product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
TLR4 Antibody (76B357.1) - BSA Free
catalog :
NB100-56566
quantity :
0.1 mg (also 0.025 mg)
price :
459 USD
clonality :
monoclonal
host :
mouse
conjugate :
DyLight 350
clone name :
76B357.1
reactivity :
human, mouse, rat, bovine, pigs
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, dot blot
more info or order :
citations: 139
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; 1:100; loading ...; fig 4e
Managò A, Audrito V, Mazzola F, Sorci L, Gaudino F, Gizzi K, et al. Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation. Nat Commun. 2019;10:4116 pubmed publisher
  • immunocytochemistry; pigs ; 1:50; loading ...; fig 1c
  • western blot; pigs ; 1:500; loading ...; fig 1b
Bernardini C, Bertocchi M, Zannoni A, Salaroli R, Tubon I, Dothel G, et al. Constitutive and LPS-stimulated secretome of porcine Vascular Wall-Mesenchymal Stem Cells exerts effects on in vitro endothelial angiogenesis. BMC Vet Res. 2019;15:123 pubmed publisher
  • western blot; mouse; loading ...; fig s2
Bhattacharjee P, Keyel P. Cholesterol-dependent cytolysins impair pro-inflammatory macrophage responses. Sci Rep. 2018;8:6458 pubmed publisher
  • flow cytometry; rat; loading ...; fig s1a
Rigo Adrover M, Franch A, Castell M, Pérez Cano F. Preclinical Immunomodulation by the Probiotic Bifidobacterium breve M-16V in Early Life. PLoS ONE. 2016;11:e0166082 pubmed publisher
  • western blot; mouse; 1:1000; fig s11
Fujita K, Motoki K, Tagawa K, Chen X, Hama H, Nakajima K, et al. HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease. Sci Rep. 2016;6:31895 pubmed publisher
  • western blot; human
Martin I, Cabán Hernández K, Figueroa Santiago O, Espino A. Fasciola hepatica fatty acid binding protein inhibits TLR4 activation and suppresses the inflammatory cytokines induced by lipopolysaccharide in vitro and in vivo. J Immunol. 2015;194:3924-36 pubmed publisher
  • western blot; rat
Zhu W, Zhu N, Bai D, Miao J, Zou S. The crosstalk between Dectin1 and TLR4 via NF-κB subunits p65/RelB in mammary epithelial cells. Int Immunopharmacol. 2014;23:417-25 pubmed publisher
  • immunohistochemistry - paraffin section; rat
Wang Y, Zhang A, Lu S, Pan X, Jia D, Yu W, et al. Adenosine 5'-monophosphate-induced hypothermia inhibits the activation of ERK1/2, JNK, p38 and NF-κB in endotoxemic rats. Int Immunopharmacol. 2014;23:205-10 pubmed publisher
  • immunohistochemistry - paraffin section; human
  • immunocytochemistry; human
Wang Y, Weng Y, Shi Y, Xia X, Wang S, Duan H. Expression and functional analysis of Toll-like receptor 4 in human cervical carcinoma. J Membr Biol. 2014;247:591-9 pubmed publisher
  • western blot; mouse
Dumas A, Amiable N, de Rivero Vaccari J, Chae J, Keane R, Lacroix S, et al. The inflammasome pyrin contributes to pertussis toxin-induced IL-1? synthesis, neutrophil intravascular crawling and autoimmune encephalomyelitis. PLoS Pathog. 2014;10:e1004150 pubmed publisher
  • immunocytochemistry; mouse
  • immunohistochemistry; mouse; 1:500; loading ...; fig 1a
  • western blot; mouse; loading ...
Schuster A, Klotz M, Schwab T, Di Liddo R, Bertalot T, Schrenk S, et al. Maintenance of the enteric stem cell niche by bacterial lipopolysaccharides? Evidence and perspectives. J Cell Mol Med. 2014;18:1429-43 pubmed publisher
  • western blot; rat
Raso G, Simeoli R, Iacono A, Santoro A, Amero P, Paciello O, et al. Effects of a Lactobacillus paracasei B21060 based synbiotic on steatosis, insulin signaling and toll-like receptor expression in rats fed a high-fat diet. J Nutr Biochem. 2014;25:81-90 pubmed publisher
  • western blot; rat
Kuhn H, Petzold K, Hammerschmidt S, Wirtz H. Interaction of cyclic mechanical stretch and toll-like receptor 4-mediated innate immunity in rat alveolar type II cells. Respirology. 2014;19:67-73 pubmed publisher
  • immunocytochemistry; human
Ramani V, Madhusoodhanan R, Kosanke S, Awasthi S. A TLR4-interacting SPA4 peptide inhibits LPS-induced lung inflammation. Innate Immun. 2013;19:596-610 pubmed publisher
  • western blot; rat
Tian J, Guo X, Liu X, Liu L, Weng Q, Dong S, et al. Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes. Cardiovasc Res. 2013;98:391-401 pubmed publisher
  • immunohistochemistry - frozen section; mouse
McCulloch L, Brown K, Mabbott N. Ablation of the cellular prion protein, PrPC, specifically on follicular dendritic cells has no effect on their maturation or function. Immunology. 2013;138:246-57 pubmed publisher
  • immunohistochemistry - paraffin section; human
  • western blot; human
Zheng Y, Yang M, Rong T, Yuan X, Ma Y, Wang Z, et al. CD74 and macrophage migration inhibitory factor as therapeutic targets in gastric cancer. World J Gastroenterol. 2012;18:2253-61 pubmed publisher
  • western blot; rat
Weile C, Josefsen K, Buschard K. Glucose activation of islets of Langerhans up-regulates Toll-like receptor 5: possible mechanism of protection. Clin Exp Immunol. 2011;166:251-7 pubmed publisher
  • immunohistochemistry; mouse
Nowicki M, Kosacka J, Serke H, Bluher M, Spanel Borowski K. Altered sciatic nerve fiber morphology and endoneural microvessels in mouse models relevant for obesity, peripheral diabetic polyneuropathy, and the metabolic syndrome. J Neurosci Res. 2012;90:122-31 pubmed publisher
  • flow cytometry; human
Brandau S, Jakob M, Hemeda H, Bruderek K, Janeschik S, Bootz F, et al. Tissue-resident mesenchymal stem cells attract peripheral blood neutrophils and enhance their inflammatory activity in response to microbial challenge. J Leukoc Biol. 2010;88:1005-15 pubmed publisher
  • immunocytochemistry; rat
Nowicki M, Muller K, Serke H, Kosacka J, Vilser C, Ricken A, et al. Oxidized low-density lipoprotein (oxLDL)-induced cell death in dorsal root ganglion cell cultures depends not on the lectin-like oxLDL receptor-1 but on the toll-like receptor-4. J Neurosci Res. 2010;88:403-12 pubmed publisher
  • flow cytometry; bovine
Worku M, Morris A. Binding of different forms of lipopolysaccharide and gene expression in bovine blood neutrophils. J Dairy Sci. 2009;92:3185-93 pubmed publisher
  • western blot; human
Lunardi C, Bason C, Dolcino M, Navone R, Simone R, Saverino D, et al. Antiflagellin antibodies recognize the autoantigens Toll-Like Receptor 5 and Pals 1-associated tight junction protein and induce monocytes activation and increased intestinal permeability in Crohn's disease. J Intern Med. 2009;265:250-65 pubmed publisher
  • immunocytochemistry; mouse
Cohen P, Koski G, Czerniecki B, Bunting K, Fu X, Wang Z, et al. STAT3- and STAT5-dependent pathways competitively regulate the pan-differentiation of CD34pos cells into tumor-competent dendritic cells. Blood. 2008;112:1832-43 pubmed publisher
Lu B, Xing L, Zhu X, Tang H, Lu B, Yuan F, et al. Tumor necrosis factor-stimulated gene-6 inhibits endoplasmic reticulum stress in the ischemic mouse kidney. iScience. 2024;27:111454 pubmed publisher
Do x11f an G, Sand x131 k xe7 x131 M, Karagen xe7 L. Stage-specific expression of Toll-like receptors in the seminiferous epithelium of mouse testis. Histochem Cell Biol. 2024;162:323-335 pubmed publisher
Cui H, Li J, Li X, Su T, Wen P, Wang C, et al. TNF-α promotes osteocyte necroptosis by upregulating TLR4 in postmenopausal osteoporosis. Bone. 2024;182:117050 pubmed publisher
Harris D, Sabe S, Xu C, Sabra M, Broadwin M, Malhotra A, et al. Sodium-glucose co-transporter 2 inhibitor canagliflozin modulates myocardial metabolism and inflammation in a swine model for chronic myocardial ischemia. Surgery. 2024;175:265-270 pubmed publisher
Zhu Z, Zhang L, Elsherbini A, Crivelli S, Tripathi P, Harper C, et al. The S1P receptor 1 antagonist Ponesimod reduces TLR4-induced neuroinflammation and increases Aβ clearance in 5XFAD mice. EBioMedicine. 2023;94:104713 pubmed publisher
Gonz xe1 lez A, Garc xed a G xf3 mez Heras S, Franco Rodr xed guez R, L xf3 pez Miranda V, Herrad xf3 n E. Cisplatin cycles treatment sustains cardiovascular and renal damage involving TLR4 and NLRP3 pathways. Pharmacol Res Perspect. 2023;11:e01108 pubmed publisher
Aamir K, Sethi G, Afrin M, Hossain C, Jusuf P, Sarker S, et al. Arjunolic acid modulate pancreatic dysfunction by ameliorating pattern recognition receptor and canonical Wnt pathway activation in type 2 diabetic rats. Life Sci. 2023;327:121856 pubmed publisher
Sanjurjo L, Castelblanco E, Julve J, Villalmanzo N, T xe9 llez x, Ramírez Morros A, et al. Contribution of Elevated Glucose and Oxidized LDL to Macrophage Inflammation: A Role for PRAS40/Akt-Dependent Shedding of Soluble CD14. Antioxidants (Basel). 2023;12: pubmed publisher
Beloosesky R, Gutzeit O, Ginsberg Y, Khatib N, Ross M, Weiner Z, et al. Intestine and brain TLR-4 modulation following N-acetyl-cysteine treatment in NEC rodent model. Sci Rep. 2023;13:8241 pubmed publisher
Zhou M, Pang F, Liao D, He X, Yang Y, Tang C. Electroacupuncture at Fengchi(GB20) and Yanglingquan(GB34) Ameliorates Paralgesia through Microglia-Mediated Neuroinflammation in a Rat Model of Migraine. Brain Sci. 2023;13: pubmed publisher
Tsioti I, Steiner B, Escher P, Zinkernagel M, Benz P, Kokona D. Endothelial Toll-like receptor 4 is required for microglia activation in the murine retina after systemic lipopolysaccharide exposure. J Neuroinflammation. 2023;20:25 pubmed publisher
Tabandeh M, Jozaie S, Ghotbedin Z, Gorani S. Dimethyl itaconic acid improves viability and steroidogenesis and suppresses cytokine production in LPS-treated bovine ovarian granulosa cells by regulating TLR4/nfkβ, NLRP3, JNK signaling pathways. Res Vet Sci. 2022;152:89-98 pubmed publisher
Abd El Aal S, Abdelrahman M, Reda A, Afify H, Ragab G, El Gazar A, et al. Galangin mitigates DOX-induced cognitive impairment in rats: Implication of NOX-1/Nrf-2/HMGB1/TLR4 and TNF-α/MAPKs/RIPK/MLKL/BDNF. Neurotoxicology. 2022;92:77-90 pubmed publisher
Kang J, Lee J, Seol I, Kim Y, Park M, Yoo H. Pharmacological Effects of Gami-Yukmijihwang-Tang on the Lipopolysaccharide-Induced Hippocampus Oxidation and Inflammation via Regulation of Sirt6. Pharmaceuticals (Basel). 2022;15: pubmed publisher
Visioli F, Nunes J, Pedicillo M, Leonardi R, Santoro A, Zannoni G, et al. TLR4 Expression in Ex-Lichenoid Lesions-Oral Squamous Cell Carcinomas and Its Surrounding Epithelium: The Role of Tumor Inflammatory Microenvironment. Biomolecules. 2022;12: pubmed publisher
Deschamps C, Uyttersprot F, Debris M, Mari xe9 C, Fouquet G, Marcq I, et al. Anti-inflammatory drugs prevent memory and hippocampal plasticity deficits following initial binge-like alcohol exposure in adolescent male rats. Psychopharmacology (Berl). 2022;239:2245-2262 pubmed publisher
Majumder S, Pushpakumar S, Juin S, Jala V, Sen U. Toll-like receptor 4 mutation protects the kidney from Ang-II-induced hypertensive injury. Pharmacol Res. 2022;175:106030 pubmed publisher
Vilpoux C, Fouquet G, Deschamps C, Lefebvre E, Gosset P, Antol J, et al. Astrogliosis and compensatory neurogenesis after the first ethanol binge drinking-like exposure in the adolescent rat. Alcohol Clin Exp Res. 2022;46:207-220 pubmed publisher
Shi Z, Mori Akiyama Y, Du W, Fultz R, Zhao Y, Ruan W, et al. Loss of H2R Signaling Disrupts Neutrophil Homeostasis and Promotes Inflammation-Associated Colonic Tumorigenesis in Mice. Cell Mol Gastroenterol Hepatol. 2022;13:717-737 pubmed publisher
Zhang C, Wang X, Wang C, He C, Ma Q, Li J, et al. Qingwenzhike Prescription Alleviates Acute Lung Injury Induced by LPS via Inhibiting TLR4/NF-kB Pathway and NLRP3 Inflammasome Activation. Front Pharmacol. 2021;12:790072 pubmed publisher
Reynolds K, Krasovska V, Scott A. Converging purinergic and immune signaling pathways drive IL-6 secretion by Fragile X cortical astrocytes via STAT3. J Neuroimmunol. 2021;361:577745 pubmed publisher
Niu F, Liao K, Hu G, Moidunny S, Roy S, Buch S. HIV Tat-Mediated Induction of Monocyte Transmigration Across the Blood-Brain Barrier: Role of Chemokine Receptor CXCR3. Front Cell Dev Biol. 2021;9:724970 pubmed publisher
Abu El Haija M, Ye Y, Chu Y, Herz H, Linden B, Shahi S, et al. Toll-like receptor 4 and myeloid differentiation factor 88 are required for gastric bypass-induced metabolic effects. Surg Obes Relat Dis. 2021;17:1996-2006 pubmed publisher
Xiao Q, Chen Y, Pratama S, Chen Y, Shirakawa H, Peng H, et al. The Prophylactic Effects of Glutamine on Muscle Protein Synthesis and Degradation in Rats with Ethanol-Induced Liver Damage. Nutrients. 2021;13: pubmed publisher
Zhong S, Zhou Z, Lin X, Liu F, Liu C, Liu Z, et al. Ketogenic diet prevents paclitaxel-induced neuropathic nociception through activation of PPARγ signalling pathway and inhibition of neuroinflammation in rat dorsal root ganglion. Eur J Neurosci. 2021;54:5341-5356 pubmed publisher
Di Cerbo A, Giusti S, Mariotti F, Spaterna A, Rossi G, Magi G. Increased Expression of Toll-Like Receptor 4 in Skin of Dogs with Discoid Lupus Erythematous (DLE). Animals (Basel). 2021;11: pubmed publisher
Alharbi M, Dutta B, Goswami R, Sharma S, Lei K, Rahaman S. Identification and functional analysis of a biflavone as a novel inhibitor of transient receptor potential vanilloid 4-dependent atherogenic processes. Sci Rep. 2021;11:8173 pubmed publisher
Liu L, Aron C, Grable C, Robles A, Liu X, Liu Y, et al. Surfactant protein A reduces TLR4 and inflammatory cytokine mRNA levels in neonatal mouse ileum. Sci Rep. 2021;11:2593 pubmed publisher
Liu J, Li L, Luo N, Liu Q, Liu L, Chen D, et al. Inflammatory signals induce MUC16 expression in ovarian cancer cells via NF-κB activation. Exp Ther Med. 2021;21:163 pubmed publisher
Yeh W, Tsai C, Ko J, Yang H. Hylocereus polyrhizus Peel Extract Retards Alcoholic Liver Disease Progression by Modulating Oxidative Stress and Inflammatory Responses in C57BL/6 Mice. Nutrients. 2020;12: pubmed publisher
Markarian M, Krattli R, Baddour J, Alikhani L, Giedzinski E, Usmani M, et al. Glia-Selective Deletion of Complement C1q Prevents Radiation-Induced Cognitive Deficits and Neuroinflammation. Cancer Res. 2021;81:1732-1744 pubmed publisher
Soto Tinoco E, Santacruz E, Basualdo Sigales M, Guerrero Vargas N, Buijs R. Time-of-Day-Dependent Gating of the Liver-Spinal Axis Initiates an Anti-Inflammatory Reflex in the Rat. Eneuro. 2020;7: pubmed publisher
Lee C, Park H, Lee B, Jeong S, Hyun S, Choi J, et al. Novel Therapeutic Effects of Pterosin B on Ang II-Induced Cardiomyocyte Hypertrophy. Molecules. 2020;25: pubmed publisher
Khan H, Aamir K, Jusuf P, Sethi G, Sisinthy S, Ghildyal R, et al. Lauric acid ameliorates lipopolysaccharide (LPS)-induced liver inflammation by mediating TLR4/MyD88 pathway in Sprague Dawley (SD) rats. Life Sci. 2021;265:118750 pubmed publisher
Holdbrooks A, Ankenbauer K, Hwang J, Bellis S. Regulation of inflammatory signaling by the ST6Gal-I sialyltransferase. PLoS ONE. 2020;15:e0241850 pubmed publisher
Min W, Wei X. Silencing SIX1 inhibits epithelial mesenchymal transition through regulating TGF-β/Smad2/3 signaling pathway in papillary thyroid carcinoma. Auris Nasus Larynx. 2020;: pubmed publisher
Chen Y, Shirakawa H, Lu N, Peng H, Xiao Q, Yang S. Impacts of fish oil on the gut microbiota of rats with alcoholic liver damage. J Nutr Biochem. 2020;86:108491 pubmed publisher
Chivero E, Liao K, Niu F, Tripathi A, Tian C, Buch S, et al. Engineered Extracellular Vesicles Loaded With miR-124 Attenuate Cocaine-Mediated Activation of Microglia. Front Cell Dev Biol. 2020;8:573 pubmed publisher
Bi Y, Ding Y, Wu J, Miao Z, Wang J, Wang F. Staphylococcus aureus induces mammary gland fibrosis through activating the TLR/NF-κB and TLR/AP-1 signaling pathways in mice. Microb Pathog. 2020;148:104427 pubmed publisher
Seimetz M, Sommer N, Bednorz M, Pak O, Veith C, Hadžić S, et al. NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD. Nat Metab. 2020;2:532-546 pubmed publisher
Halder A, Yadav K, Aggarwal A, Singhal N, Sandhir R. Activation of TNFR1 and TLR4 following oxygen glucose deprivation promotes mitochondrial fission in C6 astroglial cells. Cell Signal. 2020;75:109714 pubmed publisher
Burkovetskaya M, Small R, Guo L, Buch S, Guo M. Cocaine self-administration differentially activates microglia in the mouse brain. Neurosci Lett. 2020;728:134951 pubmed publisher
Ozbek M, Hitit M, Ergun E, Ergun L, Beyaz F, Erhan F, et al. Expression profile of Toll-like receptor 4 in rat testis and epididymis throughout postnatal development. Andrologia. 2020;52:e13518 pubmed publisher
Rodet F, Capuz A, Ozcan B, Le Beillan R, Raffo Romero A, Kobeissy F, et al. PC1/3 KD Macrophages Exhibit Resistance to the Inhibitory Effect of IL-10 and a Higher TLR4 Activation Rate, Leading to an Anti-Tumoral Phenotype. Cells. 2019;8: pubmed publisher
Evran S, Çalış F, Akkaya E, Baran O, Cevik S, Katar S, et al. The effect of high mobility group box-1 protein on cerebral edema, blood-brain barrier, oxidative stress and apoptosis in an experimental traumatic brain injury model. Brain Res Bull. 2020;154:68-80 pubmed publisher
Ryu K, Lee H, Woo H, Kang R, Han K, Park H, et al. Dasatinib regulates LPS-induced microglial and astrocytic neuroinflammatory responses by inhibiting AKT/STAT3 signaling. J Neuroinflammation. 2019;16:190 pubmed publisher
Zi S, Li J, Liu L, Deng C, Ao X, Chen D, et al. Dexmedetomidine-mediated protection against septic liver injury depends on TLR4/MyD88/NF-κB signaling downregulation partly via cholinergic anti-inflammatory mechanisms. Int Immunopharmacol. 2019;76:105898 pubmed publisher
Zhang S, Yang R, Shang J, Gao T, Wang R, Peng X, et al. FOXC1 up-regulates the expression of toll-like receptors in myocardial ischaemia. J Cell Mol Med. 2019;23:7566-7580 pubmed publisher
Yang K, Lauritzen K, Olsen M, Dahl T, Ranheim T, Ahmed M, et al. Low Cellular NAD+ Compromises Lipopolysaccharide-Induced Inflammatory Responses via Inhibiting TLR4 Signal Transduction in Human Monocytes. J Immunol. 2019;203:1598-1608 pubmed publisher
Arya R, Arankalle V. Phenotypic analysis of monocytes and CD4+ T cells in hepatitis E patients with or without pregnancy. Hum Immunol. 2019;80:855-862 pubmed publisher
Araldi D, Bogen O, Green P, Levine J. Role of Nociceptor Toll-like Receptor 4 (TLR4) in Opioid-Induced Hyperalgesia and Hyperalgesic Priming. J Neurosci. 2019;: pubmed publisher
Liu T, Liu J, Lin Y, Que B, Chang C, Zhang J, et al. IL-37 inhibits the maturation of dendritic cells through the IL-1R8-TLR4-NF-κB pathway. Biochim Biophys Acta Mol Cell Biol Lipids. 2019;1864:1338-1349 pubmed publisher
Liang L, Shao W, Shu T, Zhang Y, Xu S, Guo L, et al. Xuezhikang improves the outcomes of cardiopulmonary resuscitation in rats by suppressing the inflammation response through TLR4/NF-κB pathway. Biomed Pharmacother. 2019;114:108817 pubmed publisher
Luo Q, Cheng D, Huang C, Li Y, Lao C, Xia Y, et al. Improvement of Colonic Immune Function with Soy Isoflavones in High-Fat Diet-Induced Obese Rats. Molecules. 2019;24: pubmed publisher
Bagratuni T, Sklirou A, Kastritis E, Liacos C, Spilioti C, Eleutherakis Papaiakovou E, et al. Toll-Like Receptor 4 Activation Promotes Multiple Myeloma Cell Growth and Survival Via Suppression of The Endoplasmic Reticulum Stress Factor Chop. Sci Rep. 2019;9:3245 pubmed publisher
Wang P, Liu B, Wu M, Wei X, Sheng S, You S, et al. Moderate prenatal alcohol exposure suppresses the TLR4-mediated innate immune response in the hippocampus of young rats. Neurosci Lett. 2019;699:77-83 pubmed publisher
Zhang Z, La Placa D, Nguyen T, Kujawski M, Le K, Li L, et al. CEACAM1 regulates the IL-6 mediated fever response to LPS through the RP105 receptor in murine monocytes. BMC Immunol. 2019;20:7 pubmed publisher
Prigent A, Gonzales J, Durand T, Le Berre Scoul C, Rolli Derkinderen M, Neunlist M, et al. Acute inflammation down-regulates alpha-synuclein expression in enteric neurons. J Neurochem. 2019;148:746-760 pubmed publisher
Milanesi S, Verzola D, Cappadona F, Bonino B, Murugavel A, Pontremoli R, et al. Uric acid and angiotensin II additively promote inflammation and oxidative stress in human proximal tubule cells by activation of toll-like receptor 4. J Cell Physiol. 2019;234:10868-10876 pubmed publisher
Lee J, Joo B, Nam J, Nam H, Lee W, Nam Y, et al. An Aqueous Extract of Herbal Medicine ALWPs Enhances Cognitive Performance and Inhibits LPS-Induced Neuroinflammation via FAK/NF-κB Signaling Pathways. Front Aging Neurosci. 2018;10:269 pubmed publisher
Mukherjee P, Hough G, Chattopadhyay A, Grijalva V, O Connor E, Meriwether D, et al. Role of enterocyte stearoyl-Co-A desaturase-1 in LDLR-null mice. J Lipid Res. 2018;59:1818-1840 pubmed publisher
Choi C, Kang T, Song J, Kim Y, Chung E, Ylaya K, et al. Elevated expression of pancreatic adenocarcinoma upregulated factor (PAUF) is associated with poor prognosis and chemoresistance in epithelial ovarian cancer. Sci Rep. 2018;8:12161 pubmed publisher
Bidne K, Kvidera S, Ross J, Baumgard L, Keating A. Impact of repeated lipopolysaccharide administration on ovarian signaling during the follicular phase of the estrous cycle in post-pubertal pigs. J Anim Sci. 2018;: pubmed publisher
Bernardini C, Zannoni A, Bertocchi M, Tubon I, Fernandez M, Forni M. Water/ethanol extract of Cucumis sativus L. fruit attenuates lipopolysaccharide-induced inflammatory response in endothelial cells. BMC Complement Altern Med. 2018;18:194 pubmed publisher
Sun L, Li M, Ma X, Zhang L, Song J, Lv C, et al. Inhibiting high mobility group box-1 reduces early spinal cord edema and attenuates astrocyte activation and aquaporin-4 expression after spinal cord injury in rats. J Neurotrauma. 2018;: pubmed publisher
Domon H, Nagai K, Maekawa T, Oda M, Yonezawa D, Takeda W, et al. Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-Like Receptors and Cytokines in Pneumococcal Pneumonia. Front Immunol. 2018;9:732 pubmed publisher
Nie H, Mei Z, Wang R, Zhao B, Gao Y, Chen J, et al. Bushen recipe and its disassembled prescriptions inhibit inflammation of liver injury associated with Concanavalin A through Toll‑like receptor 3/9 signaling pathway. Mol Med Rep. 2018;18:1682-1691 pubmed publisher
Wei W, Wan H, Peng X, Zhou H, Lu Y, He Y. Antiviral effects of Ma Huang Tang against H1N1 influenza virus infection in vitro and in an ICR pneumonia mouse model. Biomed Pharmacother. 2018;102:1161-1175 pubmed publisher
Dickson M, Hager C, Al Shaibi A, Thomas P, Baumgard L, Ross J, et al. Impact of heat stress during the follicular phase on porcine ovarian steroidogenic and phosphatidylinositol-3 signaling. J Anim Sci. 2018;96:2162-2174 pubmed publisher
Dawson H, Lunney J. Porcine cluster of differentiation (CD) markers 2018 update. Res Vet Sci. 2018;118:199-246 pubmed publisher
Chen X, Yan X, Guo L. Inhibitory effect of Patrinia on BRL-3A cell apoptosis through the TLR4/PI3K/AKT/GSK3β and TLR4/P38/JNK signaling pathways. Mol Med Rep. 2018;17:5344-5349 pubmed publisher
Sun L, Li M, Ma X, Feng H, Song J, Lv C, et al. Inhibition of HMGB1 reduces rat spinal cord astrocytic swelling and AQP4 expression after oxygen-glucose deprivation and reoxygenation via TLR4 and NF-?B signaling in an IL-6-dependent manner. J Neuroinflammation. 2017;14:231 pubmed publisher
Nakano Y, Shimazawa M, Ojino K, Izawa H, Takeuchi H, Inoue Y, et al. Toll-like receptor 4 inhibitor protects against retinal ganglion cell damage induced by optic nerve crush in mice. J Pharmacol Sci. 2017;133:176-183 pubmed publisher
Tobita K, Watanabe I, Saito M. Specific vaginal lactobacilli suppress the inflammation induced by lipopolysaccharide stimulation through downregulation of toll-like receptor 4 expression in human embryonic intestinal epithelial cells. Biosci Microbiota Food Health. 2017;36:39-44 pubmed publisher
Schöniger S, Gräfe H, Schoon H. Expression of Toll-like receptors 2, 4 and 6 in different cell populations of the equine endometrium. Vet Immunol Immunopathol. 2017;185:7-13 pubmed publisher
Camps Bossacoma M, Perez Cano F, Franch A, Untersmayr E, Castell M. Effect of a cocoa diet on the small intestine and gut-associated lymphoid tissue composition in an oral sensitization model in rats. J Nutr Biochem. 2017;42:182-193 pubmed publisher
Azuma Y, Taniguchi F, Nakamura K, Nagira K, Khine Y, Kiyama T, et al. Lipopolysaccharide promotes the development of murine endometriosis-like lesions via the nuclear factor-kappa B pathway. Am J Reprod Immunol. 2017;77: pubmed publisher
Rathod S, Tripathy A. TGF-?1 and contact mediated suppression by CD4+CD25+CD127- T regulatory cells of patients with self-limiting hepatitis E. Hum Immunol. 2016;77:1254-1263 pubmed publisher
Lin S, Kuo M, Hsiao H, Lee P. Azithromycin modulates immune response of human monocyte-derived dendritic cells and CD4+ T cells. Int Immunopharmacol. 2016;40:318-326 pubmed publisher
Szasz T, Wenceslau C, Burgess B, Nunes K, Webb R. Toll-Like Receptor 4 Activation Contributes to Diabetic Bladder Dysfunction in a Murine Model of Type 1 Diabetes. Diabetes. 2016;65:3754-3764 pubmed
Chen C, Chen C, Jian C, Lin P, Chou J, Teng H, et al. Attenuation of exercise effect on inflammatory responses via novel role of TLR4/PI3K/Akt signaling in rat splenocytes. J Appl Physiol (1985). 2016;121:870-877 pubmed publisher
Burgueño J, Barba A, Eyre E, Romero C, Neunlist M, Fernández E. TLR2 and TLR9 modulate enteric nervous system inflammatory responses to lipopolysaccharide. J Neuroinflammation. 2016;13:187 pubmed publisher
Kuramochi M, Izawa T, Pervin M, Bondoc A, Kuwamura M, Yamate J. The kinetics of damage-associated molecular patterns (DAMPs) and toll-like receptors during thioacetamide-induced acute liver injury in rats. Exp Toxicol Pathol. 2016;68:471-7 pubmed publisher
Li X, Bao W, Leung C, Ma D, Zhang G, Lu A, et al. Chemical Structure and Immunomodulating Activities of an α-Glucan Purified from Lobelia chinensis Lour. Molecules. 2016;21: pubmed publisher
Okada K, Arai S, Itoh H, Adachi S, Hayashida M, Nakase H, et al. CD68 on rat macrophages binds tightly to S100A8 and S100A9 and helps to regulate the cells' immune functions. J Leukoc Biol. 2016;100:1093-1104 pubmed
Jeon Y, Kim C, Koh J, Chung D, Ha G. Pellino-1 confers chemoresistance in lung cancer cells by upregulating cIAP2 through Lys63-mediated polyubiquitination. Oncotarget. 2016;7:41811-41824 pubmed publisher
Mishima Y, Ishihara S, Oka A, Fukuba N, Oshima N, Sonoyama H, et al. Decreased Frequency of Intestinal Regulatory CD5+ B Cells in Colonic Inflammation. PLoS ONE. 2016;11:e0146191 pubmed publisher
Płóciennikowska A, Zdioruk M, Traczyk G, Świątkowska A, Kwiatkowska K. LPS-induced clustering of CD14 triggers generation of PI(4,5)P2. J Cell Sci. 2015;128:4096-111 pubmed publisher
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product information
master code :
NB100-56566
SKU :
NB100-56566
product name :
TLR4 Antibody (76B357.1) - BSA Free
unit size :
0.1 mg (also 0.025 mg)
description :
The TLR4 Antibody (76B357.1) - BSA Free from Novus is a mouse monoclonal antibody to TLR4. This antibody reacts with bovine,human,mammal,mouse,porcine,rat. The TLR4 Antibody (76B357.1) - BSA Free has been validated for the following applications: Western Blot,Immunohistochemistry,In vivo assay,Block/Neutralize,Immunocytochemistry/ Immunofluorescence,Simple Western,Chemotaxis,Cytometric Bead Assay Standard,Flow Cytometry Control,IF/IHC,In-vitro,ELISA,Flow Cytometry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,SDS-Page,Flow (Cell Surface),Knockdown Validated,In vitro assay,Dot Blot,Flow (Intracellular),ELISA Capture (Matched Antibody Pair),Chromatin Immunoprecipitation (ChIP),CyTOF-ready,Knockout Validated,Dual RNAscope ISH-IHC.
target :
TLR4
category :
Primary Antibodies
buffer :
PBS
clonality :
Monoclonal
clone :
76B357.1
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Mouse
immunogen :
This TLR4 Antibody (76B357.1) was developed against a portion of amino acids 100-200 of human TLR4 (NP_612564).
isotype :
IgG2b Kappa
purity :
Protein G purified
species :
Bovine,Human,Mammal,Mouse,Porcine,Rat
theoretical molecular weight :
95.7 kDa
gene symbol :
TLR4
Antibody validation :
Orthogonal Validation
accessionNumbers :
O00206
applications :
Immunohistochemistry,Western Blot,In vivo assay,Block/Neutralize,Immunocytochemistry/ Immunofluorescence,Simple Western,Chemotaxis,Cytometric Bead Assay Standard,Flow Cytometry Control,IF/IHC,In-vitro,ELISA,Flow Cytometry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,SDS-Page,Flow (Cell Surface),Knockdown Validated,In vitro assay,Dot Blot,Flow (Intracellular),ELISA Capture (Matched Antibody Pair),Chromatin Immunoprecipitation (ChIP),CyTOF-ready,Knockout Validated,Dual RNAscope ISH-IHC
USD :
459 USD
alt names :
76B357.1, ARMD10, CD_antigen: CD284, CD284, CD284 antigen, EC 3.2.2.6, EC:3.2.2.6, homolog of Drosophila toll, hToll, TLR4, TLR-4, tlr4 76B357.1, TLR4 facs, TLR4 flow cytometry, TLR4 human, TLR4 ihc, TLR4 western blot, TOLL, toll like receptor 4 protein, toll-like receptor 4
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.