product summary
request information :
company name :
Novus Biologicals
product type :
antibody
product name :
Mouse Monoclonal CXCR4 Antibody
catalog :
NB100-77835R
quantity :
0.05 mg
price :
429.00 USD
clonality :
monoclonal
host :
mouse
reactivity :
human, Rhesus monkey
application :
immunohistochemistry, immunocytochemistry, flow cytometry
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NB100-77835R
Product Name :
Mouse Monoclonal CXCR4 Antibody
List Price :
429.00 USD
Product Type :
Primary Antibodies
Package Size :
0.05 mg
AltNames :
CD184, chemokine (C-X-C motif) receptor 4, chemokine (C-X-C motif), receptor 4 (fusin), CXC-R4, CXCR-4, C-X-C chemokine receptor type 4, D2S201ESDF-1 receptor, FB22, Fusin, fusin, HM89NPYRL, HSY3RR, LCR1, LAP3, LESTRCD184 antigen, leukocyte-derived seven-transmembrane-domain receptor, lipopolysaccharide-associated protein 3, Leukocyte-derived seven transmembrane domain receptor, neuropeptide Y receptor Y3, NPY3RWHIM, NPYR, NPYY3R, seven transmembrane helix receptor, seven-transmembrane-segment receptor, spleen, Stromal cell-derived factor 1 receptor
Background :
CD184, also known as fusin or CXCR4, is a 45 kD seven transmembrane G-protein-linked CXC chemokine receptor. CD184 is widely expressed on blood and tissue cells, including B and T cells, monocytes, macrophages, dendritic cells, granulocytes, megakaryocytes/platelets, lymphoid, myeloid precursor cells, endothelial cells, epithelial cells, astrocytes, and neurons, among other tissue cells. CD184 is the receptor for CXC chemokine SDF-1, mediates blood cell migration, and is involved in B lympho- and myelopoiesis, cardiogenesis, blood vessel formation and cerebellar development. CXCR4 is also a coreceptor of X4 HIV-1 and an alternative receptor for some isolates of HIV-2. The 12G5 antibody has been reported to block CD4-independent infection by HIV-2 and CD4-dependent infection by some T cell-tropic isolates of HIV-1.
Buffer :
50mM sodium borate
Clonality :
Monoclonal
Clone :
12G5
Concentration :
0.5 mg/ml
Conjugate :
DyLight 550
Application Summary :
Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Frozen
Host :
Mouse
Immunogen :
The immunogen was the full length version of CXCR4
Isotype :
IgG2a Kappa
Marker :
Hematopoietic Stem Cell Marker
Preservative :
No Preservative
Purity :
Affinity purified
CrossReactivity :
Human, Expected Cross-Reactivity based on immunogen sequence: Chimpanzee, Baboon, Cynomolgus, Rhesus, Sooty Mangabey, African Green.
Storage :
Store at 4C in the dark.
Swissprot Human :
P61073
Uses :
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 1.0 microgram per one million cells in 100 microliter volume or 100 microliter of whole blood. Immunohistochemistry-frozen sections. It is recommended that the reagent be titrated for optimal performance for each application.
Research Area :
Adaptive Immunity, Cancer, Cytokine Research, GPCR, Growth and Development, Innate Immunity, Immunology, Neuronal Cell Markers, Signal Transduction
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: usa
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.