product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Peripheral Node Addressin Antibody (MECA-79) - Non-Recombinant Monoclonal
catalog :
NB100-77673
quantity :
0.5 mg (also 0.1 mg)
price :
479 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
MECA-79
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
Novus Biologicals product webpage
citations: 17
Reference
Gavish A, Tyler M, Greenwald A, Hoefflin R, Simkin D, Tschernichovsky R, et al. Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours. Nature. 2023;618:598-606 pubmed publisher
Wang Z, Shi X, Zhao Y, Zhou J, Zhang S, Wang J, et al. DC101, an anti-VEGFR2 agent, promotes high-endothelial venule formation and immune infiltration versus SAR131675 and fruquintinib. Biochem Biophys Res Commun. 2023;661:10-20 pubmed publisher
Quigley L, Pang L, Tavancheh E, Ernst M, Behren A, Huynh J, et al. Protocol for investigating tertiary lymphoid structures in human and murine fixed tissue sections using Opal™-TSA multiplex immunohistochemistry. STAR Protoc. 2023;4:101961 pubmed publisher
Zhao J, Jung S, Li X, Li L, Kasinath V, Zhang H, et al. Delivery of costimulatory blockade to lymph nodes promotes transplant acceptance in mice. J Clin Invest. 2022;132: pubmed publisher
Smith K, Minns D, McHugh B, Holloway R, O CONNOR R, Williams A, et al. The antimicrobial peptide cathelicidin drives development of experimental autoimmune encephalomyelitis in mice by affecting Th17 differentiation. PLoS Biol. 2022;20:e3001554 pubmed publisher
Li X, Zhao J, Kasinath V, Uehara M, Jiang L, Banouni N, et al. Lymph node fibroblastic reticular cells deposit fibrosis-associated collagen following organ transplantation. J Clin Invest. 2020;130:4182-4194 pubmed publisher
He B, Johansson Percival A, Backhouse J, Li J, Lee G, Hamzah J, et al. Remodeling of Metastatic Vasculature Reduces Lung Colonization and Sensitizes Overt Metastases to Immunotherapy. Cell Rep. 2020;30:714-724.e5 pubmed publisher
Matsubara S, Seki M, Suzuki S, Komori T, Takamori M. Tertiary lymphoid organs in the inflammatory myopathy associated with PD-1 inhibitors. J Immunother Cancer. 2019;7:256 pubmed publisher
Uehara M, Li X, Sheikhi A, Zandi N, Walker B, Saleh B, et al. Anti-IL-6 eluting immunomodulatory biomaterials prolong skin allograft survival. Sci Rep. 2019;9:6535 pubmed publisher
Bahmani B, Uehara M, Ordikhani F, Li X, Jiang L, Banouni N, et al. Ectopic high endothelial venules in pancreatic ductal adenocarcinoma: A unique site for targeted delivery. EBioMedicine. 2018;38:79-88 pubmed publisher
Bahmani B, Uehara M, Jiang L, Ordikhani F, Banouni N, Ichimura T, et al. Targeted delivery of immune therapeutics to lymph nodes prolongs cardiac allograft survival. J Clin Invest. 2018;128:4770-4786 pubmed publisher
Hautz T, Zelger B, Nasr I, Mundinger G, Barth R, Rodriguez E, et al. Lymphoid neogenesis in skin of human hand, nonhuman primate, and rat vascularized composite allografts. Transpl Int. 2014;27:966-76 pubmed publisher
Hirakawa J, Tsuboi K, Sato K, Kobayashi M, Watanabe S, Takakura A, et al. Novel anti-carbohydrate antibodies reveal the cooperative function of sulfated N- and O-glycans in lymphocyte homing. J Biol Chem. 2010;285:40864-78 pubmed publisher
Burke S, Dong H, Hazan A, Croy B. Aberrant endometrial features of pregnancy in diabetic NOD mice. Diabetes. 2007;56:2919-26 pubmed
Drayton D, Ying X, Lee J, Lesslauer W, Ruddle N. Ectopic LT alpha beta directs lymphoid organ neogenesis with concomitant expression of peripheral node addressin and a HEV-restricted sulfotransferase. J Exp Med. 2003;197:1153-63 pubmed
Samulowitz U, Kuhn A, Brachtendorf G, Nawroth R, Braun A, Bankfalvi A, et al. Human endomucin: distribution pattern, expression on high endothelial venules, and decoration with the MECA-79 epitope. Am J Pathol. 2002;160:1669-81 pubmed
Csencsits K, Jutila M, Pascual D. Nasal-associated lymphoid tissue: phenotypic and functional evidence for the primary role of peripheral node addressin in naive lymphocyte adhesion to high endothelial venules in a mucosal site. J Immunol. 1999;163:1382-9 pubmed
product information
brand :
Novus
master code :
NB100-77673
SKU :
NB100-77673
product name :
Peripheral Node Addressin Antibody (MECA-79) - Non-Recombinant Monoclonal
unit size :
0.5 mg (also 0.1 mg)
seo description :
The Peripheral Node Addressin Antibody (MECA-79) - Non-Recombinant Monoclonal from Novus is a rat monoclonal antibody to Peripheral Node Addressin. This antibody reacts with human,mouse. The Peripheral Node Addressin Antibody (MECA-79) - Non-Recombinant Monoclonal has been validated for the following applications: Immunohistochemistry-Frozen,IF/IHC,Immunohistochemistry,Immunohistochemistry-Paraffin,In vivo assay,Immunocytochemistry/ Immunofluorescence,Immunoprecipitation,Western Blot.
target :
Peripheral Node Addressin
category :
Primary Antibodies
buffer :
PBS
clonality :
Monoclonal
clone :
MECA-79
concentration :
1.0 mg/ml
conjugate :
Unconjugated
dilution :
Western Blot 1:100-1:2000, Immunohistochemistry 1:10-1:500, Immunocytochemistry/ Immunofluorescence reported in scientific literature (PMID 31024011), Immunoprecipitation 1:10-1:500, Immunohistochemistry-Paraffin 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500, In vivo assay reported in scientific literature (PMID 30277476)
host :
Rat
immunogen :
Mouse lymph node stromal cells
isotype :
IgM Kappa
purity :
IgM purified
species :
Human,Mouse
applications :
Immunoprecipitation,Western Blot,IF/IHC,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,In vivo assay,Immunocytochemistry/ Immunofluorescence
USD :
479 USD
alt names :
MECA-79, Peripheral Node Addressin, PNAd
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.