product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
53BP1 Antibody - BSA Free
catalog :
NB100-904
quantity :
0.1 ml (also 0.025 ml)
price :
419 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, proximity ligation assay
more info or order :
citations: 60
Reference
Chauvin S, Ando S, Holley J, Sugie A, Zhao F, Poddar S, et al. Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans. Nat Commun. 2024;15:4696 pubmed publisher
Meijer T, Martens J, Prager van der Smissen W, Verkaik N, Beaufort C, van Herk S, et al. Functional Homologous Recombination (HR) Screening Shows the Majority of BRCA1/2-Mutant Breast and Ovarian Cancer Cell Lines Are HR-Proficient. Cancers (Basel). 2024;16: pubmed publisher
Verma N, Renauer P, Dong C, Xin S, Lin Q, Zhang F, et al. Genome scale CRISPR screens identify actin capping proteins as key modulators of therapeutic responses to radiation and immunotherapy. bioRxiv. 2024;: pubmed publisher
Rubio Contreras D, G xf3 mez Herreros F. TDP1 suppresses chromosomal translocations and cell death induced by abortive TOP1 activity during gene transcription. Nat Commun. 2023;14:6940 pubmed publisher
Scaramuzza S, Jones R, Sadurni M, Reynolds Winczura A, Poovathumkadavil D, Farrell A, et al. TRAIP resolves DNA replication-transcription conflicts during the S-phase of unperturbed cells. Nat Commun. 2023;14:5071 pubmed publisher
Reuvers T, Verkaik N, Stuurman D, de Ridder C, Groningen M, De Blois E, et al. DNA-PKcs inhibitors sensitize neuroendocrine tumor cells to peptide receptor radionuclide therapy in vitro and in vivo. Theranostics. 2023;13:3117-3130 pubmed publisher
Garyn C, Bover O, Murray J, Jing M, Salas Briceno K, Ross S, et al. DNA damage primes hematopoietic stem cells for direct megakaryopoiesis. bioRxiv. 2023;: pubmed publisher
Kustatscher G, H xf6 dl M, Rullmann E, Grabowski P, Fiagbedzi E, Groth A, et al. Higher-order modular regulation of the human proteome. Mol Syst Biol. 2023;19:e9503 pubmed publisher
Dullovi A, Ozgencil M, Rajvee V, Tse W, Cutillas P, Martin S, et al. Microtubule-associated proteins MAP7 and MAP7D1 promote DNA double-strand break repair in the G1 cell cycle phase. iScience. 2023;26:106107 pubmed publisher
Pape K, L xf6 xdf ner A, William D, Czempiel T, Beyreuther E, Klimova A, et al. Sensitization of Patient-Derived Colorectal Cancer Organoids to Photon and Proton Radiation by Targeting DNA Damage Response Mechanisms. Cancers (Basel). 2022;14: pubmed publisher
Batnini K, Houles T, Kirsh O, du Manoir S, Zaroual M, Delpech H, et al. Multi-Level Control of the ATM/ATR-CHK1 Axis by the Transcription Factor E4F1 in Triple-Negative Breast Cancer. Int J Mol Sci. 2022;23: pubmed publisher
Palmerola K, Amrane S, De Los Angeles A, Xu S, Wang N, de Pinho J, et al. Replication stress impairs chromosome segregation and preimplantation development in human embryos. Cell. 2022;185:2988-3007.e20 pubmed publisher
Ruigrok E, Tamborino G, De Blois E, Roobol S, Verkaik N, de Saint Hubert M, et al. In vitro dose effect relationships of actinium-225- and lutetium-177-labeled PSMA-I&T. Eur J Nucl Med Mol Imaging. 2022;49:3627-3638 pubmed publisher
Bayley R, Borel V, Moss R, Sweatman E, Ruis P, Ormrod A, et al. H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ. Mol Cell. 2022;82:1924-1939.e10 pubmed publisher
Fletcher C, Deng L, Orafidiya F, Yuan W, Lorentzen M, Cyran O, et al. A non-coding RNA balancing act: miR-346-induced DNA damage is limited by the long non-coding RNA NORAD in prostate cancer. Mol Cancer. 2022;21:82 pubmed publisher
Abu Libdeh B, Jhujh S, Dhar S, Sommers J, Datta A, Longo G, et al. RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1. J Clin Invest. 2022;132: pubmed publisher
