Reference |
---|
Chauvin S, Ando S, Holley J, Sugie A, Zhao F, Poddar S, et al. Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans. Nat Commun. 2024;15:4696 pubmed publisher
|
Meijer T, Martens J, Prager van der Smissen W, Verkaik N, Beaufort C, van Herk S, et al. Functional Homologous Recombination (HR) Screening Shows the Majority of BRCA1/2-Mutant Breast and Ovarian Cancer Cell Lines Are HR-Proficient. Cancers (Basel). 2024;16: pubmed publisher
|
Verma N, Renauer P, Dong C, Xin S, Lin Q, Zhang F, et al. Genome scale CRISPR screens identify actin capping proteins as key modulators of therapeutic responses to radiation and immunotherapy. bioRxiv. 2024;: pubmed publisher
|
Rubio Contreras D, G xf3 mez Herreros F. TDP1 suppresses chromosomal translocations and cell death induced by abortive TOP1 activity during gene transcription. Nat Commun. 2023;14:6940 pubmed publisher
|
Scaramuzza S, Jones R, Sadurni M, Reynolds Winczura A, Poovathumkadavil D, Farrell A, et al. TRAIP resolves DNA replication-transcription conflicts during the S-phase of unperturbed cells. Nat Commun. 2023;14:5071 pubmed publisher
|
Reuvers T, Verkaik N, Stuurman D, de Ridder C, Groningen M, De Blois E, et al. DNA-PKcs inhibitors sensitize neuroendocrine tumor cells to peptide receptor radionuclide therapy in vitro and in vivo. Theranostics. 2023;13:3117-3130 pubmed publisher
|
Garyn C, Bover O, Murray J, Jing M, Salas Briceno K, Ross S, et al. DNA damage primes hematopoietic stem cells for direct megakaryopoiesis. bioRxiv. 2023;: pubmed publisher
|
Kustatscher G, H xf6 dl M, Rullmann E, Grabowski P, Fiagbedzi E, Groth A, et al. Higher-order modular regulation of the human proteome. Mol Syst Biol. 2023;19:e9503 pubmed publisher
|
Dullovi A, Ozgencil M, Rajvee V, Tse W, Cutillas P, Martin S, et al. Microtubule-associated proteins MAP7 and MAP7D1 promote DNA double-strand break repair in the G1 cell cycle phase. iScience. 2023;26:106107 pubmed publisher
|
Pape K, L xf6 xdf ner A, William D, Czempiel T, Beyreuther E, Klimova A, et al. Sensitization of Patient-Derived Colorectal Cancer Organoids to Photon and Proton Radiation by Targeting DNA Damage Response Mechanisms. Cancers (Basel). 2022;14: pubmed publisher
|
Batnini K, Houles T, Kirsh O, du Manoir S, Zaroual M, Delpech H, et al. Multi-Level Control of the ATM/ATR-CHK1 Axis by the Transcription Factor E4F1 in Triple-Negative Breast Cancer. Int J Mol Sci. 2022;23: pubmed publisher
|
Palmerola K, Amrane S, De Los Angeles A, Xu S, Wang N, de Pinho J, et al. Replication stress impairs chromosome segregation and preimplantation development in human embryos. Cell. 2022;185:2988-3007.e20 pubmed publisher
|
Ruigrok E, Tamborino G, De Blois E, Roobol S, Verkaik N, de Saint Hubert M, et al. In vitro dose effect relationships of actinium-225- and lutetium-177-labeled PSMA-I&T. Eur J Nucl Med Mol Imaging. 2022;49:3627-3638 pubmed publisher
|
Bayley R, Borel V, Moss R, Sweatman E, Ruis P, Ormrod A, et al. H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ. Mol Cell. 2022;82:1924-1939.e10 pubmed publisher
|
Fletcher C, Deng L, Orafidiya F, Yuan W, Lorentzen M, Cyran O, et al. A non-coding RNA balancing act: miR-346-induced DNA damage is limited by the long non-coding RNA NORAD in prostate cancer. Mol Cancer. 2022;21:82 pubmed publisher
|
Abu Libdeh B, Jhujh S, Dhar S, Sommers J, Datta A, Longo G, et al. RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1. J Clin Invest. 2022;132: pubmed publisher
|
Berndt N, Wolf C, Fischer K, Cura Costa E, Knuschke P, Zimmermann N, et al. Photosensitivity and cGAS-Dependent IFN-1 Activation in Patients with Lupus and TREX1 Deficiency. J Invest Dermatol. 2022;142:633-640.e6 pubmed publisher
|
Mosler T, Conte F, Longo G, Mikicic I, Kreim N, Möckel M, et al. R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instability. Nat Commun. 2021;12:7314 pubmed publisher
|
Higa M, Matsuda Y, Fujii J, Sugimoto N, Yoshida K, Fujita M. TRF2-mediated ORC recruitment underlies telomere stability upon DNA replication stress. Nucleic Acids Res. 2021;49:12234-12251 pubmed publisher
