product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
SARS Spike Protein Antibody - BSA Free
catalog :
NB100-56578
quantity :
0.1 mg (also 0.025 mg)
price :
399 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
6G6-1C9
reactivity :
SARS coronavirus
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
citations: 36
Published Application/Species/Sample/DilutionReference
  • western blot; SARS coronavirus; fig 1d
Johnson B, Xie X, Bailey A, Kalveram B, Lokugamage K, Muruato A, et al. Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis. Nature. 2021;591:293-299 pubmed publisher
Cone A, Zhou Y, McNamara R, Eason A, Arias G, Landis J, et al. CD81 fusion alters SARS-CoV-2 Spike trafficking. MBio. 2024;15:e0192224 pubmed publisher
Zhang S, El Deiry W. Transfected SARS-CoV-2 spike DNA for mammalian cell expression inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells and increases cancer cell viability after chemotherapy exposure. Oncotarget. 2024;15:275-284 pubmed publisher
Tamura T, Mizuma K, Nasser H, Deguchi S, Padilla Blanco M, Oda Y, et al. Virological characteristics of the SARS-CoV-2 BA.2.86 variant. Cell Host Microbe. 2024;: pubmed publisher
Kugathasan R, Sukhova K, Moshe M, Kellam P, Barclay W. Deep mutagenesis scanning using whole trimeric SARS-CoV-2 spike highlights the importance of NTD-RBD interactions in determining spike phenotype. PLoS Pathog. 2023;19:e1011545 pubmed publisher
Reuter N, Chen X, Kropff B, Peter A, Britt W, Mach M, et al. SARS-CoV-2 Spike Protein Is Capable of Inducing Cell-Cell Fusions Independent from Its Receptor ACE2 and This Activity Can Be Impaired by Furin Inhibitors or a Subset of Monoclonal Antibodies. Viruses. 2023;15: pubmed publisher
Tan C, Trew J, Peacock T, Mok K, Hart C, Lau K, et al. Genomic screening of 16 UK native bat species through conservationist networks uncovers coronaviruses with zoonotic potential. Nat Commun. 2023;14:3322 pubmed publisher
Eens S, Van Hecke M, Favere K, Tousseyn T, Guns P, Roskams T, et al. B-cell lymphoblastic lymphoma following intravenous BNT162b2 mRNA booster in a BALB/c mouse: A case report. Front Oncol. 2023;13:1158124 pubmed publisher
Vu M, Alvarado R, Morris D, Lokugamage K, Zhou Y, Morgan A, et al. Loss-of-function mutation in Omicron variants reduces spike protein expression and attenuates SARS-CoV-2 infection. bioRxiv. 2023;: pubmed publisher
Niemeyer D, Stenzel S, Veith T, Schroeder S, Friedmann K, Weege F, et al. SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression. PLoS Biol. 2022;20:e3001871 pubmed publisher
Meng W, Guo S, Cao S, Shuda M, Robinson McCarthy L, McCarthy K, et al. Development and characterization of a new monoclonal antibody against SARS-CoV-2 NSP12 (RdRp). J Med Virol. 2022;: pubmed publisher
Vu M, Lokugamage K, Plante J, Scharton D, Bailey A, Sotcheff S, et al. QTQTN motif upstream of the furin-cleavage site plays a key role in SARS-CoV-2 infection and pathogenesis. Proc Natl Acad Sci U S A. 2022;119:e2205690119 pubmed publisher
Rosendal E, Mihai I, Becker M, Das D, Frängsmyr L, Persson B, et al. Serine Protease Inhibitors Restrict Host Susceptibility to SARS-CoV-2 Infections. MBio. 2022;13:e0089222 pubmed publisher
Jana I, Bhttacharya P, Mayilsamy K, Banerjee S, Bhattacharje G, Das S, et al. Targeting an evolutionarily conserved "E-L-L" motif in the spike protein to develop a small molecule fusion inhibitor against SARS-CoV-2. bioRxiv. 2022;: pubmed publisher
Warner B, Santry L, Leacy A, Chan M, Pham P, Vendramelli R, et al. Intranasal vaccination with a Newcastle disease virus-vectored vaccine protects hamsters from SARS-CoV-2 infection and disease. iScience. 2021;24:103219 pubmed publisher
Garcia Dorival I, Cuesta Geijo M, Barrado Gil L, Galindo I, Garaigorta U, Urquiza J, et al. Identification of Niemann-Pick C1 protein as a potential novel SARS-CoV-2 intracellular target. Antiviral Res. 2021;194:105167 pubmed publisher
Schaller M, Sharma Y, Dupee Z, Nguyen D, Urueña J, Smolchek R, et al. Ex vivo SARS-CoV-2 infection of human lung reveals heterogeneous host defense and therapeutic responses. JCI Insight. 2021;6: pubmed publisher
Meng B, Kemp S, Papa G, Datir R, Ferreira I, Marelli S, et al. Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7. Cell Rep. 2021;35:109292 pubmed publisher
Peacock T, Goldhill D, Zhou J, Baillon L, Frise R, Swann O, et al. The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets. Nat Microbiol. 2021;6:899-909 pubmed publisher
Michaluk P, Heller J, Rusakov D. Rapid recycling of glutamate transporters on the astroglial surface. elife. 2021;10: pubmed publisher
Hörnich B, Großkopf A, Schlagowski S, Tenbusch M, Kleine Weber H, Neipel F, et al. SARS-CoV-2 and SARS-CoV Spike-Mediated Cell-Cell Fusion Differ in Their Requirements for Receptor Expression and Proteolytic Activation. J Virol. 2021;95: pubmed publisher
Sanchez Felipe L, Vercruysse T, Sharma S, Ma J, Lemmens V, Van Looveren D, et al. A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate. Nature. 2021;590:320-325 pubmed publisher
Plante J, Liu Y, Liu J, Xia H, Johnson B, Lokugamage K, et al. Spike mutation D614G alters SARS-CoV-2 fitness. Nature. 2020;: pubmed publisher
Smith T, Patel A, Ramos S, Elwood D, Zhu X, Yan J, et al. Immunogenicity of a DNA vaccine candidate for COVID-19. Nat Commun. 2020;11:2601 pubmed publisher
Ritzel R, Li Y, He J, Khan N, Doran S, Faden A, et al. Sustained neuronal and microglial alterations are associated with diverse neurobehavioral dysfunction long after experimental brain injury. Neurobiol Dis. 2020;136:104713 pubmed publisher
Marcolin M, Baumbach J, Hodges T, McCormick C. The effects of social instability stress and subsequent ethanol consumption in adolescence on brain and behavioural development in male rats. Alcohol. 2019;: pubmed publisher
Hodges T, Louth E, Bailey C, McCormick C. Adolescent social instability stress alters markers of synaptic plasticity and dendritic structure in the medial amygdala and lateral septum in male rats. Brain Struct Funct. 2019;224:643-659 pubmed publisher
Parker S, Moutal A, Cai S, Chandrasekaran S, Roman M, Koshy A, et al. High Fidelity Cryopreservation and Recovery of Primary Rodent Cortical Neurons. Eneuro. 2018;5: pubmed publisher
Simone J, Baumbach J, McCormick C. Sex-specific effects of CB1 receptor antagonism and stress in adolescence on anxiety, corticosterone concentrations, and contextual fear in adulthood in rats. Int J Dev Neurosci. 2018;69:119-131 pubmed publisher
Simone J, Baumbach J, McCormick C. Effects of CB1 receptor antagonism and stress exposures in adolescence on socioemotional behaviours, neuroendocrine stress responses, and expression of relevant proteins in the hippocampus and prefrontal cortex in rats. Neuropharmacology. 2018;128:433-447 pubmed publisher
Hussain S, Ringsevjen H, Egbenya D, Skjervold T, Davanger S. SNARE Protein Syntaxin-1 Colocalizes Closely with NMDA Receptor Subunit NR2B in Postsynaptic Spines in the Hippocampus. Front Mol Neurosci. 2016;9:10 pubmed publisher
Hussain S, Davanger S. Postsynaptic VAMP/Synaptobrevin Facilitates Differential Vesicle Trafficking of GluA1 and GluA2 AMPA Receptor Subunits. PLoS ONE. 2015;10:e0140868 pubmed publisher
Naskar S, Wan H, Kemenes G. pT305-CaMKII stabilizes a learning-induced increase in AMPA receptors for ongoing memory consolidation after classical conditioning. Nat Commun. 2014;5:3967 pubmed publisher
Giribaldi F, Milanese M, Bonifacino T, Anna Rossi P, Di Prisco S, Pittaluga A, et al. Group I metabotropic glutamate autoreceptors induce abnormal glutamate exocytosis in a mouse model of amyotrophic lateral sclerosis. Neuropharmacology. 2013;66:253-63 pubmed publisher
Reissner K, Boyle H, Ye X, Carew T. Aplysia synapse associated protein (APSAP): identification, characterization, and selective interactions with Shaker-type potassium channels. J Neurochem. 2008;105:1006-18 pubmed publisher
Fogel A, Akins M, Krupp A, Stagi M, Stein V, Biederer T. SynCAMs organize synapses through heterophilic adhesion. J Neurosci. 2007;27:12516-30 pubmed
product information
master code :
NB100-56578
SKU :
NB100-56578
product name :
SARS Spike Protein Antibody - BSA Free
unit size :
0.1 mg (also 0.025 mg)
description :
The SARS Spike Protein Antibody - BSA Free from Novus is a rabbit polyclonal antibody to SARS Spike Protein. This antibody reacts with human,sars-cov,sars-cov-2,virus - sars-cov-2. The SARS Spike Protein Antibody - BSA Free has been validated for the following applications: Western Blot,IF/IHC,Simple Western,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry.
target :
SARS Spike Protein
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
The antibody was developed by immunizing rabbits with a synthetic peptide corresponding to amino acids 1124-1140 (C-GNCDVVIGIVNNTVYDP) from the S (Spike glycoprotein)(Spike protein S2') for the Human SARS coronavirus (Genbank accession no. YP_009724390)
isotype :
IgG
purity :
Immunogen affinity purified
species :
Human,SARS-CoV,SARS-CoV-2,Virus - SARS-CoV-2
specificity :
Full length Spike protein transfected into UM92 cells was used as a positive control and an approximate 139 kDa band was observed
applications :
Western Blot,IF/IHC,Simple Western,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry
USD :
399 USD
alt names :
COVID-19 Spike, E2, E2 glycoprotein, Human coronavirus spike glycoprotein, Peplomer protein, S, S glycoprotein, SARS coronavirus S protein, SARS coronavirus Spike Protein, SARS CoV, SARS CoV S glycoprotein, SARS CoV Spike protein, SARSCoV, SARS-CoV S protein, SARS-COV Spike, SARS-COV-2 S protein, SARS-COV-2 Spike glycoprotein, SARSCOV2 Spike protein, Severe acute respiratory syndrome spike glycoprotein, Severe acute respiratory syndrome virus spike glycoprotein, Spike glycoprotein, VGL2
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.