CD68/SR-D1 Antibody (KP1) | Novus Biologicals NB100-683 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

CD68/SR-D1 Antibody (KP1)

catalog :

NB100-683

quantity :

0.025 mg

price :

179 USD

clonality :

monoclonal

host :

mouse

conjugate :

Alexa Fluor 532

clone name :

KP1

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 52

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; loading ...; fig s7	Xiong Y, Neifert S, Karuppagounder S, Liu Q, Stankowski J, Lee B, et al. Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice. Proc Natl Acad Sci U S A. 2018;115:1635-1640 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:800; loading ...	Brocks T, Fedorchenko O, Schliermann N, Stein A, Moll U, Seegobin S, et al. Macrophage migration inhibitory factor protects from nonmelanoma epidermal tumors by regulating the number of antigen-presenting cells in skin. FASEB J. 2017;31:526-543 pubmed publisher
immunohistochemistry - paraffin section; human; 1:1000; fig s1	Miao H, Ou J, Peng Y, Zhang X, Chen Y, Hao L, et al. Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM. Nat Commun. 2016;7:11716 pubmed publisher
immunohistochemistry - paraffin section; mouse	Pandurangan A, Ismail S, Saadatdoust Z, Esa N. Allicin Alleviates Dextran Sodium Sulfate- (DSS-) Induced Ulcerative Colitis in BALB/c Mice. Oxid Med Cell Longev. 2015;2015:605208 pubmed publisher
immunohistochemistry - paraffin section; rat	Lin F, Hsiao F, Huang C, Shih C, Tsao N, Tsai C, et al. Porphyromonas gingivalis GroEL induces osteoclastogenesis of periodontal ligament cells and enhances alveolar bone resorption in rats. PLoS ONE. 2014;9:e102450 pubmed publisher
immunohistochemistry - paraffin section; mouse	Joshi Barr S, Bett C, Chiang W, Trejo M, Goebel H, Sikorska B, et al. De novo prion aggregates trigger autophagy in skeletal muscle. J Virol. 2014;88:2071-82 pubmed publisher
immunohistochemistry; human	Herwig M, Bergstrom C, Wells J, Höller T, Grossniklaus H. M2/M1 ratio of tumor associated macrophages and PPAR-gamma expression in uveal melanomas with class 1 and class 2 molecular profiles. Exp Eye Res. 2013;107:52-8 pubmed publisher
immunocytochemistry; human	Spigoni V, Picconi A, Cito M, Ridolfi V, Bonomini S, Casali C, et al. Pioglitazone improves in vitro viability and function of endothelial progenitor cells from individuals with impaired glucose tolerance. PLoS ONE. 2012;7:e48283 pubmed publisher
immunohistochemistry; mouse	Chan C, Cheng L, Lin C, Huang Y, Lin H, Lee F. The protective role of natural phytoalexin resveratrol on inflammation, fibrosis and regeneration in cholestatic liver injury. Mol Nutr Food Res. 2011;55:1841-9 pubmed publisher
immunohistochemistry; mouse	Avouac J, Fürnrohr B, Tomcik M, Palumbo K, Zerr P, Horn A, et al. Inactivation of the transcription factor STAT-4 prevents inflammation-driven fibrosis in animal models of systemic sclerosis. Arthritis Rheum. 2011;63:800-9 pubmed publisher
immunocytochemistry; human immunohistochemistry; human	Thenappan T, Goel A, Marsboom G, Fang Y, Toth P, Zhang H, et al. A central role for CD68(+) macrophages in hepatopulmonary syndrome. Reversal by macrophage depletion. Am J Respir Crit Care Med. 2011;183:1080-91 pubmed publisher
immunohistochemistry - paraffin section; mouse	Sun I, Eun D, Na J, Lee S, Kim I, Youn I, et al. Heparin-coated gold nanoparticles for liver-specific CT imaging. Chemistry. 2009;15:13341-7 pubmed publisher
flow cytometry; human immunohistochemistry; human western blot; human	Gottfried E, Kunz Schughart L, Weber A, Rehli M, Peuker A, Muller A, et al. Expression of CD68 in non-myeloid cell types. Scand J Immunol. 2008;67:453-63 pubmed publisher
immunohistochemistry; human	Canioni D, Salles G, Mounier N, Brousse N, Keuppens M, Morchhauser F, et al. High numbers of tumor-associated macrophages have an adverse prognostic value that can be circumvented by rituximab in patients with follicular lymphoma enrolled onto the GELA-GOELAMS FL-2000 trial. J Clin Oncol. 2008;26:440-6 pubmed
immunohistochemistry; human	Lau S, Chu P, Weiss L. CD163: a specific marker of macrophages in paraffin-embedded tissue samples. Am J Clin Pathol. 2004;122:794-801 pubmed
