product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Caspase-3 Antibody - (active/cleaved)
catalog :
NB100-56113
quantity :
0.05 ml (also 0.025 ml)
price :
319 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 63
Published Application/Species/Sample/DilutionReference
  • western blot; rat; 1:1000; loading ...; fig 5f
Ma N, Li G, Fu X. Protective role of activating transcription factor 3 against neuronal damage in rats with cerebral ischemia. Brain Behav. 2022;12:e2522 pubmed publisher
Kaur B, Miglioranza Scavuzzi B, Yang M, Yao J, Jia L, ABCOUWER S, et al. ER Stress and Mitochondrial Perturbations Regulate Cell Death in Retinal Detachment: Exploring the Role of HIF1α. Invest Ophthalmol Vis Sci. 2024;65:39 pubmed publisher
Abdel Reheim M, Ali M, Gaafar A, Ashour A. Quillaja saponin mitigates methotrexate-provoked renal injury; insight into Nrf-2/Keap-1 pathway modulation with suppression of oxidative stress and inflammation. J Pharm Health Care Sci. 2024;10:17 pubmed publisher
Chandrakumar S, Santiago Tierno I, Agarwal M, Lessieur E, Du Y, Tang J, et al. Mechanical Regulation of Retinal Vascular Inflammation and Degeneration in Diabetes. Diabetes. 2024;73:280-291 pubmed publisher
Wang S, Chang C, Huang J, Zeng S, Zhang X, Hung M, et al. Gasdermin C sensitizes tumor cells to PARP inhibitor therapy in cancer models. J Clin Invest. 2024;134: pubmed publisher
Abdeljalil S, Wahdan S, Elghazaly H, Tolba M. Insights into the therapeutic outcomes of trimetazidine/doxorubicin combination in Ehrlich solid-phase carcinoma mouse tumor model. Life Sci. 2023;328:121874 pubmed publisher
Ruiz T, Grigio V, Ferrato L, de Souza L, Colleta S, Amaro G, et al. Impairment of steroidogenesis and follicle development after bisphenol A exposure during pregnancy and lactation in the ovaries of Mongolian gerbils aged females. Mol Cell Endocrinol. 2023;566-567:111892 pubmed publisher
ElKhoely A. Liraglutide ameliorates gentamicin-induced acute kidney injury in rats via PGC-1α- mediated mitochondrial biogenesis: Involvement of PKA/CREB and Notch/Hes-1 signaling pathways. Int Immunopharmacol. 2023;114:109578 pubmed publisher
Albadawy R, Hasanin A, Agwa S, Hamady S, Aboul Ela Y, Raafat M, et al. Rosavin Ameliorates Hepatic Inflammation and Fibrosis in the NASH Rat Model via Targeting Hepatic Cell Death. Int J Mol Sci. 2022;23: pubmed publisher
Silconi Z, Rosic V, Benazic S, Radosavljevic G, Mijajlovic M, Pantic J, et al. The Pt(S-pr-thiosal)2 and BCL1 Leukemia Lymphoma: Antitumor Activity In Vitro and In Vivo. Int J Mol Sci. 2022;23: pubmed publisher
Xu H, Ye W, Shi B. LncRNA MALAT1 Regulates USP22 Expression Through EZH2-Mediated H3K27me3 Modification to Accentuate Sepsis-Induced Myocardial Dysfunction. Cardiovasc Toxicol. 2022;22:813-830 pubmed publisher
Kelly Y, Ward C, Zhang R, Syed S, Stock P, Duh Q, et al. Effects of Multi-stage Procurement on the Viability and Function of Human Donor Parathyroid Glands. J Surg Res. 2022;276:404-415 pubmed publisher
Chen L, Xu Y, Ye X. Low temperature mitigating the paclitaxel-induced damages in mouse cell and hair follicle model. Biochem Biophys Res Commun. 2022;603:94-101 pubmed publisher
Chen Q, Li Q, Liang Y, Zu M, Chen N, Canup B, et al. Natural exosome-like nanovesicles from edible tea flowers suppress metastatic breast cancer via ROS generation and microbiota modulation. Acta Pharm Sin B. 2022;12:907-923 pubmed publisher
Liu D, Tang X, Huang Z, Wen J, Zhou Y. Histone deacetylase HDAC2 regulates microRNA-125a expression in neuroblastoma. Brain Behav. 2022;12:e2401 pubmed publisher
Ruiz T, Leonel E, Colleta S, Bedolo C, Pegorin de Campos S, Taboga S. Gestational and lactational xenoestrogen exposure disrupts morphology and inflammatory aspects in mammary gland of gerbil mothers during involution. Environ Toxicol Pharmacol. 2022;89:103785 pubmed publisher
Saha A, Saleem S, Paidi R, Biswas S. BH3-only proteins Puma and Beclin1 regulate autophagic death in neurons in response to Amyloid-β. Cell Death Discov. 2021;7:356 pubmed publisher
Zhao J, Dong L, Huo T, Cheng J, Li X, Huangfu X, et al. O-GlcNAc Transferase (OGT) Protects Cerebral Neurons from Death During Ischemia/Reperfusion (I/R) Injury by Modulating Drp1 in Mice. Neuromolecular Med. 2021;: pubmed publisher
Ahmed Z, Galal M, Drweesh E, Abou El Sherbini K, Elzahany E, Elnagar M, et al. Protective effect of starch-stabilized selenium nanoparticles against melamine-induced hepato-renal toxicity in male albino rats. Int J Biol Macromol. 2021;191:792-802 pubmed publisher
Liu Z, Liu Q, Zhang B, Liu Q, Fang L, Gou S. Blood-Brain Barrier Permeable and NO-Releasing Multifunctional Nanoparticles for Alzheimer's Disease Treatment: Targeting NO/cGMP/CREB Signaling Pathways. J Med Chem. 2021;64:13853-13872 pubmed publisher
Senol N, Oguzoglu A, Erzurumlu Y, Asci H, Savran M, Gulle K, et al. Modulation of Salubrinal-Mediated Endoplasmic Reticulum Stress in an Experimental Subarachnoid Hemorrhage Model. World Neurosurg. 2021;153:e488-e496 pubmed publisher
Bashir D, Rashad M, Ahmed Y, Drweesh E, Elzahany E, Abou El Sherbini K, et al. The ameliorative effect of nanoselenium on histopathological and biochemical alterations induced by melamine toxicity on the brain of adult male albino rats. Neurotoxicology. 2021;86:37-51 pubmed publisher
Todorovic Z, Milovanovic J, Arsenijevic D, Vukovic N, Vukic M, Arsenijević A, et al. Shikonin Derivatives from Onsoma visianii Decrease Expression of Phosphorylated STAT3 in Leukemia Cells and Exert Antitumor Activity. Nutrients. 2021;13: pubmed publisher
Hashim A, Bashir D, Yasin N, Galal M, M E. Ameliorative effect of N-acetylcysteine against glyphosate-induced hepatotoxicity in adult male albino rats: histopathological, biochemical, and molecular studies. Environ Sci Pollut Res Int. 2021;: pubmed publisher
Mounier N, Wahdan S, Gad A, Azab S. Role of inflammatory, oxidative, and ER stress signaling in the neuroprotective effect of atorvastatin against doxorubicin-induced cognitive impairment in rats. Naunyn Schmiedebergs Arch Pharmacol. 2021;394:1537-1551 pubmed publisher
Codenotti S, Marampon F, Triggiani L, Bonù M, Magrini S, Ceccaroli P, et al. Caveolin-1 promotes radioresistance in rhabdomyosarcoma through increased oxidative stress protection and DNA repair. Cancer Lett. 2021;505:1-12 pubmed publisher
Tanita K, Sakura F, Nambu R, Tsumura M, Imanaka Y, Ohnishi H, et al. Clinical and Immunological Heterogeneity in Japanese Patients with Gain-of-Function Variants in STAT3. J Clin Immunol. 2021;: pubmed publisher
Shaalan A, Teshima T, Tucker A, Proctor G. Inhibition of Aurora Kinase B activity disrupts development and differentiation of salivary glands. Cell Death Discov. 2021;7:16 pubmed publisher
Solek P, Shemedyuk N, Shemedyuk A, Dudzińska E, Koziorowski M. Risk of wild fungi treatment failure: Phallus impudicus-induced telomere damage triggers p21/p53 and p16-dependent cell cycle arrest and may contribute to male fertility reduction in vitro. Ecotoxicol Environ Saf. 2021;209:111782 pubmed publisher
Akkaya E, Evran x, xc7 al x131 x15f F, xc7 evik S, Katar S, Karata x15f E, et al. Thymoquinone ameliorates delayed cerebral injury and cerebral vasospasm secondary to experimental subarachnoid haemorrhage. Neurol Neurochir Pol. 2020;54:576-584 pubmed publisher
Dhingani N, Guo C, Pan J, Li Q, Warner N, Jardine S, et al. The E3 ubiquitin ligase UBR5 interacts with TTC7A and may be associated with very early onset inflammatory bowel disease. Sci Rep. 2020;10:18648 pubmed publisher
Tsaroucha A, Korovesis G, Valsami G, Lambropoulou M, Kollaras V, Anagnostopoulos C, et al. Silibinin-hydroxypropyl-β-cyclodextrin (SLB-HP-β-CD) complex prevents apoptosis in liver and kidney after hepatic ischemia-reperfusion injury. Food Chem Toxicol. 2020;145:111731 pubmed publisher
Gao K, Niu J, Dang X. Wnt-3a improves functional recovery through autophagy activation via inhibiting the mTOR signaling pathway after spinal cord injury. Neurosci Lett. 2020;737:135305 pubmed publisher
Rahaman M, Yamasaki S, Binte Hossain K, Hosokawa T, Saito T, Kurasaki M. Effects of curcumin, D-pinitol alone or in combination in cytotoxicity induced by arsenic in PC12 cells. Food Chem Toxicol. 2020;144:111577 pubmed publisher
Rahaman M, Banik S, Akter M, Rahman M, Sikder M, Hosokawa T, et al. Curcumin alleviates arsenic-induced toxicity in PC12 cells via modulating autophagy/apoptosis. Ecotoxicol Environ Saf. 2020;200:110756 pubmed publisher
Davis J, Bopp A, Henwood M, Baine R, Cox C, Grau J. Pharmacological Transection of Brain-Spinal Cord Communication Blocks Pain-Induced Hemorrhage and Locomotor Deficits after Spinal Cord Injury in Rats. J Neurotrauma. 2020;37:1729-1739 pubmed publisher
Peng W, de Bruijn H, ten Hagen T, van Dam G, Roodenburg J, Berg K, et al. Targeted Photodynamic Therapy of Human Head and Neck Squamous Cell Carcinoma with Anti-epidermal Growth Factor Receptor Antibody Cetuximab and Photosensitizer IR700DX in the Mouse Skin-fold Window Chamber Model. Photochem Photobiol. 2020;96:708-717 pubmed publisher
Wen S, Li S, Li L, Fan Q. circACTR2: A Novel Mechanism Regulating High Glucose-Induced Fibrosis in Renal Tubular Cells via Pyroptosis. Biol Pharm Bull. 2020;43:558-564 pubmed publisher
Martins F, Aguila M, Mandarim de Lacerda C. Eicosapentaenoic and docosapentaenoic acids lessen the expression of PPARγ/Cidec affecting adipogenesis in cultured 3T3-L1 adipocytes. Acta Histochem. 2020;122:151504 pubmed publisher
Shaalan A, Proctor G. Salivary glands require Aurora Kinase B for regeneration after transient innate immune-mediated injury. Sci Rep. 2019;9:11339 pubmed publisher
Solek P, Koszla O, Mytych J, Badura J, Chelminiak Z, Cuprys M, et al. Neuronal life or death linked to depression treatment: the interplay between drugs and their stress-related outcomes relate to single or combined drug therapies. Apoptosis. 2019;24:773-784 pubmed publisher
Zeiss C, Gatti D, Toro Salazar O, Davis C, Lutz C, Spinale F, et al. Doxorubicin-Induced Cardiotoxicity in Collaborative Cross (CC) Mice Recapitulates Individual Cardiotoxicity in Humans. G3 (Bethesda). 2019;9:2637-2646 pubmed publisher
Stojanovic B, Milovanovic J, Arsenijević A, Stojanović B, Strazic Geljic I, Arsenijevic N, et al. Galectin-3 Deficiency Facilitates TNF-α-Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection. Front Microbiol. 2019;10:185 pubmed publisher
Codenotti S, Faggi F, Ronca R, Chiodelli P, Grillo E, Guescini M, et al. Caveolin-1 enhances metastasis formation in a human model of embryonal rhabdomyosarcoma through Erk signaling cooperation. Cancer Lett. 2019;449:135-144 pubmed publisher
Corsetti G, Chen Scarabelli C, Romano C, Pasini E, Dioguardi F, Onorati F, et al. Autophagy and Oncosis/Necroptosis Are Enhanced in Cardiomyocytes from Heart Failure Patients. Med Sci Monit Basic Res. 2019;25:33-44 pubmed publisher
Hu S, Cheng M, Guo X, Wang S, Liu B, Jiang H, et al. Down-regulation of miR-200c attenuates AngII-induced cardiac hypertrophy via targeting the MLCK-mediated pathway. J Cell Mol Med. 2019;23:2505-2516 pubmed publisher
Dahiya N, Chandrasekaran B, Kolluru V, Ankem M, DAMODARAN C, Vadhanam M. A natural molecule, urolithin A, downregulates androgen receptor activation and suppresses growth of prostate cancer. Mol Carcinog. 2018;57:1332-1341 pubmed publisher
Babic Z, Zunic F, Pantic J, Radosavljevic G, Jovanovic I, Arsenijevic N, et al. IL-33 receptor (ST2) deficiency downregulates myeloid precursors, inflammatory NK and dendritic cells in early phase of sepsis. J Biomed Sci. 2018;25:56 pubmed publisher
Jurisevic M, Arsenijević A, Pantic J, Gajovic N, Milovanovic J, Milovanovic M, et al. The organic ester O,O'-diethyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate dihydrochloride attenuates murine breast cancer growth and metastasis. Oncotarget. 2018;9:28195-28212 pubmed publisher
Solek P, Majchrowicz L, Koziorowski M. Aloe arborescens juice prevents EMF-induced oxidative stress and thus protects from pathophysiology in the male reproductive system in vitro. Environ Res. 2018;166:141-149 pubmed publisher
Talreja D, Cashman S, Dasari B, Kumar B, Kumar Singh R. G-quartet oligonucleotide mediated delivery of functional X-linked inhibitor of apoptosis protein into retinal cells following intravitreal injection. Exp Eye Res. 2018;175:20-31 pubmed publisher
Guo Y, Wang F, Li H, Liang H, Li Y, Gao Z, et al. Metformin Protects Against Spinal Cord Injury by Regulating Autophagy via the mTOR Signaling Pathway. Neurochem Res. 2018;43:1111-1117 pubmed publisher
Adamson S, Polanowska Grabowska R, Marqueen K, Griffiths R, Angdisen J, Breevoort S, et al. Deficiency of Dab2 (Disabled Homolog 2) in Myeloid Cells Exacerbates Inflammation in Liver and Atherosclerotic Plaques in LDLR (Low-Density Lipoprotein Receptor)-Null Mice-Brief Report. Arterioscler Thromb Vasc Biol. 2018;38:1020-1029 pubmed publisher
Shaalan A, Carpenter G, Proctor G. Caspases are key regulators of inflammatory and innate immune responses mediated by TLR3 in vivo. Mol Immunol. 2018;94:190-199 pubmed publisher
Bozec A, Zangari J, Butori Pepino M, Ilie M, Lalvee S, Juhel T, et al. MiR-223-3p inhibits angiogenesis and promotes resistance to cetuximab in head and neck squamous cell carcinoma. Oncotarget. 2017;8:57174-57186 pubmed publisher
Mytych J, Romerowicz Misielak M, Koziorowski M. Long-term culture with lipopolysaccharide induces dose-dependent cytostatic and cytotoxic effects in THP-1 monocytes. Toxicol In Vitro. 2017;42:1-9 pubmed publisher
Solek P, Majchrowicz L, Bloniarz D, Krotoszynska E, Koziorowski M. Pulsed or continuous electromagnetic field induce p53/p21-mediated apoptotic signaling pathway in mouse spermatogenic cells in vitro and thus may affect male fertility. Toxicology. 2017;382:84-92 pubmed publisher
Phua T, Sng M, Tan E, Chee D, Li Y, Wee J, et al. Angiopoietin-like 4 Mediates Colonic Inflammation by Regulating Chemokine Transcript Stability via Tristetraprolin. Sci Rep. 2017;7:44351 pubmed publisher
Sidhar H, Giri R. Induction of Bex genes by curcumin is associated with apoptosis and activation of p53 in N2a neuroblastoma cells. Sci Rep. 2017;7:41420 pubmed publisher
Rasheed N, Ahmed L, Abdallah D, El Sayeh B. Nephro-toxic effects of intraperitoneally injected EGCG in diabetic mice: involvement of oxidative stress, inflammation and apoptosis. Sci Rep. 2017;7:40617 pubmed publisher
Corsetti G, Romano C, Stacchiotti A, Pasini E, Dioguardi F. Endoplasmic Reticulum Stress and Apoptosis Triggered by Sub-Chronic Lead Exposure in Mice Spleen: a Histopathological Study. Biol Trace Elem Res. 2017;178:86-97 pubmed publisher
Mytych J, Wos I, Solek P, Koziorowski M. Protective role of klotho protein on epithelial cells upon co-culture with activated or senescent monocytes. Exp Cell Res. 2017;350:358-367 pubmed publisher
Turtle J, Strain M, Aceves M, Huang Y, Reynolds J, Hook M, et al. Pain Input Impairs Recovery after Spinal Cord Injury: Treatment with Lidocaine. J Neurotrauma. 2017;34:1200-1208 pubmed publisher
product information
master code :
NB100-56113
SKU :
NB100-56113
product name :
Caspase-3 Antibody - (active/cleaved)
unit size :
0.05 ml (also 0.025 ml)
description :
The Caspase-3 Antibody - (active/cleaved) - BSA Free from Novus is a rabbit polyclonal antibody to Caspase-3. This antibody reacts with gerbil,human,mouse,rat. The Caspase-3 Antibody - (active/cleaved) - BSA Free has been validated for the following applications: Immunohistochemistry-Paraffin,Immunohistochemistry,Immunocytochemistry/ Immunofluorescence,Flow Cytometry Control,IF/IHC,Flow Cytometry,Western Blot,Immunohistochemistry-Frozen,Immunoprecipitation,Immunoblotting,Flow (Intracellular).
target :
Caspase-3
category :
Primary Antibodies
buffer :
Neat whole antisera
clonality :
Polyclonal
conjugate :
Unconjugated
host :
Rabbit
immunogen :
This Caspase-3 Antibody - (active/cleaved) was developed against catalytically active human caspase-3 protein.
isotype :
IgG
purity :
Unpurified
species :
Gerbil,Human,Mouse,Rat
theoretical molecular weight :
31.7 kDa
gene symbol :
CASP3
Antibody validation :
Biological Validation
applications :
Immunohistochemistry,Immunocytochemistry/ Immunofluorescence,Flow Cytometry Control,IF/IHC,Flow Cytometry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunoprecipitation,Immunoblotting,Flow (Intracellular)
USD :
319 USD
alt names :
Apopain, apoptosis-related cysteine protease, CASP-3, caspase 3, apoptosis-related cysteine peptidase, caspase-3, CPP-32, CPP32B, CPP32SREBP cleavage activity 1, Cysteine protease CPP32, EC 3.4.22, EC 3.4.22.56, PARP cleavage protease, procaspase3, Protein Yama, SCA-1, Yama
storage :
Store at -20C. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.