Caveolin-1 Antibody (7C8) | Novus Biologicals NB100-615 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

Caveolin-1 Antibody (7C8)

catalog :

NB100-615

quantity :

0.1 ml (also 0.025 ml)

price :

379 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7C8

reactivity :

human, mouse, rat, domestic sheep

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Novus Biologicals product webpage

citations: 29

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; fig 2	Yokomori H, Ando W, Yoshimura K, Yamazaki H, Takahashi Y, Oda M. Increases in endothelial caveolin-1 and cavins correlate with cirrhosis progression. Micron. 2015;76:52-61 pubmed publisher
immunohistochemistry - frozen section; mouse	Kallenborn Gerhardt W, Lu R, Bothe A, Thomas D, Schlaudraff J, Lorenz J, et al. Phosphodiesterase 2A localized in the spinal cord contributes to inflammatory pain processing. Anesthesiology. 2014;121:372-82 pubmed publisher
western blot; rat	Czeredys M, Samluk Ł, Michalec K, Tułodziecka K, Skowronek K, Nałęcz K. Caveolin-1--a novel interacting partner of organic cation/carnitine transporter (Octn2): effect of protein kinase C on this interaction in rat astrocytes. PLoS ONE. 2013;8:e82105 pubmed publisher
immunocytochemistry; human	Bielaszewska M, Rüter C, Kunsmann L, Greune L, Bauwens A, Zhang W, et al. Enterohemorrhagic Escherichia coli hemolysin employs outer membrane vesicles to target mitochondria and cause endothelial and epithelial apoptosis. PLoS Pathog. 2013;9:e1003797 pubmed publisher
immunocytochemistry; mouse	Charfi C, Levros L, Edouard E, Rassart E. Characterization and identification of PARM-1 as a new potential oncogene. Mol Cancer. 2013;12:84 pubmed publisher
immunocytochemistry; human	Grenon S, Jeanne M, Aguado Zuniga J, Conte M, Hughes Fulford M. Effects of gravitational mechanical unloading in endothelial cells: association between caveolins, inflammation and adhesion molecules. Sci Rep. 2013;3:1494 pubmed publisher
western blot; domestic sheep	Teng R, Du J, Afolayan A, Eis A, Shi Y, Konduri G. AMP kinase activation improves angiogenesis in pulmonary artery endothelial cells with in utero pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2013;304:L29-42 pubmed publisher
western blot; mouse	Catalucci D, Zhang D, DeSantiago J, Aimond F, Barbara G, Chemin J, et al. Akt regulates L-type Ca2+ channel activity by modulating Cavalpha1 protein stability. J Cell Biol. 2009;184:923-33 pubmed publisher
	Sánchez Solana B, Wang D, Qian X, Velayoudame P, Simanshu D, Acharya J, et al. The tumor suppressor activity of DLC1 requires the interaction of its START domain with Phosphatidylserine, PLCD1, and Caveolin-1. Mol Cancer. 2021;20:141 pubmed publisher
	COLLINS D, Osborn M, Steer C. Differentiation of immortalized human multi-lineage progenitor to alveolar type 2-like cells: angiotensin-converting enzyme 2 expression and binding of severe acute respiratory syndrome coronavirus 2 spike and spike 1 proteins. Cytotherapy. 2021;23:1064-1073 pubmed publisher
	Kurebayashi Y, Bajimaya S, Watanabe M, Lim N, Lutz M, Dunagan M, et al. Human parainfluenza virus type 1 regulates cholesterol biosynthesis and establishes quiescent infection in human airway cells. PLoS Pathog. 2021;17:e1009908 pubmed publisher
	Anderson Baucum E, Piñeros A, Kulkarni A, Webb Robertson B, Maier B, Anderson R, et al. Deoxyhypusine synthase promotes a pro-inflammatory macrophage phenotype. Cell Metab. 2021;33:1883-1893.e7 pubmed publisher
	Daneva Z, Ottolini M, Chen Y, Klimentova E, Kuppusamy M, Shah S, et al. Endothelial pannexin 1-TRPV4 channel signaling lowers pulmonary arterial pressure in mice. elife. 2021;10: pubmed publisher
	Jiang H, Wu T, Liu J, Yu X, Liu H, Bao C, et al. Caveolae/rafts protect human cerebral microvascular endothelial cells from Streptococcus suis serotype 2 α-enolase-mediated injury. Vet Microbiol. 2021;254:108981 pubmed publisher
	Srisomboon Y, Squillace D, Maniak P, Kita H, O Grady S. Fungal allergen-induced IL-33 secretion involves cholesterol-dependent, VDAC-1-mediated ATP release from the airway epithelium. J Physiol. 2020;598:1829-1845 pubmed publisher
	Savio L, de Andrade Mello P, Santos S, de Sousa J, Oliveira S, Minshall R, et al. P2X7 receptor activation increases expression of caveolin-1 and formation of macrophage lipid rafts, thereby boosting CD39 activity. J Cell Sci. 2020;133: pubmed publisher
	Kim S, Kim S, Choi Y, Yoon H, Kim A, Lee J. Retinal VEGFA maintains the ultrastructure and function of choriocapillaris by preserving the endothelial PLVAP. Biochem Biophys Res Commun. 2020;522:240-246 pubmed publisher
	de Andrade Mello P, Bian S, Savio L, Zhang H, Zhang J, Junger W, et al. Hyperthermia and associated changes in membrane fluidity potentiate P2X7 activation to promote tumor cell death. Oncotarget. 2017;8:67254-67268 pubmed publisher
	Liu C, Liu T, Yu X, Gu Y. A preliminary study on the interaction between Asn-Gly-Arg (NGR)-modified multifunctional nanoparticles and vascular epithelial cells. Acta Pharm Sin B. 2017;7:361-372 pubmed publisher
	Elıyatkin N, Aktas S, Diniz G, Ozgur H, Ekin Z, Kupelioglu A. Expression of Stromal Caveolin- 1 May Be a Predictor for Aggressive Behaviour of Breast Cancer. Pathol Oncol Res. 2018;24:59-65 pubmed publisher
	Arima M, Cui D, Kimura T, Sonoda K, Ishibashi T, Matsuda S, et al. Basigin can be a therapeutic target to restore the retinal vascular barrier function in the mouse model of diabetic retinopathy. Sci Rep. 2016;6:38445 pubmed publisher
	Ayaz D, Diniz G, Kahraman D, Sayhan S, Uncel M, Karadeniz T, et al. The evaluation of the caveolin-1 and AT-rich interactive domain 1 alpha expressions in uterine smooth muscle tumors. Indian J Pathol Microbiol. 2016;59:301-4 pubmed publisher
	Li Z, Scott M, Fan E, Li Y, Liu J, Xiao G, et al. Tissue damage negatively regulates LPS-induced macrophage necroptosis. Cell Death Differ. 2016;23:1428-47 pubmed publisher
	Gabanella F, Pisani C, Borreca A, Farioli Vecchioli S, Ciotti M, Ingegnere T, et al. SMN affects membrane remodelling and anchoring of the protein synthesis machinery. J Cell Sci. 2016;129:804-16 pubmed publisher
	Boyce A, Kim M, Wicki Stordeur L, Swayne L. ATP stimulates pannexin 1 internalization to endosomal compartments. Biochem J. 2015;470:319-30 pubmed publisher
	Munjal C, Tyagi N, Lominadze D, Tyagi S. Matrix metalloproteinase-9 in homocysteine-induced intestinal microvascular endothelial paracellular and transcellular permeability. J Cell Biochem. 2012;113:1159-69 pubmed publisher
	Rudnick J, Arendt L, Klebba I, Hinds J, Iyer V, Gupta P, et al. Functional heterogeneity of breast fibroblasts is defined by a prostaglandin secretory phenotype that promotes expansion of cancer-stem like cells. PLoS ONE. 2011;6:e24605 pubmed publisher
	Davalos A, Fernandez Hernando C, Sowa G, Derakhshan B, Lin M, Lee J, et al. Quantitative proteomics of caveolin-1-regulated proteins: characterization of polymerase i and transcript release factor/CAVIN-1 IN endothelial cells. Mol Cell Proteomics. 2010;9:2109-24 pubmed publisher
	Souto R, Vallega G, Wharton J, Vinten J, Tranum Jensen J, Pilch P. Immunopurification and characterization of rat adipocyte caveolae suggest their dissociation from insulin signaling. J Biol Chem. 2003;278:18321-9 pubmed

product information

brand :

Novus

master code :

NB100-615

SKU :

NB100-615

product name :

Caveolin-1 Antibody (7C8)

description :

The Caveolin-1 Antibody (7C8) from NB100-615 is a nb100-615 antibody to . This antibody reacts with cancer, caveolae markers, cellular markers, cholesterol metabolism, hypoxia, lipid and metabolism, lipid droplets, signal transduction.

target :

Caveolin-1

category :

Primary Antibodies

unit sizes :

0.1 ml (also 0.025 ml)

buffer :

Tris-Glycine, 0.15 M NaCl

clonality :

Monoclonal

clone :

7C8

concentration :

1.0 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

Intracellular membrane protein-containing vesicles (containing GLUT4) from rat adipocytes

isotype :

IgG2b

purity :

Protein A purified

species :

Human, Mouse, Rat, Sheep

specificity :

This is specific for caveolin alpha and beta proteins

theoretical molecular weight :

23 kDa

gene symbol :

CAV1

applications :

Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunoblotting

USD :

379 USD

product details :

Caveolin 1 and 2 are usually both expressed and assembled into hetero-oligomers in the endoplasmic reticulum and Golgi apparatus. Caveolin 1 also interacts with lipids and lipid anchors, and may therefore function in both membrane traffic and lipid traffic. In vitro assays confirm that Caveolin 1 interacts with cholesterol, suggesting that Caveolin 1 may organize membrane cholesterol in caveolae. Caveolin 1 has high affinity to long chain unsaturated fatty acids. Additionally, Caveolin 1 may play a role in the export and import of cellular cholesterol by caveolae.

alt names :

CAV, caveolae protein, 22kD, caveolin 1, caveolae protein, 22kDa, cell growth-inhibiting protein 32, MSTP085

storage :

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage