product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Proinsulin Antibody (CCI-17) - BSA Free
catalog :
NB100-73013
quantity :
0.2 mg
price :
319 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
CCI-17
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunocytochemistry
more info or order :
Novus Biologicals product webpage
citations: 11
Reference
Liu Y, Yang X, Zhou J, Yang H, Yang R, Zhu P, et al. OSGEP regulates islet β-cell function by modulating proinsulin translation and maintaining ER stress homeostasis in mice. Nat Commun. 2024;15:10479 pubmed publisher
Arunagiri A, Alam M, Haataja L, Draz H, Alasad B, Samy P, et al. Proinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis. Protein Sci. 2024;33:e4949 pubmed publisher
Xu X, Arunagiri A, Alam M, Haataja L, Evans C, Zhao I, et al. Nutrient-dependent regulation of β-cell proinsulin content. J Biol Chem. 2023;299:104836 pubmed publisher
Xu X, Arunagiri A, Haataja L, Alam M, Ji S, Qi L, et al. Proteasomal degradation of WT proinsulin in pancreatic beta cells. J Biol Chem. 2022;298:102406 pubmed publisher
Chen C, Guan B, Alzahrani M, Gao Z, Gao L, Bracey S, et al. Adaptation to chronic ER stress enforces pancreatic β-cell plasticity. Nat Commun. 2022;13:4621 pubmed publisher
Miyake M, Sobajima M, Kurahashi K, Shigenaga A, Denda M, Otaka A, et al. Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells. Cell Chem Biol. 2022;29:996-1009.e9 pubmed publisher
Xu X, Huang Y, Li X, Arvan P, Liu M. The Role of TRAPγ/SSR3 in Preproinsulin Translocation Into the Endoplasmic Reticulum. Diabetes. 2022;71:440-452 pubmed publisher
Herlea Pana O, Eeda V, Undi R, Lim H, Wang W. Pharmacological Inhibition of Inositol-Requiring Enzyme 1α RNase Activity Protects Pancreatic Beta Cell and Improves Diabetic Condition in Insulin Mutation-Induced Diabetes. Front Endocrinol (Lausanne). 2021;12:749879 pubmed publisher
Chen Y, Knupp J, Arunagiri A, Haataja L, Arvan P, Tsai B. PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones. Nat Commun. 2021;12:5991 pubmed publisher
Huang Y, Xu X, Arvan P, Liu M. Deficient endoplasmic reticulum translocon-associated protein complex limits the biosynthesis of proinsulin and insulin. FASEB J. 2021;35:e21515 pubmed publisher
Liu S, Li X, Yang J, Zhu R, Fan Z, Xu X, et al. Misfolded proinsulin impairs processing of precursor of insulin receptor and insulin signaling in β cells. FASEB J. 2019;33:11338-11348 pubmed publisher
product information
brand :
Novus
catalog number base :
NB100-73013
SKU :
NB100-73013
product name :
Proinsulin Antibody (CCI-17) - BSA Free
units size :
0.2 mg
description :
The Proinsulin Antibody (CCI-17) - BSA Free from Novus is a mouse monoclonal antibody to Proinsulin. This antibody reacts with human,mouse,rat. The Proinsulin Antibody (CCI-17) - BSA Free has been validated for the following applications: ELISA,Western Blot,Sandwich ELISA,Immunocytochemistry/ Immunofluorescence.
target :
Proinsulin
category :
Primary Antibodies
buffer :
PBS (pH 7.4)
clonality :
Monoclonal
clone :
CCI-17
conjugate :
Unconjugated
all_available conjugate :
Unconjugated
host :
Mouse
immunogen :
Hybridoma clone has been derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice immunized with fragment of rat proinsulin conjugated with a carrier protein.
isotype :
IgG1
purity :
Protein A purified
species :
Human,Mouse,Rat
specificity :
Affinity (Kd) > 1 x 10^8
gene symbol :
INS
review stars :
5
applications :
ELISA,Western Blot,Sandwich ELISA,Immunocytochemistry/ Immunofluorescence
USD :
319 USD
alt names :
IDDM2, ILPR, insulin, IRDN, MODY10, proinsulin
storage :
Store at 4C. Do not freeze.
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.