| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; rat; loading ...; fig 5c
| Zhang Y, He Y, Yu H, Ma F, Wu J, Zhang X. Liquiritigenin Protects Rats from Carbon Tetrachloride Induced Hepatic Injury through PGC-1α Pathway. Evid Based Complement Alternat Med. 2015;2015:649568 pubmed publisher |
| Blanchard Z, Paul B, Craft B, ElShamy W. BRCA1-IRIS inactivation overcomes paclitaxel resistance in triple negative breast cancers. Breast Cancer Res. 2015;17:5 pubmed publisher |
- immunohistochemistry - paraffin section; mouse
- western blot; mouse
| Das U, Manna K, Sinha M, Datta S, Das D, Chakraborty A, et al. Role of ferulic acid in the amelioration of ionizing radiation induced inflammation: a murine model. PLoS ONE. 2014;9:e97599 pubmed publisher |
- immunohistochemistry - paraffin section; human
| Ren S, Fan X, Peng L, Pan L, Yu C, Tong J, et al. Expression of NF-?B, CD68 and CD105 in carotid atherosclerotic plaque. J Thorac Dis. 2013;5:771-6 pubmed publisher |
- immunohistochemistry - paraffin section; human
| Santhi W, Sebastian P, Varghese B, Prakash O, Pillai M. NF-kappaB and COX-2 during oral tumorigenesis and in assessment of minimal residual disease in surgical margins. Exp Mol Pathol. 2006;81:123-30 pubmed |
- immunohistochemistry - paraffin section; human
| Chang M, Lee H, Jung E, Kim C, Lee B, Kim W. Cell-cycle regulators, bcl-2 and NF-kappaB in Epstein-Barr virus-positive gastric carcinomas. Int J Oncol. 2005;27:1265-72 pubmed |
| Aamir K, Sethi G, Afrin M, Hossain C, Jusuf P, Sarker S, et al. Arjunolic acid modulate pancreatic dysfunction by ameliorating pattern recognition receptor and canonical Wnt pathway activation in type 2 diabetic rats. Life Sci. 2023;327:121856 pubmed publisher |
| Lin F, Cheng Y, Chen L, Ho J, Yen J, Wang M, et al. Retinal protection by fungal product theissenolactone B in a sodium iodate-induced AMD model through targeting retinal pigment epithelial matrix metalloproteinase-9 and microglia activity. Biomed Pharmacother. 2023;158:114138 pubmed publisher |
| Chen X, Lu D, Liu W, Xie J, Lu Z, Yang H, et al. Therapeutic effect of Atractylenolide I on Aspergillus fumigatus keratitis by affecting MyD88/ NF-κB pathway and IL-1β, IL-10 expression. Cytokine. 2023;162:156112 pubmed publisher |
| Prieux R, Ferrara F, Cervellati F, Guiotto A, Benedusi M, Valacchi G. Inflammasome involvement in CS-induced damage in HaCaT keratinocytes. In Vitro Cell Dev Biol Anim. 2022;58:335-348 pubmed publisher |
| Okuyan H, Terzi M, Karaboga I, Dogan S, Kalaci A. In vivo protective effects of upper zone of growth plate and cartilage matrix associated protein against cartilage degeneration in a monosodium iodoacetate induced osteoarthritis model. Can J Physiol Pharmacol. 2020;98:763-770 pubmed publisher |
| Tseng H, Dreyer J, Emran A, Gunatilake D, Pirozyan M, Cullinane C, et al. Co-targeting bromodomain and extra-terminal proteins and MCL1 induces synergistic cell death in melanoma. Int J Cancer. 2020;: pubmed publisher |
| Djajawi T, Liu L, Gong J, Huang A, Luo M, Xu Z, et al. MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex. Cell Death Differ. 2020;: pubmed publisher |
| Wang X, Cao Y, Liu Z, Wang Z, Chu X, Wang L, et al. Alveolar Bone Density Reduction in Rats Caused by Unilateral Nasal Obstruction. Balkan Med J. 2019;36:311-319 pubmed publisher |
| Pilling A, Hwang C. Targeting prosurvival BCL2 signaling through Akt blockade sensitizes castration-resistant prostate cancer cells to enzalutamide. Prostate. 2019;79:1347-1359 pubmed publisher |
| Gonzalez P, O Prey J, Cardaci S, Barthet V, Sakamaki J, Beaumatin F, et al. Mannose impairs tumour growth and enhances chemotherapy. Nature. 2018;563:719-723 pubmed publisher |
| Minieri V, De Dominici M, Porazzi P, Mariani S, Spinelli O, Rambaldi A, et al. Targeting STAT5 or STAT5-Regulated Pathways Suppresses Leukemogenesis of Ph+ Acute Lymphoblastic Leukemia. Cancer Res. 2018;78:5793-5807 pubmed publisher |
| Tumer T, Yılmaz B, Ozleyen A, Kurt B, Tok T, Taşkin K, et al. GR24, a synthetic analog of Strigolactones, alleviates inflammation and promotes Nrf2 cytoprotective response: In vitro and in silico evidences. Comput Biol Chem. 2018;76:179-190 pubmed publisher |
| Chowdhury A, Arnold L, Wang Z, Pennington K, Dodmane P, Farragut Cardoso A, et al. Effect of polyhexamethylene biguanide on rat liver. Toxicol Lett. 2018;285:94-103 pubmed publisher |
| Gallagher S, Gunatilake D, Beaumont K, Sharp D, Tiffen J, Heinemann A, et al. HDAC inhibitors restore BRAF-inhibitor sensitivity by altering PI3K and survival signalling in a subset of melanoma. Int J Cancer. 2018;142:1926-1937 pubmed publisher |
| Antignani A, Segal D, Simon N, Kreitman R, Huang D, Fitzgerald D. Essential role for Bim in mediating the apoptotic and antitumor activities of immunotoxins. Oncogene. 2017;36:4953-4962 pubmed publisher |
| Zhang J, Huang K, O Neill K, Pang X, Luo X. Bax/Bak activation in the absence of Bid, Bim, Puma, and p53. Cell Death Dis. 2016;7:e2266 pubmed publisher |
| Heinemann A, Cullinane C, De Paoli Iseppi R, Wilmott J, Gunatilake D, Madore J, et al. Combining BET and HDAC inhibitors synergistically induces apoptosis of melanoma and suppresses AKT and YAP signaling. Oncotarget. 2015;6:21507-21 pubmed |
| Wang Y, Lv J, Cheng Y, DU J, Chen D, Li C, et al. Apoptosis induced by Ginkgo biloba (EGb761) in melanoma cells is Mcl-1-dependent. PLoS ONE. 2015;10:e0124812 pubmed publisher |
| Sigurðsson H, Olesen C, Dybboe R, Lauritzen G, Pedersen S. Constitutively active ErbB2 regulates cisplatin-induced cell death in breast cancer cells via pro- and antiapoptotic mechanisms. Mol Cancer Res. 2015;13:63-77 pubmed publisher |
| Wei J, Noto J, Zaika E, Romero Gallo J, Piazuelo M, Schneider B, et al. Bacterial CagA protein induces degradation of p53 protein in a p14ARF-dependent manner. Gut. 2015;64:1040-8 pubmed publisher |
| Pang X, Zhang J, Lopez H, Wang Y, Li W, O Neill K, et al. The carboxyl-terminal tail of Noxa protein regulates the stability of Noxa and Mcl-1. J Biol Chem. 2014;289:17802-11 pubmed publisher |
| Sikder K, Kesh S, Das N, Manna K, Dey S. The high antioxidative power of quercetin (aglycone flavonoid) and its glycone (rutin) avert high cholesterol diet induced hepatotoxicity and inflammation in Swiss albino mice. Food Funct. 2014;5:1294-303 pubmed publisher |
| Thorburn J, Andrysik Z, Staskiewicz L, Gump J, Maycotte P, Oberst A, et al. Autophagy controls the kinetics and extent of mitochondrial apoptosis by regulating PUMA levels. Cell Rep. 2014;7:45-52 pubmed publisher |
| Rao F, Cha J, Xu J, Xu R, Vandiver M, Tyagi R, et al. Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2. Mol Cell. 2014;54:119-132 pubmed publisher |
| Godbersen J, Humphries L, Danilova O, Kebbekus P, Brown J, Eastman A, et al. The Nedd8-activating enzyme inhibitor MLN4924 thwarts microenvironment-driven NF-?B activation and induces apoptosis in chronic lymphocytic leukemia B cells. Clin Cancer Res. 2014;20:1576-89 pubmed publisher |
| Wroblewski D, Jiang C, Croft A, Farrelly M, Zhang X, Hersey P. OBATOCLAX and ABT-737 induce ER stress responses in human melanoma cells that limit induction of apoptosis. PLoS ONE. 2013;8:e84073 pubmed publisher |
| Parrondo R, de las Pozas A, Reiner T, Perez Stable C. ABT-737, a small molecule Bcl-2/Bcl-xL antagonist, increases antimitotic-mediated apoptosis in human prostate cancer cells. Peerj. 2013;1:e144 pubmed publisher |
| Pascutti M, Jak M, Tromp J, Derks I, Remmerswaal E, Thijssen R, et al. IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells. Blood. 2013;122:3010-9 pubmed publisher |
