| Published Application/Species/Sample/Dilution | Reference |
|---|
| Queen J, Agarwal S, Dolores J, Stehlik C, Satchell K. Mechanisms of inflammasome activation by Vibrio cholerae secreted toxins vary with strain biotype. Infect Immun. 2015;83:2496-506 pubmed publisher |
| Rimessi A, Bezzerri V, Patergnani S, Marchi S, Cabrini G, Pinton P. Mitochondrial Ca2+-dependent NLRP3 activation exacerbates the Pseudomonas aeruginosa-driven inflammatory response in cystic fibrosis. Nat Commun. 2015;6:6201 pubmed publisher |
- immunohistochemistry - paraffin section; human
- western blot; human
| de Rivero Vaccari J, Brand F, Adamczak S, Lee S, Perez Barcena J, Wang M, et al. Exosome-mediated inflammasome signaling after central nervous system injury. J Neurochem. 2016;136 Suppl 1:39-48 pubmed publisher |
| Paciello I, Silipo A, Lembo Fazio L, Curcurù L, Zumsteg A, Noël G, et al. Intracellular Shigella remodels its LPS to dampen the innate immune recognition and evade inflammasome activation. Proc Natl Acad Sci U S A. 2013;110:E4345-54 pubmed publisher |
| Mawhinney L, de Rivero Vaccari J, Dale G, Keane R, Bramlett H. Heightened inflammasome activation is linked to age-related cognitive impairment in Fischer 344 rats. BMC Neurosci. 2011;12:123 pubmed publisher |
| Gao F, Xiong D, Sun Z, Shao J, Wei D, Nie S. ARC@DPBNPs suppress LPS-induced acute lung injury via inhibiting macrophage pyroptosis and M1 polarization by ERK pathway in mice. Int Immunopharmacol. 2024;131:111794 pubmed publisher |
| Spurlock M, An W, Reshetnikova G, Wen R, Wang H, Braha M, et al. The Inflammasome-Dependent Dysfunction and Death of Retinal Ganglion Cells after Repetitive Intraocular Pressure Spikes. Cells. 2023;12: pubmed publisher |
| Yang L, Lu P, Qi X, Yang Q, Liu L, Dou T, et al. Metformin inhibits inflammatory response and endoplasmic reticulum stress to improve hypothalamic aging in obese mice. iScience. 2023;26:108082 pubmed publisher |
| Chen J, Shan T, Wei T, Jiang Q, Du C, Gu L, et al. SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice. Arch Toxicol. 2023;97:3209-3226 pubmed publisher |
| Landau D, Shukri N, Arazi E, Tobar A, Segev Y. Beneficiary Effects of Colchicine on Inflammation and Fibrosis in a Mouse Model of Kidney Injury. Nephron. 2023;147:693-700 pubmed publisher |
| Fu Y, Cao J, Wei X, Ge Y, Su Z, Yu D. Klotho alleviates contrast-induced acute kidney injury by suppressing oxidative stress, inflammation, and NF-KappaB/NLRP3-mediated pyroptosis. Int Immunopharmacol. 2023;118:110105 pubmed publisher |
| Yue R, Li Y, Su B, Li C, Zeng R. Atorvastatin reduces contrast media-induced pyroptosis of renal tubular epithelial cells by inhibiting the TLR4/MyD88/NF-κB signaling pathway. BMC Nephrol. 2023;24:25 pubmed publisher |
| Sobrano Fais R, Menezes da Costa R, Carvalho Mendes A, Mestriner F, Comerma Steffensen S, Tostes R, et al. NLRP3 activation contributes to endothelin-1-induced erectile dysfunction. J Cell Mol Med. 2023;27:1-14 pubmed publisher |
| Missiroli S, Perrone M, Gaf xe0 R, Nicoli F, Bonora M, Morciano G, et al. PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment. Cell Death Differ. 2023;30:429-441 pubmed publisher |
| Xie J, Zhu C, Wan X, Zhao Z, Meng Y, Li P, et al. GSDMD-mediated NETosis promotes the development of acute respiratory distress syndrome. Eur J Immunol. 2023;53:e2250011 pubmed publisher |
| Luo T, Zhou X, Qin M, Lin Y, Lin J, Chen G, et al. Corilagin Restrains NLRP3 Inflammasome Activation and Pyroptosis through the ROS/TXNIP/NLRP3 Pathway to Prevent Inflammation. Oxid Med Cell Longev. 2022;2022:1652244 pubmed publisher |
| Zhao K, Li S, Chen J, Jin Q. Inhibitory Effect of Trihydroxy Isoflavone on Neuronal Apoptosis in Natural Aging Rats. Dis Markers. 2022;2022:4688203 pubmed publisher |
| Zhang Z, Tan Q, Guo P, Huang S, Jia Z, Liu X, et al. NLRP3 inflammasome-mediated choroid plexus hypersecretion contributes to hydrocephalus after intraventricular hemorrhage via phosphorylated NKCC1 channels. J Neuroinflammation. 2022;19:163 pubmed publisher |
| Zhang Z, Dang S, Li S, Liu Y, Qi M, Wang N, et al. Glucose Fluctuations Aggravate Myocardial Fibrosis via the Nuclear Factor-κB-Mediated Nucleotide-Binding Oligomerization Domain-Like Receptor Protein 3 Inflammasome Activation. Front Cardiovasc Med. 2022;9:748183 pubmed publisher |
| Wu X, Chen Y, Liu C, Gong J, Xu X. STING Induces Liver Ischemia-Reperfusion Injury by Promoting Calcium-Dependent Caspase 1-GSDMD Processing in Macrophages. Oxid Med Cell Longev. 2022;2022:8123157 pubmed publisher |
| Sousa A, Vale G, Nascimento J, Awata W, Silva C, Assis V, et al. Inhibition of inducible nitric oxide synthase protects against the deleterious effects of sub-lethal sepsis and ethanol in the cardiorenal system. Can J Physiol Pharmacol. 2021;99:1324-1332 pubmed publisher |
| Cau S, Bruder Nascimento A, Silva M, Ramalho F, Mestriner F, Alves Lopes R, et al. Angiotensin-II activates vascular inflammasome and induces vascular damage. Vascul Pharmacol. 2021;139:106881 pubmed publisher |
| El Rous M, Saber S, Raafat E, Ahmed A. Dapagliflozin, an SGLT2 inhibitor, ameliorates acetic acid-induced colitis in rats by targeting NFκB/AMPK/NLRP3 axis. Inflammopharmacology. 2021;29:1169-1185 pubmed publisher |
| Lin Y, Luo T, Weng A, Huang X, Yao Y, Fu Z, et al. Gallic Acid Alleviates Gouty Arthritis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling. Front Immunol. 2020;11:580593 pubmed publisher |
| Bourgeois J, Kalyanasundaram G, Figueroa C, Srinivasan A, Kopec A. A semi-automated brain atlas-based analysis pipeline for c-Fos immunohistochemical data. J Neurosci Methods. 2020;:108982 pubmed publisher |
| Lu Q, Zhang Y, Kasetti R, Gaddipati S, Cvm N, Borchman D, et al. Heterozygous Loss of Yap1 in Mice Causes Progressive Cataracts. Invest Ophthalmol Vis Sci. 2020;61:21 pubmed publisher |
| Liu L, Chen M, Lin K, Xiang X, Zheng Y, Zhu S. Inhibiting Caspase-12 Mediated Inflammasome Activation protects against Oxygen-Glucose Deprivation Injury in Primary Astrocytes. Int J Med Sci. 2020;17:1936-1945 pubmed publisher |
| Kerr N, de Rivero Vaccari J, Weaver C, Dietrich W, Ahmed T, Keane R. Enoxaparin Attenuates Acute Lung Injury and Inflammasome Activation after Traumatic Brain Injury. J Neurotrauma. 2021;38:646-654 pubmed publisher |
| Pan H, Lin Y, Dou J, Fu Z, Yao Y, Ye S, et al. Wedelolactone facilitates Ser/Thr phosphorylation of NLRP3 dependent on PKA signalling to block inflammasome activation and pyroptosis. Cell Prolif. 2020;:e12868 pubmed publisher |
| Rimessi A, Pozzato C, Carparelli L, Rossi A, Ranucci S, De Fino I, et al. Pharmacological modulation of mitochondrial calcium uniporter controls lung inflammation in cystic fibrosis. Sci Adv. 2020;6:eaax9093 pubmed publisher |
| Xie W, Ding J, Xie X, Yang X, Wu X, Chen Z, et al. Hepatitis B virus X protein promotes liver cell pyroptosis under oxidative stress through NLRP3 inflammasome activation. Inflamm Res. 2020;69:683-696 pubmed publisher |
| Dang S, Zhang Z, LI K, Zheng J, Qian L, Liu X, et al. Blockade of β-adrenergic signaling suppresses inflammasome and alleviates cardiac fibrosis. Ann Transl Med. 2020;8:127 pubmed publisher |
| Pereira C, Carlos D, Ferreira N, Silva J, Zanotto C, Zamboni D, et al. Mitochondrial DNA Promotes NLRP3 Inflammasome Activation and Contributes to Endothelial Dysfunction and Inflammation in Type 1 Diabetes. Front Physiol. 2019;10:1557 pubmed publisher |
| Köse Vogel N, Stengel S, Gardey E, Kirchberger Tolstik T, Reuken P, Stallmach A, et al. Transcriptional Suppression of the NLRP3 Inflammasome and Cytokine Release in Primary Macrophages by Low-Dose Anthracyclines. Cells. 2019;9: pubmed publisher |
| Ferreira N, Bruder Nascimento T, Pereira C, Zanotto C, Prado D, Silva J, et al. NLRP3 Inflammasome and Mineralocorticoid Receptors Are Associated with Vascular Dysfunction in Type 2 Diabetes Mellitus. Cells. 2019;8: pubmed publisher |
| Chueh T, Cheng Y, Chen K, Chien C. Thromboxane A2 Synthase and Thromboxane Receptor Deletion Reduces Ischaemia/Reperfusion-Evoked Inflammation, Apoptosis, Autophagy and Pyroptosis. Thromb Haemost. 2020;120:329-343 pubmed publisher |
| Madsen P, Desu H, de Rivero Vaccari J, Florimon Y, Ellman D, Keane R, et al. Oligodendrocytes modulate the immune-inflammatory response in EAE via TNFR2 signaling. Brain Behav Immun. 2020;84:132-146 pubmed publisher |
| Wang J, Li R, Peng Z, Hu B, Rao X, Li J. HMGB1 participates in LPS‑induced acute lung injury by activating the AIM2 inflammasome in macrophages and inducing polarization of M1 macrophages via TLR2, TLR4, and RAGE/NF‑κB signaling pathways. Int J Mol Med. 2020;45:61-80 pubmed publisher |
| Fais R, Rodrigues F, Pereira C, Mendes A, Mestriner F, Tostes R, et al. The inflammasome NLRP3 plays a dual role on mouse corpora cavernosa relaxation. Sci Rep. 2019;9:16224 pubmed publisher |
| Li Y, Su Y, Zhou T, Hu Z, Wei J, Wang W, et al. Activation of the NLRP3 Inflammasome Pathway by Prokineticin 2 in Testicular Macrophages of Uropathogenic Escherichia coli- Induced Orchitis. Front Immunol. 2019;10:1872 pubmed publisher |
| Frew J, Hawkes J, Krueger J. A systematic review and critical evaluation of immunohistochemical associations in hidradenitis suppurativa. F1000Res. 2018;7:1923 pubmed publisher |
| Pronin A, Pham D, An W, Dvoriantchikova G, Reshetnikova G, Qiao J, et al. Inflammasome Activation Induces Pyroptosis in the Retina Exposed to Ocular Hypertension Injury. Front Mol Neurosci. 2019;12:36 pubmed publisher |
| Mejias N, Martinez C, Stephens M, de Rivero Vaccari J. Contribution of the inflammasome to inflammaging. J Inflamm (Lond). 2018;15:23 pubmed publisher |
| Kerr N, Garcia Contreras M, Abbassi S, Mejias N, Desousa B, Ricordi C, et al. Inflammasome Proteins in Serum and Serum-Derived Extracellular Vesicles as Biomarkers of Stroke. Front Mol Neurosci. 2018;11:309 pubmed publisher |
| Raval A, Schatz M, Bhattacharya P, d Adesky N, Rundek T, Dietrich W, et al. Whole Body Vibration Therapy after Ischemia Reduces Brain Damage in Reproductively Senescent Female Rats. Int J Mol Sci. 2018;19: pubmed publisher |
| Furuya M, Asano T, Sumichika Y, Sato S, Kobayashi H, Watanabe H, et al. Tofacitinib inhibits granulocyte-macrophage colony-stimulating factor-induced NLRP3 inflammasome activation in human neutrophils. Arthritis Res Ther. 2018;20:196 pubmed publisher |
| d Adesky N, de Rivero Vaccari J, Bhattacharya P, Schatz M, Perez Pinzon M, Bramlett H, et al. Nicotine Alters Estrogen Receptor-Beta-Regulated Inflammasome Activity and Exacerbates Ischemic Brain Damage in Female Rats. Int J Mol Sci. 2018;19: pubmed publisher |
| Chen D, Chen Y, Chen H, Hsieh C, Gung N, Hung W, et al. Human parvovirus B19 nonstructural protein NS1 activates NLRP3 inflammasome signaling in adult‑onset Still's disease. Mol Med Rep. 2018;17:3364-3371 pubmed publisher |
| Fleetwood A, Lee M, Singleton W, Achuthan A, Lee M, O Brien Simpson N, et al. Metabolic Remodeling, Inflammasome Activation, and Pyroptosis in Macrophages Stimulated by Porphyromonas gingivalis and Its Outer Membrane Vesicles. Front Cell Infect Microbiol. 2017;7:351 pubmed publisher |
| Hua X, Yuan X, Li Y, Chen H, Yuan J, Tanumiharjo S, et al. Desiccating stress worsens alkali burn injury by magnifying caspase-8-induced imbalance of NLRP3 and NLRP6. J Allergy Clin Immunol. 2017;140:1172-1176.e3 pubmed publisher |
| Chi W, Hua X, Chen X, Bian F, Yuan X, Zhang L, et al. Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye. J Autoimmun. 2017;80:65-76 pubmed publisher |
| Lévesque S, Paré A, Mailhot B, Bellver Landete V, Kébir H, Lécuyer M, et al. Myeloid cell transmigration across the CNS vasculature triggers IL-1β-driven neuroinflammation during autoimmune encephalomyelitis in mice. J Exp Med. 2016;213:929-49 pubmed publisher |
| Lin Q, Li C, Zha Q, Xu L, Pan H, Zhao G, et al. Gossypol induces pyroptosis in mouse macrophages via a non-canonical inflammasome pathway. Toxicol Appl Pharmacol. 2016;292:56-64 pubmed publisher |
| Fernandez M, Miller E, Krammer F, Gopal R, Greenbaum B, Bhardwaj N. Ion efflux and influenza infection trigger NLRP3 inflammasome signaling in human dendritic cells. J Leukoc Biol. 2016;99:723-34 pubmed publisher |
| Melehani J, James D, Dumont A, Torres V, Duncan J. Staphylococcus aureus Leukocidin A/B (LukAB) Kills Human Monocytes via Host NLRP3 and ASC when Extracellular, but Not Intracellular. PLoS Pathog. 2015;11:e1004970 pubmed publisher |
| Zhang X, Ibrahim E, de Rivero Vaccari J, Lotocki G, Aballa T, Dietrich W, et al. Involvement of the inflammasome in abnormal semen quality of men with spinal cord injury. Fertil Steril. 2013;99:118-24 pubmed publisher |
| Taxman D, Swanson K, Broglie P, Wen H, Holley Guthrie E, Huang M, et al. Porphyromonas gingivalis mediates inflammasome repression in polymicrobial cultures through a novel mechanism involving reduced endocytosis. J Biol Chem. 2012;287:32791-9 pubmed |
| Tomura S, de Rivero Vaccari J, Keane R, Bramlett H, Dietrich W. Effects of therapeutic hypothermia on inflammasome signaling after traumatic brain injury. J Cereb Blood Flow Metab. 2012;32:1939-47 pubmed publisher |
| de Rivero Vaccari J, Sawaya M, Brand F, Nusbaum B, Bauman A, Bramlett H, et al. Caspase-1 level is higher in the scalp in androgenetic alopecia. Dermatol Surg. 2012;38:1033-9 pubmed publisher |
| de Rivero Vaccari J, Bastien D, Yurcisin G, Pineau I, Dietrich W, De Koninck Y, et al. P2X4 receptors influence inflammasome activation after spinal cord injury. J Neurosci. 2012;32:3058-66 pubmed publisher |
| Nadeau S, Filali M, Zhang J, Kerr B, Rivest S, Soulet D, et al. Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1? and TNF: implications for neuropathic pain. J Neurosci. 2011;31:12533-42 pubmed publisher |
| Taxman D, Holley Guthrie E, Huang M, Moore C, Bergstralh D, Allen I, et al. The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome. J Biol Chem. 2011;286:19605-16 pubmed publisher |
| Atay S, Gercel Taylor C, Taylor D. Human trophoblast-derived exosomal fibronectin induces pro-inflammatory IL-1? production by macrophages. Am J Reprod Immunol. 2011;66:259-69 pubmed publisher |
| Rawat R, Cohen T, Ampong B, Francia D, Henriques Pons A, Hoffman E, et al. Inflammasome up-regulation and activation in dysferlin-deficient skeletal muscle. Am J Pathol. 2010;176:2891-900 pubmed publisher |
| Banerjee M, Datta M, Majumder P, Mukhopadhyay D, Bhattacharyya N. Transcription regulation of caspase-1 by R393 of HIPPI and its molecular partner HIP-1. Nucleic Acids Res. 2010;38:878-92 pubmed publisher |
| Craven R, Gao X, Allen I, Gris D, Bubeck Wardenburg J, McElvania TeKippe E, et al. Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells. PLoS ONE. 2009;4:e7446 pubmed publisher |
| Duncan J, Gao X, Huang M, O Connor B, Thomas C, Willingham S, et al. Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome. J Immunol. 2009;182:6460-9 pubmed publisher |
| Hurst J, Prinz N, Lorenz M, Bauer S, Chapman J, Lackner K, et al. TLR7 and TLR8 ligands and antiphospholipid antibodies show synergistic effects on the induction of IL-1beta and caspase-1 in monocytes and dendritic cells. Immunobiology. 2009;214:683-91 pubmed publisher |
| Dostert C, Petrilli V, van Bruggen R, Steele C, Mossman B, Tschopp J. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science. 2008;320:674-7 pubmed publisher |
| Dorfleutner A, Bryan N, Talbott S, Funya K, Rellick S, Reed J, et al. Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation. Infect Immun. 2007;75:1484-92 pubmed |
