IkB-alpha Antibody (6A920) - BSA Free | Novus Biologicals NB100-56507 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

IkB-alpha Antibody (6A920) - BSA Free

catalog :

NB100-56507

quantity :

0.1 mg (also 0.025 mg)

price :

409 USD

clonality :

monoclonal

host :

mouse

conjugate :

DyLight488

clone name :

6A920

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Novus Biologicals product webpage

citations: 43

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; fig 4	Gao Q, Liu Y, Wu Y, Zhao Q, Wang L, Gao S, et al. IL-17 intensifies IFN-Î³-induced NOS2 upregulation in RAW 264.7 cells by further activating STAT1 and NF-ÎºB. Int J Mol Med. 2016;37:347-58 pubmed publisher
western blot; human; fig 3a	Hochrainer K, Pejanovic N, Olaseun V, Zhang S, Iadecola C, Anrather J. The ubiquitin ligase HERC3 attenuates NF-ÎºB-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation. Nucleic Acids Res. 2015;43:9889-904 pubmed publisher
western blot; human	Ikeno H, Apel M, Zouboulis C, Luger T, BÃ¶hm M. L-Ascorbyl-2-phosphate attenuates NF-ÎºB signaling in SZ95 sebocytes without affecting IL-6 and IL-8 secretion. Arch Dermatol Res. 2015;307:595-605 pubmed publisher
immunohistochemistry - paraffin section; rat	Yang X, Zhao N, Liu Y, Hu B, Sun K, Chang X, et al. Inhibition of NADPH Oxidase Mediates Protective Effect of Cardiotonic Pills against Rat Heart Ischemia/Reperfusion Injury. Evid Based Complement Alternat Med. 2013;2013:728020 pubmed publisher
immunocytochemistry; human	Tabit C, Shenouda S, Holbrook M, Fetterman J, Kiani S, Frame A, et al. Protein kinase C-? contributes to impaired endothelial insulin signaling in humans with diabetes mellitus. Circulation. 2013;127:86-95 pubmed publisher
western blot; human	Endo T, Nishio M, Enzler T, Cottam H, Fukuda T, James D, et al. BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway. Blood. 2007;109:703-10 pubmed
western blot; mouse	Ishiguro K, Ando T, Maeda O, Hasegawa M, Kadomatsu K, Ohmiya N, et al. Paeonol attenuates TNBS-induced colitis by inhibiting NF-kappaB and STAT1 transactivation. Toxicol Appl Pharmacol. 2006;217:35-42 pubmed
western blot; human	Strozyk E, Poppelmann B, Schwarz T, Kulms D. Differential effects of NF-kappaB on apoptosis induced by DNA-damaging agents: the type of DNA damage determines the final outcome. Oncogene. 2006;25:6239-51 pubmed
western blot; mouse	Perez Moreno M, Davis M, Wong E, Pasolli H, Reynolds A, Fuchs E. p120-catenin mediates inflammatory responses in the skin. Cell. 2006;124:631-44 pubmed
western blot; human	Napolitani G, Rinaldi A, Bertoni F, Sallusto F, Lanzavecchia A. Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat Immunol. 2005;6:769-76 pubmed
western blot; human	Bernasconi D, Amici C, La Frazia S, Ianaro A, Santoro M. The IkappaB kinase is a key factor in triggering influenza A virus-induced inflammatory cytokine production in airway epithelial cells. J Biol Chem. 2005;280:24127-34 pubmed
western blot; human	Saccani S, Pantano S, Natoli G. p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment. Nat Immunol. 2002;3:69-75 pubmed
western blot; mouse	Saccani S, Pantano S, Natoli G. Two waves of nuclear factor kappaB recruitment to target promoters. J Exp Med. 2001;193:1351-9 pubmed
	Zhao L, Lai Y, Jiao H, Huang J. Nerve growth factor receptor limits inflammation to promote remodeling and repair of osteoarthritic joints. Nat Commun. 2024;15:3225 pubmed publisher
	Zhao L, Lai Y, Jiao H, Huang J. Nerve Growth Factor Receptor Limits Inflammation to Promote Remodeling and Repair of Osteoarthritic Joints. bioRxiv. 2023;: pubmed publisher
	Zeng L, Herdman D, Lee S, Tao A, Das M, Bertin S, et al. Loss of cAMP Signaling in CD11c Immune Cells Protects Against Diet-Induced Obesity. Diabetes. 2023;72:1235-1250 pubmed publisher
	Ohta S, Asanoma M, Irie N, Tachibana N, Kohno M. Soy Phospholipids Exert a Renoprotective Effect by Inhibiting the Nuclear Factor Kappa B Pathway in Macrophages. Metabolites. 2022;12: pubmed publisher
	Sartori G, Napoli S, Cascione L, Chung E, Priebe V, Arribas A, et al. ASB2 is a direct target of FLI1 that sustains NF-κB pathway activation in germinal center-derived diffuse large B-cell lymphoma. J Exp Clin Cancer Res. 2021;40:357 pubmed publisher
	Stanfield B, Purves T, Palmer S, Sullenger B, Welty Wolf K, Haines K, et al. IL-10 and class 1 histone deacetylases act synergistically and independently on the secretion of proinflammatory mediators in alveolar macrophages. PLoS ONE. 2021;16:e0245169 pubmed publisher
