product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
DNMT1 Antibody (60B1220.1) - BSA Free
catalog :
NB100-56519
quantity :
0.1 mg (also 0.025 mg)
price :
479 USD
clonality :
monoclonal
host :
mouse
conjugate :
DyLight 594
clone name :
60B1220.1
reactivity :
human, mouse, rat, bovine, pigs , domestic sheep
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, RNA immunoprecipitation
more info or order :
citations: 142
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; fig 4a
Raciti G, Spinelli R, Desiderio A, Longo M, Parrillo L, Nigro C, et al. Specific CpG hyper-methylation leads to Ankrd26 gene down-regulation in white adipose tissue of a mouse model of diet-induced obesity. Sci Rep. 2017;7:43526 pubmed publisher
  • western blot; human; fig 6a
Wilson R, Biasutto A, Wang L, Fischer R, Baple E, Crosby A, et al. PCNA dependent cellular activities tolerate dramatic perturbations in PCNA client interactions. DNA Repair (Amst). 2017;50:22-35 pubmed publisher
  • western blot; mouse; 1:1000
Cicchini C, de Nonno V, Battistelli C, Cozzolino A, De Santis Puzzonia M, Ciafrè S, et al. Epigenetic control of EMT/MET dynamics: HNF4α impacts DNMT3s through miRs-29. Biochim Biophys Acta. 2015;1849:919-29 pubmed publisher
  • western blot; mouse
Neri F, Incarnato D, Krepelova A, Rapelli S, Anselmi F, Parlato C, et al. Single-Base Resolution Analysis of 5-Formyl and 5-Carboxyl Cytosine Reveals Promoter DNA Methylation Dynamics. Cell Rep. 2015;10:674-683 pubmed publisher
  • western blot; human
Guo Y, Shu L, Zhang C, Su Z, Kong A. Curcumin inhibits anchorage-independent growth of HT29 human colon cancer cells by targeting epigenetic restoration of the tumor suppressor gene DLEC1. Biochem Pharmacol. 2015;94:69-78 pubmed publisher
  • chromatin immunoprecipitation; human
Poposki J, Peterson S, Welch K, Schleimer R, Hulse K, Peters A, et al. Elevated presence of myeloid dendritic cells in nasal polyps of patients with chronic rhinosinusitis. Clin Exp Allergy. 2015;45:384-93 pubmed publisher
  • western blot; mouse
Swiech L, Heidenreich M, Banerjee A, Habib N, Li Y, Trombetta J, et al. In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9. Nat Biotechnol. 2015;33:102-6 pubmed publisher
  • western blot; mouse
Wang L, Zhang C, Guo Y, Su Z, Yang Y, Shu L, et al. Blocking of JB6 cell transformation by tanshinone IIA: epigenetic reactivation of Nrf2 antioxidative stress pathway. AAPS J. 2014;16:1214-25 pubmed publisher
  • chromatin immunoprecipitation; human
  • immunoprecipitation; human
Fang M, Ou J, Hutchinson L, Green M. The BRAF oncoprotein functions through the transcriptional repressor MAFG to mediate the CpG Island Methylator phenotype. Mol Cell. 2014;55:904-915 pubmed publisher
  • immunohistochemistry - paraffin section; human
Guimarães D, Antunes D, Duarte C, Ferro L, Nunes F. DNA methyltransferase immunohistochemical expression in odontogenic tumours. J Oral Pathol Med. 2015;44:59-66 pubmed publisher
  • chromatin immunoprecipitation; mouse
  • western blot; mouse
Tajrishi M, Shin J, Hetman M, Kumar A. DNA methyltransferase 3a and mitogen-activated protein kinase signaling regulate the expression of fibroblast growth factor-inducible 14 (Fn14) during denervation-induced skeletal muscle atrophy. J Biol Chem. 2014;289:19985-99 pubmed publisher
  • western blot; human
Anwar S, Krech T, Hasemeier B, Schipper E, Schweitzer N, Vogel A, et al. Deregulation of RB1 expression by loss of imprinting in human hepatocellular carcinoma. J Pathol. 2014;233:392-401 pubmed publisher
  • western blot; mouse
Paredes Gonzalez X, Fuentes F, Su Z, Kong A. Apigenin reactivates Nrf2 anti-oxidative stress signaling in mouse skin epidermal JB6 P + cells through epigenetics modifications. AAPS J. 2014;16:727-35 pubmed publisher
  • western blot; human
Calabrese R, Valentini E, Ciccarone F, Guastafierro T, Bacalini M, Ricigliano V, et al. TET2 gene expression and 5-hydroxymethylcytosine level in multiple sclerosis peripheral blood cells. Biochim Biophys Acta. 2014;1842:1130-6 pubmed publisher
  • chromatin immunoprecipitation; human
Serra R, Fang M, Park S, Hutchinson L, Green M. A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. elife. 2014;3:e02313 pubmed publisher
  • chromatin immunoprecipitation; human
Teneng I, Tellez C, Picchi M, Klinge D, Yingling C, Snider A, et al. Global identification of genes targeted by DNMT3b for epigenetic silencing in lung cancer. Oncogene. 2015;34:621-30 pubmed publisher
  • western blot; mouse
Su Z, Zhang C, Lee J, Shu L, Wu T, Khor T, et al. Requirement and epigenetics reprogramming of Nrf2 in suppression of tumor promoter TPA-induced mouse skin cell transformation by sulforaphane. Cancer Prev Res (Phila). 2014;7:319-29 pubmed publisher
  • immunocytochemistry; human
Hara E, Ono M, Eguchi T, Kubota S, Pham H, Sonoyama W, et al. miRNA-720 controls stem cell phenotype, proliferation and differentiation of human dental pulp cells. PLoS ONE. 2013;8:e83545 pubmed publisher
  • chromatin immunoprecipitation; mouse
Otani J, Kimura H, Sharif J, Endo T, Mishima Y, Kawakami T, et al. Cell cycle-dependent turnover of 5-hydroxymethyl cytosine in mouse embryonic stem cells. PLoS ONE. 2013;8:e82961 pubmed publisher
  • western blot; human
Watson C, Collier P, Tea I, Neary R, Watson J, Robinson C, et al. Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype. Hum Mol Genet. 2014;23:2176-88 pubmed publisher
  • immunocytochemistry; pigs
Giraldo A, DeCourcy K, Ball S, Hylan D, Ayares D. Gene expression of Dnmt1 isoforms in porcine oocytes, embryos, and somatic cells. Cell Reprogram. 2013;15:309-21 pubmed publisher
  • immunohistochemistry - frozen section; mouse
  • western blot; mouse
Kadriu B, Guidotti A, Chen Y, Grayson D. DNA methyltransferases1 (DNMT1) and 3a (DNMT3a) colocalize with GAD67-positive neurons in the GAD67-GFP mouse brain. J Comp Neurol. 2012;520:1951-64 pubmed publisher
  • western blot; human
Yang J, Corsello T, Ma Y. Stem cell gene SALL4 suppresses transcription through recruitment of DNA methyltransferases. J Biol Chem. 2012;287:1996-2005 pubmed publisher
  • immunocytochemistry; mouse
Dhawan S, Georgia S, Tschen S, Fan G, Bhushan A. Pancreatic ? cell identity is maintained by DNA methylation-mediated repression of Arx. Dev Cell. 2011;20:419-29 pubmed publisher
  • western blot; mouse
Nasonkin I, Lazo K, Hambright D, Brooks M, Fariss R, Swaroop A. Distinct nuclear localization patterns of DNA methyltransferases in developing and mature mammalian retina. J Comp Neurol. 2011;519:1914-30 pubmed publisher
  • western blot; mouse
Molognoni F, Cruz A, Meliso F, Morais A, Souza C, Xander P, et al. Epigenetic reprogramming as a key contributor to melanocyte malignant transformation. Epigenetics. 2011;6:450-64 pubmed
  • western blot; domestic sheep
Pierard V, Guiguen A, Colin L, Wijmeersch G, Vanhulle C, Van Driessche B, et al. DNA cytosine methylation in the bovine leukemia virus promoter is associated with latency in a lymphoma-derived B-cell line: potential involvement of direct inhibition of cAMP-responsive element (CRE)-binding protein/CRE modulator/activation transcri. J Biol Chem. 2010;285:19434-49 pubmed publisher
  • western blot; human
Wu Y, Alvarez M, Slamon D, Koeffler P, Vadgama J. Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation. BMC Cancer. 2010;10:32 pubmed publisher
  • western blot; rat
Perisic T, Zimmermann N, Kirmeier T, Asmus M, Tuorto F, Uhr M, et al. Valproate and amitriptyline exert common and divergent influences on global and gene promoter-specific chromatin modifications in rat primary astrocytes. Neuropsychopharmacology. 2010;35:792-805 pubmed publisher
  • chromatin immunoprecipitation; human
Ye Y, McDevitt M, Guo M, Zhang W, Galm O, Gore S, et al. Progressive chromatin repression and promoter methylation of CTNNA1 associated with advanced myeloid malignancies. Cancer Res. 2009;69:8482-90 pubmed publisher
  • immunoprecipitation; mouse
Hwang C, Song K, Kim C, Choi H, Guo X, Law P, et al. Epigenetic programming of mu-opioid receptor gene in mouse brain is regulated by MeCP2 and Brg1 chromatin remodelling factor. J Cell Mol Med. 2009;13:3591-615 pubmed publisher
  • western blot; mouse
Zampieri M, Passananti C, Calabrese R, Perilli M, Corbi N, De Cave F, et al. Parp1 localizes within the Dnmt1 promoter and protects its unmethylated state by its enzymatic activity. PLoS ONE. 2009;4:e4717 pubmed publisher
  • chromatin immunoprecipitation; human
Lin H, Zuo T, Lin C, Kuo C, Liyanarachchi S, Sun S, et al. Breast cancer-associated fibroblasts confer AKT1-mediated epigenetic silencing of Cystatin M in epithelial cells. Cancer Res. 2008;68:10257-66 pubmed publisher
  • immunoprecipitation; human
O Hagan H, Mohammad H, Baylin S. Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island. PLoS Genet. 2008;4:e1000155 pubmed publisher
  • western blot; mouse
Guastafierro T, Cecchinelli B, Zampieri M, Reale A, Riggio G, Sthandier O, et al. CCCTC-binding factor activates PARP-1 affecting DNA methylation machinery. J Biol Chem. 2008;283:21873-80 pubmed publisher
  • western blot; human
Xia G, Schneider Stock R, Diestel A, Habold C, Krueger S, Roessner A, et al. Helicobacter pylori regulates p21(WAF1) by histone H4 acetylation. Biochem Biophys Res Commun. 2008;369:526-31 pubmed publisher
  • immunohistochemistry; human
Hodge D, Cho E, Copeland T, Guszczynski T, Yang E, Seth A, et al. IL-6 enhances the nuclear translocation of DNA cytosine-5-methyltransferase 1 (DNMT1) via phosphorylation of the nuclear localization sequence by the AKT kinase. Cancer Genomics Proteomics. 2007;4:387-98 pubmed
  • chromatin immunoprecipitation; human
Ji W, Yang L, Yu L, Yuan J, Hu D, Zhang W, et al. Epigenetic silencing of O6-methylguanine DNA methyltransferase gene in NiS-transformed cells. Carcinogenesis. 2008;29:1267-75 pubmed publisher
  • immunoprecipitation; mouse
Gazin C, Wajapeyee N, Gobeil S, Virbasius C, Green M. An elaborate pathway required for Ras-mediated epigenetic silencing. Nature. 2007;449:1073-7 pubmed
  • western blot; human
Mabaera R, Greene M, Richardson C, Conine S, Kozul C, Lowrey C. Neither DNA hypomethylation nor changes in the kinetics of erythroid differentiation explain 5-azacytidine's ability to induce human fetal hemoglobin. Blood. 2008;111:411-20 pubmed
  • western blot; mouse
Park I, Sohn B, Choo J, Joe C, Seong J, Lee Y, et al. Deregulation of DNA methyltransferases and loss of parental methylation at the insulin-like growth factor II (Igf2)/H19 loci in p53 knockout mice prior to tumor development. J Cell Biochem. 2005;94:585-96 pubmed
  • western blot; human
Suzuki M, Sunaga N, Shames D, Toyooka S, Gazdar A, Minna J. RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cells. Cancer Res. 2004;64:3137-43 pubmed
  • western blot; human
Kimura F, Seifert H, Florl A, Santourlidis S, Steinhoff C, Swiatkowski S, et al. Decrease of DNA methyltransferase 1 expression relative to cell proliferation in transitional cell carcinoma. Int J Cancer. 2003;104:568-78 pubmed
Weidner A, Roy A, Vann K, Walczyk A, Astapova O. Paxillin regulates androgen receptor expression associated with granulosa cell focal adhesions. Mol Hum Reprod. 2024;30: pubmed publisher
Yang C, Deng L, Bao F, Jiang H, Zhang L. Sevoflurane with Low Concentration Decrease DNA Methylation on Chronic Obstructive Pulmonary Disease (COPD)-Related Gene Promoter in COPD Rat. COPD. 2023;20:348-356 pubmed publisher
Chen X, Liu J, Li Y, Zeng Y, Wang F, Cheng Z, et al. IDH1 mutation impairs antiviral response and potentiates oncolytic virotherapy in glioma. Nat Commun. 2023;14:6781 pubmed publisher
Shin H, Leung A, Costello K, Senapati P, Kato H, Moore R, et al. Inhibition of DNMT1 methyltransferase activity via glucose-regulated O-GlcNAcylation alters the epigenome. elife. 2023;12: pubmed publisher
Tang Y, Hong F, Ding S, Yang J, Zhang M, Ma Y, et al. METTL3-mediated m6A modification of IGFBP7-OT promotes osteoarthritis progression by regulating the DNMT1/DNMT3a-IGFBP7 axis. Cell Rep. 2023;42:112589 pubmed publisher
Okuno K, Pratama M, Li J, Tokunaga M, Wang X, Kinugasa Y, et al. Ginseng mediates its anticancer activity by inhibiting the expression of DNMTs and reactivating methylation-silenced genes in colorectal cancer. Carcinogenesis. 2023;44:394-403 pubmed publisher
da C Fernandes C, da Silva R, de Almeida G, Ferreira M, de Morais P, Bezerra F, et al. Epigenetic Differences Arise in Endothelial Cells Responding to Cobalt-Chromium. J Funct Biomater. 2023;14: pubmed publisher
Mahadevan K, McAndrews K, LeBleu V, Yang S, Lyu H, Li B, et al. Oncogenic Kras G12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8 + T cells dependent manner. bioRxiv. 2023;: pubmed publisher
Subramani P, Nagarajan N, Mariaraj S, Vilwanathan R. Knockdown of sirtuin6 positively regulates acetylation of DNMT1 to inhibit NOTCH signaling pathway in non-small cell lung cancer cell lines. Cell Signal. 2023;105:110629 pubmed publisher
Varshney R, Das S, Trahan G, Farriester J, Mullen G, Kyere Davies G, et al. Neonatal intake of Omega-3 fatty acids enhances lipid oxidation in adipocyte precursors. iScience. 2023;26:105750 pubmed publisher
Dai Z, Liu X, Zeng H, Chen Y. Long noncoding RNA HOTAIR facilitates pulmonary vascular endothelial cell apoptosis via DNMT1 mediated hypermethylation of Bcl-2 promoter in COPD. Respir Res. 2022;23:356 pubmed publisher
Sheth V, Sharma N, Kabeer S, Tikoo K. Lactobacillus rhamnosus supplementation ameliorates high fat diet-induced epigenetic alterations and prevents its intergenerational inheritance. Life Sci. 2022;311:121151 pubmed publisher
Zhong R, Zhang F, Yang Z, Li Y, Xu Q, Lan H, et al. Epigenetic mechanism of L-type calcium channel β-subunit downregulation in short QT human induced pluripotent stem cell-derived cardiomyocytes with CACNB2 mutation. Europace. 2022;24:2028-2036 pubmed publisher
Zeng W, Jiang H, Wang Y, Wang C, Yu B. TCF3 Induces DNMT1 Expression to Regulate Wnt Signaling Pathway in Glioma. Neurotox Res. 2022;40:721-732 pubmed publisher
Liu X, Cui H. The palliative effects of folic acid on retinal microvessels in diabetic retinopathy via regulating the metabolism of DNA methylation and hydroxymethylation. Bioengineered. 2021;12:10766-10774 pubmed publisher
Kawai T, Richards J, Shimada M. Large-scale DNA demethylation occurs in proliferating ovarian granulosa cells during mouse follicular development. Commun Biol. 2021;4:1334 pubmed publisher
Shen Y, Zhao H, Zhang L, Hu Y, Cai L, Li J, et al. The roles of DNA methylation and hydroxymethylation at short interspersed nuclear elements in the hypothalamic arcuate nucleus during puberty. Mol Ther Nucleic Acids. 2021;26:242-252 pubmed publisher
Bruine de Bruin L, Clausen M, Slagter Menkema L, de Bock G, Langendijk J, van der Vegt B, et al. High DNMT1 Is Associated With Worse Local Control in Early-Stage Laryngeal Squamous Cell Carcinoma. Laryngoscope. 2021;: pubmed publisher
Vohhodina J, Goehring L, Liu B, Kong Q, Botchkarev V, Huynh M, et al. BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage. Nat Commun. 2021;12:3542 pubmed publisher
Kaczynski P, Baryla M, Goryszewska E, Waclawik A. Estradiol-17β Regulates Expression of Luteal DNA Methyltransferases and Genes Involved in the Porcine Corpus Luteum Function In Vivo. Int J Mol Sci. 2021;22: pubmed publisher
González Alvarez M, McGuire B, Keating A. Obesity alters the ovarian proteomic response to zearalenone exposure†. Biol Reprod. 2021;105:278-289 pubmed publisher
Huang Z, Yu J, Cui W, Johnson B, Kim K, Pfeifer G. The chromosomal protein SMCHD1 regulates DNA methylation and the 2c-like state of embryonic stem cells by antagonizing TET proteins. Sci Adv. 2021;7: pubmed publisher
Zhu A, Hopkins K, Friedman R, Bernstock J, Broustas C, Lieberman H. DNMT1 and DNMT3B regulate tumorigenicity of human prostate cancer cells by controlling RAD9 expression through targeted methylation. Carcinogenesis. 2020;: pubmed publisher
Magno Guimarães D, deLucas da Silva Almeida F, Moraes Castilho R, Eduardo Nor J, Daumas Nunes F. DNA methyltransferase expression is associated with cell proliferation in salivary mucoepidermoid carcinoma. J Oral Pathol Med. 2020;49:1053-1060 pubmed publisher
Ebelt N, Zuniga E, Johnson B, Diamond D, Manuel E. 5-Azacytidine Potentiates Anti-tumor Immunity in a Model of Pancreatic Ductal Adenocarcinoma. Front Immunol. 2020;11:538 pubmed publisher
So J, Skrypek N, Yang H, Merchant A, Nelson G, Chen W, et al. Induction of DNMT3B by PGE2 and IL6 at Distant Metastatic Sites Promotes Epigenetic Modification and Breast Cancer Colonization. Cancer Res. 2020;80:2612-2627 pubmed publisher
Uribe Etxebarria V, Garcia Gallastegui P, Pérez Garrastachu M, Casado Andrés M, Irastorza I, Unda F, et al. Wnt-3a Induces Epigenetic Remodeling in Human Dental Pulp Stem Cells. Cells. 2020;9: pubmed publisher
Li T, Garcia Gomez A, Morante Palacios O, Ciudad L, Özkaramehmet S, Van Dijck E, et al. SIRT1/2 orchestrate acquisition of DNA methylation and loss of histone H3 activating marks to prevent premature activation of inflammatory genes in macrophages. Nucleic Acids Res. 2020;48:665-681 pubmed publisher
Sun X, Cui Y, Feng H, Liu H, Liu X. TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity. J Exp Med. 2019;216:2819-2837 pubmed publisher
Kuo H, Wu R, Li S, Yang A, Kong A. Anthocyanin Delphinidin Prevents Neoplastic Transformation of Mouse Skin JB6 P+ Cells: Epigenetic Re-activation of Nrf2-ARE Pathway. AAPS J. 2019;21:83 pubmed publisher
Fisslthaler B, Zippel N, Abdel Malik R, Delgado Lagos F, Zukunft S, Thoele J, et al. Myeloid-Specific Deletion of the AMPKα2 Subunit Alters Monocyte Protein Expression and Atherogenesis. Int J Mol Sci. 2019;20: pubmed publisher
Gatta E, Grayson D, Auta J, Saudagar V, Dong E, Chen Y, et al. Genome-wide methylation in alcohol use disorder subjects: implications for an epigenetic regulation of the cortico-limbic glucocorticoid receptors (NR3C1). Mol Psychiatry. 2019;: pubmed publisher
Huang M, Chou Y, Li M, Shih T, Lin S, Chuang H, et al. Epigenetic targeting DNMT1 of pancreatic ductal adenocarcinoma using interstitial control release biodegrading polymer reduced tumor growth through hedgehog pathway inhibition. Pharmacol Res. 2019;139:50-61 pubmed publisher
Miotto B, Marchal C, Adelmant G, Guinot N, Xie P, Marto J, et al. Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells. Nucleic Acids Res. 2018;46:4392-4404 pubmed publisher
Meliso F, Micali D, Silva C, Sabedot T, Coetzee S, Koch A, et al. SIRT1 regulates Mxd1 during malignant melanoma progression. Oncotarget. 2017;8:114540-114553 pubmed publisher
Yang J, Wu R, Li W, Gao L, Yang Y, Li P, et al. The triterpenoid corosolic acid blocks transformation and epigenetically reactivates Nrf2 in TRAMP-C1 prostate cells. Mol Carcinog. 2018;57:512-521 pubmed publisher
Li W, Su Z, Guo Y, Zhang C, Wu R, Gao L, et al. Curcumin Derivative Epigenetically Reactivates Nrf2 Antioxidative Stress Signaling in Mouse Prostate Cancer TRAMP C1 Cells. Chem Res Toxicol. 2017;: pubmed publisher
Chu Y, Ko C, Wang S, Lin P, Wang H, Lin W, et al. Bortezomib-induced miRNAs direct epigenetic silencing of locus genes and trigger apoptosis in leukemia. Cell Death Dis. 2017;8:e3167 pubmed publisher
Kuang H, Tang Z, Zhang C, Wang Z, Li W, Yang C, et al. Taxifolin Activates the Nrf2 Anti-Oxidative Stress Pathway in Mouse Skin Epidermal JB6 P+ Cells through Epigenetic Modifications. Int J Mol Sci. 2017;18: pubmed publisher
Sheikh M, Malik Y, Zhu X. RA-Induced Transcriptional Silencing of Checkpoint Kinase-2 through Promoter Methylation by Dnmt3b Is Required for Neuronal Differentiation of P19 Cells. J Mol Biol. 2017;429:2463-2473 pubmed publisher
Miozzo F, Arnould H, de Thonel A, Schang A, Sabéran Djoneidi D, Baudry A, et al. Alcohol exposure promotes DNA methyltransferase DNMT3A upregulation through reactive oxygen species-dependent mechanisms. Cell Stress Chaperones. 2018;23:115-126 pubmed publisher
He J, Pei L, Jiang H, Yang W, Chen J, Liang H. Chemoresistance of colorectal cancer to 5-fluorouracil is associated with silencing of the BNIP3 gene through aberrant methylation. J Cancer. 2017;8:1187-1196 pubmed publisher
Szarc vel Szic K, Declerck K, Crans R, Diddens J, Scherf D, Gerhäuser C, et al. Epigenetic silencing of triple negative breast cancer hallmarks by Withaferin A. Oncotarget. 2017;8:40434-40453 pubmed publisher
Anwar S, Krech T, Hasemeier B, Schipper E, Schweitzer N, Vogel A, et al. hsa-mir-183 is frequently methylated and related to poor survival in human hepatocellular carcinoma. World J Gastroenterol. 2017;23:1568-1575 pubmed publisher
Neri F, Rapelli S, Krepelova A, Incarnato D, Parlato C, Basile G, et al. Intragenic DNA methylation prevents spurious transcription initiation. Nature. 2017;543:72-77 pubmed publisher
Koh H, Scruggs A, Huang S. Transforming Growth Factor-β1 Increases DNA Methyltransferase 1 and 3a Expression through Distinct Post-transcriptional Mechanisms in Lung Fibroblasts. J Biol Chem. 2016;291:19287-98 pubmed publisher
Daniel F, Alves S, Vieira D, Biz M, Daniel I, Modolo F. Immunohistochemical expression of DNA methyltransferases 1, 3a, and 3b in actinic cheilitis and lip squamous cell carcinomas. J Oral Pathol Med. 2016;45:774-779 pubmed publisher
Li W, Pung D, Su Z, Guo Y, Zhang C, Yang A, et al. Epigenetics Reactivation of Nrf2 in Prostate TRAMP C1 Cells by Curcumin Analogue FN1. Chem Res Toxicol. 2016;29:694-703 pubmed publisher
Hong B, Su Z, Zhang C, Yang Y, Guo Y, Li W, et al. Reserpine Inhibit the JB6 P+ Cell Transformation Through Epigenetic Reactivation of Nrf2-Mediated Anti-oxidative Stress Pathway. AAPS J. 2016;18:659-69 pubmed publisher
Miao C, Qin D, Du C, Ye H, Shi W, Xiong Y, et al. DNMT1 activates the canonical Wnt signaling in rheumatoid arthritis model rats via a crucial functional crosstalk between miR-152 and the DNMT1, MeCP2. Int Immunopharmacol. 2015;28:344-53 pubmed publisher
Kopparapu P, Miranda C, Fogelstrand L, Mishra K, Andersson P, Kanduri C, et al. MCPH1 maintains long-term epigenetic silencing of ANGPT2 in chronic lymphocytic leukemia. FEBS J. 2015;282:1939-52 pubmed publisher
Huichalaf C, Micheloni S, Ferri G, Caccia R, Gabellini D. DNA methylation analysis of the macrosatellite repeat associated with FSHD muscular dystrophy at single nucleotide level. PLoS ONE. 2014;9:e115278 pubmed publisher
Bittencourt D, Lee B, Gao L, Gerke D, Stallcup M. Role of distinct surfaces of the G9a ankyrin repeat domain in histone and DNA methylation during embryonic stem cell self-renewal and differentiation. Epigenetics Chromatin. 2014;7:27 pubmed publisher
Fang P, Zhang D, Cheng Z, Yan C, Jiang X, Kruger W, et al. Hyperhomocysteinemia potentiates hyperglycemia-induced inflammatory monocyte differentiation and atherosclerosis. Diabetes. 2014;63:4275-90 pubmed publisher
Chuang C, Wang W, Li C, Ko C, Chou Y, Chuu C, et al. The combination of the prodrugs perforin-CEBPD and perforin-granzyme B efficiently enhances the activation of caspase signaling and kills prostate cancer. Cell Death Dis. 2014;5:e1220 pubmed publisher
Neidhart M, Karouzakis E, Jungel A, Gay R, Gay S. Inhibition of spermidine/spermine N1-acetyltransferase activity: a new therapeutic concept in rheumatoid arthritis. Arthritis Rheumatol. 2014;66:1723-33 pubmed publisher
Kanduri M, Sander B, Ntoufa S, Papakonstantinou N, Sutton L, Stamatopoulos K, et al. A key role for EZH2 in epigenetic silencing of HOX genes in mantle cell lymphoma. Epigenetics. 2013;8:1280-8 pubmed publisher
Sheikh M, Malik Y, Yu H, Lai M, Wang X, Zhu X. Epigenetic regulation of Dpp6 expression by Dnmt3b and its novel role in the inhibition of RA induced neuronal differentiation of P19 cells. PLoS ONE. 2013;8:e55826 pubmed publisher
Anwar S, Albat C, Krech T, Hasemeier B, Schipper E, Schweitzer N, et al. Concordant hypermethylation of intergenic microRNA genes in human hepatocellular carcinoma as new diagnostic and prognostic marker. Int J Cancer. 2013;133:660-70 pubmed publisher
Grau L, Luque Garcia J, Gonzalez Peramato P, Theodorescu D, Palou J, Fernández Gómez J, et al. A quantitative proteomic analysis uncovers the relevance of CUL3 in bladder cancer aggressiveness. PLoS ONE. 2013;8:e53328 pubmed publisher
Anwar S, Krech T, Hasemeier B, Schipper E, Schweitzer N, Vogel A, et al. Loss of imprinting and allelic switching at the DLK1-MEG3 locus in human hepatocellular carcinoma. PLoS ONE. 2012;7:e49462 pubmed publisher
Ji W, Yang L, Yuan J, Yang L, Zhang M, Qi D, et al. MicroRNA-152 targets DNA methyltransferase 1 in NiS-transformed cells via a feedback mechanism. Carcinogenesis. 2013;34:446-53 pubmed publisher
Ip J, Canham P, Choo K, Inaba Y, Jacobs S, Kalitsis P, et al. Normal DNA methylation dynamics in DICER1-deficient mouse embryonic stem cells. PLoS Genet. 2012;8:e1002919 pubmed publisher
Zimmermann N, Zschocke J, Perisic T, Yu S, Holsboer F, Rein T. Antidepressants inhibit DNA methyltransferase 1 through reducing G9a levels. Biochem J. 2012;448:93-102 pubmed publisher
Mohammad F, Pandey G, Mondal T, Enroth S, Redrup L, Gyllensten U, et al. Long noncoding RNA-mediated maintenance of DNA methylation and transcriptional gene silencing. Development. 2012;139:2792-803 pubmed publisher
Bhardwaj A, Song H, Beildeck M, Kerkhofs S, Castoro R, Shanker S, et al. DNA demethylation-dependent AR recruitment and GATA factors drive Rhox5 homeobox gene transcription in the epididymis. Mol Endocrinol. 2012;26:538-49 pubmed publisher
Selvakumar T, Gjidoda A, Hovde S, Henry R. Regulation of human RNA polymerase III transcription by DNMT1 and DNMT3a DNA methyltransferases. J Biol Chem. 2012;287:7039-50 pubmed publisher
Rochlin I, Turbow D, GOMEZ F, Ninivaggi D, Campbell S. Predictive mapping of human risk for West Nile virus (WNV) based on environmental and socioeconomic factors. PLoS ONE. 2011;6:e23280 pubmed publisher
Saito S, Kato J, Hiraoka S, Horii J, Suzuki H, Higashi R, et al. DNA methylation of colon mucosa in ulcerative colitis patients: correlation with inflammatory status. Inflamm Bowel Dis. 2011;17:1955-65 pubmed publisher
Fan H, Cinar M, Phatsara C, Tesfaye D, Tholen E, Looft C, et al. Molecular mechanism underlying the differential MYF6 expression in postnatal skeletal muscle of Duroc and Pietrain breeds. Gene. 2011;486:8-14 pubmed publisher
Yamanaka K, Sakatani M, Kubota K, Balboula A, Sawai K, Takahashi M. Effects of downregulating DNA methyltransferase 1 transcript by RNA interference on DNA methylation status of the satellite I region and in vitro development of bovine somatic cell nuclear transfer embryos. J Reprod Dev. 2011;57:393-402 pubmed
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product information
master code :
NB100-56519
SKU :
NB100-56519
product name :
DNMT1 Antibody (60B1220.1) - BSA Free
unit size :
0.1 mg (also 0.025 mg)
description :
The DNMT1 Antibody (60B1220.1) - BSA Free from Novus is a mouse monoclonal antibody to DNMT1. This antibody reacts with bovine,human,mouse,ovine,porcine,rat,sheep. The DNMT1 Antibody (60B1220.1) - BSA Free has been validated for the following applications: Chemotaxis,Flow Cytometry Control,IF/IHC,Simple Western,Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Chromatin Immunoprecipitation (ChIP),Knockdown Validated,RNA immunoprecipitation,Immunocytochemistry/ Immunofluorescence,Flow (Intracellular),Immunohistochemistry Free-Floating,CyTOF-ready.
target :
DNMT1
category :
Primary Antibodies
buffer :
PBS
clonality :
Monoclonal
clone :
60B1220.1
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Mouse
immunogen :
This antibody was raised against a synthetic peptide corresponding to amino acids 637-650 (EKDDREDKENAFKR) of human Dnmt1 (Genbank Accession No. NP_001370).
isotype :
IgG1 Kappa
purity :
Protein G purified
species :
Bovine,Human,Mouse,Ovine,Porcine,Rat,Sheep
gene symbol :
DNMT1
accessionNumbers :
P26358
applications :
Chemotaxis,Flow Cytometry Control,IF/IHC,Simple Western,Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Chromatin Immunoprecipitation (ChIP),Knockdown Validated,RNA immunoprecipitation,Immunocytochemistry/ Immunofluorescence,Flow (Intracellular),Immunohistochemistry Free-Floating,CyTOF-ready
USD :
479 USD
alt names :
AIM, CXXC9CXXC finger protein 9, CXXC-type zinc finger protein 9, DNA (cytosine-5-)-methyltransferase 1, DNA (cytosine-5)-methyltransferase 1, DNA methyltransferase 1, DNA methyltransferase HsaI, DNA MTase HsaI, DNMT, Dnmt1, EC 2.1.1.37, FLJ16293, m.HsaI, MCMTMGC104992
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.