product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
PARP Antibody (194C1439) - Cleaved - BSA Free
catalog :
NB100-56599
quantity :
0.1 mg (also 0.025 mg)
price :
359 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
194C1439
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
more info or order :
citations: 13
Reference
Wang S, Chang C, Huang J, Zeng S, Zhang X, Hung M, et al. Gasdermin C sensitizes tumor cells to PARP inhibitor therapy in cancer models. J Clin Invest. 2024;134: pubmed publisher
Szab xf3 V, Cs xe1 k xe1 ny Papp N, G xf6 r xf6 g M, Mad xe1 csy T, Varga x, Kiss A, et al. Orai1 calcium channel inhibition prevents progression of chronic pancreatitis. JCI Insight. 2023;8: pubmed publisher
Erdogan S, Türkekul K. Neferine inhibits proliferation and migration of human prostate cancer stem cells through p38 MAPK/JNK activation. J Food Biochem. 2020;44:e13253 pubmed publisher
Traub S, Heilker R. hiPS Cell-Derived Neurons for High-Throughput Screening. Methods Mol Biol. 2019;1994:243-263 pubmed publisher
Mega Tiber P, Kocyigit Sevinc S, Kilinc O, Orun O. Biological effects of whole Z.Officinale extract on chronic myeloid leukemia cell line K562. Gene. 2019;692:217-222 pubmed publisher
Modarai S, Gupta A, Opdenaker L, Kowash R, Masters G, Viswanathan V, et al. The anti-cancer effect of retinoic acid signaling in CRC occurs via decreased growth of ALDH+ colon cancer stem cells and increased differentiation of stem cells. Oncotarget. 2018;9:34658-34669 pubmed publisher
Dou X, Li S, Hu L, Ding L, Ma Y, Ma W, et al. Glutathione disulfide sensitizes hepatocytes to TNFα-mediated cytotoxicity via IKK-β S-glutathionylation: a potential mechanism underlying non-alcoholic fatty liver disease. Exp Mol Med. 2018;50:7 pubmed publisher
Jung Y, Cackowski F, Yumoto K, Decker A, Wang J, Kim J, et al. CXCL12γ Promotes Metastatic Castration-Resistant Prostate Cancer by Inducing Cancer Stem Cell and Neuroendocrine Phenotypes. Cancer Res. 2018;78:2026-2039 pubmed publisher
Melão A, Spit M, Cardoso B, Barata J. Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on casein kinase 2 activity. Haematologica. 2016;101:1368-1379 pubmed
Kamal A, Sreekanth K, Kumar P, Shankaraiah N, Balakishan G, Ramaiah M, et al. Synthesis and potential cytotoxic activity of new phenanthrylphenol-pyrrolobenzodiazepines. Eur J Med Chem. 2010;45:2173-81 pubmed publisher
Ko C, Shen S, Chen Y. Hydroxylation at C4' or C6 is essential for apoptosis-inducing activity of flavanone through activation of the caspase-3 cascade and production of reactive oxygen species. Free Radic Biol Med. 2004;36:897-910 pubmed
Chen Y, Shen S, Lin H. Rutinoside at C7 attenuates the apoptosis-inducing activity of flavonoids. Biochem Pharmacol. 2003;66:1139-50 pubmed
Chen Y, Shen S, Lee W, Hsu F, Lin H, Ko C, et al. Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production. Biochem Pharmacol. 2002;64:1713-24 pubmed
product information
master code :
NB100-56599
SKU :
NB100-56599
product name :
PARP Antibody (194C1439) - Cleaved - BSA Free
unit size :
0.1 mg (also 0.025 mg)
description :
The PARP Antibody (194C1439) - Cleaved - BSA Free from Novus is a mouse monoclonal antibody to PARP. This antibody reacts with human,mouse,rat (negative). The PARP Antibody (194C1439) - Cleaved - BSA Free has been validated for the following applications: Western Blot,Immunohistochemistry-Paraffin,Flow Cytometry,Flow (Intracellular),Immunocytochemistry/ Immunofluorescence.
target :
PARP
category :
Primary Antibodies
buffer :
PBS
clonality :
Monoclonal
clone :
194C1439
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Mouse
immunogen :
This antibody was developed by immunizing mice with a synthetic peptide containing amino acids near 214/215-cleavage site of human PARP.
isotype :
IgG2b Kappa
purity :
Protein G purified
species :
Human,Mouse,Rat (Negative)
specificity :
This monoclonal antibody specifically detects a 89-kDa cleavage fragment containing the catalytic and auto modification domain
gene symbol :
PARP1
Antibody validation :
Biological Validation
applications :
Western Blot,Immunohistochemistry-Paraffin,Flow Cytometry,Flow (Intracellular),Immunocytochemistry/ Immunofluorescence
USD :
359 USD
alt names :
ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase), ADPRT 1, ADPRTADP-ribosyltransferase NAD(+), cleaved PARP, cleaved PARP 1, cleaved PARP apoptosis, cleaved PARP western blot, cleaved PARP-1, EC 2.4.2, EC 2.4.2.30, NAD(+) ADP-ribosyltransferase 1, PARP apoptosis, PARP-1, PARPADPRT1, poly (ADP-ribose) polymerase 1, poly (ADP-ribose) polymerase family, member 1, poly [ADP-ribose] polymerase 1, poly(ADP-ribose) polymerase, poly(ADP-ribose) synthetase, poly(ADP-ribosyl)transferase, Poly[ADP-ribose] synthase 1, PPOLpADPRT-1
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.