	Korgaonkar A, Nguyen S, Li Y, Sekhar D, Subramanian D, Guevarra J, et al. Distinct cellular mediators drive the Janus faces of toll-like receptor 4 regulation of network excitability which impacts working memory performance after brain injury. Brain Behav Immun. 2020;88:381-395 pubmed publisher
	Kamohara A, Hirata H, Xu X, Shiraki M, Yamada S, Zhang J, et al. IgG immune complexes with Staphylococcus aureus protein A enhance osteoclast differentiation and bone resorption by stimulating Fc receptors and TLR2. Int Immunol. 2020;32:89-104 pubmed publisher
	Chen Z, Yao L, Liu Y, Pan Z, Peng S, Wan G, et al. Astragaloside IV regulates NF-κB-mediated cellular senescence and apoptosis of hepatic stellate cells to suppress PDGF-BB-induced activation. Exp Ther Med. 2019;18:3741-3750 pubmed publisher
	Sikorski K, Mehta A, Inngjerdingen M, Thakor F, Kling S, Kalina T, et al. A high-throughput pipeline for validation of antibodies. Nat Methods. 2018;15:909-912 pubmed publisher
	Zhu F, Willette Brown J, Song N, Lomada D, Song Y, Xue L, et al. Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis. Cell Host Microbe. 2017;21:478-493.e7 pubmed publisher
	Tomasi M, Ramani K, Ryoo M. Ubiquitin-Conjugating Enzyme 9 Phosphorylation as a Novel Mechanism for Potentiation of the Inflammatory Response. Am J Pathol. 2016;186:2326-36 pubmed publisher
	Pejanovic N, Hochrainer K, Liu T, Aerne B, Soares M, Anrather J. Regulation of nuclear factor ?B (NF-?B) transcriptional activity via p65 acetylation by the chaperonin containing TCP1 (CCT). PLoS ONE. 2012;7:e42020 pubmed publisher
	Delhase M, Kim S, Lee H, Naiki Ito A, Chen Y, Ahn E, et al. TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2. Proc Natl Acad Sci U S A. 2012;109:E177-86 pubmed publisher
	Harikumar K, Sung B, Pandey M, Guha S, Krishnan S, Aggarwal B. Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway. Mol Pharmacol. 2010;77:818-27 pubmed publisher
	Yu M, Su L, Zou L, Liu Y, Wu N, Kong L, et al. An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells. Nat Immunol. 2008;9:898-907 pubmed publisher
	Nishioka C, Ikezoe T, Jing Y, Umezawa K, Yokoyama A. DHMEQ, a novel nuclear factor-kappaB inhibitor, induces selective depletion of alloreactive or phytohaemagglutinin-stimulated peripheral blood mononuclear cells, decreases production of T helper type 1 cytokines, and blocks maturation of dendritic ce. Immunology. 2008;124:198-205 pubmed publisher
	Shakibaei M, John T, Schulze Tanzil G, Lehmann I, Mobasheri A. Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis. Biochem Pharmacol. 2007;73:1434-45 pubmed
	Vilimas T, Mascarenhas J, Palomero T, Mandal M, Buonamici S, Meng F, et al. Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia. Nat Med. 2007;13:70-7 pubmed
	Santhi W, Sebastian P, Varghese B, Prakash O, Pillai M. NF-kappaB and COX-2 during oral tumorigenesis and in assessment of minimal residual disease in surgical margins. Exp Mol Pathol. 2006;81:123-30 pubmed
	Macagno A, Molteni M, Rinaldi A, Bertoni F, Lanzavecchia A, Rossetti C, et al. A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression. J Exp Med. 2006;203:1481-92 pubmed
	Chang L, Kamata H, Solinas G, Luo J, Maeda S, Venuprasad K, et al. The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell. 2006;124:601-13 pubmed
	Yang M, Hase H, Legarda Addison D, Varughese L, Seed B, Ting A. B cell maturation antigen, the receptor for a proliferation-inducing ligand and B cell-activating factor of the TNF family, induces antigen presentation in B cells. J Immunol. 2005;175:2814-24 pubmed
	Xia Y, Ye B, Li Y, Wang J, He X, Lin X, et al. Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50. J Immunol. 2004;173:4207-17 pubmed
	Saccani S, Marazzi I, Beg A, Natoli G. Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB response. J Exp Med. 2004;200:107-13 pubmed
	Ikezoe T, Yang Y, Heber D, Taguchi H, Koeffler H. PC-SPES: a potent inhibitor of nuclear factor-kappa B rescues mice from lipopolysaccharide-induced septic shock. Mol Pharmacol. 2003;64:1521-9 pubmed
	Saccani S, Pantano S, Natoli G. Modulation of NF-kappaB activity by exchange of dimers. Mol Cell. 2003;11:1563-74 pubmed
	Goodkin M, Ting A, Blaho J. NF-kappaB is required for apoptosis prevention during herpes simplex virus type 1 infection. J Virol. 2003;77:7261-80 pubmed
	Han H, Karabiyikoglu M, Kelly S, Sobel R, Yenari M. Mild hypothermia inhibits nuclear factor-kappaB translocation in experimental stroke. J Cereb Blood Flow Metab. 2003;23:589-98 pubmed
	Delhase M. IkappaB kinase and NF-kappaB signaling in response to pro-inflammatory cytokines. Methods Mol Biol. 2003;225:7-17 pubmed

product information

master code :

NB100-56507

SKU :

NB100-56507

product name :

IkB-alpha Antibody (6A920) - BSA Free

unit size :

0.1 mg (also 0.025 mg)

description :

The IkB-alpha Antibody (6A920) - BSA Free from Novus is a mouse monoclonal antibody to IkB-alpha. This antibody reacts with human,mouse,rat. The IkB-alpha Antibody (6A920) - BSA Free has been validated for the following applications: Western Blot,Simple Western,Immunoprecipitation,Immunohistochemistry-Paraffin,Immunocytochemistry/ Immunofluorescence,Flow Cytometry,Immunohistochemistry,CyTOF-ready,Knockout Validated.

target :

IkB-alpha

category :

Primary Antibodies

buffer :

PBS

clonality :

Monoclonal

clone :

6A920

concentration :

1.0 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

Partial recombinant protein corresponding to amino acid residues 32-291 of human IkB-alpha.

isotype :

IgG1 Kappa

purity :

Protein G purified

species :

Human,Mouse,Rat

gene symbol :

NFKBIA

Antibody validation :

Biological Validation

accessionNumbers :

P25963

applications :

Western Blot,Simple Western,Immunoprecipitation,Immunohistochemistry-Paraffin,Immunocytochemistry/ Immunofluorescence,Flow Cytometry,Immunohistochemistry,CyTOF-ready,Knockout Validated

USD :

409 USD

alt names :

alpha, I-kappa-B-alpha, IkappaBalphaNF-kappa-B inhibitor alpha, IKBAikB-alpha, IkB-alpha, MAD3, MAD-3, Major histocompatibility complex enhancer-binding protein MAD3, NFKBI, nuclear factor of kappa light chain gene enhancer in B-cells, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage