TLR2 Antibody (TL2.1) - Azide Free | Novus Biologicals NB100-56726 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

TLR2 Antibody (TL2.1) - Azide Free

catalog :

NB100-56726

quantity :

0.1 mg (also 0.025 mg)

price :

499 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

TL2.1

reactivity :

human, mouse, rat, dogs

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Novus Biologicals product webpage

citations: 39

Reference
Ji X, Zhang X, Sun L, Hou X, Song H, Han L, et al. The Heparin-Binding Hemagglutinin of Nocardia cyriacigeorgica GUH-2 Stimulates Inflammatory Cytokine Secretion Through Activation of Nuclear Factor κB and Mitogen-Activated Protein Kinase Pathways via TLR4. Front Cell Infect Microbiol. 2020;10:3 pubmed publisher
The E, Yao Q, Zhang P, Zhai Y, Ao L, Fullerton D, et al. Mechanistic Roles of Matrilin-2 and Klotho in Modulating the Inflammatory Activity of Human Aortic Valve Cells. Cells. 2020;9: pubmed publisher
Ji X, Zhang X, Li H, Sun L, Hou X, Song H, et al. Nfa34810 Facilitates Nocardia farcinica Invasion of Host Cells and Stimulates Tumor Necrosis Factor Alpha Secretion through Activation of the NF-κB and Mitogen-Activated Protein Kinase Pathways via Toll-Like Receptor 4. Infect Immun. 2020;88: pubmed publisher
Li F, Song R, Ao L, Reece T, Cleveland J, Dong N, et al. ADAMTS5 Deficiency in Calcified Aortic Valves Is Associated With Elevated Pro-Osteogenic Activity in Valvular Interstitial Cells. Arterioscler Thromb Vasc Biol. 2017;37:1339-1351 pubmed publisher
KÃ¤bisch R, MejÃas Luque R, Gerhard M, Prinz C. Involvement of Toll-like receptors on Helicobacter pylori-induced immunity. PLoS ONE. 2014;9:e104804 pubmed publisher
Rojas Bernabé A, Garcia Hernández O, Maldonado Bernal C, Delegado Dominguez J, Ortega E, Gutiérrez Kobeh L, et al. Leishmania mexicana lipophosphoglycan activates ERK and p38 MAP kinase and induces production of proinflammatory cytokines in human macrophages through TLR2 and TLR4. Parasitology. 2014;141:788-800 pubmed publisher
Klink M, Brzezinska M, Szulc I, Brzostek A, Kielbik M, Sulowska Z, et al. Cholesterol oxidase is indispensable in the pathogenesis of Mycobacterium tuberculosis. PLoS ONE. 2013;8:e73333 pubmed publisher
Tsai C, Lin C, Tsai H, Chen C, Li W, Yu H, et al. The immunologically active oligosaccharides isolated from wheatgrass modulate monocytes via Toll-like receptor-2 signaling. J Biol Chem. 2013;288:17689-97 pubmed publisher
Abdi J, Mutis T, Garssen J, Redegeld F. Characterization of the Toll-like receptor expression profile in human multiple myeloma cells. PLoS ONE. 2013;8:e60671 pubmed publisher
Brzezinska M, Szulc I, Brzostek A, Klink M, Kielbik M, Sulowska Z, et al. The role of 3-ketosteroid 1(2)-dehydrogenase in the pathogenicity of Mycobacterium tuberculosis. BMC Microbiol. 2013;13:43 pubmed publisher
Harman A, Bye C, Nasr N, Sandgren K, Kim M, Mercier S, et al. Identification of lineage relationships and novel markers of blood and skin human dendritic cells. J Immunol. 2013;190:66-79 pubmed publisher
Shimizu T, Kida Y, Kuwano K. Cytoadherence-dependent induction of inflammatory responses by Mycoplasma pneumoniae. Immunology. 2011;133:51-61 pubmed publisher
Dasgupta G, Chentoufi A, You S, Falatoonzadeh P, Urbano L, Akhtarmalik A, et al. Engagement of TLR2 reverses the suppressor function of conjunctiva CD4+CD25+ regulatory T cells and promotes herpes simplex virus epitope-specific CD4+CD25- effector T cell responses. Invest Ophthalmol Vis Sci. 2011;52:3321-33 pubmed publisher
Melchjorsen J, Rintahaka J, Søby S, Horan K, Poltajainen A, Østergaard L, et al. Early innate recognition of herpes simplex virus in human primary macrophages is mediated via the MDA5/MAVS-dependent and MDA5/MAVS/RNA polymerase III-independent pathways. J Virol. 2010;84:11350-8 pubmed publisher
Oberg H, Ly T, Ussat S, Meyer T, Kabelitz D, Wesch D. Differential but direct abolishment of human regulatory T cell suppressive capacity by various TLR2 ligands. J Immunol. 2010;184:4733-40 pubmed publisher
Kasari V, Kurg K, Margus T, Tenson T, Kaldalu N. The Escherichia coli mqsR and ygiT genes encode a new toxin-antitoxin pair. J Bacteriol. 2010;192:2908-19 pubmed publisher
Ding J, Rapista A, Teleshova N, Mosoyan G, Jarvis G, Klotman M, et al. Neisseria gonorrhoeae enhances HIV-1 infection of primary resting CD4+ T cells through TLR2 activation. J Immunol. 2010;184:2814-24 pubmed publisher
Rydberg C, Mansson A, Uddman R, Riesbeck K, Cardell L. Toll-like receptor agonists induce inflammation and cell death in a model of head and neck squamous cell carcinomas. Immunology. 2009;128:e600-11 pubmed publisher
Yang X, Fullerton D, Su X, Ao L, Cleveland J, Meng X. Pro-osteogenic phenotype of human aortic valve interstitial cells is associated with higher levels of Toll-like receptors 2 and 4 and enhanced expression of bone morphogenetic protein 2. J Am Coll Cardiol. 2009;53:491-500 pubmed publisher
Ji S, Shin J, Kim Y, Oh J, Min B, Choi Y. Toll-like receptor 2 and NALP2 mediate induction of human beta-defensins by fusobacterium nucleatum in gingival epithelial cells. Infect Immun. 2009;77:1044-52 pubmed publisher
Guzy C, Paclik D, Schirbel A, Sonnenborn U, Wiedenmann B, Sturm A. The probiotic Escherichia coli strain Nissle 1917 induces gammadelta T cell apoptosis via caspase- and FasL-dependent pathways. Int Immunol. 2008;20:829-40 pubmed publisher
Burgener I, Jungi T. Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry. Vet Immunol Immunopathol. 2008;124:184-91 pubmed publisher
Prabha C, Rajashree P, Sulochana D. TLR2 and TLR4 expression on the immune cells of tuberculous pleural fluid. Immunol Lett. 2008;117:26-34 pubmed publisher
Pegu A, Qin S, Fallert Junecko B, Nisato R, Pepper M, Reinhart T. Human lymphatic endothelial cells express multiple functional TLRs. J Immunol. 2008;180:3399-405 pubmed
Wong C, Cheung P, Ip W, Lam C. Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils. Am J Respir Cell Mol Biol. 2007;37:85-96 pubmed
Menzies B, Kenoyer A. Signal transduction and nuclear responses in Staphylococcus aureus-induced expression of human beta-defensin 3 in skin keratinocytes. Infect Immun. 2006;74:6847-54 pubmed
Xu S, Koldovsky U, Xu M, Wang D, Fitzpatrick E, Son G, et al. High-avidity antitumor T-cell generation by toll receptor 8-primed, myeloid- derived dendritic cells is mediated by IL-12 production. Surgery. 2006;140:170-8 pubmed
Shimizu T, Kida Y, Kuwano K. A dipalmitoylated lipoprotein from Mycoplasma pneumoniae activates NF-kappa B through TLR1, TLR2, and TLR6. J Immunol. 2005;175:4641-6 pubmed
Srivastava M, Srivastava B. Expression of mRNA and proteins for toll-like receptors, associated molecules, defensins and LL-37 by SRIK-NKL, a CD8+ NK/T cell line. Leuk Res. 2005;29:813-20 pubmed
Cognasse F, Hamzeh H, Chavarin P, Acquart S, Genin C, Garraud O. Evidence of Toll-like receptor molecules on human platelets. Immunol Cell Biol. 2005;83:196-8 pubmed
Bazzocchi C, Mortarino M, Comazzi S, Bandi C, Franceschi A, Genchi C. Expression and function of Toll-like receptor 2 in canine blood phagocytes. Vet Immunol Immunopathol. 2005;104:15-9 pubmed
Zhong F, Cao W, Chan E, Tay P, Cahya F, Zhang H, et al. Deviation from major codons in the Toll-like receptor genes is associated with low Toll-like receptor expression. Immunology. 2005;114:83-93 pubmed
Gibson F, Hong C, Chou H, Yumoto H, Chen J, Lien E, et al. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2004;109:2801-6 pubmed
Mempel M, Voelcker V, Köllisch G, Plank C, Rad R, Gerhard M, et al. Toll-like receptor expression in human keratinocytes: nuclear factor kappaB controlled gene activation by Staphylococcus aureus is toll-like receptor 2 but not toll-like receptor 4 or platelet activating factor receptor dependent. J Invest Dermatol. 2003;121:1389-96 pubmed
Lotz S, Aga E, Wilde I, van Zandbergen G, Hartung T, Solbach W, et al. Highly purified lipoteichoic acid activates neutrophil granulocytes and delays their spontaneous apoptosis via CD14 and TLR2. J Leukoc Biol. 2004;75:467-77 pubmed
Medvedev A, Lentschat A, Wahl L, Golenbock D, Vogel S. Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells. J Immunol. 2002;169:5209-16 pubmed
Flo T, Halaas O, Torp S, Ryan L, Lien E, Dybdahl B, et al. Differential expression of Toll-like receptor 2 in human cells. J Leukoc Biol. 2001;69:474-81 pubmed
Faure E, Thomas L, Xu H, Medvedev A, Equils O, Arditi M. Bacterial lipopolysaccharide and IFN-gamma induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: role of NF-kappa B activation. J Immunol. 2001;166:2018-24 pubmed
Flo T, Halaas O, Lien E, Ryan L, Teti G, Golenbock D, et al. Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide. J Immunol. 2000;164:2064-9 pubmed

