product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
TLR2 Antibody (TL2.1)
catalog :
NB100-56722
quantity :
0.1 mg (also 0.025 mg)
price :
329 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
TL2.1
reactivity :
human, mouse, rat, dogs
application :
western blot, ELISA, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, dot blot
more info or order :
citations: 60
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human
Menzies B, Kenoyer A. Signal transduction and nuclear responses in Staphylococcus aureus-induced expression of human beta-defensin 3 in skin keratinocytes. Infect Immun. 2006;74:6847-54 pubmed
  • flow cytometry; dogs
Bazzocchi C, Mortarino M, Comazzi S, Bandi C, Franceschi A, Genchi C. Expression and function of Toll-like receptor 2 in canine blood phagocytes. Vet Immunol Immunopathol. 2005;104:15-9 pubmed
  • flow cytometry; human
  • western blot; human
Medvedev A, Lentschat A, Wahl L, Golenbock D, Vogel S. Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells. J Immunol. 2002;169:5209-16 pubmed
Chenwen X, Quanan J, Yee H, Yan L, Jiaoyu W, Qiang W, et al. Efficacy of Rg1-Oil Adjuvant on Inducing Immune Responses against Bordetella bronchiseptica in Rabbits. J Immunol Res. 2021;2021:8835919 pubmed publisher
Ji X, Zhang X, Sun L, Hou X, Song H, Han L, et al. The Heparin-Binding Hemagglutinin of Nocardia cyriacigeorgica GUH-2 Stimulates Inflammatory Cytokine Secretion Through Activation of Nuclear Factor κB and Mitogen-Activated Protein Kinase Pathways via TLR4. Front Cell Infect Microbiol. 2020;10:3 pubmed publisher
The E, Yao Q, Zhang P, Zhai Y, Ao L, Fullerton D, et al. Mechanistic Roles of Matrilin-2 and Klotho in Modulating the Inflammatory Activity of Human Aortic Valve Cells. Cells. 2020;9: pubmed publisher
Ji X, Zhang X, Li H, Sun L, Hou X, Song H, et al. Nfa34810 Facilitates Nocardia farcinica Invasion of Host Cells and Stimulates Tumor Necrosis Factor Alpha Secretion through Activation of the NF-κB and Mitogen-Activated Protein Kinase Pathways via Toll-Like Receptor 4. Infect Immun. 2020;88: pubmed publisher
Akhter N, Madhoun A, Arefanian H, Wilson A, Kochumon S, Thomas R, et al. Oxidative Stress Induces Expression of the Toll-Like Receptors (TLRs) 2 and 4 in the Human Peripheral Blood Mononuclear Cells: Implications for Metabolic Inflammation. Cell Physiol Biochem. 2019;53:1-18 pubmed publisher
de Tymowski C, Heming N, Correia M, Abbad L, Chavarot N, Le Stang M, et al. CD89 Is a Potent Innate Receptor for Bacteria and Mediates Host Protection from Sepsis. Cell Rep. 2019;27:762-775.e5 pubmed publisher
Coelho da Silva F, Covre L, Stringari L, Palaci M, Dietze R, Gomes D, et al. Toll-like receptors blocking restores in vitro microbicidal activity in latent tuberculosis-infected subjects. Int J Tuberc Lung Dis. 2019;23:212-218 pubmed publisher
Haruna T, Kariya S, Fujiwara T, Yuta A, Higaki T, Zhao P, et al. Role of whole saliva in the efficacy of sublingual immunotherapy in seasonal allergic rhinitis. Allergol Int. 2019;68:82-89 pubmed publisher
Kołodzińska A, Czarzasta K, Szczepankiewicz B, Główczyńska R, Fojt A, Ilczuk T, et al. Toll-like receptor expression and apoptosis morphological patterns in female rat hearts with takotsubo syndrome induced by isoprenaline. Life Sci. 2018;199:112-121 pubmed publisher
Li F, Song R, Ao L, Reece T, Cleveland J, Dong N, et al. ADAMTS5 Deficiency in Calcified Aortic Valves Is Associated With Elevated Pro-Osteogenic Activity in Valvular Interstitial Cells. Arterioscler Thromb Vasc Biol. 2017;37:1339-1351 pubmed publisher
Subramanian K, Bergman P, Henriques Normark B. Vitamin D Promotes Pneumococcal Killing and Modulates Inflammatory Responses in Primary Human Neutrophils. J Innate Immun. 2017;9:375-386 pubmed publisher
Damien P, Cognasse F, Payrastre B, Spinelli S, Blumberg N, Arthaud C, et al. NF-κB Links TLR2 and PAR1 to Soluble Immunomodulator Factor Secretion in Human Platelets. Front Immunol. 2017;8:85 pubmed publisher
Larsson O, Tengroth L, Xu Y, Uddman R, Kumlien Georén S, Cardell L. Substance P represents a novel first-line defense mechanism in the nose. J Allergy Clin Immunol. 2018;141:128-136.e3 pubmed publisher
Lin S, Kuo M, Hsiao H, Lee P. Azithromycin modulates immune response of human monocyte-derived dendritic cells and CD4+ T cells. Int Immunopharmacol. 2016;40:318-326 pubmed publisher
Jeon Y, Kim C, Koh J, Chung D, Ha G. Pellino-1 confers chemoresistance in lung cancer cells by upregulating cIAP2 through Lys63-mediated polyubiquitination. Oncotarget. 2016;7:41811-41824 pubmed publisher
Mastorci K, Muraro E, Pasini E, Furlan C, Sigalotti L, Cinco M, et al. Toll-Like Receptor 1/2 and 5 Ligands Enhance the Expression of Cyclin D1 and D3 and Induce Proliferation in Mantle Cell Lymphoma. PLoS ONE. 2016;11:e0153823 pubmed publisher
Wong C, Chu I, Hon K, Tsang M, Lam C. Aberrant Expression of Bacterial Pattern Recognition Receptor NOD2 of Basophils and Microbicidal Peptides in Atopic Dermatitis. Molecules. 2016;21:471 pubmed publisher
Nagata E, Oho T. Invasive Streptococcus mutans induces inflammatory cytokine production in human aortic endothelial cells via regulation of intracellular toll-like receptor 2 and nucleotide-binding oligomerization domain 2. Mol Oral Microbiol. 2017;32:131-141 pubmed publisher
Moreira M, Costa Pereira C, Alves M, Marteleto B, Ribeiro V, Peruhype Magalhães V, et al. Vaccination against canine leishmaniosis increases the phagocytic activity, nitric oxide production and expression of cell activation/migration molecules in neutrophils and monocytes. Vet Parasitol. 2016;220:33-45 pubmed publisher
Komine Aizawa S, Hirohata N, Aizawa S, Abiko Y, Hayakawa S. Porphyromonas gingivalis lipopolysaccharide inhibits trophoblast invasion in the presence of nicotine. Placenta. 2015;36:27-33 pubmed publisher
Song R, Fullerton D, Ao L, Zheng D, Zhao K, Meng X. BMP-2 and TGF-β1 mediate biglycan-induced pro-osteogenic reprogramming in aortic valve interstitial cells. J Mol Med (Berl). 2015;93:403-12 pubmed publisher
Käbisch R, Mejías Luque R, Gerhard M, Prinz C. Involvement of Toll-like receptors on Helicobacter pylori-induced immunity. PLoS ONE. 2014;9:e104804 pubmed publisher
Green T, Santos M, Ejaeidi A, Craft B, Lewis R, Cruse J. Toll-like receptor (TLR) expression of immune system cells from metastatic breast cancer patients with circulating tumor cells. Exp Mol Pathol. 2014;97:44-8 pubmed publisher
Rojas Bernabé A, Garcia Hernández O, Maldonado Bernal C, Delegado Dominguez J, Ortega E, Gutiérrez Kobeh L, et al. Leishmania mexicana lipophosphoglycan activates ERK and p38 MAP kinase and induces production of proinflammatory cytokines in human macrophages through TLR2 and TLR4. Parasitology. 2014;141:788-800 pubmed publisher
Verma R, Jung J, Kim J. 1,25-Dihydroxyvitamin D3 up-regulates TLR10 while down-regulating TLR2, 4, and 5 in human monocyte THP-1. J Steroid Biochem Mol Biol. 2014;141:1-6 pubmed publisher
Klink M, Brzezinska M, Szulc I, Brzostek A, Kielbik M, Sulowska Z, et al. Cholesterol oxidase is indispensable in the pathogenesis of Mycobacterium tuberculosis. PLoS ONE. 2013;8:e73333 pubmed publisher
Tsai C, Lin C, Tsai H, Chen C, Li W, Yu H, et al. The immunologically active oligosaccharides isolated from wheatgrass modulate monocytes via Toll-like receptor-2 signaling. J Biol Chem. 2013;288:17689-97 pubmed publisher
Abdi J, Mutis T, Garssen J, Redegeld F. Characterization of the Toll-like receptor expression profile in human multiple myeloma cells. PLoS ONE. 2013;8:e60671 pubmed publisher
Brzezinska M, Szulc I, Brzostek A, Klink M, Kielbik M, Sulowska Z, et al. The role of 3-ketosteroid 1(2)-dehydrogenase in the pathogenicity of Mycobacterium tuberculosis. BMC Microbiol. 2013;13:43 pubmed publisher
Harman A, Bye C, Nasr N, Sandgren K, Kim M, Mercier S, et al. Identification of lineage relationships and novel markers of blood and skin human dendritic cells. J Immunol. 2013;190:66-79 pubmed publisher
Merline R, Moreth K, Beckmann J, Nastase M, Zeng Brouwers J, Tralhão J, et al. Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21. Sci Signal. 2011;4:ra75 pubmed publisher
Shimizu T, Kida Y, Kuwano K. Cytoadherence-dependent induction of inflammatory responses by Mycoplasma pneumoniae. Immunology. 2011;133:51-61 pubmed publisher
Dasgupta G, Chentoufi A, You S, Falatoonzadeh P, Urbano L, Akhtarmalik A, et al. Engagement of TLR2 reverses the suppressor function of conjunctiva CD4+CD25+ regulatory T cells and promotes herpes simplex virus epitope-specific CD4+CD25- effector T cell responses. Invest Ophthalmol Vis Sci. 2011;52:3321-33 pubmed publisher
Melchjorsen J, Rintahaka J, Søby S, Horan K, Poltajainen A, Østergaard L, et al. Early innate recognition of herpes simplex virus in human primary macrophages is mediated via the MDA5/MAVS-dependent and MDA5/MAVS/RNA polymerase III-independent pathways. J Virol. 2010;84:11350-8 pubmed publisher
Oberg H, Ly T, Ussat S, Meyer T, Kabelitz D, Wesch D. Differential but direct abolishment of human regulatory T cell suppressive capacity by various TLR2 ligands. J Immunol. 2010;184:4733-40 pubmed publisher
Kasari V, Kurg K, Margus T, Tenson T, Kaldalu N. The Escherichia coli mqsR and ygiT genes encode a new toxin-antitoxin pair. J Bacteriol. 2010;192:2908-19 pubmed publisher
Ding J, Rapista A, Teleshova N, Mosoyan G, Jarvis G, Klotman M, et al. Neisseria gonorrhoeae enhances HIV-1 infection of primary resting CD4+ T cells through TLR2 activation. J Immunol. 2010;184:2814-24 pubmed publisher
Rydberg C, Mansson A, Uddman R, Riesbeck K, Cardell L. Toll-like receptor agonists induce inflammation and cell death in a model of head and neck squamous cell carcinomas. Immunology. 2009;128:e600-11 pubmed publisher
Yang X, Fullerton D, Su X, Ao L, Cleveland J, Meng X. Pro-osteogenic phenotype of human aortic valve interstitial cells is associated with higher levels of Toll-like receptors 2 and 4 and enhanced expression of bone morphogenetic protein 2. J Am Coll Cardiol. 2009;53:491-500 pubmed publisher
Ji S, Shin J, Kim Y, Oh J, Min B, Choi Y. Toll-like receptor 2 and NALP2 mediate induction of human beta-defensins by fusobacterium nucleatum in gingival epithelial cells. Infect Immun. 2009;77:1044-52 pubmed publisher
Guzy C, Paclik D, Schirbel A, Sonnenborn U, Wiedenmann B, Sturm A. The probiotic Escherichia coli strain Nissle 1917 induces gammadelta T cell apoptosis via caspase- and FasL-dependent pathways. Int Immunol. 2008;20:829-40 pubmed publisher
Burgener I, Jungi T. Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry. Vet Immunol Immunopathol. 2008;124:184-91 pubmed publisher
Prabha C, Rajashree P, Sulochana D. TLR2 and TLR4 expression on the immune cells of tuberculous pleural fluid. Immunol Lett. 2008;117:26-34 pubmed publisher
Pegu A, Qin S, Fallert Junecko B, Nisato R, Pepper M, Reinhart T. Human lymphatic endothelial cells express multiple functional TLRs. J Immunol. 2008;180:3399-405 pubmed
Wong C, Cheung P, Ip W, Lam C. Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils. Am J Respir Cell Mol Biol. 2007;37:85-96 pubmed
Xu S, Koldovsky U, Xu M, Wang D, Fitzpatrick E, Son G, et al. High-avidity antitumor T-cell generation by toll receptor 8-primed, myeloid- derived dendritic cells is mediated by IL-12 production. Surgery. 2006;140:170-8 pubmed
Shimizu T, Kida Y, Kuwano K. A dipalmitoylated lipoprotein from Mycoplasma pneumoniae activates NF-kappa B through TLR1, TLR2, and TLR6. J Immunol. 2005;175:4641-6 pubmed
Srivastava M, Srivastava B. Expression of mRNA and proteins for toll-like receptors, associated molecules, defensins and LL-37 by SRIK-NKL, a CD8+ NK/T cell line. Leuk Res. 2005;29:813-20 pubmed
Cognasse F, Hamzeh H, Chavarin P, Acquart S, Genin C, Garraud O. Evidence of Toll-like receptor molecules on human platelets. Immunol Cell Biol. 2005;83:196-8 pubmed
Zhong F, Cao W, Chan E, Tay P, Cahya F, Zhang H, et al. Deviation from major codons in the Toll-like receptor genes is associated with low Toll-like receptor expression. Immunology. 2005;114:83-93 pubmed
Shimizu T, Kida Y, Kuwano K. Lipid-associated membrane proteins of Mycoplasma fermentans and M. penetrans activate human immunodeficiency virus long-terminal repeats through Toll-like receptors. Immunology. 2004;113:121-9 pubmed
Gibson F, Hong C, Chou H, Yumoto H, Chen J, Lien E, et al. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2004;109:2801-6 pubmed
Mempel M, Voelcker V, Köllisch G, Plank C, Rad R, Gerhard M, et al. Toll-like receptor expression in human keratinocytes: nuclear factor kappaB controlled gene activation by Staphylococcus aureus is toll-like receptor 2 but not toll-like receptor 4 or platelet activating factor receptor dependent. J Invest Dermatol. 2003;121:1389-96 pubmed
Lotz S, Aga E, Wilde I, van Zandbergen G, Hartung T, Solbach W, et al. Highly purified lipoteichoic acid activates neutrophil granulocytes and delays their spontaneous apoptosis via CD14 and TLR2. J Leukoc Biol. 2004;75:467-77 pubmed
Flo T, Halaas O, Torp S, Ryan L, Lien E, Dybdahl B, et al. Differential expression of Toll-like receptor 2 in human cells. J Leukoc Biol. 2001;69:474-81 pubmed
Faure E, Thomas L, Xu H, Medvedev A, Equils O, Arditi M. Bacterial lipopolysaccharide and IFN-gamma induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: role of NF-kappa B activation. J Immunol. 2001;166:2018-24 pubmed
Flo T, Halaas O, Lien E, Ryan L, Teti G, Golenbock D, et al. Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide. J Immunol. 2000;164:2064-9 pubmed
product information
brand :
Novus
master code :
NB100-56722
SKU :
NB100-56722
product name :
TLR2 Antibody (TL2.1)
description :
The TLR2 Antibody (TL2.1) from NB100-56722 is a nb100-56722 antibody to . This antibody reacts with immunology, innate immunity, signal transduction.
target :
TLR2
category :
Primary Antibodies
unit sizes :
0.1 mg (also 0.025 mg)
buffer :
PBS
clonality :
Monoclonal
clone :
TL2.1
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Mouse
immunogen :
This antibody was raised by immunizing mice with CHO cells transfected with human TLR2 cDNA (Flo et al, 2000). The hybridoma supernatants were selected by flow cytometry.
isotype :
IgG2a
purity :
Protein G purified
species :
Human, Mouse, Rat, Canine, Rabbit
gene symbol :
TLR2
applications :
Western Blot, Flow Cytometry, ELISA, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Functional, In vitro assay, Dot Blot, Flow (Cell Surface), Block/Neutralize
USD :
329 USD
alt names :
CD282 antigen, TIL4CD282, toll/interleukin 1 receptor-like 4, Toll/interleukin-1 receptor-like protein 4, toll-like receptor 2
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.