|
Chakraborty P, Hiom K. DHX9-dependent recruitment of BRCA1 to RNA promotes DNA end resection in homologous recombination. Nat Commun. 2021;12:4126 pubmed publisher
|
Bader S, Ma T, Simpson C, Liang J, Maezono S, Olcina M, et al. Replication catastrophe induced by cyclic hypoxia leads to increased APOBEC3B activity. Nucleic Acids Res. 2021;49:7492-7506 pubmed publisher
|
Yang C, Zhang Y, Segar N, Huang C, Zeng P, Tan X, et al. Nuclear IGF1R interacts with NuMA and regulates 53BP1‑dependent DNA double‑strand break repair in colorectal cancer. Oncol Rep. 2021;46: pubmed publisher
|
Garbarino J, Eckroate J, Sundaram R, Jensen R, Bindra R. Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity. Transl Oncol. 2021;14:101147 pubmed publisher
|
Xu X, Ni K, He Y, Ren J, Sun C, Liu Y, et al. The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation. Nat Commun. 2021;12:3520 pubmed publisher
|
Hargreaves C, Salatino S, Sasson S, Charlesworth J, Bateman E, Patel A, et al. Decreased ATM Function Causes Delayed DNA Repair and Apoptosis in Common Variable Immunodeficiency Disorders. J Clin Immunol. 2021;41:1315-1330 pubmed publisher
|
Tamborino G, Nonnekens J, de Saint Hubert M, Struelens L, Feijtel D, de Jong M, et al. Dosimetric evaluation of receptor-heterogeneity on the therapeutic efficacy of peptide receptor radionuclide therapy: correlation with DNA damage induction and in vivo survival. J Nucl Med. 2021;: pubmed publisher
|
Feijtel D, Doeswijk G, Verkaik N, Haeck J, Chicco D, Angotti C, et al. Inter and intra-tumor somatostatin receptor 2 heterogeneity influences peptide receptor radionuclide therapy response. Theranostics. 2021;11:491-505 pubmed publisher
|
Ruigrok E, van Vliet N, Dalm S, De Blois E, van Gent D, Haeck J, et al. Extensive preclinical evaluation of lutetium-177-labeled PSMA-specific tracers for prostate cancer radionuclide therapy. Eur J Nucl Med Mol Imaging. 2020;: pubmed publisher
|
Deville S, Luft S, Kaufmann M, Cordes N. Keap1 inhibition sensitizes head and neck squamous cell carcinoma cells to ionizing radiation via impaired non-homologous end joining and induced autophagy. Cell Death Dis. 2020;11:887 pubmed publisher
|
Layer J, Debaize L, Van Scoyk A, House N, Brown A, Liu Y, et al. Polymerase δ promotes chromosomal rearrangements and imprecise double-strand break repair. Proc Natl Acad Sci U S A. 2020;117:27566-27577 pubmed publisher
|
Deville S, Delgadillo Silva L, Vehlow A, Cordes N. c-Abl Tyrosine Kinase Is Regulated Downstream of the Cytoskeletal Protein Synemin in Head and Neck Squamous Cell Carcinoma Radioresistance and DNA Repair. Int J Mol Sci. 2020;21: pubmed publisher
|
Wikiniyadhanee R, Lerksuthirat T, Stitchantrakul W, Chitphuk S, Sura T, Dejsuphong D. TRIM29 is required for efficient recruitment of 53BP1 in response to DNA double-strand breaks in vertebrate cells. FEBS Open Bio. 2020;10:2055-2071 pubmed publisher
|
Singh V, McKinney S, Gerton J. Persistent DNA Damage and Senescence in the Placenta Impacts Developmental Outcomes of Embryos. Dev Cell. 2020;54:333-347.e7 pubmed publisher
|
Kim H, Xu H, George E, Hallberg D, Kumar S, Jagannathan V, et al. Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models. Nat Commun. 2020;11:3726 pubmed publisher
|
Zhang H, Zhao R, Tones J, Liu M, Dilley R, Chenoweth D, et al. Nuclear body phase separation drives telomere clustering in ALT cancer cells. Mol Biol Cell. 2020;31:2048-2056 pubmed publisher
|
Bergstrand S, Böhm S, Malmgren H, Norberg A, Sundin M, Nordgren A, et al. Biallelic mutations in WRAP53 result in dysfunctional telomeres, Cajal bodies and DNA repair, thereby causing Hoyeraal-Hreidarsson syndrome. Cell Death Dis. 2020;11:238 pubmed publisher
|
O Dea R, Santocanale C. Non-canonical regulation of homologous recombination DNA repair by the USP9X deubiquitylase. J Cell Sci. 2020;133: pubmed publisher
|
Jin S, Cordes N. ATM controls DNA repair and mitochondria transfer between neighboring cells. Cell Commun Signal. 2019;17:144 pubmed publisher
|
Zhang W, Liao C, Chtatou H, Incrocci L, van Gent D, Van Weerden W, et al. Apalutamide Sensitizes Prostate Cancer to Ionizing Radiation via Inhibition of Non-Homologous End-Joining DNA Repair. Cancers (Basel). 2019;11: pubmed publisher
|
Cebrià Costa J, Pascual Reguant L, Gonzalez Perez A, Serra Bardenys G, Querol J, Cosín M, et al. LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells. Oncogene. 2020;39:79-121 pubmed publisher
|
He B, Gnawali N, Hinman A, Mattingly A, Osimani A, Cimini D. Chromosomes missegregated into micronuclei contribute to chromosomal instability by missegregating at the next division. Oncotarget. 2019;10:2660-2674 pubmed publisher
|
Yost K, Clatterbuck Soper S, Walker R, Pineda M, Zhu Y, Ester C, et al. Rapid and reversible suppression of ALT by DAXX in osteosarcoma cells. Sci Rep. 2019;9:4544 pubmed publisher
|
Shine E, Xue M, Patel J, Healy A, Surovtseva Y, Herzon S, et al. Model Colibactins Exhibit Human Cell Genotoxicity in the Absence of Host Bacteria. ACS Chem Biol. 2018;13:3286-3293 pubmed publisher
|
Chakraborty P, Huang J, Hiom K. DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing. Nat Commun. 2018;9:4346 pubmed publisher
|
Bayley R, Blakemore D, Cancian L, Dumon S, Volpe G, Ward C, et al. MYBL2 Supports DNA Double Strand Break Repair in Hematopoietic Stem Cells. Cancer Res. 2018;78:5767-5779 pubmed publisher
|
Kang Y, Yan C. Regulation of DNA repair in the absence of classical non-homologous end joining. DNA Repair (Amst). 2018;68:34-40 pubmed publisher
|
Bueno M, Baldascini M, Richard S, Lowndes N. Recruitment of lysine demethylase 2A to DNA double strand breaks and its interaction with 53BP1 ensures genome stability. Oncotarget. 2018;9:15915-15930 pubmed publisher
|
Borude P, Bhushan B, Apte U. DNA Damage Response Regulates Initiation of Liver Regeneration Following Acetaminophen Overdose. Gene Expr. 2018;18:115-123 pubmed publisher
|
Biswas U, Stevense M, Jessberger R. SMC1α Substitutes for Many Meiotic Functions of SMC1β but Cannot Protect Telomeres from Damage. Curr Biol. 2018;28:249-261.e4 pubmed publisher
|
Hassan S, Esch A, Liby T, Gray J, Heiser L. Pathway-Enriched Gene Signature Associated with 53BP1 Response to PARP Inhibition in Triple-Negative Breast Cancer. Mol Cancer Ther. 2017;16:2892-2901 pubmed publisher
|
Bao X, Siprashvili Z, Zarnegar B, Shenoy R, Rios E, Nady N, et al. CSNK1a1 Regulates PRMT1 to Maintain the Progenitor State in Self-Renewing Somatic Tissue. Dev Cell. 2017;43:227-239.e5 pubmed publisher
|
Sivanand S, Rhoades S, Jiang Q, Lee J, Benci J, Zhang J, et al. Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination. Mol Cell. 2017;67:252-265.e6 pubmed publisher
|
Foskolou I, Jorgensen C, Leszczynska K, Olcina M, Tarhonskaya H, Haisma B, et al. Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication. Mol Cell. 2017;66:206-220.e9 pubmed publisher
|
Ho T, Warr M, Adelman E, Lansinger O, Flach J, Verovskaya E, et al. Autophagy maintains the metabolism and function of young and old stem cells. Nature. 2017;543:205-210 pubmed publisher
|
Li S, Shu F, Li Z, Jaafar L, Zhao S, Dynan W. Cell-type specific role of the RNA-binding protein, NONO, in the DNA double-strand break response in the mouse testes. DNA Repair (Amst). 2017;51:70-78 pubmed publisher
|
Cheng L, Tan V, Ganesan S, Drake J. Integrating phosphoproteomics into the clinical management of prostate cancer. Clin Transl Med. 2017;6:9 pubmed publisher
|
Kang Y, Balter B, Csizmadia E, Haas B, Sharma H, Bronson R, et al. Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival. Nat Commun. 2017;8:14013 pubmed publisher
|
Demaria M, O Leary M, Chang J, Shao L, Liu S, Alimirah F, et al. Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse. Cancer Discov. 2017;7:165-176 pubmed publisher
|
Jaafar L, Li Z, Li S, Dynan W. SFPQ•NONO and XLF function separately and together to promote DNA double-strand break repair via canonical nonhomologous end joining. Nucleic Acids Res. 2017;45:1848-1859 pubmed publisher
|
Moureau S, Luessing J, Harte E, Voisin M, Lowndes N. A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining. Open Biol. 2016;6: pubmed
|