product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Caspase-8 Antibody
catalog :
NB100-56116
quantity :
0.05 ml (also 0.025 ml)
price :
399 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 45
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 3c
Jin Y, Liu Y, Xu L, Xu J, Xiong Y, Peng Y, et al. Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis. Cell Death Dis. 2022;13:512 pubmed publisher
Lee G, Bang G, Byun J, Lee C, Chen W, Jeung D, et al. Dysregulated CREB3 cleavage at the nuclear membrane induces karyoptosis-mediated cell death. Exp Mol Med. 2024;56:686-699 pubmed publisher
Pennel K, Hatthakarnkul P, Wood C, Lian G, Al Badran S, Quinn J, et al. JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. J Exp Clin Cancer Res. 2024;43:64 pubmed publisher
Wang S, Chang C, Huang J, Zeng S, Zhang X, Hung M, et al. Gasdermin C sensitizes tumor cells to PARP inhibitor therapy in cancer models. J Clin Invest. 2024;134: pubmed publisher
Luk C, Chan C, Chiu F, Shi S, Misra P, Li Y, et al. Dual Role of Caspase 8 in Adipocyte Apoptosis and Metabolic Inflammation. Diabetes. 2023;72:1751-1765 pubmed publisher
Subramanya S, Fernando R, Goswami M, Besirli C, Weh E, Wubben T. Flow cytometric method for the detection and quantification of retinal cell death and oxidative stress. Exp Eye Res. 2023;233:109563 pubmed publisher
Zhang L, Zhu D, Jiang J, Min Z, Fa Z. The ubiquitin E3 ligase MDM2 induces chemoresistance in colorectal cancer by degradation of ING3. Carcinogenesis. 2023;44:562-575 pubmed publisher
Zhou J, Xiang W, Zhang K, Zhao Q, Xu Z, Li Z. IL1RAP Knockdown in LPS-Stimulated Normal Human Astrocytes Suppresses LPS-Induced Reactive Astrogliosis and Promotes Neuronal Cell Proliferation. Neurochem Res. 2022;: pubmed publisher
Lee S, Ok S, Ahn S, Sim G, Kim H, Kim M, et al. Lipid emulsion inhibits the cardiac toxicity caused by chloroquine via inhibition of reactive oxygen species production. Korean J Anesthesiol. 2022;: pubmed publisher
Crudele A, Smeriglio A, Ingegneri M, Panera N, Bianchi M, Braghini M, et al. Hydroxytyrosol Recovers SARS-CoV-2-PLpro-Dependent Impairment of Interferon Related Genes in Polarized Human Airway, Intestinal and Liver Epithelial Cells. Antioxidants (Basel). 2022;11: pubmed publisher
Ok S, Ahn S, Lee S, Kim H, Sim G, Park J, et al. Lipid emulsion attenuates propranolol-induced early apoptosis in rat cardiomyoblasts. Hum Exp Toxicol. 2022;41:9603271221110852 pubmed publisher
Montecillo Aguado M, Tirado Rodriguez B, Antonio Andres G, Morales Martinez M, Tong Z, Yang J, et al. Omega-6 Polyunsaturated Fatty Acids Enhance Tumor Aggressiveness in Experimental Lung Cancer Model: Important Role of Oxylipins. Int J Mol Sci. 2022;23: pubmed publisher
Wu S, Hu S, Fan W, Zhang X, Wang H, Li C, et al. Nitrite exposure may induce infertility in mice. J Toxicol Pathol. 2022;35:75-82 pubmed publisher
Chen L, Shi H, Wang X, Wang T, Wang Y, Wu Z, et al. Hepatocyte nuclear factor 4 gamma (HNF4G) is correlated with poor prognosis and promotes tumor cell growth by inhibiting caspase-dependent intrinsic apoptosis in colorectal cancer. Eur J Pharmacol. 2022;916:174727 pubmed publisher
Kearon J, Kocherry S, Zoumboulakis D, Rivera D, Lourenssen S, Blennerhassett M. GDNF requires HIF-1α and RET activation for suppression of programmed cell death of enteric neurons by metabolic challenge. Mol Cell Neurosci. 2021;115:103655 pubmed publisher
Li Y, Li Z, Quan Y, Cheng H, Riquelme M, Li X, et al. Macrophage recruitment in immune-privileged lens during capsule repair, necrotic fiber removal, and fibrosis. iScience. 2021;24:102533 pubmed publisher
Fasolato S, Ruvoletto M, Nardo G, Rasola A, Sciacovelli M, Zanus G, et al. Low P66shc with High SerpinB3 Levels Favors Necroptosis and Better Survival in Hepatocellular Carcinoma. Biology (Basel). 2021;10: pubmed publisher
Nishio A, Bolte F, Takeda K, Park N, Yu Z, Park H, et al. Clearance of pegylated interferon by Kupffer cells limits NK cell activation and therapy response of patients with HBV infection. Sci Transl Med. 2021;13: pubmed publisher
Fletcher R, Tong J, Risnik D, Leibowitz B, Wang Y, Concha Benavente F, et al. Non-steroidal anti-inflammatory drugs induce immunogenic cell death in suppressing colorectal tumorigenesis. Oncogene. 2021;40:2035-2050 pubmed publisher
Arman T, Lynch K, Goedken M, Clarke J. Sub-chronic microcystin-LR renal toxicity in rats fed a high fat/high cholesterol diet. Chemosphere. 2021;269:128773 pubmed publisher
Ruera C, Miculán E, Perez F, Ducca G, Carasi P, Chirdo F. Sterile inflammation drives multiple programmed cell death pathways in the gut. J Leukoc Biol. 2020;: pubmed publisher
Doganlar O, Doganlar Z, Ovali M, Guclu O, Demir U, Doğan A, et al. Melatonin regulates oxidative stress and apoptosis in fetal hearts of pinealectomised RUPP rats. Hypertens Pregnancy. 2020;39:429-443 pubmed publisher
Tummers B, Mari L, Guy C, Heckmann B, Rodriguez D, Rühl S, et al. Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis. Immunity. 2020;52:994-1006.e8 pubmed publisher
Ando Y, Ohuchida K, Otsubo Y, Kibe S, Takesue S, Abe T, et al. Necroptosis in pancreatic cancer promotes cancer cell migration and invasion by release of CXCL5. PLoS ONE. 2020;15:e0228015 pubmed publisher
Riegger J, Huber Lang M, Brenner R. Crucial role of the terminal complement complex in chondrocyte death and hypertrophy after cartilage trauma. Osteoarthritis Cartilage. 2020;28:685-697 pubmed publisher
Popper B, Rammer M, Gasparitsch M, Singer T, Keller U, Döring Y, et al. Neonatal obstructive nephropathy induces necroptosis and necroinflammation. Sci Rep. 2019;9:18600 pubmed publisher
Sinha S, Renganathan A, Nagendra P, Bhat V, Mathew B, Rao M. AEBP1 down regulation induced cell death pathway depends on PTEN status of glioma cells. Sci Rep. 2019;9:14577 pubmed publisher
Riegger J, Brenner R. Evidence of necroptosis in osteoarthritic disease: investigation of blunt mechanical impact as possible trigger in regulated necrosis. Cell Death Dis. 2019;10:683 pubmed publisher
Guclu O, Doganlar O, Yuksel V, Doganlar Z. FOLFIRI-Mediated Toxicity in Human Aortic Smooth Muscle Cells and Possible Amelioration with Curcumin and Quercetin. Cardiovasc Toxicol. 2019;: pubmed publisher
Chen S, Yang C, Sun C, Sun Y, Yang Z, Cheng S, et al. miR-21-5p Suppressed the Sensitivity of Hepatocellular Carcinoma Cells to Cisplatin by Targeting FASLG. DNA Cell Biol. 2019;38:865-873 pubmed publisher
Xu S, Luo W, Xu X, Qian Y, Xu Z, Yu W, et al. MD2 blockade prevents oxLDL-induced renal epithelial cell injury and protects against high-fat-diet-induced kidney dysfunction. J Nutr Biochem. 2019;70:47-55 pubmed publisher
Doganlar Z, Guclu H, Öztopuz Ö, Turkon H, Doğan A, Uzun M, et al. The Role of Melatonin in Oxidative Stress, DNA Damage, Apoptosis and Angiogenesis in Fetal Eye under Preeclampsia and Melatonin Deficiency Stress. Curr Eye Res. 2019;44:1157-1169 pubmed publisher
Messenger Z, Hall J, Jima D, House J, Tam H, Tokarz D, et al. C/EBPβ deletion in oncogenic Ras skin tumors is a synthetic lethal event. Cell Death Dis. 2018;9:1054 pubmed publisher
Turtle J, Strain M, Reynolds J, Huang Y, Lee K, Henwood M, et al. Pain Input After Spinal Cord Injury (SCI) Undermines Long-Term Recovery and Engages Signal Pathways That Promote Cell Death. Front Syst Neurosci. 2018;12:27 pubmed publisher
Wiberg R, Novikova L, Kingham P. Evaluation of apoptotic pathways in dorsal root ganglion neurons following peripheral nerve injury. Neuroreport. 2018;29:779-785 pubmed publisher
Guclu H, Doganlar Z, Gürlü V, Özal A, Doğan A, Turhan M, et al. Effects of cisplatin-5-fluorouracil combination therapy on oxidative stress, DNA damage, mitochondrial apoptosis, and death receptor signalling in retinal pigment epithelium cells. Cutan Ocul Toxicol. 2018;37:291-304 pubmed publisher
Lotti R, Shu E, Petrachi T, Marconi A, Palazzo E, Quadri M, et al. Soluble Fas Ligand Is Essential for Blister Formation in Pemphigus. Front Immunol. 2018;9:370 pubmed publisher
Philion C, Ma D, Ruvinov I, Mansour F, Pignanelli C, Noel M, et al. Cymbopogon citratus and Camellia sinensis extracts selectively induce apoptosis in cancer cells and reduce growth of lymphoma xenografts in vivo. Oncotarget. 2017;8:110756-110773 pubmed publisher
Tian J, Guo S, Chen H, Peng J, Jia M, Li N, et al. Combination of Emricasan with Ponatinib Synergistically Reduces Ischemia/Reperfusion Injury in Rat Brain Through Simultaneous Prevention of Apoptosis and Necroptosis. Transl Stroke Res. 2018;9:382-392 pubmed publisher
Li F, Wang T, Wang Z, Chen X, Liu R. Histone deacetylase inhibitor quisinostat activates caspase signaling and upregulates p53 acetylation to inhibit the proliferation of HepG2 cells. Mol Med Rep. 2017;16:6094-6101 pubmed publisher
Zhou X, Xie L, Xia L, Bergmann F, Buchler M, Kroemer G, et al. RIP3 attenuates the pancreatic damage induced by deletion of ATG7. Cell Death Dis. 2017;8:e2918 pubmed publisher
Liu P, Hu Y, Kang B, Tseng Y, Wu P, Liang C, et al. Expression levels of cleaved caspase-3 and caspase-3 in tumorigenesis and prognosis of oral tongue squamous cell carcinoma. PLoS ONE. 2017;12:e0180620 pubmed publisher
Hua X, Yuan X, Li Y, Chen H, Yuan J, Tanumiharjo S, et al. Desiccating stress worsens alkali burn injury by magnifying caspase-8-induced imbalance of NLRP3 and NLRP6. J Allergy Clin Immunol. 2017;140:1172-1176.e3 pubmed publisher
Xiao J, Yao J, Jia L, Lin C, Zacks D. Protective Effect of Met12, a Small Peptide Inhibitor of Fas, on the Retinal Pigment Epithelium and Photoreceptor After Sodium Iodate Injury. Invest Ophthalmol Vis Sci. 2017;58:1801-1810 pubmed publisher
Chi W, Hua X, Chen X, Bian F, Yuan X, Zhang L, et al. Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye. J Autoimmun. 2017;80:65-76 pubmed publisher
product information
master code :
NB100-56116
SKU :
NB100-56116
product name :
Caspase-8 Antibody
unit size :
0.05 ml (also 0.025 ml)
description :
The Caspase-8 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to Caspase-8. This antibody reacts with gerbil,human,mouse,rat. The Caspase-8 Antibody - BSA Free has been validated for the following applications: Immunoprecipitation,Western Blot,Immunohistochemistry,Simple Western,IF/IHC,WB/IP,Flow Cytometry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence.
target :
Caspase-8
category :
Primary Antibodies
buffer :
Whole antisera
clonality :
Polyclonal
conjugate :
Unconjugated
host :
Rabbit
immunogen :
Recombinant catalytically active human Caspase-8 protein.
isotype :
IgG
purity :
Unpurified
species :
Gerbil,Human,Mouse,Rat
specificity :
Detects Caspase-8 and cleavage products
theoretical molecular weight :
55.4 kDa
gene symbol :
CASP8
accessionNumbers :
Q14790
applications :
Immunohistochemistry,Western Blot,Simple Western,IF/IHC,WB/IP,Flow Cytometry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence,Immunoprecipitation
USD :
399 USD
alt names :
AIS, androgen receptor, DHTRTFM, Dihydrotestosterone receptorHYSP1, HUMARA, NR3C4KD, Nuclear receptor subfamily 3 group C member 4, SMAX1SBMA, spinal and bulbar muscular atrophy
storage :
Store at -20C. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.