| Dabir S, Kluge A, McColl K, Liu Y, Lam M, Halmos B, et al. PIAS3 activates the intrinsic apoptotic pathway in non-small cell lung cancer cells independent of p53 status. Int J Cancer. 2014;134:1045-54 pubmed publisher |
| Thomas R, Roberts D, Kubli D, Lee Y, Quinsay M, Owens J, et al. Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure. Genes Dev. 2013;27:1365-77 pubmed publisher |
| Adamski J, Price A, Dive C, Makin G. Hypoxia-induced cytotoxic drug resistance in osteosarcoma is independent of HIF-1Alpha. PLoS ONE. 2013;8:e65304 pubmed publisher |
| Zinn R, Gardner E, Dobromilskaya I, Murphy S, Marchionni L, Hann C, et al. Combination treatment with ABT-737 and chloroquine in preclinical models of small cell lung cancer. Mol Cancer. 2013;12:16 pubmed publisher |
| Ryder C, McColl K, Zhong F, Distelhorst C. Acidosis promotes Bcl-2 family-mediated evasion of apoptosis: involvement of acid-sensing G protein-coupled receptor Gpr65 signaling to Mek/Erk. J Biol Chem. 2012;287:27863-75 pubmed publisher |
| Wong C, Anderson D, Lee E, Fairlie W, Ludlam M. Direct visualization of Bcl-2 family protein interactions using live cell fluorescent protein redistribution assays. Cell Death Dis. 2012;3:e288 pubmed publisher |
| Tromp J, Geest C, Breij E, Elias J, van Laar J, Luijks D, et al. Tipping the Noxa/Mcl-1 balance overcomes ABT-737 resistance in chronic lymphocytic leukemia. Clin Cancer Res. 2012;18:487-98 pubmed publisher |
| Chen M, Felix K, Wang J. Immune regulation through mitochondrion-dependent dendritic cell death induced by T regulatory cells. J Immunol. 2011;187:5684-92 pubmed publisher |
| Chu R, Terrano D, Chambers T. Cdk1/cyclin B plays a key role in mitotic arrest-induced apoptosis by phosphorylation of Mcl-1, promoting its degradation and freeing Bak from sequestration. Biochem Pharmacol. 2012;83:199-206 pubmed publisher |
| Kuo K, Chen Y, Chen L, Li C, Lan Y, Chang F, et al. Involvement of phorbol-12-myristate-13-acetate-induced protein 1 in goniothalamin-induced TP53-dependent and -independent apoptosis in hepatocellular carcinoma-derived cells. Toxicol Appl Pharmacol. 2011;256:8-23 pubmed publisher |
| Ishikita H. Proton-binding sites of acid-sensing ion channel 1. PLoS ONE. 2011;6:e16920 pubmed publisher |
| Chen C, Huang P, Chu P, Chen M, Chou C, Wang D, et al. Energy restriction-mimetic agents induce apoptosis in prostate cancer cells in part through epigenetic activation of KLF6 tumor suppressor gene expression. J Biol Chem. 2011;286:9968-76 pubmed publisher |
| Poulsen R, Carr A, Hulley P. Protection against glucocorticoid-induced damage in human tenocytes by modulation of ERK, Akt, and forkhead signaling. Endocrinology. 2011;152:503-14 pubmed publisher |
| Zhang L, Lopez H, George N, Liu X, Pang X, Luo X. Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways. Cell Death Differ. 2011;18:864-73 pubmed publisher |
| Bodet L, Menoret E, Descamps G, Pellat Deceunynck C, Bataille R, Le Gouill S, et al. BH3-only protein Bik is involved in both apoptosis induction and sensitivity to oxidative stress in multiple myeloma. Br J Cancer. 2010;103:1808-14 pubmed publisher |
| Fahham N, Sardari S, Ostad S, Vaziri B, Ghahremani M. C-terminal domain of p16(INK4a) is adequate in inducing cell cycle arrest, growth inhibition and CDK4/6 interaction similar to the full length protein in HT-1080 fibrosarcoma cells. J Cell Biochem. 2010;111:1598-606 pubmed publisher |
| Tonino S, van Laar J, Van Oers M, Wang J, Eldering E, Kater A. ROS-mediated upregulation of Noxa overcomes chemoresistance in chronic lymphocytic leukemia. Oncogene. 2011;30:701-13 pubmed publisher |
| Hadji A, Clybouw C, Auffredou M, Alexia C, Poalas K, Burlion A, et al. Caspase-3 triggers a TPCK-sensitive protease pathway leading to degradation of the BH3-only protein puma. Apoptosis. 2010;15:1529-39 pubmed publisher |
