80:19-26 pubmed publisher
Luo W, Chen I, Chen Y, Alkam D, Wang Y, Semenza G. PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia. Oncotarget. 2016;7:6379-97 pubmed publisher
Efstathopoulos P, Kourgiantaki A, Karali K, Sidiropoulou K, Margioris A, Gravanis A, et al. Fingolimod induces neurogenesis in adult mouse hippocampus and improves contextual fear memory. Transl Psychiatry. 2015;5:e685 pubmed publisher
Chan E, Teng G, Corbett E, Choudhury K, Bassing C, Schatz D, et al. Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2. Proc Natl Acad Sci U S A. 2013;110:E4628-37 pubmed publisher
Kato H, Okazaki K, Iida T, Nakayama J, Murakami Y, Urano T. Spt6 prevents transcription-coupled loss of posttranslationally modified histone H3. Sci Rep. 2013;3:2186 pubmed publisher
Cheng J, Torkamani A, Peng Y, Jones T, Lerner R. Plasma membrane associated transcription of cytoplasmic DNA. Proc Natl Acad Sci U S A. 2012;109:10827-31 pubmed publisher
Walsh H, Shupnik M. Proteasome regulation of dynamic transcription factor occupancy on the GnRH-stimulated luteinizing hormone beta-subunit promoter. Mol Endocrinol. 2009;23:237-50 pubmed publisher
Reid J, Svejstrup J. DNA damage-induced Def1-RNA polymerase II interaction and Def1 requirement for polymerase ubiquitylation in vitro. J Biol Chem. 2004;279:29875-8 pubmed
product information
master code :
NB100-98682
SKU :
NB100-98682
product name :
BDNF Antibody
unit size :
0.1 ml (also 0.025 ml)
description :
The BDNF Antibody from Novus is a rabbit polyclonal antibody to BDNF. This antibody reacts with human,mouse,rat,zebrafish,fish - danio rerio (zebrafish). The BDNF Antibody has been validated for the following applications: Western Blot,Immunohistochemistry,IF/IHC,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence.
target :
BDNF
category :
Primary Antibodies
buffer :
Lyophilized from whole antisera
clonality :
Polyclonal
conjugate :
Unconjugated
host :
Rabbit
immunogen :
A synthetic peptide from n-terminal region of human mature BDNF conjugated to blue carrier protein was used as the antigen. The peptide is homologous in many other species including rat, mouse, zebra fish and xenopus.
isotype :
IgG
purity :
Unpurified
species :
Human,Mouse,Rat,Zebrafish,Fish - Danio rerio (Zebrafish)
specificity :
Specific for mature BDNF
theoretical molecular weight :
28 kDa
gene symbol :
BDNF
Antibody validation :
Biological Validation
accessionNumbers :
P23560
applications :
Immunohistochemistry,Western Blot,IF/IHC,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence
USD :
409 USD
alt names :
abrineurin, brain-derived neurotrophic factor, MGC34632, neurotrophin
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.