product summary
Loading...
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Tryptophan hydroxylase 2 Antibody - BSA Free
catalog :
NB100-74555
quantity :
100 ul (also 0.025 ml)
price :
429 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
DyLight 405
clone name :
711-66
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
Novus Biologicals product webpage
citations: 28
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 4a
Lee J, Jeon Y, Park S, Son C. An Adrenalectomy Mouse Model Reflecting Clinical Features for Chronic Fatigue Syndrome. Biomolecules. 2020;10: pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 6b
Pomeranz L, Ekstrand M, Latcha K, Smith G, Enquist L, Friedman J. Gene Expression Profiling with Cre-Conditional Pseudorabies Virus Reveals a Subset of Midbrain Neurons That Participate in Reward Circuitry. J Neurosci. 2017;37:4128-4144 pubmed publisher
Baytas O, Kauer J, Morrow E. Loss of mitochondrial enzyme GPT2 causes early neurodegeneration in locus coeruleus. Neurobiol Dis. 2022;173:105831 pubmed publisher
Pouchelon G, Dwivedi D, Bollmann Y, Agba C, Xu Q, Mirow A, et al. The organization and development of cortical interneuron presynaptic circuits are area specific. Cell Rep. 2021;37:109993 pubmed publisher
Lee J, Lee S, Kim D, Shin N, Jeong S, Yang C, et al. Social isolation-related depression accelerates ethanol intake via microglia-derived neuroinflammation. Sci Adv. 2021;7:eabj3400 pubmed publisher
Ortuño M, Schneeberger M, Ilanges A, Marchildon F, Pellegrino K, Friedman J, et al. Melanocortin 4 receptor stimulation prevents antidepressant-associated weight gain in mice caused by long-term fluoxetine exposure. J Clin Invest. 2021;131: pubmed publisher
Seigneur E, Wang J, Dai J, Polepalli J, Sudhof T. Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors. Mol Psychiatry. 2021;: pubmed publisher
Vieira J, de Souza G, Kalil Cutti B, Giusti Paiva A, Vilela F. Post-traumatic stress disorder increases pain sensitivity by reducing descending noradrenergic and serotoninergic modulation. Behav Brain Res. 2021;411:113367 pubmed publisher
Cheng H, Qi Y, Lai N, Yang L, Xu C, Wang S, et al. Inhibition of hyperactivity of the dorsal raphe 5-HTergic neurons ameliorates hippocampal seizure. CNS Neurosci Ther. 2021;27:963-972 pubmed publisher
König N, Bimpisidis Z, Dumas S, Wallén Mackenzie A. Selective Knockout of the Vesicular Monoamine Transporter 2 (Vmat2) Gene in Calbindin2/Calretinin-Positive Neurons Results in Profound Changes in Behavior and Response to Drugs of Abuse. Front Behav Neurosci. 2020;14:578443 pubmed publisher
Okaty B, Sturrock N, Escobedo Lozoya Y, Chang Y, Senft R, Lyon K, et al. A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons. elife. 2020;9: pubmed publisher
Tudeau L, Acuña M, Albisetti G, Neumann E, Ralvenius W, Scheurer L, et al. Mice lacking spinal α2GABAA receptors: Altered GABAergic neurotransmission, diminished GABAergic antihyperalgesia, and potential compensatory mechanisms preventing a hyperalgesic phenotype. Brain Res. 2020;1741:146889 pubmed publisher
Dombret C, Naulé L, Trouillet A, Parmentier C, Hardin Pouzet H, Mhaouty Kodja S. Effects of neural estrogen receptor beta deletion on social and mood-related behaviors and underlying mechanisms in male mice. Sci Rep. 2020;10:6242 pubmed publisher
Ren J, Isakova A, Friedmann D, Zeng J, Grutzner S, Pun A, et al. Single-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei. elife. 2019;8: pubmed publisher
Li Y, Li C, Xi W, Jin S, Wu Z, Jiang P, et al. Rostral and Caudal Ventral Tegmental Area GABAergic Inputs to Different Dorsal Raphe Neurons Participate in Opioid Dependence. Neuron. 2019;101:748-761.e5 pubmed publisher
Thier M, Hommerding O, Panten J, Pinna R, García González D, Berger T, et al. Identification of Embryonic Neural Plate Border Stem Cells and Their Generation by Direct Reprogramming from Adult Human Blood Cells. Cell Stem Cell. 2019;24:166-182.e13 pubmed publisher
Dosumu Johnson R, Cocoran A, Chang Y, Nattie E, Dymecki S. Acute perturbation of Pet1-neuron activity in neonatal mice impairs cardiorespiratory homeostatic recovery. elife. 2018;7: pubmed publisher
Soiza Reilly M, Meye F, Olusakin J, Telley L, Petit E, Chen X, et al. SSRIs target prefrontal to raphe circuits during development modulating synaptic connectivity and emotional behavior. Mol Psychiatry. 2019;24:726-745 pubmed publisher
Ehlinger D, Commons K. Cav1.2 L-type calcium channels regulate stress coping behavior via serotonin neurons. Neuropharmacology. 2019;144:282-290 pubmed publisher
Ren J, Friedmann D, Xiong J, Liu C, Ferguson B, Weerakkody T, et al. Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems. Cell. 2018;175:472-487.e20 pubmed publisher
Ma J, Wang F, Yang J, Dong Y, Su G, Zhang K, et al. Xiaochaihutang attenuates depressive/anxiety-like behaviors of social isolation-reared mice by regulating monoaminergic system, neurogenesis and BDNF expression. J Ethnopharmacol. 2017;208:94-104 pubmed publisher
Natarajan R, Forrester L, Chiaia N, Yamamoto B. Chronic-Stress-Induced Behavioral Changes Associated with Subregion-Selective Serotonin Cell Death in the Dorsal Raphe. J Neurosci. 2017;37:6214-6223 pubmed publisher
Goto S, Ogi H, Fushiki S, Itoh K. Prenatal and lactational bisphenol A exposure does not alter serotonergic neurons morphologically in the murine dorsal raphe nucleus. Brain Dev. 2017;39:475-482 pubmed publisher
Coyle D, Murphy J, Doyle B, O Donnell A, Gillick J, Puri P. Altered tryptophan hydroxylase 2 expression in enteric serotonergic nerves in Hirschsprung's-associated enterocolitis. World J Gastroenterol. 2016;22:4662-72 pubmed publisher
Barrett K, Dosumu Johnson R, Daubenspeck J, Brust R, Kreouzis V, Kim J, et al. Partial Raphe Dysfunction in Neurotransmission Is Sufficient to Increase Mortality after Anoxic Exposures in Mice at a Critical Period in Postnatal Development. J Neurosci. 2016;36:3943-53 pubmed publisher
Commons K. Ascending serotonin neuron diversity under two umbrellas. Brain Struct Funct. 2016;221:3347-60 pubmed publisher
Alter S, Stout K, Lohr K, Taylor T, Shepherd K, Wang M, et al. Reduced vesicular monoamine transport disrupts serotonin signaling but does not cause serotonergic degeneration. Exp Neurol. 2016;275 Pt 1:17-24 pubmed publisher
Näslund J, Studer E, Pettersson R, Hagsäter M, Nilsson S, Nissbrandt H, et al. Differences in Anxiety-Like Behavior within a Batch of Wistar Rats Are Associated with Differences in Serotonergic Transmission, Enhanced by Acute SRI Administration, and Abolished By Serotonin Depletion. Int J Neuropsychopharmacol. 2015;18: pubmed publisher
product information
brand :
Novus
master code :
NB100-74555
SKU :
NB100-74555
product name :
Tryptophan hydroxylase 2 Antibody - BSA Free
description :
The Tryptophan hydroxylase 2 Antibody - BSA Free from Novus Biologicals is a rabbit polyclonal antibody to Tryptophan hydroxylase 2. This antibody reacts with human, mouse, rat, primate, rabbit. The Tryptophan hydroxylase 2 Antibody - BSA Free has been validated for the following applications: Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunohistochemistry Free-Floating.
target :
Tryptophan hydroxylase 2
category :
Primary Antibodies
sizes available :
100 ul (also 0.025 ml)
buffer :
PBS
clonality :
Polyclonal
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
Synthetic peptide make to an internal portion of the mouse Tryptophan hydroxylase 2 protein (between amino acids 10-75) [UniProt Q8CGV2]
isotype :
IgG
purity :
Immunogen affinity purified
species :
Human, Mouse, Rat, Primate, Rabbit
gene symbol :
TPH2
accessionNumbers :
Q8IWU9
applications :
Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunohistochemistry Free-Floating
USD :
410
USD 2023 :
429 USD
alt names :
ADHD7, EC 1.14.16, EC 1.14.16.4, FLJ37295, MGC138872, Neuronal tryptophan hydroxylase, NTPHMGC138871, tryptophan 5-hydroxylase 2, Tryptophan 5-monooxygenase 2, tryptophan hydroxylase 2
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.