image

image 1 :

Flow Cytometry: TLR2 Antibody (TL2.1) - Azide Free [NB100-56726] - Analysis using Azide/BSA FREE version of NB100-56726. Cell surface flow analysis of TLR2 in 10^6 PBMCs using 1 ug of this antibody. Shaded histogram represents cells without antibody; green represents isotype control; red represents anti-TLR2 antibody.

product information

brand :

Novus Biologicals, a Bio-Techne brand

catalog number base :

NB100-56726

SKU :

NB100-56726

product name :

TLR2 Antibody (TL2.1) - Azide Free

description :

The TLR2 Antibody (TL2.1) - Azide Free from Novus Biologicals is a mouse monoclonal antibody to TLR2. This antibody reacts with canine,human,mouse,rabbit,rat. The TLR2 Antibody (TL2.1) - Azide Free has been validated for the following applications: ELISA,Immunohistochemistry,Immunoprecipitation,Flow (Intracellular),CyTOF-ready,Flow Cytometry Control,Flow Cytometry,Western Blot,Immunohistochemistry-Paraffin,In vitro assay,Flow (Cell Surface),Block/Neutralize,Immunocytochemistry/ Immunofluorescence.

target :

TLR2

unit size :

0.1 mg (also 0.025 mg)

category :

Primary Antibodies

buffer :

Filter (0.2 micron) sterilized PBS

clonality :

Monoclonal

clone :

TL2.1

conjugate :

Unconjugated

host :

Mouse

immunogen :

This antibody was raised by immunizing mice with CHO cells transfected with human TLR2 cDNA (Flo et al, 2000). The hybridoma supernatants were selected by flow cytometry.

isotype :

IgG2a

purity :

Protein G purified

species :

Canine,Human,Mouse,Rabbit,Rat

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

gene symbol :

TLR2

applications :

ELISA,Immunohistochemistry,Immunoprecipitation,Flow (Intracellular),CyTOF-ready,Flow Cytometry Control,Flow Cytometry,Western Blot,Immunohistochemistry-Paraffin,In vitro assay,Flow (Cell Surface),Block/Neutralize,Immunocytochemistry/ Immunofluorescence

extended description :

Clone TL2.1 was used by HLDA to establish CD designation.

USD :

469

USD 2025 :

499 USD

product details :

Clone TL2.1 was used by HLDA to establish CD designation.

alt names :

CD282 antigen, TIL4CD282, toll/interleukin 1 receptor-like 4, Toll/interleukin-1 receptor-like protein 4, toll-like receptor 2

more info or order :

Novus Biologicals product webpage