immunocytochemistry; human	King B, Crisi G, Tsai S, Haffty B, Phillips R, Rimm D. Immunocytochemical analysis of breast cells obtained by ductal lavage. Cancer. 2002;96:244-9 pubmed
immunohistochemistry; human	Chang C, Eshoa C, Kampalath B, Shidham V, Perkins S. Immunophenotypic profile of myeloid cells in granulocytic sarcoma by immunohistochemistry. Correlation with blast differentiation in bone marrow. Am J Clin Pathol. 2000;114:807-11 pubmed
immunohistochemistry; human	Mallat Z, Heymes C, Ohan J, Faggin E, Leseche G, Tedgui A. Expression of interleukin-10 in advanced human atherosclerotic plaques: relation to inducible nitric oxide synthase expression and cell death. Arterioscler Thromb Vasc Biol. 1999;19:611-6 pubmed
immunohistochemistry; human	Gravallese E, Harada Y, Wang J, Gorn A, Thornhill T, Goldring S. Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis. Am J Pathol. 1998;152:943-51 pubmed
flow cytometry; human immunocytochemistry; human western blot; human	Ramprasad M, Terpstra V, Kondratenko N, Quehenberger O, Steinberg D. Cell surface expression of mouse macrosialin and human CD68 and their role as macrophage receptors for oxidized low density lipoprotein. Proc Natl Acad Sci U S A. 1996;93:14833-8 pubmed
immunohistochemistry; human	Sugiyama M, Tsukazaki T, Yonekura A, Matsuzaki S, Yamashita S, Iwasaki K. Localisation of apoptosis and expression of apoptosis related proteins in the synovium of patients with rheumatoid arthritis. Ann Rheum Dis. 1996;55:442-9 pubmed
immunohistochemistry; human	Rugtveit J, Brandtzaeg P, Halstensen T, Fausa O, Scott H. Increased macrophage subset in inflammatory bowel disease: apparent recruitment from peripheral blood monocytes. Gut. 1994;35:669-74 pubmed
	Jaén R, Fernandez Velasco M, Terrón V, Sánchez García S, Zaragoza C, Canales Bueno N, et al. BML-111 treatment prevents cardiac apoptosis and oxidative stress in a mouse model of autoimmune myocarditis. FASEB J. 2020;: pubmed publisher
	Chen W, Lin C, Kuo S, Liu S, Lu Y, Chen Y, et al. Resistin Enhances VCAM-1 Expression and Monocyte Adhesion in Human Osteoarthritis Synovial Fibroblasts by Inhibiting MiR-381 Expression through the PKC, p38, and JNK Signaling Pathways. Cells. 2020;9: pubmed publisher
	Wang M, Li H, Wang Y, Hao Y, Huang Y, Wang X, et al. Anti-Rheumatic Properties of Gentiopicroside Are Associated With Suppression of ROS-NF-κB-NLRP3 Axis in Fibroblast-Like Synoviocytes and NF-κB Pathway in Adjuvant-Induced Arthritis. Front Pharmacol. 2020;11:515 pubmed publisher
	Schoenenberger A, Tempfer H, Lehner C, Egloff J, Mauracher M, Bird A, et al. Macromechanics and polycaprolactone fiber organization drive macrophage polarization and regulate inflammatory activation of tendon in vitro and in vivo. Biomaterials. 2020;249:120034 pubmed publisher
	Liu Y, Li M, Wei C, Tang L, Sheng Y, Liu Y, et al. TSP1-CD47-SIRPα signaling facilitates the development of endometriosis by mediating the survival of ectopic endometrium. Am J Reprod Immunol. 2020;83:e13236 pubmed publisher
	McCloskey C, Cook D, Kelly B, Azzi F, Allen C, Forsyth A, et al. Metformin Abrogates Age-Associated Ovarian Fibrosis. Clin Cancer Res. 2020;26:632-642 pubmed publisher
	Liu X, Chen J, Zhang B, Liu G, Zhao H, Hu Q. KDM3A inhibition modulates macrophage polarization to aggravate post-MI injuries and accelerates adverse ventricular remodeling via an IRF4 signaling pathway. Cell Signal. 2019;64:109415 pubmed publisher
	Wu Y, Qin Y, Liu Y, Zhu L, Zhao X, Liu Y, et al. Cardiac troponin I autoantibody induces myocardial dysfunction by PTEN signaling activation. EBioMedicine. 2019;47:329-340 pubmed publisher
	Liu W, Kämpfe Nordström C, Danckwardt Lillieström N, Rask Andersen H. Human Inner Ear Immune Activity: A Super-Resolution Immunohistochemistry Study. Front Neurol. 2019;10:728 pubmed publisher
	Ding J, Yin T, Yan N, Cheng Y, Yang J. FasL on decidual macrophages mediates trophoblast apoptosis: A potential cause of recurrent miscarriage. Int J Mol Med. 2019;43:2376-2386 pubmed publisher
	Triulzi T, Forte L, Regondi V, Di Modica M, Ghirelli C, Carcangiu M, et al. HER2 signaling regulates the tumor immune microenvironment and trastuzumab efficacy. Oncoimmunology. 2019;8:e1512942 pubmed publisher
	Kämpfe Nordström C, Danckwardt Lillieström N, Laurell G, Liu W, Rask Andersen H. The Human Endolymphatic Sac and Inner Ear Immunity: Macrophage Interaction and Molecular Expression. Front Immunol. 2018;9:3181 pubmed publisher
	Triulzi T, Regondi V, De Cecco L, Cappelletti M, Di Modica M, Paolini B, et al. Early immune modulation by single-agent trastuzumab as a marker of trastuzumab benefit. Br J Cancer. 2018;119:1487-1494 pubmed publisher
	van Rooijen J, Qiu S, Timmer Bosscha H, van der Vegt B, Boers J, Schröder C, et al. Androgen receptor expression inversely correlates with immune cell infiltration in human epidermal growth factor receptor 2-positive breast cancer. Eur J Cancer. 2018;103:52-60 pubmed publisher
	Li D, Wang C, Li Z, Wang H, He J, Zhu J, et al. Nano-sized Al2O3 particle-induced autophagy reduces osteolysis in aseptic loosening of total hip arthroplasty by negative feedback regulation of RANKL expression in fibroblasts. Cell Death Dis. 2018;9:840 pubmed publisher
	Xiang W, Shi R, Kang X, Zhang X, Chen P, Zhang L, et al. Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression. Nat Commun. 2018;9:2574 pubmed publisher
	Ao J, Zhu X, Chai Z, Cai H, Zhang Y, Zhang K, et al. Colony-Stimulating Factor 1 Receptor Blockade Inhibits Tumor Growth by Altering the Polarization of Tumor-Associated Macrophages in Hepatocellular Carcinoma. Mol Cancer Ther. 2017;16:1544-1554 pubmed publisher
	Liu X, Guo X, Li J, Wu M, Zhan X. Interferon-? Aggravated L-Arginine-Induced Acute Pancreatitis in Sprague-Dawley Rats and Its Possible Mechanism: Trypsinogen Activation and Autophagy Up-regulation. Pancreas. 2017;46:619-625 pubmed publisher
	Lhotak S, Gyulay G, Cutz J, Al Hashimi A, Trigatti B, Richards C, et al. Characterization of Proliferating Lesion-Resident Cells During All Stages of Atherosclerotic Growth. J Am Heart Assoc. 2016;5: pubmed publisher
	Feng X, Weng D, Zhou F, Owen Y, Qin H, Zhao J, et al. Activation of PPAR? by a Natural Flavonoid Modulator, Apigenin Ameliorates Obesity-Related Inflammation Via Regulation of Macrophage Polarization. EBioMedicine. 2016;9:61-76 pubmed publisher
	Koh M, Gagea M, Sargis T, Lemos R, Grandjean G, Charbono A, et al. A new HIF-1Î±/RANTES-driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF in mice. Hepatology. 2016;63:1576-91 pubmed publisher
	Della Puppa A, Persano L, Masi G, Rampazzo E, Sinigaglia A, Pistollato F, et al. MGMT expression and promoter methylation status may depend on the site of surgical sample collection within glioblastoma: a possible pitfall in stratification of patients?. J Neurooncol. 2012;106:33-41 pubmed publisher
	Petrovichev N, Chistyakova O, Smirnov A, Poltoranina V, Rudinskaya T. Antimacrophage monoclonal antibody D11 in the diagnosis of tumors of histiocytic origin. Acta Cytol. 1997;41:357-63 pubmed
	Tupitsyn N, Frenkel M, Rudinskaya T, Poltoranina V, Sholokhova E, Lebedeva N, et al. Reactivity of anti-macrophage monoclonal antibody D11 in human leukemia and malignant lymphoma. Int J Cancer. 1996;68:160-3 pubmed
	Petrovichev N, Chistiakova O, Smirnov A, Rudinskaia T, Poltoranina V. [Anti-macrophage monoclonal antibody D-11 in the diagnosis of histiocytic tumors]. Arkh Patol. 1995;57:25-30 pubmed
	Warnke R, Pulford K, Pallesen G, Ralfkiaer E, Brown D, Gatter K, et al. Diagnosis of myelomonocytic and macrophage neoplasms in routinely processed tissue biopsies with monoclonal antibody KP1. Am J Pathol. 1989;135:1089-95 pubmed
	Pulford K, Rigney E, Micklem K, Jones M, Stross W, Gatter K, et al. KP1: a new monoclonal antibody that detects a monocyte/macrophage associated antigen in routinely processed tissue sections. J Clin Pathol. 1989;42:414-21 pubmed
	Horny H, Schaumburg Lever G, Bolz S, Geerts M, Kaiserling E. Use of monoclonal antibody KP1 for identifying normal and neoplastic human mast cells. J Clin Pathol. 1990;43:719-22 pubmed
	Facchetti F, Bertalot G, Grigolato P. KP1 (CD 68) staining of malignant melanomas. Histopathology. 1991;19:141-5 pubmed
	Saito N, Pulford K, Breton Gorius J, Masse J, Mason D, Cramer E. Ultrastructural localization of the CD68 macrophage-associated antigen in human blood neutrophils and monocytes. Am J Pathol. 1991;139:1053-9 pubmed

product information

brand :

Novus

master code :

NB100-683

SKU :

NB100-683-0.025mg

product name :

CD68/SR-D1 Antibody (KP1)

description :

The CD68/SR-D1 Antibody (KP1) from Novus Biologicals is a mouse monoclonal antibody to CD68/SR-D1. This antibody reacts with human, mouse, rat. The CD68/SR-D1 Antibody (KP1) has been validated for the following applications: Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Electron Microscopy.

target :

CD68/SR-D1

category :

Primary Antibodies

unit size :

0.025 mg

buffer :

PBS

clonality :

Monoclonal

clone :

KP1

concentration :

1.0 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

Subcellular fraction of human alveolar macrophages.

isotype :

IgG1 Kappa

purity :

Protein G purified

species :

Human, Mouse, Rat

specificity :

This is specific to macrophages in a wide variety of human tissues. It reacts with myeloid precursors and peripheral blood granulocytes. It also stains a cell population known as Plasmacytoid T cells.

gene symbol :

CD68

catalog number base :

NB100-683

accessionNumbers :

P34810

applications :

Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Electron Microscopy

2020 USD :

179

2021 USD :

179 USD

alt names :

CD_antigen: CD68, CD68, CD68 antigen, CD68 molecule, DKFZp686M18236, GP110, LAMP4, macrophage antigen CD68, macrosialin, SCARD1, scavenger receptor class D, member 1

storage :

Store at 4C. Do not freeze.