product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
FUS Antibody - BSA Free
catalog :
NB100-565
quantity :
100 ul
price :
529 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
PC10
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 47
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; human; 1:500; loading ...; fig 6e, s16d
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 6e, s16d
Devoy A, Price G, De Giorgio F, Bunton Stasyshyn R, Thompson D, Gasco S, et al. Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models. iScience. 2021;24:103463 pubmed publisher
  • western blot; mouse; 1:5000; loading ...
Birsa N, Ule A, Garone M, Tsang B, Mattedi F, Chong P, et al. FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation. Sci Adv. 2021;7: pubmed publisher
Mamontova E, Cl xe9 ment M, Sukhanova M, Joshi V, Bouhss A, Rengifo Gonzalez J, et al. FUS RRM regulates poly(ADP-ribose) levels after transcriptional arrest and PARP-1 activation on DNA damage. Cell Rep. 2023;42:113199 pubmed publisher
Tavares M, Khandelwal G, Muter J, Viiri K, Beltran M, Brosens J, et al. JAZF1-SUZ12 dysregulates PRC2 function and gene expression during cell differentiation. Cell Rep. 2022;39:110889 pubmed publisher
Chennampally P, Sayed Zahid A, Soundararajan P, Sharp J, Cox G, Collins S, et al. A microfluidic approach to rescue ALS motor neuron degeneration using rapamycin. Sci Rep. 2021;11:18168 pubmed publisher
Skalska L, Begley V, Beltran M, Lukauskas S, Khandelwal G, Faull P, et al. Nascent RNA antagonizes the interaction of a set of regulatory proteins with chromatin. Mol Cell. 2021;81:2944-2959.e10 pubmed publisher
van den Berk P, Lancini C, Company C, Serresi M, Sanchez Bailon M, Hulsman D, et al. USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells. Cell Rep. 2020;33:108533 pubmed publisher
Jutzi D, Campagne S, Schmidt R, Reber S, Mechtersheimer J, Gypas F, et al. Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis. Nat Commun. 2020;11:6341 pubmed publisher
Verboom L, Martens A, Priem D, Hoste E, Sze M, Vikkula H, et al. OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis. Cell Rep. 2020;30:2237-2247.e6 pubmed publisher
Dees C, Potter S, Zhang Y, Bergmann C, Zhou X, Luber M, et al. TGF-β-induced epigenetic deregulation of SOCS3 facilitates STAT3 signaling to promote fibrosis. J Clin Invest. 2020;130:2347-2363 pubmed publisher
Wong M, Uchida M, Tsukada T. Histological differentiation of mucus cell subtypes suggests functional compartmentation in the eel esophagus. Cell Tissue Res. 2020;380:499-512 pubmed publisher
Yazdankhah M, Shang P, Ghosh S, Bhutto I, Stepicheva N, Grebe R, et al. Modulating EGFR-MTORC1-autophagy as a potential therapy for persistent fetal vasculature (PFV) disease. Autophagy. 2020;16:1130-1142 pubmed publisher
Singatulina A, Hamon L, Sukhanova M, Desforges B, Joshi V, Bouhss A, et al. PARP-1 Activation Directs FUS to DNA Damage Sites to Form PARG-Reversible Compartments Enriched in Damaged DNA. Cell Rep. 2019;27:1809-1821.e5 pubmed publisher
Martínez Macías M, Moore D, Green R, Gómez Herreros F, Naumann M, Hermann A, et al. FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I-induced DNA breakage and transcriptional stress. Life Sci Alliance. 2019;2: pubmed publisher
Di Emidio G, Santini S, D Alessandro A, Vetuschi A, Sferra R, Artini P, et al. SIRT1 participates in the response to methylglyoxal-dependent glycative stress in mouse oocytes and ovary. Biochim Biophys Acta Mol Basis Dis. 2019;1865:1389-1401 pubmed publisher
Gittings L, Foti S, Benson B, Gami Patel P, Isaacs A, Lashley T. Heterogeneous nuclear ribonucleoproteins R and Q accumulate in pathological inclusions in FTLD-FUS. Acta Neuropathol Commun. 2019;7:18 pubmed publisher
Bajc Česnik A, Darovic S, Prpar Mihevc S, Stalekar M, Malnar M, Motaln H, et al. Nuclear RNA foci from C9ORF72 expansion mutation form paraspeckle-like bodies. J Cell Sci. 2019;132: pubmed publisher
Fukasawa H, Hashimoto H, Hiramoto K, Sugiyama M, Taniguchi K, Yoshioka K. Morphological characterization of small hepatocytes after bile duct ligation in chicken. Poult Sci. 2019;98:717-721 pubmed publisher
Yasuda T, Ishikawa Y, Shioya N, Itoh K, Kamahori M, Nagata K, et al. Radical change of apoptotic strategy following irradiation during later period of embryogenesis in medaka (Oryzias latipes). PLoS ONE. 2018;13:e0201790 pubmed publisher
Römer S, Bender H, Knabe W, Zimmermann E, Rubsamen R, Seeger J, et al. Neural Progenitors in the Developing Neocortex of the Northern Tree Shrew (Tupaia belangeri) Show a Closer Relationship to Gyrencephalic Primates Than to Lissencephalic Rodents. Front Neuroanat. 2018;12:29 pubmed publisher
Pansarasa O, Bordoni M, Drufuca L, Diamanti L, Sproviero D, Trotti R, et al. Lymphoblastoid cell lines as a model to understand amyotrophic lateral sclerosis disease mechanisms. Dis Model Mech. 2018;11: pubmed publisher
Qin Y, Zhu Y, Luo F, Chen C, Chen X, Wu M. Killing two birds with one stone: dual blockade of integrin and FGF signaling through targeting syndecan-4 in postoperative capsular opacification. Cell Death Dis. 2017;8:e2920 pubmed publisher
Prpar Mihevc S, Pavlin M, Darovic S, Živin M, Podbregar M, Rogelj B, et al. Modelling FUS Mislocalisation in an In Vitro Model of Innervated Human Muscle. J Mol Neurosci. 2017;62:318-328 pubmed publisher
Lojk J, Prpar Mihevc S, Bregar V, Pavlin M, Rogelj B. The Effect of Different Types of Nanoparticles on FUS and TDP-43 Solubility and Subcellular Localization. Neurotox Res. 2017;32:325-339 pubmed publisher
Stock P, Bielohuby M, Staege M, Hsu M, Bidlingmaier M, Christ B. Impairment of Host Liver Repopulation by Transplanted Hepatocytes in Aged Rats and the Release by Short-Term Growth Hormone Treatment. Am J Pathol. 2017;187:553-569 pubmed publisher
Xiong W, Luo Y, Wu L, Liu F, Liu H, Li J, et al. Chemerin Stimulates Vascular Smooth Muscle Cell Proliferation and Carotid Neointimal Hyperplasia by Activating Mitogen-Activated Protein Kinase Signaling. PLoS ONE. 2016;11:e0165305 pubmed publisher
Gami Patel P, Bandopadhyay R, Brelstaff J, Revesz T, Lashley T. The presence of heterogeneous nuclear ribonucleoproteins in frontotemporal lobar degeneration with FUS-positive inclusions. Neurobiol Aging. 2016;46:192-203 pubmed publisher
Stoica R, Paillusson S, Gomez Suaga P, Mitchell J, Lau D, Gray E, et al. ALS/FTD-associated FUS activates GSK-3? to disrupt the VAPB-PTPIP51 interaction and ER-mitochondria associations. EMBO Rep. 2016;17:1326-42 pubmed publisher
Pushchina E, Shukla S, Varaksin A, Obukhov D. Cell proliferation and apoptosis in optic nerve and brain integration centers of adult trout Oncorhynchus mykiss after optic nerve injury. Neural Regen Res. 2016;11:578-90 pubmed publisher
Hu Y, Cong X, Chen L, Qi J, Wu X, Zhou M, et al. Synergy of TLR3 and 7 ligands significantly enhances function of DCs to present inactivated PRRSV antigen through TRIF/MyD88-NF-?B signaling pathway. Sci Rep. 2016;6:23977 pubmed publisher
Ivanova I, Maringele L. Polymerases ε and ∂ repair dysfunctional telomeres facilitated by salt. Nucleic Acids Res. 2016;44:3728-38 pubmed publisher
Engler A, Tange C, Frank Bertoncelj M, Gay R, Gay S, Ospelt C. Regulation and function of SIRT1 in rheumatoid arthritis synovial fibroblasts. J Mol Med (Berl). 2016;94:173-82 pubmed publisher
Sibley C, Emmett W, Blázquez L, Faro A, Haberman N, Briese M, et al. Recursive splicing in long vertebrate genes. Nature. 2015;521:371-375 pubmed publisher
Houlihan S, Feng Y. The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation. elife. 2014;3:e03297 pubmed publisher
Sawosz E, Jaworski S, Kutwin M, Hotowy A, Wierzbicki M, Grodzik M, et al. Toxicity of pristine graphene in experiments in a chicken embryo model. Int J Nanomedicine. 2014;9:3913-22 pubmed publisher
Zhu J, Zhu C, Ge S, Zhang M, Jiang L, Cui J, et al. Lactobacillus salivarius Ren prevent the early colorectal carcinogenesis in 1, 2-dimethylhydrazine-induced rat model. J Appl Microbiol. 2014;117:208-16 pubmed publisher
Zhang M, Wang F, Jiang L, Liu R, Zhang L, LEI X, et al. Lactobacillus salivarius REN inhibits rat oral cancer induced by 4-nitroquioline 1-oxide. Cancer Prev Res (Phila). 2013;6:686-94 pubmed publisher
Sheu M, Lin H, Yang Y, Chou C, Chien Y, Wu T, et al. Demethoxycurcumin, a major active curcuminoid from Curcuma longa, suppresses balloon injury induced vascular smooth muscle cell migration and neointima formation: an in vitro and in vivo study. Mol Nutr Food Res. 2013;57:1586-97 pubmed publisher
Errami Y, Brim H, Oumouna Benachour K, Oumouna M, Naura A, Kim H, et al. ICAD deficiency in human colon cancer and predisposition to colon tumorigenesis: linkage to apoptosis resistance and genomic instability. PLoS ONE. 2013;8:e57871 pubmed publisher
Chien Y, Huang G, Cheng H, Wu C, Sheu M. Hispolon attenuates balloon-injured neointimal formation and modulates vascular smooth muscle cell migration via AKT and ERK phosphorylation. J Nat Prod. 2012;75:1524-33 pubmed
Montaldi A, Sakamoto Hojo E. Methoxyamine sensitizes the resistant glioblastoma T98G cell line to the alkylating agent temozolomide. Clin Exp Med. 2013;13:279-88 pubmed publisher
Hasenstein J, Kasmerchak K, Buehler D, Hafez G, Cleary K, Moody J, et al. Efficacy of Tie2 receptor antagonism in angiosarcoma. Neoplasia. 2012;14:131-40 pubmed
Kuo W, Yu M, Lee J, Tsai C, Chen T, Chen M. Imatinib mesylate improves liver regeneration and attenuates liver fibrogenesis in CCL4-treated mice. J Gastrointest Surg. 2012;16:361-9 pubmed publisher
Williams S, Wilson J, Clark A, Mitson Salazar A, Tomashevski A, Ananth S, et al. Functional and physical interaction between the mismatch repair and FA-BRCA pathways. Hum Mol Genet. 2011;20:4395-410 pubmed publisher
Ishikawa Y, Yamamoto N, Yasuda T, Yoshimoto M, Ito H. Morphogenesis of the medaka cerebellum, with special reference to the mesencephalic sheet, a structure homologous to the rostrolateral part of mammalian anterior medullary velum. Brain Behav Evol. 2010;75:88-103 pubmed publisher
Kawamura K, Tachibana M, Sunanaga T. Cell proliferation dynamics of somatic and germline tissues during zooidal life span in the colonial tunicate Botryllus primigenus. Dev Dyn. 2008;237:1812-25 pubmed publisher
Woods A, Hall P, Shepherd N, Hanby A, Waseem N, Lane D, et al. The assessment of proliferating cell nuclear antigen (PCNA)immunostaining in primary gastrointestinal lymphomas and its relationship to histological grade, S + G2 + M phase fraction (flow cytometric analysis) and prognosis. Histopathology. 2002;41:165-71 pubmed
product information
master code :
NB100-565
SKU :
NB100-565
product name :
FUS Antibody - BSA Free
unit size :
100 ul
description :
The FUS Antibody - BSA Free from Novus is a rabbit polyclonal antibody to FUS. This antibody reacts with human,mouse,rat. The FUS Antibody - BSA Free has been validated for the following applications: Immunohistochemistry,Western Blot,Immunocytochemistry/ Immunofluorescence,IF/IHC,Immunoprecipitation,Immunohistochemistry-Paraffin,Knockout Validated.
target :
FUS
category :
Primary Antibodies
buffer :
Tris-Citrate/Phosphate (pH 7.0 - 8.0)
clonality :
Polyclonal
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
The immunogen recognized by this antibody maps to a region between residues 1 and 50 of human fusion (involved in t(12;16) in malignant liposarcoma) using the numbering given in SwissProt entry P35637 (GeneID 2521).
isotype :
IgG
purity :
Immunogen affinity purified
species :
Human,Mouse,Rat
theoretical molecular weight :
53 kDa
gene symbol :
FUS
Antibody validation :
Independent Anitbodies
accessionNumbers :
P35637
applications :
Immunohistochemistry,Western Blot,Immunocytochemistry/ Immunofluorescence,IF/IHC,Immunoprecipitation,Immunohistochemistry-Paraffin,Knockout Validated
USD :
529 USD
alt names :
75 kDa DNA-pairing protein, ALS6, amyotrophic lateral sclerosis 6, FUS1, fused in sarcoma, fusion (involved in t(12;16) in malignant liposarcoma), fusion gene in myxoid liposarcoma, fusion, derived from t(12;16) malignant liposarcoma, fus-like protein, heterogeneous nuclear ribonucleoprotein P2, HNRNPP2, Oncogene FUS, Oncogene TLS, POMp75, RNA-binding protein FUS, TLShnRNP-P2, Translocated in liposarcoma protein
storage :
Store at 4C. Do not freeze.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.