product summary
request information :
company name :
Novus Biologicals
product type :
antibody
product name :
Rat Monoclonal c-Kit Antibody
catalog :
NB100-77477C
quantity :
0.1 mg
price :
429.00 USD
clonality :
monoclonal
host :
rat
reactivity :
human, mouse
application :
immunoprecipitation, immunohistochemistry, flow cytometry
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NB100-77477C
Product Name :
Rat Monoclonal c-Kit Antibody
List Price :
429.00 USD
Product Type :
Primary Antibodies
Package Size :
0.1 mg
AltNames :
CD117, CD117 antigen, ckit, C-Kit, EC 2.7.10.1, EC 2.7.10, PBT, piebald trait, proto-oncogene tyrosine-protein kinase Kit, Proto-oncogene c-Kit, SCFRmast/stem cell growth factor receptor, soluble KIT variant 1, Tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Background :
CD117 is a 145 kD immunoglobulin superfamily member, also known as c-Kit and stem cell factor receptor (SCFR). It is a transmembrane tyrosine-kinase receptor that binds the c-Kit ligand (also known as steel factor, stem cell factor, and mast cell growth factor). CD117 is expressed on hematopoietic stem cells (including multipotent hematopoietic stem cells, progenitors committed to myeloid and/or erythroid lineages, and T and B cell precursors), mast cells, and acute myeloid leukemia (AML) cells. CD117 interaction with it's ligand is critical for the development of hematopoietic stem cells. The 2B8 antibody does not block c-Kit activity.
Buffer :
50mM sodium borate
Clonality :
Monoclonal
Clone :
2B8
Concentration :
0.5 mg/ml
Conjugate :
DyLight 650
Application Summary :
Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Frozen, Immunoprecipitation
Host :
Rat
Immunogen :
Mouse bone marrow mast cells
Isotype :
IgG2b Kappa
Marker :
Hematopoietic Stem Cell Marker
Preservative :
No Preservative
Purity :
Affinity purified
CrossReactivity :
Mouse, Expected Cross-Reactivity based on immunogen sequence: Swine (Pig, Porcine). Human reactivity reported in scientific literature (PMID: 23967247)
Specificity :
CD117 (2B8)
Storage :
Store at 4C in the dark.
Uses :
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 0.25 microgram per one million cells in 100 microliter volume. Immunohistochemistry-frozen sections. It is recommended that the reagent be titrated for optimal performance for each application.
Research Area :
Cancer, CD Markers, Cytokine Research, Hematopoietic Stem Cell Markers, Immunology, Innate Immunity, Mesenchymal Stem Cell Markers, Mast Cell Markers, Signal Transduction, Protein Kinase, Stem Cell Markers, Tyrosine Kinases
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: usa
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.