Proinsulin Antibody (CCI-17) | Novus Biologicals NB100-73013 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

Proinsulin Antibody (CCI-17)

catalog :

NB100-73013

quantity :

0.2 mg

price :

319 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CCI-17

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunocytochemistry

more info or order :

Novus Biologicals product webpage

citations: 7

Reference
Xu X, Arunagiri A, Haataja L, Alam M, Ji S, Qi L, et al. Proteasomal degradation of WT proinsulin in pancreatic beta cells. J Biol Chem. 2022;298:102406 pubmed publisher
Chen C, Guan B, Alzahrani M, Gao Z, Gao L, Bracey S, et al. Adaptation to chronic ER stress enforces pancreatic β-cell plasticity. Nat Commun. 2022;13:4621 pubmed publisher
Xu X, Huang Y, Li X, Arvan P, Liu M. The Role of TRAPγ/SSR3 in Preproinsulin Translocation Into the Endoplasmic Reticulum. Diabetes. 2022;71:440-452 pubmed publisher
Herlea Pana O, Eeda V, Undi R, Lim H, Wang W. Pharmacological Inhibition of Inositol-Requiring Enzyme 1α RNase Activity Protects Pancreatic Beta Cell and Improves Diabetic Condition in Insulin Mutation-Induced Diabetes. Front Endocrinol (Lausanne). 2021;12:749879 pubmed publisher
Chen Y, Knupp J, Arunagiri A, Haataja L, Arvan P, Tsai B. PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones. Nat Commun. 2021;12:5991 pubmed publisher
Huang Y, Xu X, Arvan P, Liu M. Deficient endoplasmic reticulum translocon-associated protein complex limits the biosynthesis of proinsulin and insulin. FASEB J. 2021;35:e21515 pubmed publisher
Liu S, Li X, Yang J, Zhu R, Fan Z, Xu X, et al. Misfolded proinsulin impairs processing of precursor of insulin receptor and insulin signaling in β cells. FASEB J. 2019;33:11338-11348 pubmed publisher

product information

brand :

Novus Biologicals, a Bio-Techne brand

catalog number base :

NB100-73013

SKU :

NB100-73013

product name :

Proinsulin Antibody (CCI-17)

description :

The Proinsulin Antibody (CCI-17) from Novus Biologicals is a mouse monoclonal antibody to Proinsulin. This antibody reacts with human,mouse,rat. The Proinsulin Antibody (CCI-17) has been validated for the following applications: ELISA,Sandwich ELISA,Western Blot,Immunocytochemistry/ Immunofluorescence.

target :

Proinsulin

unit size :

0.2 mg

category :

Primary Antibodies

buffer :

PBS (pH 7.4)

clonality :

Monoclonal

clone :

CCI-17

conjugate :

Unconjugated

host :

Mouse

immunogen :

Hybridoma clone has been derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice immunized with fragment of rat proinsulin conjugated with a carrier protein.

isotype :

IgG1

purity :

Protein A purified

species :

Human,Mouse,Rat

storage :

Store at 4C. Do not freeze.

gene symbol :

INS

applications :

ELISA,Sandwich ELISA,Western Blot,Immunocytochemistry/ Immunofluorescence

USD :

309

USD 2025 :

319 USD

alt names :

IDDM2, ILPR, insulin, IRDN, MODY10, proinsulin

more info or order :

Novus Biologicals product webpage