| Zall H, Weber A, Besch R, Zantl N, Hacker G. Chemotherapeutic drugs sensitize human renal cell carcinoma cells to ABT-737 by a mechanism involving the Noxa-dependent inactivation of Mcl-1 or A1. Mol Cancer. 2010;9:164 pubmed publisher |
| Sosa Seda I, Mott J, Akazawa Y, Barreyro F, Bronk S, Kaufmann S, et al. Noxa mediates hepatic stellate cell apoptosis by proteasome inhibition. Hepatol Res. 2010;40:701-10 pubmed publisher |
| de Bruijn M, Raats D, Hoogwater F, van Houdt W, Cameron K, Medema J, et al. Oncogenic KRAS sensitises colorectal tumour cells to chemotherapy by p53-dependent induction of Noxa. Br J Cancer. 2010;102:1254-64 pubmed publisher |
| Lopez H, Zhang L, George N, Liu X, Pang X, Evans J, et al. Perturbation of the Bcl-2 network and an induced Noxa/Bcl-xL interaction trigger mitochondrial dysfunction after DNA damage. J Biol Chem. 2010;285:15016-26 pubmed publisher |
| Vilgelm A, Washington M, Wei J, Chen H, Prassolov V, Zaika A. Interactions of the p53 protein family in cellular stress response in gastrointestinal tumors. Mol Cancer Ther. 2010;9:693-705 pubmed publisher |
| Streetly M, Maharaj L, Joel S, Schey S, Gribben J, Cotter F. GCS-100, a novel galectin-3 antagonist, modulates MCL-1, NOXA, and cell cycle to induce myeloma cell death. Blood. 2010;115:3939-48 pubmed publisher |
| Tahir S, Wass J, Joseph M, Devanarayan V, Hessler P, Zhang H, et al. Identification of expression signatures predictive of sensitivity to the Bcl-2 family member inhibitor ABT-263 in small cell lung carcinoma and leukemia/lymphoma cell lines. Mol Cancer Ther. 2010;9:545-57 pubmed publisher |
| Ackler S, Mitten M, Foster K, Oleksijew A, Refici M, Tahir S, et al. The Bcl-2 inhibitor ABT-263 enhances the response of multiple chemotherapeutic regimens in hematologic tumors in vivo. Cancer Chemother Pharmacol. 2010;66:869-80 pubmed publisher |
| Paoluzzi L, Scotto L, Marchi E, Zain J, Seshan V, O Connor O. Romidepsin and belinostat synergize the antineoplastic effect of bortezomib in mantle cell lymphoma. Clin Cancer Res. 2010;16:554-65 pubmed publisher |
| High L, Szymanska B, Wilczynska Kalak U, Barber N, O Brien R, Khaw S, et al. The Bcl-2 homology domain 3 mimetic ABT-737 targets the apoptotic machinery in acute lymphoblastic leukemia resulting in synergistic in vitro and in vivo interactions with established drugs. Mol Pharmacol. 2010;77:483-94 pubmed publisher |
| Cheung M, Pei J, Pei Y, Jhanwar S, Pass H, Testa J. The promyelocytic leukemia zinc-finger gene, PLZF, is frequently downregulated in malignant mesothelioma cells and contributes to cell survival. Oncogene. 2010;29:1633-40 pubmed publisher |
| Burgos J, King Lyons N, Connell T. Expression of BfrH, a putative siderophore receptor of Bordetella bronchiseptica, is regulated by iron, Fur1, and the extracellular function sigma factor EcfI. Infect Immun. 2010;78:1147-62 pubmed publisher |
| Amschler K, Schön M, Pletz N, Wallbrecht K, Erpenbeck L, Schön M. NF-kappaB inhibition through proteasome inhibition or IKKbeta blockade increases the susceptibility of melanoma cells to cytostatic treatment through distinct pathways. J Invest Dermatol. 2010;130:1073-86 pubmed publisher |
| Rasheed Z, Anbazhagan A, Akhtar N, Ramamurthy S, Voss F, Haqqi T. Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-alpha and matrix metalloproteinase-13 in human chondrocytes. Arthritis Res Ther. 2009;11:R71 pubmed publisher |
| Stankiewicz A, Livingstone A, Mohseni N, Mosser D. Regulation of heat-induced apoptosis by Mcl-1 degradation and its inhibition by Hsp70. Cell Death Differ. 2009;16:638-47 pubmed publisher |
| Lee W, Belkhiri A, Lockhart A, Merchant N, Glaeser H, Harris E, et al. Overexpression of OATP1B3 confers apoptotic resistance in colon cancer. Cancer Res. 2008;68:10315-23 pubmed publisher |
| van Gent R, Kater A, Otto S, Jaspers A, Borghans J, Vrisekoop N, et al. In vivo dynamics of stable chronic lymphocytic leukemia inversely correlate with somatic hypermutation levels and suggest no major leukemic turnover in bone marrow. Cancer Res. 2008;68:10137-44 pubmed publisher |
| Hallaert D, Jaspers A, van Noesel C, van Oers M, Kater A, Eldering E. c-Abl kinase inhibitors overcome CD40-mediated drug resistance in CLL: implications for therapeutic targeting of chemoresistant niches. Blood. 2008;112:5141-9 pubmed publisher |
| Jiang C, Lucas K, Avery Kiejda K, Wade M, deBock C, Thorne R, et al. Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress. Cancer Res. 2008;68:6708-17 pubmed publisher |
| Zhang L, Hao Y, Hu C, Ye Y, Xie Q, Thorne R, et al. Inhibition of apoptosis facilitates necrosis induced by cisplatin in gastric cancer cells. Anticancer Drugs. 2008;19:159-66 pubmed publisher |
| Lee T, Yeh J, Friedman J, Yan B, Yang X, Yeh N, et al. A signal network involving coactivated NF-kappaB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas. Int J Cancer. 2008;122:1987-98 pubmed publisher |
| Condorelli F, Gnemmi I, Vallario A, Genazzani A, Canonico P. Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells. Br J Pharmacol. 2008;153:657-68 pubmed |
| Tahir S, Yang X, Anderson M, Morgan Lappe S, Sarthy A, Chen J, et al. Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737. Cancer Res. 2007;67:1176-83 pubmed |
| Yu F, Watts R, Zhang X, Borrow J, Hersey P. Involvement of BH3-only proapoptotic proteins in mitochondrial-dependent Phenoxodiol-induced apoptosis of human melanoma cells. Anticancer Drugs. 2006;17:1151-61 pubmed |
| Smit L, Hallaert D, Spijker R, de Goeij B, Jaspers A, Kater A, et al. Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity. Blood. 2007;109:1660-8 pubmed |
| Yoshida A, Takemura H, Inoue H, Miyashita T, Ueda T. Inhibition of glutathione synthesis overcomes Bcl-2-mediated topoisomerase inhibitor resistance and induces nonapoptotic cell death via mitochondrial-independent pathway. Cancer Res. 2006;66:5772-80 pubmed |
| Xie W, Jiang P, Miao L, Zhao Y, Zhimin Z, Qing L, et al. Novel link between E2F1 and Smac/DIABLO: proapoptotic Smac/DIABLO is transcriptionally upregulated by E2F1. Nucleic Acids Res. 2006;34:2046-55 pubmed |
| Simbulan Rosenthal C, Daher A, Trabosh V, Chen W, Gerstel D, Soeda E, et al. Id3 induces a caspase-3- and -9-dependent apoptosis and mediates UVB sensitization of HPV16 E6/7 immortalized human keratinocytes. Oncogene. 2006;25:3649-60 pubmed |
| Chen W, Wang D, Yen R, Luo J, Gu W, Baylin S. Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell. 2005;123:437-48 pubmed |
| Kojima K, Konopleva M, Samudio I, Shikami M, Cabreira Hansen M, McQueen T, et al. MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy. Blood. 2005;106:3150-9 pubmed |
| Wittmann M, Purwar R, Hartmann C, Gutzmer R, Werfel T. Human keratinocytes respond to interleukin-18: implication for the course of chronic inflammatory skin diseases. J Invest Dermatol. 2005;124:1225-33 pubmed |
| Erster S, Mihara M, Kim R, Petrenko O, Moll U. In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation. Mol Cell Biol. 2004;24:6728-41 pubmed |
| Yakovlev A, Di Giovanni S, Wang G, Liu W, Stoica B, Faden A. BOK and NOXA are essential mediators of p53-dependent apoptosis. J Biol Chem. 2004;279:28367-74 pubmed |
| Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, et al. p53 has a direct apoptogenic role at the mitochondria. Mol Cell. 2003;11:577-90 pubmed |
| Deverman B, Cook B, Manson S, Niederhoff R, Langer E, Rosová I, et al. Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage. Cell. 2002;111:51-62 pubmed |