Berndt N, Wolf C, Fischer K, Cura Costa E, Knuschke P, Zimmermann N, et al. Photosensitivity and cGAS-Dependent IFN-1 Activation in Patients with Lupus and TREX1 Deficiency. J Invest Dermatol. 2022;142:633-640.e6 pubmed publisher
Mosler T, Conte F, Longo G, Mikicic I, Kreim N, Möckel M, et al. R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instability. Nat Commun. 2021;12:7314 pubmed publisher
Higa M, Matsuda Y, Fujii J, Sugimoto N, Yoshida K, Fujita M. TRF2-mediated ORC recruitment underlies telomere stability upon DNA replication stress. Nucleic Acids Res. 2021;49:12234-12251 pubmed publisher
Chakraborty P, Hiom K. DHX9-dependent recruitment of BRCA1 to RNA promotes DNA end resection in homologous recombination. Nat Commun. 2021;12:4126 pubmed publisher
Bader S, Ma T, Simpson C, Liang J, Maezono S, Olcina M, et al. Replication catastrophe induced by cyclic hypoxia leads to increased APOBEC3B activity. Nucleic Acids Res. 2021;49:7492-7506 pubmed publisher
Yang C, Zhang Y, Segar N, Huang C, Zeng P, Tan X, et al. Nuclear IGF1R interacts with NuMA and regulates 53BP1‑dependent DNA double‑strand break repair in colorectal cancer. Oncol Rep. 2021;46: pubmed publisher
Garbarino J, Eckroate J, Sundaram R, Jensen R, Bindra R. Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity. Transl Oncol. 2021;14:101147 pubmed publisher
Xu X, Ni K, He Y, Ren J, Sun C, Liu Y, et al. The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation. Nat Commun. 2021;12:3520 pubmed publisher
Hargreaves C, Salatino S, Sasson S, Charlesworth J, Bateman E, Patel A, et al. Decreased ATM Function Causes Delayed DNA Repair and Apoptosis in Common Variable Immunodeficiency Disorders. J Clin Immunol. 2021;41:1315-1330 pubmed publisher
Tamborino G, Nonnekens J, de Saint Hubert M, Struelens L, Feijtel D, de Jong M, et al. Dosimetric evaluation of receptor-heterogeneity on the therapeutic efficacy of peptide receptor radionuclide therapy: correlation with DNA damage induction and in vivo survival. J Nucl Med. 2021;: pubmed publisher
Feijtel D, Doeswijk G, Verkaik N, Haeck J, Chicco D, Angotti C, et al. Inter and intra-tumor somatostatin receptor 2 heterogeneity influences peptide receptor radionuclide therapy response. Theranostics. 2021;11:491-505 pubmed publisher
Ruigrok E, van Vliet N, Dalm S, De Blois E, van Gent D, Haeck J, et al. Extensive preclinical evaluation of lutetium-177-labeled PSMA-specific tracers for prostate cancer radionuclide therapy. Eur J Nucl Med Mol Imaging. 2020;: pubmed publisher
Deville S, Luft S, Kaufmann M, Cordes N. Keap1 inhibition sensitizes head and neck squamous cell carcinoma cells to ionizing radiation via impaired non-homologous end joining and induced autophagy. Cell Death Dis. 2020;11:887 pubmed publisher
Layer J, Debaize L, Van Scoyk A, House N, Brown A, Liu Y, et al. Polymerase δ promotes chromosomal rearrangements and imprecise double-strand break repair. Proc Natl Acad Sci U S A. 2020;117:27566-27577 pubmed publisher
Deville S, Delgadillo Silva L, Vehlow A, Cordes N. c-Abl Tyrosine Kinase Is Regulated Downstream of the Cytoskeletal Protein Synemin in Head and Neck Squamous Cell Carcinoma Radioresistance and DNA Repair. Int J Mol Sci. 2020;21: pubmed publisher
Wikiniyadhanee R, Lerksuthirat T, Stitchantrakul W, Chitphuk S, Sura T, Dejsuphong D. TRIM29 is required for efficient recruitment of 53BP1 in response to DNA double-strand breaks in vertebrate cells. FEBS Open Bio. 2020;10:2055-2071 pubmed publisher
Singh V, McKinney S, Gerton J. Persistent DNA Damage and Senescence in the Placenta Impacts Developmental Outcomes of Embryos. Dev Cell. 2020;54:333-347.e7 pubmed publisher
Kim H, Xu H, George E, Hallberg D, Kumar S, Jagannathan V, et al. Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models. Nat Commun. 2020;11:3726 pubmed publisher
Zhang H, Zhao R, Tones J, Liu M, Dilley R, Chenoweth D, et al. Nuclear body phase separation drives telomere clustering in ALT cancer cells. Mol Biol Cell. 2020;31:2048-2056 pubmed publisher
Bergstrand S, Böhm S, Malmgren H, Norberg A, Sundin M, Nordgren A, et al. Biallelic mutations in WRAP53 result in dysfunctional telomeres, Cajal bodies and DNA repair, thereby causing Hoyeraal-Hreidarsson syndrome. Cell Death Dis. 2020;11:238 pubmed publisher
O Dea R, Santocanale C. Non-canonical regulation of homologous recombination DNA repair by the USP9X deubiquitylase. J Cell Sci. 2020;133: pubmed publisher
Jin S, Cordes N. ATM controls DNA repair and mitochondria transfer between neighboring cells. Cell Commun Signal. 2019;17:144 pubmed publisher
Zhang W, Liao C, Chtatou H, Incrocci L, van Gent D, Van Weerden W, et al. Apalutamide Sensitizes Prostate Cancer to Ionizing Radiation via Inhibition of Non-Homologous End-Joining DNA Repair. Cancers (Basel). 2019;11: pubmed publisher
Cebrià Costa J, Pascual Reguant L, Gonzalez Perez A, Serra Bardenys G, Querol J, Cosín M, et al. LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells. Oncogene. 2020;39:79-121 pubmed publisher
He B, Gnawali N, Hinman A, Mattingly A, Osimani A, Cimini D. Chromosomes missegregated into micronuclei contribute to chromosomal instability by missegregating at the next division. Oncotarget. 2019;10:2660-2674 pubmed publisher
Yost K, Clatterbuck Soper S, Walker R, Pineda M, Zhu Y, Ester C, et al. Rapid and reversible suppression of ALT by DAXX in osteosarcoma cells. Sci Rep. 2019;9:4544 pubmed publisher
Shine E, Xue M, Patel J, Healy A, Surovtseva Y, Herzon S, et al. Model Colibactins Exhibit Human Cell Genotoxicity in the Absence of Host Bacteria. ACS Chem Biol. 2018;13:3286-3293 pubmed publisher
Chakraborty P, Huang J, Hiom K. DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing. Nat Commun. 2018;9:4346 pubmed publisher
Bayley R, Blakemore D, Cancian L, Dumon S, Volpe G, Ward C, et al. MYBL2 Supports DNA Double Strand Break Repair in Hematopoietic Stem Cells. Cancer Res. 2018;78:5767-5779 pubmed publisher
Kang Y, Yan C. Regulation of DNA repair in the absence of classical non-homologous end joining. DNA Repair (Amst). 2018;68:34-40 pubmed publisher
Bueno M, Baldascini M, Richard S, Lowndes N. Recruitment of lysine demethylase 2A to DNA double strand breaks and its interaction with 53BP1 ensures genome stability. Oncotarget. 2018;9:15915-15930 pubmed publisher
Borude P, Bhushan B, Apte U. DNA Damage Response Regulates Initiation of Liver Regeneration Following Acetaminophen Overdose. Gene Expr. 2018;18:115-123 pubmed publisher
Biswas U, Stevense M, Jessberger R. SMC1α Substitutes for Many Meiotic Functions of SMC1β but Cannot Protect Telomeres from Damage. Curr Biol. 2018;28:249-261.e4 pubmed publisher
Hassan S, Esch A, Liby T, Gray J, Heiser L. Pathway-Enriched Gene Signature Associated with 53BP1 Response to PARP Inhibition in Triple-Negative Breast Cancer. Mol Cancer Ther. 2017;16:2892-2901 pubmed publisher
Bao X, Siprashvili Z, Zarnegar B, Shenoy R, Rios E, Nady N, et al. CSNK1a1 Regulates PRMT1 to Maintain the Progenitor State in Self-Renewing Somatic Tissue. Dev Cell. 2017;43:227-239.e5 pubmed publisher
Sivanand S, Rhoades S, Jiang Q, Lee J, Benci J, Zhang J, et al. Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination. Mol Cell. 2017;67:252-265.e6 pubmed publisher
Foskolou I, Jorgensen C, Leszczynska K, Olcina M, Tarhonskaya H, Haisma B, et al. Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication. Mol Cell. 2017;66:206-220.e9 pubmed publisher
Ho T, Warr M, Adelman E, Lansinger O, Flach J, Verovskaya E, et al. Autophagy maintains the metabolism and function of young and old stem cells. Nature. 2017;543:205-210 pubmed publisher
Li S, Shu F, Li Z, Jaafar L, Zhao S, Dynan W. Cell-type specific role of the RNA-binding protein, NONO, in the DNA double-strand break response in the mouse testes. DNA Repair (Amst). 2017;51:70-78 pubmed publisher
Cheng L, Tan V, Ganesan S, Drake J. Integrating phosphoproteomics into the clinical management of prostate cancer. Clin Transl Med. 2017;6:9 pubmed publisher
Kang Y, Balter B, Csizmadia E, Haas B, Sharma H, Bronson R, et al. Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival. Nat Commun. 2017;8:14013 pubmed publisher
Demaria M, O Leary M, Chang J, Shao L, Liu S, Alimirah F, et al. Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse. Cancer Discov. 2017;7:165-176 pubmed publisher
Jaafar L, Li Z, Li S, Dynan W. SFPQ•NONO and XLF function separately and together to promote DNA double-strand break repair via canonical nonhomologous end joining. Nucleic Acids Res. 2017;45:1848-1859 pubmed publisher
Moureau S, Luessing J, Harte E, Voisin M, Lowndes N. A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining. Open Biol. 2016;6: pubmed
product information
brand :
Novus
master code :
NB100-904
SKU :
NB100-904
product name :
53BP1 Antibody - BSA Free
unit size :
0.1 ml (also 0.025 ml)
seo description :
The 53BP1 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to 53BP1. This antibody reacts with human,mouse,other. The 53BP1 Antibody - BSA Free has been validated for the following applications: Immunocytochemistry/ Immunofluorescence,IF/IHC,Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Proximity Ligation Assay,Immunocytochemistry,Knockdown Validated,Block/Neutralize,Immunohistochemistry-Paraffin,In-situ Hybridization.
target :
53BP1
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1 mg/ml
conjugate :
Unconjugated
dilution :
Western Blot 1:1000 - 1:10000, Flow Cytometry 2 - 5 ug/mL, Immunohistochemistry 1:400, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation reported in scientific literature (PMID 25512560), Immunohistochemistry-Paraffin 1:400, Proximity Ligation Assay reported in scientific literature (PMID 26734725), In-situ Hybridization reported in scientific literature (PMID 25407517), Knockdown Validated reported in scientific literature (PMID 31635359)
host :
Rabbit
immunogen :
53BP1 Antibody was made to a synthetic peptide corresponding to a portion of human 53BP1 encoded in exon 11, 12 and 19 [Uniprot: Q12888]. This antibody is a cocktail hybrid of NB100-304 and NB100-305.
isotype :
IgG
purity :
Immunogen affinity purified
species :
Human,Mouse,Other
gene symbol :
TP53BP1
Antibody validation :
Biological Validation
accessionNumbers :
Q12888
applications :
Immunohistochemistry-Paraffin,In-situ Hybridization,IF/IHC,Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Proximity Ligation Assay,Immunocytochemistry,Knockdown Validated,Block/Neutralize,Immunocytochemistry/ Immunofluorescence
USD :
419 USD
alt names :
53BP1, p202, p53-binding protein 1, p53bp1, TDRD30, TP53-Binding Protein 1, tumor protein 53-binding protein, 1, tumor protein p53 binding protein 1, tumor protein p53-binding protein, 1, tumor suppressor p53-binding protein 1
storage :
Store at -20 ░C.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.