TBK1 Antibody (108A429) - BSA Free | Novus Biologicals NB100-56705 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

TBK1 Antibody (108A429) - BSA Free

catalog :

NB100-56705

quantity :

0.1 mg (also 0.025 mg)

price :

409 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

108A429

reactivity :

human, mouse, rat, dogs, bovine

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Novus Biologicals product webpage

citations: 31

Published Application/Species/Sample/Dilution	Reference
immunoprecipitation; mouse; loading ...; fig s7a	Deng M, Tam J, Wang L, Liang K, Li S, Zhang L, et al. TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination. Nat Commun. 2020;11:2193 pubmed publisher
western blot; human	Yu H, Croxen M, Marchiando A, Ferreira R, Cadwell K, Foster L, et al. Autophagy facilitates Salmonella replication in HeLa cells. MBio. 2014;5:e00865-14 pubmed publisher
western blot; mouse	Marchlik E, Thakker P, Carlson T, Jiang Z, Ryan M, Marusic S, et al. Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality. J Leukoc Biol. 2010;88:1171-80 pubmed publisher
western blot; human	Tamassia N, Le Moigne V, Rossato M, Donini M, McCartney S, Calzetti F, et al. Activation of an immunoregulatory and antiviral gene expression program in poly(I:C)-transfected human neutrophils. J Immunol. 2008;181:6563-73 pubmed
western blot; human	McCoy C, Carpenter S, Palsson McDermott E, Gearing L, O Neill L. Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like receptor-3 and -4 by targeting TBK1 activation. J Biol Chem. 2008;283:14277-85 pubmed publisher
western blot; human	Péant B, Diallo J, Lessard L, Delvoye N, Le Page C, Saad F, et al. Regulation of IkappaB kinase epsilon expression by the androgen receptor and the nuclear factor-kappaB transcription factor in prostate cancer. Mol Cancer Res. 2007;5:87-94 pubmed
western blot; human	Aksoy E, Albarani V, Nguyen M, Laes J, Ruelle J, De Wit D, et al. Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells. Blood. 2007;109:2887-93 pubmed
	Gulen M, Samson N, Keller A, Schwabenland M, Liu C, Gl xfc ck S, et al. cGAS-STING drives ageing-related inflammation and neurodegeneration. Nature. 2023;620:374-380 pubmed publisher
	Hage A, Bharaj P, van Tol S, Giraldo M, Gonzalez Orozco M, Valerdi K, et al. The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity. Cell Rep. 2022;38:110434 pubmed publisher
	Xing J, Zhang A, Du Y, Fang M, Minze L, Liu Y, et al. Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells. Nat Commun. 2021;12:2681 pubmed publisher
	Qiu W, Zhang Q, Zhang R, Lu Y, Wang X, Tian H, et al. N6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA. Nat Commun. 2021;12:1582 pubmed publisher
	Shi D, Chen M, Liu L, Wang Q, Liu S, Wang L, et al. Anti-influenza A virus mechanism of three representative compounds from Flos Trollii via TLRs signaling pathways. J Ethnopharmacol. 2020;253:112634 pubmed publisher
	van Tol S, Atkins C, Bharaj P, Johnson K, Hage A, Freiberg A, et al. VAMP8 Contributes to the TRIM6-Mediated Type I Interferon Antiviral Response during West Nile Virus Infection. J Virol. 2020;94: pubmed publisher
	Wuerth J, Habjan M, Wulle J, Superti Furga G, Pichlmair A, Weber F. NSs protein of Sandfly fever Sicilian phlebovirus counteracts interferon induction by masking the DNA-binding domain of interferon regulatory factor 3. J Virol. 2018;: pubmed publisher
	Li F, Li Y, Liang H, Xu T, Kong Y, Huang M, et al. HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection. J Clin Invest. 2018;128:4148-4162 pubmed publisher
	Gulen M, Koch U, Haag S, Schüler F, Apetoh L, Villunger A, et al. Signalling strength determines proapoptotic functions of STING. Nat Commun. 2017;8:427 pubmed publisher
	Kwon D, Park E, Sesaki H, Kang S. Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) suppresses STING-mediated DNA sensing pathway through inducing mitochondrial fission. Biochem Biophys Res Commun. 2017;493:737-743 pubmed publisher
	Slowicka K, Vereecke L, Mc Guire C, Sze M, Maelfait J, Kolpe A, et al. Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-ÎºB signaling. Eur J Immunol. 2016;46:971-80 pubmed publisher
	Mukawera E, Chartier S, Williams V, Pagano P, Lapointe R, Grandvaux N. Redox-modulating agents target NOX2-dependent IKKε oncogenic kinase expression and proliferation in human breast cancer cell lines. Redox Biol. 2015;6:9-18 pubmed publisher
	Conlon J, Burdette D, Sharma S, Bhat N, Thompson M, Jiang Z, et al. Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid. J Immunol. 2013;190:5216-25 pubmed publisher
	Tamassia N, Bazzoni F, Le Moigne V, Calzetti F, Masala C, Grisendi G, et al. IFN-? expression is directly activated in human neutrophils transfected with plasmid DNA and is further increased via TLR-4-mediated signaling. J Immunol. 2012;189:1500-9 pubmed publisher
	Delhase M, Kim S, Lee H, Naiki Ito A, Chen Y, Ahn E, et al. TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2. Proc Natl Acad Sci U S A. 2012;109:E177-86 pubmed publisher
	Ogasawara N, Sasaki M, Itoh Y, Tokudome K, Kondo Y, Ito Y, et al. Rebamipide suppresses TLR-TBK1 signaling pathway resulting in regulating IRF3/7 and IFN-α/β reduction. J Clin Biochem Nutr. 2011;48:154-60 pubmed publisher
	Joung S, Park Z, Rani S, Takeuchi O, Akira S, Lee J. Akt contributes to activation of the TRIF-dependent signaling pathways of TLRs by interacting with TANK-binding kinase 1. J Immunol. 2011;186:499-507 pubmed publisher
	Berthet J, Damien P, Hamzeh Cognasse H, Pozzetto B, Garraud O, Cognasse F. Toll-like receptor 4 signal transduction in platelets: novel pathways. Br J Haematol. 2010;151:89-92 pubmed publisher
	Radtke A, O Riordan M. Homeostatic maintenance of pathogen-containing vacuoles requires TBK1-dependent regulation of aquaporin-1. Cell Microbiol. 2008;10:2197-207 pubmed publisher
	Tamassia N, Le Moigne V, Calzetti F, Donini M, Gasperini S, Ear T, et al. The MyD88-independent pathway is not mobilized in human neutrophils stimulated via TLR4. J Immunol. 2007;178:7344-56 pubmed
	Merimi M, Klener P, Szynal M, Cleuter Y, Kerkhofs P, Burny A, et al. Suppression of viral gene expression in bovine leukemia virus-associated B-cell malignancy: interplay of epigenetic modifications leading to chromatin with a repressive histone code. J Virol. 2007;81:5929-39 pubmed
	Sankar S, Chan H, Romanow W, Li J, Bates R. IKK-i signals through IRF3 and NFkappaB to mediate the production of inflammatory cytokines. Cell Signal. 2006;18:982-93 pubmed
	Osterlund P, Veckman V, Sirén J, Klucher K, Hiscott J, Matikainen S, et al. Gene expression and antiviral activity of alpha/beta interferons and interleukin-29 in virus-infected human myeloid dendritic cells. J Virol. 2005;79:9608-17 pubmed
	Fitzgerald K, McWhirter S, Faia K, Rowe D, Latz E, Golenbock D, et al. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol. 2003;4:491-6 pubmed

product information

master code :

NB100-56705

SKU :

NB100-56705

product name :

TBK1 Antibody (108A429) - BSA Free

unit size :

0.1 mg (also 0.025 mg)

description :

The TBK1 Antibody (108A429) - BSA Free from Novus is a mouse monoclonal antibody to TBK1. This antibody reacts with bovine,canine,human,mouse,rat. The TBK1 Antibody (108A429) - BSA Free has been validated for the following applications: Flow Cytometry,Immunoprecipitation,Western Blot,Immunohistochemistry,Immunohistochemistry-Paraffin,Simple Western,Knockout Validated,Immunocytochemistry/ Immunofluorescence.

target :

TBK1

category :

Primary Antibodies

buffer :

PBS

clonality :

Monoclonal

clone :

108A429

concentration :

1.0 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

A synthetic peptide corresponding to amino acids 563-577 (YYQFKKDKAERRLAYC) of human TBK1 was used as immunogen for this antibody (NP_037386).

isotype :

IgG1 Kappa

purity :

Protein G purified

species :

Bovine,Canine,Human,Mouse,Rat

theoretical molecular weight :

84 kDa

gene symbol :

TBK1

Antibody validation :

Knockout/Knockdown

accessionNumbers :

Q9UHD2

applications :

Flow Cytometry,Immunoprecipitation,Western Blot,Immunohistochemistry,Immunohistochemistry-Paraffin,Simple Western,Knockout Validated,Immunocytochemistry/ Immunofluorescence

USD :

409 USD

alt names :

EC 2.7.11, EC 2.7.11.1, FLJ11330, NAK, NAK serine, NAK serine/threonine-protein kinase TBK 1, NAKserine/threonine-protein kinase TBK1, NF-kappa-B-activating kinase, T2K, TANK, TANK binding kinase, TANK-binding kinase 1NF-kB-activating kinase, TBK 1

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage