product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
TRAILR2/TNFRSF10B Antibody - BSA Free
catalog :
NB100-56618
quantity :
0.1 mg (also 0.025 mg)
price :
409 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
biotin
clone name :
711-66
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
more info or order :
Novus Biologicals product webpage
citations: 12
Reference
Haagsma J, Kolendowski B, Buensuceso A, Valdes Y, DiMattia G, Shepherd T. Gain-of-function p53R175H blocks apoptosis in a precursor model of ovarian high-grade serous carcinoma. Sci Rep. 2023;13:11424 pubmed publisher
Joung J, Kirchgatterer P, Singh A, Cho J, Nety S, Larson R, et al. CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity. Nat Commun. 2022;13:1606 pubmed publisher
Chen L, Hao M, Yan J, Sun L, Tai G, Cheng H, et al. Citrus-derived DHCP inhibits mitochondrial complex II to enhance TRAIL sensitivity via ROS-induced DR5 upregulation. J Biol Chem. 2021;296:100515 pubmed publisher
Arrillaga Romany I, Odia Y, Prabhu V, Tarapore R, Merdinger K, Stogniew M, et al. Biological activity of weekly ONC201 in adult recurrent glioblastoma patients. Neuro Oncol. 2020;22:94-102 pubmed publisher
Stein M, Malhotra J, Tarapore R, Malhotra U, Silk A, Chan N, et al. Safety and enhanced immunostimulatory activity of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration. J Immunother Cancer. 2019;7:136 pubmed publisher
Xue M, Ge Y, Yu C, Zheng Z, He X, Zhao J. Apoptosis is induced by docosahexaenoic acid in breast cancer cells via death receptor and mitochondria-mediated pathways. Mol Med Rep. 2017;16:978-982 pubmed publisher
Shin G, Kang H, Lee A, Kim K. Hepatitis B virus-triggered autophagy targets TNFRSF10B/death receptor 5 for degradation to limit TNFSF10/TRAIL response. Autophagy. 2016;12:2451-2466 pubmed
Allen J, Crowder R, Crowder R, El Deiry W. First-In-Class Small Molecule ONC201 Induces DR5 and Cell Death in Tumor but Not Normal Cells to Provide a Wide Therapeutic Index as an Anti-Cancer Agent. PLoS ONE. 2015;10:e0143082 pubmed publisher
Liu Y, Hawkins O, Vilgelm A, Pawlikowski J, Ecsedy J, Sosman J, et al. Combining an Aurora Kinase Inhibitor and a Death Receptor Ligand/Agonist Antibody Triggers Apoptosis in Melanoma Cells and Prevents Tumor Growth in Preclinical Mouse Models. Clin Cancer Res. 2015;21:5338-48 pubmed publisher
Foster K, Jane E, Premkumar D, Morales A, Pollack I. NVP-BKM120 potentiates apoptosis in tumor necrosis factor-related apoptosis-inducing ligand-resistant glioma cell lines via upregulation of Noxa and death receptor 5. Int J Oncol. 2015;47:506-16 pubmed publisher
Talekar M, Allen J, Dicker D, El Deiry W. ONC201 induces cell death in pediatric non-Hodgkin's lymphoma cells. Cell Cycle. 2015;14:2422-8 pubmed publisher
Prabhu V, Allen J, Dicker D, El Deiry W. Small-Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem-like Cells in an Akt/Foxo3a/TRAIL-Dependent Manner. Cancer Res. 2015;75:1423-32 pubmed publisher
product information
master code :
NB100-56618
SKU :
NB100-56618
product name :
TRAILR2/TNFRSF10B Antibody - BSA Free
unit size :
0.1 mg (also 0.025 mg)
description :
The TRAILR2/TNFRSF10B Antibody - BSA Free from Novus is a rabbit polyclonal antibody to TRAILR2/TNFRSF10B. This antibody reacts with human,mouse. The TRAILR2/TNFRSF10B Antibody - BSA Free has been validated for the following applications: IF/IHC,Flow Cytometry,Western Blot,Immunohistochemistry-Paraffin,Flow (Cell Surface),Immunocytochemistry/ Immunofluorescence,Immunohistochemistry.
target :
TRAILR2/TNFRSF10B
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
Rabbit anti-DR5 polyclonal antibody was raised against a peptide corresponding to amino acids 388 to 407 (isoform 2) of human DR5 precursor (1,2). The same sequence is found in isoform 1 at amino acids 417-436.
isotype :
IgG
purity :
Protein G purified
species :
Human,Mouse
gene symbol :
TNFRSF10B
Antibody validation :
Biological Validation
applications :
IF/IHC,Flow Cytometry,Western Blot,Immunohistochemistry-Paraffin,Flow (Cell Surface),Immunocytochemistry/ Immunofluorescence,Immunohistochemistry
USD :
409 USD
alt names :
CD262, CD262 antigen, death domain containing receptor for TRAIL/Apo-2L, Death receptor 5, DR5TRICK2B, Fas-like protein, KILLER/DR5, KILLERapoptosis inducing protein TRICK2A/2B, TNF-related apoptosis-inducing ligand receptor 2, TRAIL receptor 2, TRAIL-R2apoptosis inducing receptor TRAIL-R2, TRAILR2cytotoxic TRAIL receptor-2, TRICK2, TRICK2A, TRICKB, tumor necrosis factor receptor superfamily member 10B, tumor necrosis factor receptor superfamily, member 10b, tumor necrosis factor receptor-like protein ZTNFR9, ZTNFR9
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.