product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
HIF-1 alpha Antibody - BSA Free
catalog :
NB100-479
quantity :
0.1 ml (also 0.025 ml)
price :
459 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
Alexa Fluor 405
clone name :
OTI2B3
reactivity :
human, mouse, rat, dogs, zebrafish
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 350
Published Application/Species/Sample/DilutionReference
  • chromatin immunoprecipitation; human; loading ...; fig 1d, s2
Wang Y, Lyu Y, Tu K, Xu Q, Yang Y, Salman S, et al. Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization. Sci Adv. 2021;7: pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 3a
Wang N, Peng Y, Su X, Prabhakar N, Nanduri J. Histone Deacetylase 5 Is an Early Epigenetic Regulator of Intermittent Hypoxia Induced Sympathetic Nerve Activation and Blood Pressure. Front Physiol. 2021;12:688322 pubmed publisher
  • immunohistochemistry; human; 1:100; loading ...; fig s15
Choi Y, Kim Y, Oh S, Suh K, Kim Y, Lee G, et al. Senescent Tumor Cells Build a Cytokine Shield in Colorectal Cancer. Adv Sci (Weinh). 2021;8:2002497 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5, s8a
  • western blot; mouse; 1:1000; loading ...; fig s7a
Isomura H, Taguchi A, Kajino T, Asai N, Nakatochi M, Kato S, et al. Conditional Ror1 knockout reveals crucial involvement in lung adenocarcinoma development and identifies novel HIF-1α regulator. Cancer Sci. 2021;: pubmed publisher
  • immunohistochemistry; rat; 1:200; loading ...; fig 4a
  • western blot; rat; 1:10,000; loading ...; fig s1a
Li J, Tao T, Xu J, Liu Z, Zou Z, Jin M. HIF‑1α attenuates neuronal apoptosis by upregulating EPO expression following cerebral ischemia‑reperfusion injury in a rat MCAO model. Int J Mol Med. 2020;45:1027-1036 pubmed publisher
  • western blot; human; loading ...; fig 3a
Guo H, Ci X, Ahmed M, Hua J, Soares F, Lin D, et al. ONECUT2 is a driver of neuroendocrine prostate cancer. Nat Commun. 2019;10:278 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig s4a
Aoki A, Nakashima A, Kusabiraki T, Ono Y, Yoshino O, Muto M, et al. Trophoblast-Specific Conditional Atg7 Knockout Mice Develop Gestational Hypertension. Am J Pathol. 2018;188:2474-2486 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 2o
Takai K, Drain A, Lawson D, Littlepage L, Karpuj M, Kessenbrock K, et al. Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers. Genes Dev. 2018;32:244-257 pubmed publisher
  • western blot; human; 1:500; tbl s1
Yasui T, Uezono N, Nakashima H, Noguchi H, Matsuda T, Noda Andoh T, et al. Hypoxia Epigenetically Confers Astrocytic Differentiation Potential on Human Pluripotent Cell-Derived Neural Precursor Cells. Stem Cell Reports. 2017;8:1743-1756 pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Myllymäki M, Määttä J, Dimova E, Izzi V, Väisänen T, Myllyharju J, et al. Notch Downregulation and Extramedullary Erythrocytosis in Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2-Deficient Mice. Mol Cell Biol. 2017;37: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2c
Guimarães T, Farias L, Santos E, De Carvalho Fraga C, Orsini L, de Freitas Teles L, et al. Metformin increases PDH and suppresses HIF-1? under hypoxic conditions and induces cell death in oral squamous cell carcinoma. Oncotarget. 2016;7:55057-55068 pubmed publisher
  • western blot; human; fig 1
Ruf M, Moch H, Schraml P. PD-L1 expression is regulated by hypoxia inducible factor in clear cell renal cell carcinoma. Int J Cancer. 2016;139:396-403 pubmed publisher
  • western blot; rat; 1:1000; fig 5
Zhou F, Dai A, Jiang Y, Tan X, Zhang X. SENP‑1 enhances hypoxia‑induced proliferation of rat pulmonary artery smooth muscle cells by regulating hypoxia‑inducible factor‑1α. Mol Med Rep. 2016;13:3482-90 pubmed publisher
  • western blot; human; fig 2a
Regan Anderson T, Ma S, Raj G, Cidlowski J, Helle T, Knutson T, et al. Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer. Cancer Res. 2016;76:1653-63 pubmed publisher
  • immunocytochemistry; human; 1:100; fig 4
  • western blot; human; 1:500; fig 3
Aquino Gálvez A, González Ávila G, Delgado Tello J, Castillejos López M, Mendoza Milla C, Zúñiga J, et al. Effects of 2-methoxyestradiol on apoptosis and HIF-1α and HIF-2α expression in lung cancer cells under normoxia and hypoxia. Oncol Rep. 2016;35:577-83 pubmed publisher
  • western blot; mouse
  • western blot; human
Valbuena G, Rizzardini M, Cimini S, Siskos A, Bendotti C, Cantoni L, et al. Metabolomic Analysis Reveals Increased Aerobic Glycolysis and Amino Acid Deficit in a Cellular Model of Amyotrophic Lateral Sclerosis. Mol Neurobiol. 2016;53:2222-40 pubmed publisher
Ahn J, da Silva Pedrosa M, Lopez L, Tibbs T, Jeyachandran J, Vignieri E, et al. Intestinal E. coli-produced yersiniabactin promotes profibrotic macrophages in Crohn's disease. Cell Host Microbe. 2025;33:71-88.e9 pubmed publisher
Benoit A, Lequeux A, Harter P, Berchem G, Janji B. Atypical chemokine receptor 2 expression is directly regulated by hypoxia inducible factor-1 alpha in cancer cells under hypoxia. Sci Rep. 2024;14:26589 pubmed publisher
Yang G, Xiang J, Yang X, Liu X, Li Y, Li L, et al. Nuclear translocation of SIRT4 mediates deacetylation of U2AF2 to modulate renal fibrosis through alternative splicing-mediated upregulation of CCN2. elife. 2024;13: pubmed publisher
Soler Agesta R, Moreno Loshuertos R, Yim C, Congenie M, Ames T, Johnson H, et al. Cancer cell-selective induction of mitochondrial stress and immunogenic cell death by PT-112 in human prostate cell lines. J Transl Med. 2024;22:927 pubmed publisher
Ohgaki R, Hirase Y, Xu M, Okanishi H, Kanai Y. LAT1 expression in colorectal cancer cells is unresponsive to HIF-1/2α accumulation under experimental hypoxia. Sci Rep. 2024;14:19635 pubmed publisher
Chen M, Wang Y, Dalal R, Du J, Vollrath D. Alternative oxidase blunts pseudohypoxia and photoreceptor degeneration due to RPE mitochondrial dysfunction. Proc Natl Acad Sci U S A. 2024;121:e2402384121 pubmed publisher
Lee B, Chuah Y, Yoon J, Grinchuk O, Liang Y, Hirpara J, et al. METTL8 links mt-tRNA m3C modification to the HIF1α/RTK/Akt axis to sustain GBM stemness and tumorigenicity. Cell Death Dis. 2024;15:338 pubmed publisher
Lyu Y, Yang Y, Talwar V, Lu H, Chen C, Salman S, et al. Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes. Cell Rep. 2024;43:113972 pubmed publisher
Elbassiouny A, Buck L, Abatti L, Mitchell J, Crampton W, Lovejoy N, et al. Evolution of a novel regulatory mechanism of hypoxia inducible factor (HIF1⍺) in hypoxia tolerant electric fishes. J Biol Chem. 2024;:105727 pubmed publisher
Jin Y, Peng Y, Xu J, Yuan Y, Yang N, Zhang Z, et al. LUBAC promotes angiogenesis and lung tumorigenesis by ubiquitinating and antagonizing autophagic degradation of HIF1α. Oncogenesis. 2024;13:6 pubmed publisher
Pham D, Nguyen T, Nguyen B, Kim J, Jeong J, Choi I, et al. Adiponectin restores the obesity-induced impaired immunomodulatory function of mesenchymal stromal cells via glycolytic reprogramming. Acta Pharm Sin B. 2024;14:273-291 pubmed publisher
Kim Y, Park N, Jo D, Bae J, Kim J, Park K, et al. Inhibition of VHL by VH298 Accelerates Pexophagy by Activation of HIF-1α in HeLa Cells. Molecules. 2024;29: pubmed publisher
Wang N, Su X, Sams D, Prabhakar N, Nanduri J. P300/CBP Regulates HIF-1-Dependent Sympathetic Activation and Hypertension by Intermittent Hypoxia. Am J Respir Cell Mol Biol. 2024;70:110-118 pubmed publisher
Zhu X, Chen J, Li W, Xu Y, Shan J, Hong J, et al. Hypoxia-Responsive CAR-T Cells Exhibit Reduced Exhaustion and Enhanced Efficacy in Solid Tumors. Cancer Res. 2024;84:84-100 pubmed publisher
Gille A, Givelet M, Pehlic D, Lapoujade C, Lassalle B, Barroca V, et al. Impact of the hypoxic microenvironment on spermatogonial stem cells in culture. Front Cell Dev Biol. 2023;11:1293068 pubmed publisher
Correa Gallegos D, Ye H, Dasgupta B, Sardogan A, Kadri S, Kandi R, et al. CD201+ fascia progenitors choreograph injury repair. Nature. 2023;623:792-802 pubmed publisher
Wang Y, Halawani D, Estill M, Ramakrishnan A, Shen L, Friedel R, et al. Aryl hydrocarbon receptor restricts axon regeneration of DRG neurons in response to injury. bioRxiv. 2023;: pubmed publisher
Downes N, Niskanen H, Tomas Bosch V, Taipale M, Godiwala M, V xe4 xe4 n xe4 nen M, et al. Hypoxic regulation of hypoxia inducible factor 1 alpha via antisense transcription. J Biol Chem. 2023;299:105291 pubmed publisher
Yamazaki T, Mimura I, Kurata Y, Tanaka T, Nangaku M. Dznep, a histone modification inhibitor, inhibits HIF1α binding to TIMP2 gene and suppresses TIMP2 expression under hypoxia. Physiol Rep. 2023;11:e15810 pubmed publisher
Wang D, Zhu Z, Fu Y, Zhang Q, Zhang Y, Wang T, et al. Bromodomain-containing protein 4 activates androgen receptor transcription and promotes ovarian fibrosis in PCOS. Cell Rep. 2023;42:113090 pubmed publisher
Maduabuchi W, Tansi F, Heller R, Hilger I. Hyperthermia Influences the Secretion Signature of Tumor Cells and Affects Endothelial Cell Sprouting. Biomedicines. 2023;11: pubmed publisher
Kunke M, Kn xf6 fler H, Dahlke E, Zanon Rodríguez L, B xf6 ttner M, Larionov A, et al. Targeted deletion of von-Hippel-Lindau in the proximal tubule conditions the kidney against early diabetic kidney disease. Cell Death Dis. 2023;14:562 pubmed publisher
Vellama H, Eskla K, Eichelmann H, H xfc va A, Tennant D, Thakker A, et al. VHL-deficiency leads to reductive stress in renal cells. Free Radic Biol Med. 2023;208:1-12 pubmed publisher
Ouhaddi Y, Dalisson B, Rastinfard A, Gilardino M, Watters K, Job D, et al. Necrosis reduction efficacy of subdermal biomaterial mediated oxygen delivery in ischemic skin flaps. Biomater Adv. 2023;153:213519 pubmed publisher
Mawambo G, Oubaha M, Ichiyama Y, Blot G, Crespo Garcia S, Dejda A, et al. HIF1α-dependent hypoxia response in myeloid cells requires IRE1α. J Neuroinflammation. 2023;20:145 pubmed publisher
Samuel T, Rapic S, O Brien C, Edson M, Zhong Y, Dacosta R. Quantitative intravital imaging for real-time monitoring of pancreatic tumor cell hypoxia and stroma in an orthotopic mouse model. Sci Adv. 2023;9:eade8672 pubmed publisher
Pathmanapan S, Poon R, de Renshaw T, Nadesan P, Nakagawa M, Seesankar G, et al. Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation. Cell Rep. 2023;42:112578 pubmed publisher
Zhang H, Wang J, Prakash J, Zhang Z, Kaul S, Wadhwa R. Three-Way Cell-Based Screening of Antistress Compounds: Identification, Validation, and Relevance to Old-Age-Related Pathologies. J Gerontol A Biol Sci Med Sci. 2023;78:1569-1577 pubmed publisher
Cheng Y, Li J, Zhang X, Li Y, Shi X, Shi R, et al. Protective Effect of Qingchang Wenzhong Decoction on Colitis and Colitis-Related Carcinogenesis by Regulating Inflammation and Intestinal Fibrosis. J Inflamm Res. 2023;16:1479-1495 pubmed publisher
Shin J, Nunomiya A, Gonda K, Nagatomi R. Specification of skeletal muscle fiber-type is determined by the calcineurin/NFATc1 signaling pathway during muscle regeneration. Biochem Biophys Res Commun. 2023;659:20-28 pubmed publisher
Okuda C, Ueda Y, Muroi M, Sanada E, Osada H, Shiono Y, et al. Allantopyrone A interferes with the degradation of hypoxia-inducible factor 1α protein by reducing proteasome activity in human fibrosarcoma HT-1080 cells. J Antibiot (Tokyo). 2023;76:324-334 pubmed publisher
Lerma Clavero A, Boqvist P, Ingelshed K, Bosdotter C, Sedimbi S, Jiang L, et al. MDM2 inhibitors, nutlin-3a and navtemadelin, retain efficacy in human and mouse cancer cells cultured in hypoxia. Sci Rep. 2023;13:4583 pubmed publisher
Zuo Q, Yang Y, Lyu Y, Yang C, Chen C, Salman S, et al. Plexin-B3 expression stimulates MET signaling, breast cancer stem cell specification, and lung metastasis. Cell Rep. 2023;42:112164 pubmed publisher
Seike K, Kiledal A, Fujiwara H, Henig I, Burgos da Silva M, van den Brink M, et al. Ambient oxygen levels regulate intestinal dysbiosis and GVHD severity after allogeneic stem cell transplantation. Immunity. 2023;56:353-368.e6 pubmed publisher
Maki T, Sawahata M, Uta D, Irie K, Kume T. Chronic Treatment with Aβ42 with a Toxic Conformer and LPS Induces Inflammatory Responses in BV-2 Microglia with Dysregulation of Hypoxia-Inducible Factor Expression. Biol Pharm Bull. 2023;46:359-363 pubmed publisher
Silwal P, Kim Y, Lee Y, Kim I, Jeon S, Roh T, et al. Chemical mimetics of the N-degron pathway alleviate systemic inflammation by activating mitophagy and immunometabolic remodeling. Exp Mol Med. 2023;55:333-346 pubmed publisher
Karreman M, Bauer A, Solecki G, Berghoff A, Mayer C, Frey K, et al. Active Remodeling of Capillary Endothelium via Cancer Cell-Derived MMP9 Promotes Metastatic Brain Colonization. Cancer Res. 2023;83:1299-1314 pubmed publisher
Chen Z, Bordieanu B, Kesavan R, Lesner N, Venigalla S, Shelton S, et al. Lactate metabolism is essential in early-onset mitochondrial myopathy. Sci Adv. 2023;9:eadd3216 pubmed publisher
Stobart J, Erlebach E, Gl xfc ck C, Huang S, Barrett M, Li M, et al. Altered hemodynamics and vascular reactivity in a mouse model with severe pericyte deficiency. J Cereb Blood Flow Metab. 2023;43:763-777 pubmed publisher
Chen Y, Zhang S, Ye L, Chen H, Yu L, Wu D. An Acute Bout of Exercise Suppresses Appetite via Central Lactate Metabolism. Neuroscience. 2023;510:49-59 pubmed publisher
Bao S, Chen Z, Qin D, Xu H, Deng X, Zhang R, et al. Single-cell profiling reveals mechanisms of uncontrolled inflammation and glycolysis in decidual stromal cell subtypes in recurrent miscarriage. Hum Reprod. 2023;38:57-74 pubmed publisher
Saha D, Mitra D, Alam N, Sen S, Mustafi S, Majumder P, et al. Lupeol and Paclitaxel cooperate in hindering hypoxia induced vasculogenic mimicry via suppression of HIF-1α-EphA2-Laminin-5γ2 network in human oral cancer. J Cell Commun Signal. 2023;17:591-608 pubmed publisher
Kostyuk S, Ershova E, Martynov A, Artyushin A, Porokhovnik L, Malinovskaya E, et al. In Vitro Analysis of Biological Activity of Circulating Cell-Free DNA Isolated from Blood Plasma of Schizophrenic Patients and Healthy Controls-Part 2: Adaptive Response. Genes (Basel). 2022;13: pubmed publisher
Yang Y, Chen C, Zuo Q, Lu H, Salman S, Lyu Y, et al. NARF is a hypoxia-induced coactivator for OCT4-mediated breast cancer stem cell specification. Sci Adv. 2022;8:eabo5000 pubmed publisher
Chidlow G, Chan W, Wood J, Casson R. Investigations into photoreceptor energy metabolism during experimental retinal detachment. Front Cell Neurosci. 2022;16:1036834 pubmed publisher
Kim D, Khin P, Lim O, Jun H. LPA/LPAR1 signaling induces PGAM1 expression via AKT/mTOR/HIF-1α pathway and increases aerobic glycolysis, contributing to keratinocyte proliferation. Life Sci. 2022;311:121201 pubmed publisher
Maki T, Sawahata M, Akutsu I, Amaike S, Hiramatsu G, Uta D, et al. APP Knock-In Mice Produce E22P-Aβ Exhibiting an Alzheimer's Disease-like Phenotype with Dysregulation of Hypoxia-Inducible Factor Expression. Int J Mol Sci. 2022;23: pubmed publisher
Yegen C, Haine L, Da Costa Ferreira K, Marchant D, Bernaudin J, Plan xe8 s C, et al. A New Model of Acute Exacerbation of Experimental Pulmonary Fibrosis in Mice. Cells. 2022;11: pubmed publisher
Qian L, Rawashdeh O, Kasas L, Milne M, Garner N, Sankorrakul K, et al. Cholinergic basal forebrain degeneration due to sleep-disordered breathing exacerbates pathology in a mouse model of Alzheimer's disease. Nat Commun. 2022;13:6543 pubmed publisher
Yerlikaya E, Toro A, Sunilkumar S, VanCleave A, Leung M, Kawasawa Y, et al. Spleen Tyrosine Kinase Contributes to Müller Glial Expression of Proangiogenic Cytokines in Diabetes. Invest Ophthalmol Vis Sci. 2022;63:25 pubmed publisher
Yin L, Zhang J, Sun Y. Early growth response-1 is a new substrate of the GSK3β-FBXW7 axis. Neoplasia. 2022;34:100839 pubmed publisher
Martinez C, Jiramongkol Y, Bal N, Alwis I, Nedoboy P, Farnham M, et al. Intermittent hypoxia enhances the expression of hypoxia inducible factor HIF1A through histone demethylation. J Biol Chem. 2022;298:102536 pubmed publisher
Wang X, Jia Y, Zhao J, Lesner N, Menezes C, Shelton S, et al. A mitofusin 2/HIF1α axis sets a maturation checkpoint in regenerating skeletal muscle. J Clin Invest. 2022;132: pubmed publisher
Soler Agesta R, Marco Brualla J, Minj xe1 rez S xe1 enz M, Yim C, Mart xed nez J xfa lvez M, Price M, et al. PT-112 Induces Mitochondrial Stress and Immunogenic Cell Death, Targeting Tumor Cells with Mitochondrial Deficiencies. Cancers (Basel). 2022;14: pubmed publisher
Simmler P, Cortijo C, Koch L, Galliker P, Angori S, Bolck H, et al. SF3B1 facilitates HIF1-signaling and promotes malignancy in pancreatic cancer. Cell Rep. 2022;40:111266 pubmed publisher
Chen J, Tang T, Cao J, Li Z, Zhong X, Wen Y, et al. KIM-1 augments hypoxia-induced tubulointerstitial inflammation through uptake of small extracellular vesicles by tubular epithelial cells. Mol Ther. 2022;: pubmed publisher
Chang Y, Vuong C, Ngo N, Yamashita T, Ye X, Futamura Y, et al. Extracellular vesicles derived from Wharton's Jelly mesenchymal stem cells inhibit the tumor environment via the miR-125b/HIF1α signaling pathway. Sci Rep. 2022;12:13550 pubmed publisher
Wang H, Wang X, Ma L, Huang X, Peng Y, Huang H, et al. PGC-1 alpha regulates mitochondrial biogenesis to ameliorate hypoxia-inhibited cementoblast mineralization. Ann N Y Acad Sci. 2022;1516:300-311 pubmed publisher
Takiyama T, Sera T, Nakamura M, Hoshino M, Uesugi K, Horike S, et al. A maternal high-fat diet induces fetal origins of NASH-HCC in mice. Sci Rep. 2022;12:13136 pubmed publisher
Li G, Li D, Wu C, Li S, Chen F, Li P, et al. Homocysteine-targeting compounds as a new treatment strategy for diabetic wounds via inhibition of the histone methyltransferase SET7/9. Exp Mol Med. 2022;54:988-998 pubmed publisher
Ollonen T, Kurkela M, Laitakari A, Sakko S, Koivisto H, Myllyharju J, et al. Activation of the hypoxia response protects mice from amyloid-β accumulation. Cell Mol Life Sci. 2022;79:432 pubmed publisher
Gertsenshteyn I, Epel B, Ahluwalia A, Kim H, Fan X, Barth E, et al. The optimal 18F-fluoromisonidazole PET threshold to define tumor hypoxia in preclinical squamous cell carcinomas using pO2 electron paramagnetic resonance imaging as reference truth. Eur J Nucl Med Mol Imaging. 2022;49:4014-4024 pubmed publisher
Tapio J, Halmetoja R, Dimova E, M xe4 ki J, Laitala A, Walkinshaw G, et al. Contribution of HIF-P4H isoenzyme inhibition to metabolism indicates major beneficial effects being conveyed by HIF-P4H-2 antagonism. J Biol Chem. 2022;298:102222 pubmed publisher
Chen M, Hu R, Cavinato C, Zhuang Z, Zhang J, Yun S, et al. Fibronectin-Integrin α5 Signaling in Vascular Complications of Type 1 Diabetes. Diabetes. 2022;71:2020-2033 pubmed publisher
Li S, Li W, Yuan J, Bullova P, Wu J, Zhang X, et al. Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome. Nat Metab. 2022;4:739-758 pubmed publisher
Tang X, Cui K, Lu X, Wu P, Yu S, Yang B, et al. A Novel Hypoxia-inducible Factor 1α Inhibitor KC7F2 Attenuates Oxygen-induced Retinal Neovascularization. Invest Ophthalmol Vis Sci. 2022;63:13 pubmed publisher
Zhang W, Gong P, Tian Q, Han S, Wang J, He P, et al. The eIF4A Inhibitor Silvestrol Blocks the Growth of Human Glioblastoma Cells by Inhibiting AKT/mTOR and ERK1/2 Signaling Pathway. J Oncol. 2022;2022:4396316 pubmed publisher
Mirchandani A, Jenkins S, Bain C, Sánchez García M, Lawson H, Coelho P, et al. Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation. Nat Immunol. 2022;23:927-939 pubmed publisher
Burda J, O Shea T, Ao Y, Suresh K, Wang S, Bernstein A, et al. Divergent transcriptional regulation of astrocyte reactivity across disorders. Nature. 2022;606:557-564 pubmed publisher
Zhang R, Tiedemann K, Muthu M, Dinesh N, Komarova S, Ramkhelawon B, et al. Fibrillin-1-regulated miR-122 has a critical role in thoracic aortic aneurysm formation. Cell Mol Life Sci. 2022;79:314 pubmed publisher
Baran N, Lodi A, Dhungana Y, Herbrich S, Collins M, Sweeney S, et al. Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia. Nat Commun. 2022;13:2801 pubmed publisher
Mart xed nez Torres I, Tepale Segura A, Castro Escamilla O, Cancino Diaz J, Rodr xed guez Mart xed nez S, Pérez Tapia S, et al. The Protective Role of pVHL in Imiquimod-Induced Psoriasis-like Skin Inflammation. Int J Mol Sci. 2022;23: pubmed publisher
S A F, K S C, L D, M G, S P, R L L, et al. Engineering Vascularized Islet Macroencapsulation Devices: An in vitro Platform to Study Oxygen Transport in Perfused Immobilized Pancreatic Beta Cell Cultures. Front Bioeng Biotechnol. 2022;10:884071 pubmed publisher
Salman S, Meyers D, Wicks E, Lee S, Datan E, Thomas A, et al. HIF inhibitor 32-134D eradicates murine hepatocellular carcinoma in combination with anti-PD1 therapy. J Clin Invest. 2022;132: pubmed publisher
Leigh T, Kawai T, Preston K, Kelemen S, Okune R, St Paul A, et al. Deletion of LDLRAP1 Induces Atherosclerotic Plaque Formation, Insulin Resistance, and Dysregulated Insulin Response in Adipose Tissue. Am J Pathol. 2022;192:1092-1108 pubmed publisher
Wu X, Chen J, Liu C, Wang X, Zhou H, Mai K, et al. Slc38a9 Deficiency Induces Apoptosis and Metabolic Dysregulation and Leads to Premature Death in Zebrafish. Int J Mol Sci. 2022;23: pubmed publisher
Xu Z, Wang C, He Y, Mao X, Zhang M, Hou Y, et al. Hypoxia-inducible factor protects against acute kidney injury via the Wnt/β-catenin signaling pathway. Am J Physiol Renal Physiol. 2022;322:F611-F624 pubmed publisher
Kirschner K, Kelterborn S, Stehr H, Penzlin J, Jacobi C, Endesfelder S, et al. Adaptation of the Oxygen Sensing System during Lung Development. Oxid Med Cell Longev. 2022;2022:9714669 pubmed publisher
Jatho A, Zieseniss A, Brechtel Curth K, Guo J, Böker K, Salinas G, et al. The HIFα-Stabilizing Drug Roxadustat Increases the Number of Renal Epo-Producing Sca-1+ Cells. Cells. 2022;11: pubmed publisher
Zheng X, Narayanan S, Xu C, Eliasson Angelstig S, Gr xfc nler J, Zhao A, et al. Repression of hypoxia-inducible factor-1 contributes to increased mitochondrial reactive oxygen species production in diabetes. elife. 2022;11: pubmed publisher
Snyder B, Wu H, Tillman B, Floyd T. Aged Mouse Hippocampus Exhibits Signs of Chronic Hypoxia and an Impaired HIF-Controlled Response to Acute Hypoxic Exposures. Cells. 2022;11: pubmed publisher
Yang Y, Lu H, Chen C, Lyu Y, Cole R, Semenza G. HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia. Nat Commun. 2022;13:316 pubmed publisher
Krzywinska E, Sobecki M, Nagarajan S, Zacharjasz J, Tambuwala M, Pelletier A, et al. The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut. J Exp Med. 2022;219: pubmed publisher
Elamaa H, Kaakinen M, N xe4 tynki M, Szabo Z, Ronkainen V, xc4 ij xe4 l xe4 V, et al. PHD2 deletion in endothelial or arterial smooth muscle cells reveals vascular cell type-specific responses in pulmonary hypertension and fibrosis. Angiogenesis. 2022;25:259-274 pubmed publisher
Michon S, Rodier F, Yu F. Targeted Anti-Cancer Provascular Therapy Using Ultrasound, Microbubbles, and Nitrite to Increase Radiotherapy Efficacy. Bioconjug Chem. 2022;33:1093-1105 pubmed publisher
Röning T, Magga J, Laitakari A, Halmetoja R, Tapio J, Dimova E, et al. Activation of the hypoxia response pathway protects against age-induced cardiac hypertrophy. J Mol Cell Cardiol. 2022;164:148-155 pubmed publisher
Ali F, Mohammed H, Elroby Ali D. Protective effect of hydrogen sulfide against stress-induced lung injury: involvement of Nrf2, NFκB/iNOS, and HIF-1α signaling pathways. Cell Stress Chaperones. 2022;27:55-70 pubmed publisher
Borella R, De Biasi S, Paolini A, Boraldi F, Lo Tartaro D, Mattioli M, et al. Metabolic reprograming shapes neutrophil functions in severe COVID-19. Eur J Immunol. 2022;52:484-502 pubmed publisher
Angeles C, Velez A, Rios J, Laxa B, Shum D, Ruiz P, et al. A High-Content Screen for C/EBPα Expression Identifies Novel Therapeutic Agents in Dedifferentiated Liposarcoma. Clin Cancer Res. 2022;28:175-186 pubmed publisher
Foglia B, Sutti S, Cannito S, Rosso C, Maggiora M, Autelli R, et al. Hepatocyte-Specific Deletion of HIF2α Prevents NASH-Related Liver Carcinogenesis by Decreasing Cancer Cell Proliferation. Cell Mol Gastroenterol Hepatol. 2022;13:459-482 pubmed publisher
Liu Y, Gu Y, Ng S, Deng Z, Lyon C, Koay E, et al. Circulating levels of hydroxylated bradykinin function as an indicator of tissue HIF-1α expression. Sci Bull (Beijing). 2020;65:1570-1579 pubmed publisher
Te Boekhorst V, Jiang L, Mählen M, Meerlo M, Dunkel G, Durst F, et al. Calpain-2 regulates hypoxia/HIF-induced plasticity toward amoeboid cancer cell migration and metastasis. Curr Biol. 2021;: pubmed publisher
Suwa T, Kobayashi M, Shirai Y, Nam J, Tabuchi Y, Takeda N, et al. SPINK1 as a plasma marker for tumor hypoxia and a therapeutic target for radiosensitization. JCI Insight. 2021;6: pubmed publisher
Wang J, Zhang H, Kaul A, Li K, Priyandoko D, Kaul S, et al. Effect of Ashwagandha Withanolides on Muscle Cell Differentiation. Biomolecules. 2021;11: pubmed publisher
Kumar A, Vaish M, Karuppagounder S, Gazaryan I, Cave J, Starkov A, et al. HIF1α stabilization in hypoxia is not oxidant-initiated. elife. 2021;10: pubmed publisher
Lu H, Lyu Y, Tran L, Lan J, Xie Y, Yang Y, et al. HIF-1 recruits NANOG as a coactivator for TERT gene transcription in hypoxic breast cancer stem cells. Cell Rep. 2021;36:109757 pubmed publisher
Pang L, Ng K, Liu J, Yeung W, Zhu J, Chiu T, et al. Plasmacytoid dendritic cells recruited by HIF-1α/eADO/ADORA1 signaling induce immunosuppression in hepatocellular carcinoma. Cancer Lett. 2021;522:80-92 pubmed publisher
Wakefield Z, Tanaka M, Pampo C, Lepler S, Rice L, Guingab Cagmat J, et al. Normal tissue and tumor microenvironment adaptations to aerobic exercise enhance doxorubicin anti-tumor efficacy and ameliorate its cardiotoxicity in retired breeder mice. Oncotarget. 2021;12:1737-1748 pubmed publisher
Sun G, Chen J, Liang J, Yin X, Zhang M, Yao J, et al. Integrated exome and RNA sequencing of TFE3-translocation renal cell carcinoma. Nat Commun. 2021;12:5262 pubmed publisher
Sun D, Lu F, Sheldon A, Jiang X, Ferriero D. Neuronal deficiency of hypoxia-inducible factor 2α increases hypoxic-ischemic brain injury in neonatal mice. J Neurosci Res. 2021;99:2964-2975 pubmed publisher
Jeny F, Bernaudin J, Valeyre D, Kambouchner M, Pretolani M, Nunes H, et al. Hypoxia Promotes a Mixed Inflammatory-Fibrotic Macrophages Phenotype in Active Sarcoidosis. Front Immunol. 2021;12:719009 pubmed publisher
Helena J, Joubert A, Mabeta P, Coetzee M, Lakier R, Mercier A. Intracellular Signaling Responses Induced by Radiation within an In Vitro Bone Metastasis Model after Pre-Treatment with an Estrone Analogue. Cells. 2021;10: pubmed publisher
Wang J, Liu R, Wang Y, Mo H, Niu Y, Xu Q, et al. Repression of the miR-627-5p by histone deacetylase 3 contributes to hypoxia-induced hepatocellular carcinoma progression. J Cancer. 2021;12:5320-5330 pubmed publisher
Nanduri J, Wang N, Wang B, Prabhakar N. Lysine demethylase KDM6B regulates HIF-1α mediated systemic and cellular responses to intermittent hypoxia. Physiol Genomics. 2021;: pubmed publisher
Ju S, Lim L, Wi K, Park C, Ki Y, Choi D, et al. LRP5 Regulates HIF-1α Stability via Interaction with PHD2 in Ischemic Myocardium. Int J Mol Sci. 2021;22: pubmed publisher
Williams A, Walton C, Pinell B, Khadka V, Dunn B, Lee K, et al. Ischemic heart injury leads to HIF1-dependent differential splicing of CaMK2γ. Sci Rep. 2021;11:13116 pubmed publisher
Simmen S, Maane M, Rogler S, Baebler K, Lang S, Cosin Roger J, et al. Hypoxia Reduces the Transcription of Fibrotic Markers in the Intestinal Mucosa. Inflamm Intest Dis. 2021;6:87-100 pubmed publisher
Grubman A, Choo X, Chew G, Ouyang J, Sun G, Croft N, et al. Transcriptional signature in microglia associated with Aβ plaque phagocytosis. Nat Commun. 2021;12:3015 pubmed publisher
Bae W, Choi J, Nam S, Jeong J. β-arrestin 2 stimulates degradation of HIF-1α and modulates tumor progression of glioblastoma. Cell Death Differ. 2021;28:3092-3104 pubmed publisher
Silwal P, Kim J, Jeon S, Lee J, Kim Y, Kim Y, et al. Mitofusin-2 boosts innate immunity through the maintenance of aerobic glycolysis and activation of xenophagy in mice. Commun Biol. 2021;4:548 pubmed publisher
Wang R, Godet I, Yang Y, Salman S, Lu H, Lyu Y, et al. Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Kuwano A, Kurokawa M, Kohjima M, Imoto K, Tashiro S, Suzuki H, et al. Microcirculatory disturbance in acute liver injury. Exp Ther Med. 2021;21:596 pubmed publisher
Xue Y, Wang S, Rana P, West E, Hong C, Feng H, et al. AAV-Txnip prolongs cone survival and vision in mouse models of retinitis pigmentosa. elife. 2021;10: pubmed publisher
Ertle C, Rommel F, Tumala S, Moriwaki Y, Klein J, Kruse J, et al. New Pathways for the Skin's Stress Response: The Cholinergic Neuropeptide SLURP-1 Can Activate Mast Cells and Alter Cytokine Production in Mice. Front Immunol. 2021;12:631881 pubmed publisher
Pantazopoulou V, Jeannot P, Rosberg R, Berg T, Pietras A. Hypoxia-Induced Reactivity of Tumor-Associated Astrocytes Affects Glioma Cell Properties. Cells. 2021;10: pubmed publisher
Yano M, Miyazawa M, Ogane N, Ogasawara A, Hasegawa K, Narahara H, et al. Up-regulation of HDAC6 Results in Poor Prognosis and Chemoresistance in Patients With Advanced Ovarian High-grade Serous Carcinoma. Anticancer Res. 2021;41:1647-1654 pubmed publisher
Hutami I, Izawa T, Khurel Ochir T, Sakamaki T, Iwasa A, Tomita S, et al. HIF-1α controls palatal wound healing by regulating macrophage motility via S1P/S1P1 signaling axis. Oral Dis. 2021;: pubmed publisher
Khuu M, Nallamothu T, Castro Rivera C, Arias Cavieres A, Szujewski C, Garcia Iii A. Stage-dependent effects of intermittent hypoxia influence the outcome of hippocampal adult neurogenesis. Sci Rep. 2021;11:6005 pubmed publisher
Menendez Montes I, Escobar B, Gómez M, Albendea Gomez T, Palacios B, Bonzon Kulichenko E, et al. Activation of amino acid metabolic program in cardiac HIF1-alpha-deficient mice. iScience. 2021;24:102124 pubmed publisher
Akyüz E, Doğanyiğit Z, Eroglu E, Moscovicz F, Merelli A, Lazarowski A, et al. Myocardial Iron Overload in an Experimental Model of Sudden Unexpected Death in Epilepsy. Front Neurol. 2021;12:609236 pubmed publisher
Plastino F, Santana Garrido Á, Pesce N, Aronsson M, Lardner E, Mate A, et al. Echinomycin mitigates ocular angiogenesis by transcriptional inhibition of the hypoxia-inducible factor-1. Exp Eye Res. 2021;206:108518 pubmed publisher
Tanimura A, Nakazato A, Tanaka N. MYD88 signals induce tumour-initiating cell generation through the NF-κB-HIF-1α activation cascade. Sci Rep. 2021;11:3991 pubmed publisher
Chung Y, Swietach P, Curtis M, Ball V, Robbins P, Lakhal Littleton S. Iron-Deficiency Anemia Results in Transcriptional and Metabolic Remodeling in the Heart Toward a Glycolytic Phenotype. Front Cardiovasc Med. 2020;7:616920 pubmed publisher
Pesce N, Canovai A, Lardner E, Cammalleri M, Kvanta A, André H, et al. Autophagy Involvement in the Postnatal Development of the Rat Retina. Cells. 2021;10: pubmed publisher
Goggins B, Minahan K, Sherwin S, Soh W, Pryor J, Bruce J, et al. Pharmacological HIF-1 stabilization promotes intestinal epithelial healing through regulation of α-integrin expression and function. Am J Physiol Gastrointest Liver Physiol. 2021;320:G420-G438 pubmed publisher
Markolin P, Davidson N, Hirt C, Chabbert C, Zamboni N, Schwank G, et al. Identification of HIF-dependent alternative splicing in gastrointestinal cancers and characterization of a long, coding isoform of SLC35A3. Genomics. 2021;113:515-529 pubmed publisher
Tran C, Gold M, Garcia Batres C, Tai K, Elford A, Himmel M, et al. Hypoxia-inducible factor 1 alpha limits dendritic cell stimulation of CD8 T cell immunity. PLoS ONE. 2020;15:e0244366 pubmed publisher
Pelaz S, Jaraíz Rodríguez M, Álvarez Vázquez A, Talaverón R, García Vicente L, Flores Hernández R, et al. Targeting metabolic plasticity in glioma stem cells in vitro and in vivo through specific inhibition of c-Src by TAT-Cx43266-283. EBioMedicine. 2020;62:103134 pubmed publisher
Almeida L, Dhillon LaBrooy A, Castro C, Adossa N, Carriche G, Guderian M, et al. Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis. Immunity. 2021;54:68-83.e6 pubmed publisher
Gomez Lado N, López Arias E, Iglesias Rey R, Díaz Platas L, Medín Aguerre S, Fernández Ferreiro A, et al. [18F]-FMISO PET/MRI Imaging Shows Ischemic Tissue around Hematoma in Intracerebral Hemorrhage. Mol Pharm. 2020;17:4667-4675 pubmed publisher
Zhang Y, Yan X, Xu S, Pang Z, Li L, Yang Y, et al. α-Lipoic Acid Maintains Brain Glucose Metabolism via BDNF/TrkB/HIF-1α Signaling Pathway in P301S Mice. Front Aging Neurosci. 2020;12:262 pubmed publisher
Yang X, Zhong D, Gao W, Liao Z, Chen Y, Zhang S, et al. Conditional ablation of MAPK7 expression in chondrocytes impairs endochondral bone formation in limbs and adaptation of chondrocytes to hypoxia. Cell Biosci. 2020;10:103 pubmed publisher
Patel U, Pandey M, Kannan S, Samant T, Gera P, Mittal N, et al. Prognostic and predictive significance of nuclear HIF1α expression in locally advanced HNSCC patients treated with chemoradiation with or without nimotuzumab. Br J Cancer. 2020;123:1757-1766 pubmed publisher
Wang N, Shi X, Khan S, Wang B, Semenza G, Prabhakar N, et al. Hypoxia-inducible factor-1 mediates pancreatic β-cell dysfunction by intermittent hypoxia. Am J Physiol Cell Physiol. 2020;319:C922-C932 pubmed publisher
Kim C, Ding X, Allmeroth K, Biggs L, Kolenc O, L Hoest N, et al. Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle. Cell Metab. 2020;32:629-642.e8 pubmed publisher
Samanta D, Huang T, Shah R, Yang Y, Pan F, Semenza G. BIRC2 Expression Impairs Anti-Cancer Immunity and Immunotherapy Efficacy. Cell Rep. 2020;32:108073 pubmed publisher
Thomas A, Samykutty A, Gomez Gutierrez J, Yin W, Egger M, McNally M, et al. Actively Targeted Nanodelivery of Echinomycin Induces Autophagy-Mediated Death in Chemoresistant Pancreatic Cancer In Vivo. Cancers (Basel). 2020;12: pubmed publisher
Huang B, Liu Y, Lai S, Lin H, Shen C, Yang L, et al. CAIX Regulates GBM Motility and TAM Adhesion and Polarization through EGFR/STAT3 under Hypoxic Conditions. Int J Mol Sci. 2020;21: pubmed publisher
Babetto E, Wong K, Beirowski B. A glycolytic shift in Schwann cells supports injured axons. Nat Neurosci. 2020;: pubmed publisher
Hoefflin R, Harlander S, Schäfer S, Metzger P, Kuo F, Schönenberger D, et al. HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice. Nat Commun. 2020;11:4111 pubmed publisher
Tiwari A, Tashiro K, Dixit A, Soni A, Vogel K, Hall B, et al. Loss of HIF1A From Pancreatic Cancer Cells Increases Expression of PPP1R1B and Degradation of p53 to Promote Invasion and Metastasis. Gastroenterology. 2020;159:1882-1897.e5 pubmed publisher
Ye Y, Chen Y, Sun J, Zhang H, Meng Y, Li W, et al. Hyperglycemia suppresses the regulatory effect of hypoxia-inducible factor-1α in pulmonary Aspergillus fumigatus infection. Pathog Dis. 2020;78: pubmed publisher
Ma J, Stefanoska D, Stone L, Hildebrand M, van Donkelaar C, Zou X, et al. Hypoxic stress enhances extension and branching of dorsal root ganglion neuronal outgrowth. JOR Spine. 2020;3:e1090 pubmed publisher
Shen Y, Wang X, Lu J, Salfenmoser M, Wirsik N, Schleussner N, et al. Reduction of Liver Metastasis Stiffness Improves Response to Bevacizumab in Metastatic Colorectal Cancer. Cancer Cell. 2020;37:800-817.e7 pubmed publisher
Lourenssen S, Blennerhassett M. M2 Macrophages and Phenotypic Modulation of Intestinal Smooth Muscle Cells Characterize Inflammatory Stricture Formation in Rats. Am J Pathol. 2020;190:1843-1858 pubmed publisher
Tran M, Bibby B, Yang L, Lo F, Warren A, Shukla D, et al. Independence of HIF1a and androgen signaling pathways in prostate cancer. BMC Cancer. 2020;20:469 pubmed publisher
Lu H, Xie Y, Tran L, Lan J, Yang Y, Murugan N, et al. Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness. J Clin Invest. 2020;: pubmed publisher
Simanjuntak Y, Ko H, Lee Y, Yu G, Lin Y. Preventive effects of folic acid on Zika virus-associated poor pregnancy outcomes in immunocompromised mice. PLoS Pathog. 2020;16:e1008521 pubmed publisher
Casciello F, Al Ejeh F, Miranda M, Kelly G, Baxter E, Windloch K, et al. G9a-mediated repression of CDH10 in hypoxia enhances breast tumour cell motility and associates with poor survival outcome. Theranostics. 2020;10:4515-4529 pubmed publisher
Park K, Han J, Kim S, Lim Y. Gamma-Aminobutyric Acid Increases Erythropoietin by Activation of Citrate Cycle and Stimulation of Hypoxia-Inducible Factors Expression in Rats. Biomolecules. 2020;10: pubmed publisher
Fu C, An N, Liu J, A J, Zhang B, Liu M, et al. The transcription factor ZFHX3 is crucial for the angiogenic function of hypoxia-inducible factor 1α in liver cancer cells. J Biol Chem. 2020;295:7060-7074 pubmed publisher
Sharma M, Boytard L, Hadi T, Koelwyn G, Simon R, Ouimet M, et al. Enhanced glycolysis and HIF-1α activation in adipose tissue macrophages sustains local and systemic interleukin-1β production in obesity. Sci Rep. 2020;10:5555 pubmed publisher
Grassi E, Pantazopoulou V, Pietras A. Hypoxia-induced release, nuclear translocation, and signaling activity of a DLK1 intracellular fragment in glioma. Oncogene. 2020;39:4028-4044 pubmed publisher
Fitzpatrick S, Lambden S, Macías D, Puthucheary Z, Pietsch S, Mendil L, et al. 2-Hydroxyglutarate Metabolism Is Altered in an in vivo Model of LPS Induced Endotoxemia. Front Physiol. 2020;11:147 pubmed publisher
Ukeba D, Sudo H, Tsujimoto T, Ura K, Yamada K, Iwasaki N. Bone marrow mesenchymal stem cells combined with ultra-purified alginate gel as a regenerative therapeutic strategy after discectomy for degenerated intervertebral discs. EBioMedicine. 2020;53:102698 pubmed publisher
Rahman M, Cumming B, Addicott K, Pacl H, Russell S, Nargan K, et al. Hydrogen sulfide dysregulates the immune response by suppressing central carbon metabolism to promote tuberculosis. Proc Natl Acad Sci U S A. 2020;117:6663-6674 pubmed publisher
Laitakari A, Huttunen R, Kuvaja P, Hannuksela P, Szabo Z, Heikkilä M, et al. Systemic long-term inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 ameliorates aging-induced changes in mice without affecting their life span. FASEB J. 2020;34:5590-5609 pubmed publisher
Ajime T, Serré J, Wüst R, Messa G, Poffé C, Swaminathan A, et al. Two weeks smoking cessation reverses cigarette smoke-induced skeletal muscle atrophy and mitochondrial dysfunction in mice. Nicotine Tob Res. 2020;: pubmed publisher
Klee K, Storti F, Maggi J, Todorova V, Karademir D, Berger W, et al. The Expression of Decidual Protein Induced by Progesterone (DEPP) is Controlled by Three Distal Consensus Hypoxia Responsive Element (HRE) in Hypoxic Retinal Epithelial Cells. Genes (Basel). 2020;11: pubmed publisher
Roelants C, Pillet C, Franquet Q, Sarrazin C, Peilleron N, Giacosa S, et al. Ex-Vivo Treatment of Tumor Tissue Slices as a Predictive Preclinical Method to Evaluate Targeted Therapies for Patients with Renal Carcinoma. Cancers (Basel). 2020;12: pubmed publisher
Fine J, Kosyakovsky J, Baillargeon A, Tokarev J, Cooner J, Svitak A, et al. Intranasal deferoxamine can improve memory in healthy C57 mice, suggesting a partially non-disease-specific pathway of functional neurologic improvement. Brain Behav. 2020;10:e01536 pubmed publisher
Persson C, von Stedingk K, Fredlund E, Bexell D, Påhlman S, Wigerup C, et al. ARNT-dependent HIF-2 transcriptional activity is not sufficient to regulate downstream target genes in neuroblastoma. Exp Cell Res. 2020;388:111845 pubmed publisher
Chen X, Wu B, Wang S, Liu J, Gao H, Zhou F, et al. Hypoxia: involved but not essential for endometrial breakdown in mouse menstural-like model. Reproduction. 2020;159:133-144 pubmed publisher
Cannito S, Foglia B, Villano G, Turato C, Delgado T, Morello E, et al. SerpinB3 Differently Up-Regulates Hypoxia Inducible Factors -1α and -2α in Hepatocellular Carcinoma: Mechanisms Revealing Novel Potential Therapeutic Targets. Cancers (Basel). 2019;11: pubmed publisher
Chavdoula E, Habiel D, Roupakia E, Markopoulos G, Vasilaki E, Kokkalis A, et al. CHUK/IKK-α loss in lung epithelial cells enhances NSCLC growth associated with HIF up-regulation. Life Sci Alliance. 2019;2: pubmed publisher
Kim Y, Hwang S, Khalmuratova R, Kang S, Lee M, Song Y, et al. α-Helical cell-penetrating peptide-mediated nasal delivery of resveratrol for inhibition of epithelial-to-mesenchymal transition. J Control Release. 2020;317:181-194 pubmed publisher
Liou A, Liao C, Chou S, Chang Y, Chang C, Shih C. Hypoxia and therapeutic treatment of EV-A71 with an immune modulator TLR7 agonist in a new immunocompetent mouse model. J Biomed Sci. 2019;26:93 pubmed publisher
Lin Y, Huang S, Wu J, Chu T, Huang S, Lee C, et al. Novel HDGF/HIF-1α/VEGF axis in oral cancer impacts disease prognosis. BMC Cancer. 2019;19:1083 pubmed publisher
Oliynyk G, Ruiz Pérez M, Sainero Alcolado L, Dzieran J, Zirath H, Gallart Ayala H, et al. MYCN-enhanced Oxidative and Glycolytic Metabolism Reveals Vulnerabilities for Targeting Neuroblastoma. iScience. 2019;21:188-204 pubmed publisher
Valle Tenney R, Rebolledo D, Lipson K, Brandan E. Role of hypoxia in skeletal muscle fibrosis: Synergism between hypoxia and TGF-β signaling upregulates CCN2/CTGF expression specifically in muscle fibers. Matrix Biol. 2020;87:48-65 pubmed publisher
Komabayashi Suzuki M, Yamanishi E, Watanabe C, Okamura M, Tabata H, Iwai R, et al. Spatiotemporally Dependent Vascularization Is Differently Utilized among Neural Progenitor Subtypes during Neocortical Development. Cell Rep. 2019;29:1113-1129.e5 pubmed publisher
Gong L, Pan X, Abali G, Little J, Yuan Z. Functional interplay between p53 and Δ133p53 in adaptive stress response. Cell Death Differ. 2020;27:1618-1632 pubmed publisher
Sampurno S, Chittleborough T, Carpinteri S, Hiller J, Heriot A, Lynch A, et al. Modes of carbon dioxide delivery during laparoscopy generate distinct differences in peritoneal damage and hypoxia in a porcine model. Surg Endosc. 2019;: pubmed publisher
Mahiddine K, Blaisdell A, Ma S, Créquer Grandhomme A, Lowell C, Erlebacher A. Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils. J Clin Invest. 2020;130:389-403 pubmed publisher
Bobek J, Oralová V, Kratochvilova A, Zvackova I, Lesot H, Matalova E. Tuftelin and HIFs expression in osteogenesis. Histochem Cell Biol. 2019;152:355-363 pubmed publisher
Kataria N, Martinez C, Kerr B, Zaiter S, Morgan M, McAlpine S, et al. C-Terminal HSP90 Inhibitors Block the HIF-1 Hypoxic Response by Degrading HIF-1α through the Oxygen-Dependent Degradation Pathway. Cell Physiol Biochem. 2019;53:480-495 pubmed publisher
Chau K, Bobek G, Xu B, Stait Gardner T, Price W, Hennessy A, et al. Effect of placental growth factor in models of experimental pre-eclampsia and trophoblast invasion. Clin Exp Pharmacol Physiol. 2019;: pubmed publisher
Yekelchyk M, Guenther S, Preussner J, Braun T. Mono- and multi-nucleated ventricular cardiomyocytes constitute a transcriptionally homogenous cell population. Basic Res Cardiol. 2019;114:36 pubmed publisher
Preston K, Rom I, Vrakas C, Landesberg G, Etwebi Z, Muraoka S, et al. Postprandial activation of leukocyte-endothelium interaction by fatty acids in the visceral adipose tissue microcirculation. FASEB J. 2019;33:11993-12007 pubmed publisher
Magae J, Furukawa C, Kuwahara S, Jeong Y, Nakajima H, Chang Y. 4-O-methylascochlorin stabilizes hypoxia-inducible factor-1 in a manner different from hydroxylase inhibition by iron chelating or substrate competition. Biosci Biotechnol Biochem. 2019;83:2244-2248 pubmed publisher
Adamska A, Domenichini A, Capone E, Damiani V, Akkaya B, Linton K, et al. Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer. J Exp Clin Cancer Res. 2019;38:312 pubmed publisher
Harris K, Gelberg H, Kiupel M, Helfand S. Immunohistochemical Features of Epithelial-Mesenchymal Transition in Feline Oral Squamous Cell Carcinoma. Vet Pathol. 2019;56:826-839 pubmed publisher
Choi S, Kim M, Yoon Y, Koh D, Kim M, Cho S, et al. Hypoxia-induced RelA/p65 derepresses SLC16A3 (MCT4) by downregulating ZBTB7A. Biochim Biophys Acta Gene Regul Mech. 2019;1862:771-785 pubmed publisher
Stephens O, Weiss K, Frimel M, Rose J, Sun Y, Asosingh K, et al. Interdependence of hypoxia and β-adrenergic receptor signaling in pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2019;317:L369-L380 pubmed publisher
Bohuslavova R, Cerychova R, Papousek F, Olejnickova V, Bartos M, Gorlach A, et al. HIF-1α is required for development of the sympathetic nervous system. Proc Natl Acad Sci U S A. 2019;: pubmed publisher
Yamamoto A, Hester J, Macklin P, Kawai K, Uchiyama M, Biggs D, et al. Systemic silencing of PHD2 causes reversible immune regulatory dysfunction. J Clin Invest. 2019;130:3640-3656 pubmed publisher
Matsuyama M, WuWong D, Horvath S, Matsuyama S. Epigenetic clock analysis of human fibroblasts in vitro: effects of hypoxia, donor age, and expression of hTERT and SV40 largeT. Aging (Albany NY). 2019;11:3012-3022 pubmed publisher
Yao Q, Khan M, Merceron C, LaGory E, Tata Z, Mangiavini L, et al. Suppressing Mitochondrial Respiration Is Critical for Hypoxia Tolerance in the Fetal Growth Plate. Dev Cell. 2019;: pubmed publisher
Adamska A, Ferro R, Lattanzio R, Capone E, Domenichini A, Damiani V, et al. ABCC3 is a novel target for the treatment of pancreatic cancer. Adv Biol Regul. 2019;: pubmed publisher
Bechmann N, Poser I, Seifert V, Greunke C, Ullrich M, Qin N, et al. Impact of Extrinsic and Intrinsic Hypoxia on Catecholamine Biosynthesis in Absence or Presence of Hif2α in Pheochromocytoma Cells. Cancers (Basel). 2019;11: pubmed publisher
Cui D, Arima M, Hirayama T, Ikeda E. Hypoxia-induced disruption of neural vascular barrier is mediated by the intracellular induction of Fe(II) ion. Exp Cell Res. 2019;: pubmed publisher
Delbrel E, Uzunhan Y, Soumare A, Gille T, Marchant D, Planes C, et al. ER Stress is Involved in Epithelial-To-Mesenchymal Transition of Alveolar Epithelial Cells Exposed to a Hypoxic Microenvironment. Int J Mol Sci. 2019;20: pubmed publisher
Laitakari A, Ollonen T, Kietzmann T, Walkinshaw G, Mennerich D, Izzi V, et al. Systemic inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 in mice protects from alcohol-induced fatty liver disease. Redox Biol. 2019;22:101145 pubmed publisher
Kondo T, Takeda K, Muko R, Ito A, Chang Y, Magae J, et al. 4-O-Methylascochlorin inhibits the prolyl hydroxylation of hypoxia-inducible factor-1α, which is attenuated by ascorbate. J Antibiot (Tokyo). 2019;72:271-281 pubmed publisher
Merceron C, Ranganathan K, WANG E, Tata Z, Makkapati S, Khan M, et al. Hypoxia-inducible factor 2α is a negative regulator of osteoblastogenesis and bone mass accrual. Bone Res. 2019;7:7 pubmed publisher
Yano M, Katoh T, Miyazawa M, Miyazawa M, Ogane N, Miwa M, et al. Clinicopathological correlation of ARID1A status with HDAC6 and its related factors in ovarian clear cell carcinoma. Sci Rep. 2019;9:2397 pubmed publisher
Sato E, Maeda Y, Sato Y, Hinata A, Gomi H, Koga D, et al. Culture in 10% O2 enhances the production of active hormones in neuro-endocrine cells by up-regulating the expression of processing enzymes. Biochem J. 2019;476:827-842 pubmed publisher
Chung Y, Luo A, Park K, Loonat A, Lakhal Littleton S, Robbins P, et al. Iron-deficiency anemia reduces cardiac contraction by downregulating RyR2 channels and suppressing SERCA pump activity. JCI Insight. 2019;4: pubmed publisher
Abu Remaileh M, Abu Remaileh M, Akkawi R, Knani I, Udi S, Pacold M, et al. WWOX somatic ablation in skeletal muscles alters glucose metabolism. Mol Metab. 2019;22:132-140 pubmed publisher
Chen C, Sun J, Chen S, Liu Y, Zhu S, Wang Z, et al. A multifunctional-targeted nanoagent for dual-mode image-guided therapeutic effects on ovarian cancer cells. Int J Nanomedicine. 2019;14:753-769 pubmed publisher
Adam R, Xia Z, Pravoverov K, Hong J, Case A, Schultz H, et al. Sympathoexcitation in response to cardiac and pulmonary afferent stimulation of TRPA1 channels is attenuated in rats with chronic heart failure. Am J Physiol Heart Circ Physiol. 2019;316:H862-H872 pubmed publisher
Simmen S, Cosin Roger J, Melhem H, Maliachovas N, Maane M, Baebler K, et al. Iron Prevents Hypoxia-Associated Inflammation Through the Regulation of Nuclear Factor-κB in the Intestinal Epithelium. Cell Mol Gastroenterol Hepatol. 2019;7:339-355 pubmed publisher
Ito F, Mori T, Tarumi Y, Okimura H, Kataoka H, Tanaka Y, et al. Equilin in conjugated equine estrogen increases monocyte-endothelial adhesion via NF-κB signaling. PLoS ONE. 2019;14:e0211462 pubmed publisher
Martinez C, Kerr B, Jin C, Cistulli P, Cook K. Obstructive Sleep Apnea Activates HIF-1 in a Hypoxia Dose-Dependent Manner in HCT116 Colorectal Carcinoma Cells. Int J Mol Sci. 2019;20: pubmed publisher
Vogel J, Thiel C, Tauber S, Stockmann C, Gassmann M, Ullrich O. Expression of Hypoxia-Inducible Factor 1α (HIF-1α) and Genes of Related Pathways in Altered Gravity. Int J Mol Sci. 2019;20: pubmed publisher
Leinhos L, Peters J, Krull S, Helbig L, Vogler M, Lévay M, et al. Hypoxia suppresses myofibroblast differentiation by changing RhoA activity. J Cell Sci. 2019;132: pubmed publisher
Lam G, Sefton M. Hypoxia-inducible factor drives vascularization of modularly assembled engineered tissue. Tissue Eng Part A. 2018;: pubmed publisher
Williams A, Walton C, MacCannell K, Avelar A, Shohet R. HIF-1 regulation of miR-29c impairs SERCA2 expression and cardiac contractility. Am J Physiol Heart Circ Physiol. 2019;316:H554-H565 pubmed publisher
Delbrel E, Soumare A, Naguez A, Label R, Bernard O, Bruhat A, et al. HIF-1α triggers ER stress and CHOP-mediated apoptosis in alveolar epithelial cells, a key event in pulmonary fibrosis. Sci Rep. 2018;8:17939 pubmed publisher
Novoyatleva T, Kojonazarov B, Owczarek A, Veeroju S, Rai N, Henneke I, et al. Evidence for Fucoidan-P-selectin Axis as a Therapeutic Target on Hypoxia-induced Pulmonary Hypertension. Am J Respir Crit Care Med. 2018;: pubmed publisher
Lee S, Abel E, Long F. Glucose metabolism induced by Bmp signaling is essential for murine skeletal development. Nat Commun. 2018;9:4831 pubmed publisher
Bíliková P, Svandova E, Veselá B, Doubek J, Poliard A, Matalova E. Coupling activation of pro-apoptotic caspases with autophagy in the Meckel´s cartilage. Physiol Res. 2019;68:135-140 pubmed
Han J, Lee J, Kong J, Ji Y, Kim J, Choe S, et al. Hypoxia Restrains Lipid Utilization via Protein Kinase A and Adipose Triglyceride Lipase Downregulation through Hypoxia-Inducible Factor. Mol Cell Biol. 2019;39: pubmed publisher
Wang Z, Yang K, Zheng Q, Zhang C, Tang H, Babicheva A, et al. Divergent changes of p53 in pulmonary arterial endothelial and smooth muscle cells involved in the development of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2019;316:L216-L228 pubmed publisher
Wang Y, Zhong S, Schofield C, Ratcliffe P, Lu X. Nuclear entry and export of FIH are mediated by HIF1α and exportin1, respectively. J Cell Sci. 2018;131: pubmed publisher
Chowdhury A, Aich A, Jain G, Wozny K, Lüchtenborg C, Hartmann M, et al. Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia. Cell Rep. 2018;25:561-570.e6 pubmed publisher
Reddy S, Agarwal H, Barthwal M. Cilostazol ameliorates heart failure with preserved ejection fraction and diastolic dysfunction in obese and non-obese hypertensive mice. J Mol Cell Cardiol. 2018;123:46-57 pubmed publisher
Burman A, Kropski J, Calvi C, Serezani A, Pascoalino B, Han W, et al. Localized hypoxia links ER stress to lung fibrosis through induction of C/EBP homologous protein. JCI Insight. 2018;3: pubmed publisher
Heikal L, Ghezzi P, Mengozzi M, Ferns G. Assessment of HIF-1α expression and release following endothelial injury in-vitro and in-vivo. Mol Med. 2018;24:22 pubmed publisher
Logue S, McGrath E, Cleary P, Greene S, Mnich K, Almanza A, et al. Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy. Nat Commun. 2018;9:3267 pubmed publisher
Ow C, Ngo J, Ullah M, Barsha G, Meex R, Watt M, et al. Absence of renal hypoxia in the subacute phase of severe renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2018;315:F1358-F1369 pubmed publisher
Tong B, Pantazopoulou V, Johansson E, Pietras A. The p75 neurotrophin receptor enhances HIF-dependent signaling in glioma. Exp Cell Res. 2018;371:122-129 pubmed publisher
Wu J, Tsai H, Liu G, Wu C, Tai M. Autophagic cell death participates in POMC-induced melanoma suppression. Cell Death Discov. 2018;4:11 pubmed publisher
Regan Anderson T, Ma S, Perez Kerkvliet C, Peng Y, Helle T, Krutilina R, et al. Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF-driven Signaling Axis. Mol Cancer Res. 2018;16:1761-1772 pubmed publisher
Dai Z, Zhu M, Peng Y, Machireddy N, Evans C, Machado R, et al. Therapeutic Targeting of Vascular Remodeling and Right Heart Failure in Pulmonary Arterial Hypertension with a HIF-2α Inhibitor. Am J Respir Crit Care Med. 2018;198:1423-1434 pubmed publisher
Nascimento B, Bocco B, Fernandes G, Fonseca T, McAninch E, Cardoso C, et al. Induction of Type 2 Iodothyronine Deiodinase After Status Epilepticus Modifies Hippocampal Gene Expression in Male Mice. Endocrinology. 2018;159:3090-3104 pubmed publisher
Nakazeki F, Nishiga M, Horie T, Nishi H, Nakashima Y, Baba O, et al. Loss of periostin ameliorates adipose tissue inflammation and fibrosis in vivo. Sci Rep. 2018;8:8553 pubmed publisher
Baay Guzman G, Durán Padilla M, Rangel Santiago J, Tirado Rodriguez B, Antonio Andres G, Barrios Payán J, et al. Dual role of hypoxia-inducible factor 1 α in experimental pulmonary tuberculosis: its implication as a new therapeutic target. Future Microbiol. 2018;13:785-798 pubmed publisher
Chen A, Sceneay J, Godde N, Kinwel T, Ham S, Thompson E, et al. Intermittent hypoxia induces a metastatic phenotype in breast cancer. Oncogene. 2018;37:4214-4225 pubmed publisher
Eskla K, Porosk R, Reimets R, Visnapuu T, Vasar E, Hundahl C, et al. Hypothermia augments stress response in mammalian cells. Free Radic Biol Med. 2018;121:157-168 pubmed publisher
Raykhel I, Moafi F, Myllym ki S, Greciano P, Matlin K, Moyano J, et al. BAMBI is a novel HIF1-dependent modulator of TGFβ-mediated disruption of cell polarity during hypoxia. J Cell Sci. 2018;131: pubmed publisher
Barben M, Ail D, Storti F, Klee K, Schori C, Samardzija M, et al. Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress. Cell Death Differ. 2018;25:2071-2085 pubmed publisher
Williams A, Khadka V, Tang M, Avelar A, Schunke K, Menor M, et al. HIF1 mediates a switch in pyruvate kinase isoforms after myocardial infarction. Physiol Genomics. 2018;50:479-494 pubmed publisher
Wang T, Wei W, Mansai H, Huang C, Li L, Ye Q, et al. Overexpression of appoptosin promotes mitochondrial damage in MIN6 cells. Mol Med Rep. 2018;17:7149-7155 pubmed publisher
Yamashita M, Ogasawara M, Kawasaki Y, Niisato M, Saito H, Kasai S, et al. Deficiency of protein-L-isoaspartate (D-aspartate) O-methyl-transferase expression under endoplasmic reticulum stress promotes epithelial mesenchymal transition in lung adenocarcinoma. Oncotarget. 2018;9:13287-13300 pubmed publisher
Cui H, Banerjee S, Guo S, Xie N, Liu G. IFN Regulatory Factor 2 Inhibits Expression of Glycolytic Genes and Lipopolysaccharide-Induced Proinflammatory Responses in Macrophages. J Immunol. 2018;200:3218-3230 pubmed publisher
Zhu N, Yi B, Guo Z, Zhang G, Huang S, Qin Y, et al. Pim-1 Kinase Phosphorylates Cardiac Troponin I and Regulates Cardiac Myofilament Function. Cell Physiol Biochem. 2018;45:2174-2186 pubmed publisher
Conotte S, Tassin A, Conotte R, Colet J, Zouaoui Boudjeltia K, Legrand A. Metabonomic profiling of chronic intermittent hypoxia in a mouse model. Respir Physiol Neurobiol. 2018;256:157-173 pubmed publisher
Barben M, Schori C, Samardzija M, Grimm C. Targeting Hif1a rescues cone degeneration and prevents subretinal neovascularization in a model of chronic hypoxia. Mol Neurodegener. 2018;13:12 pubmed publisher
Wong K, Beirowski B. Multiple lines of inhibitory feedback on AKT kinase in Schwann cells lacking TSC1/2 hint at distinct functions of mTORC1 and AKT in nerve development. Commun Integr Biol. 2018;11:e1433441 pubmed publisher
Lin C, Kurashige M, Liu Y, Terabayashi T, Ishimoto Y, Wang T, et al. A cleavage product of Polycystin-1 is a mitochondrial matrix protein that affects mitochondria morphology and function when heterologously expressed. Sci Rep. 2018;8:2743 pubmed publisher
Lennikov A, Mirabelli P, Mukwaya A, Schaupper M, Thangavelu M, Lachota M, et al. Selective IKK2 inhibitor IMD0354 disrupts NF-κB signaling to suppress corneal inflammation and angiogenesis. Angiogenesis. 2018;21:267-285 pubmed publisher
Buart S, Terry S, Noman M, Lanoy E, Boutros C, Fogel P, et al. Transcriptional response to hypoxic stress in melanoma and prognostic potential of GBE1 and BNIP3. Oncotarget. 2017;8:108786-108801 pubmed publisher
Liu L, Liu W, Wang L, Zhu T, Zhong J, Xie N. Hypoxia-inducible factor 1 mediates intermittent hypoxia-induced migration of human breast cancer MDA-MB-231 cells. Oncol Lett. 2017;14:7715-7722 pubmed publisher
Tojo K, Tamada N, Nagamine Y, Yazawa T, Ota S, Goto T. Enhancement of glycolysis by inhibition of oxygen-sensing prolyl hydroxylases protects alveolar epithelial cells from acute lung injury. FASEB J. 2017;: pubmed publisher
Heid J, Cencioni C, Ripa R, Baumgart M, Atlante S, Milano G, et al. Age-dependent increase of oxidative stress regulates microRNA-29 family preserving cardiac health. Sci Rep. 2017;7:16839 pubmed publisher
Carpinteri S, Sampurno S, Malaterre J, Millen R, Dean M, Kong J, et al. Experimental study of delivery of humidified-warm carbon dioxide during open abdominal surgery. Br J Surg. 2017;: pubmed publisher
Bernard O, Jeny F, Uzunhan Y, Dondi E, Terfous R, Label R, et al. Mesenchymal stem cells reduce hypoxia-induced apoptosis in alveolar epithelial cells by modulating HIF and ROS hypoxic signalings. Am J Physiol Lung Cell Mol Physiol. 2017;:ajplung.00153.2017 pubmed publisher
Sethumadhavan S, Silva M, Philbrook P, Nguyen T, Hatfield S, Ohta A, et al. Hypoxia and hypoxia-inducible factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor cell recognition by T cells. PLoS ONE. 2017;12:e0187314 pubmed publisher
Ho J, Abdullah L, Pang Q, Jha S, Chow E, Yang H, et al. Inhibition of the H3K9 methyltransferase G9A attenuates oncogenicity and activates the hypoxia signaling pathway. PLoS ONE. 2017;12:e0188051 pubmed publisher
Ognibene M, Cangelosi D, Morini M, Segalerba D, Bosco M, Sementa A, et al. Immunohistochemical analysis of PDK1, PHD3 and HIF-1? expression defines the hypoxic status of neuroblastoma tumors. PLoS ONE. 2017;12:e0187206 pubmed publisher
Sodi V, Bacigalupa Z, Ferrer C, Lee J, Gocal W, Mukhopadhyay D, et al. Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation. Oncogene. 2018;37:924-934 pubmed publisher
Strowitzki M, Ritter A, Radhakrishnan P, Harnoss J, Opitz V, Biller M, et al. Pharmacological HIF-inhibition attenuates postoperative adhesion formation. Sci Rep. 2017;7:13151 pubmed publisher
Sharma B, Ho L, Ford G, Chen H, Goldstone A, Woo Y, et al. Alternative Progenitor Cells Compensate to Rebuild the Coronary Vasculature in Elabela- and Apj-Deficient Hearts. Dev Cell. 2017;42:655-666.e3 pubmed publisher
Huang R, Hayashi Y, Yan X, Bu J, Wang J, Zhang Y, et al. HIF1A is a critical downstream mediator for hemophagocytic lymphohistiocytosis. Haematologica. 2017;102:1956-1968 pubmed publisher
Johansson E, Grassi E, Pantazopoulou V, Tong B, Lindgren D, Berg T, et al. CD44 Interacts with HIF-2α to Modulate the Hypoxic Phenotype of Perinecrotic and Perivascular Glioma Cells. Cell Rep. 2017;20:1641-1653 pubmed publisher
Sun W, Kato H, Kitajima S, Lee K, Gradin K, Okamoto T, et al. Interaction between von Hippel-Lindau Protein and Fatty Acid Synthase Modulates Hypoxia Target Gene Expression. Sci Rep. 2017;7:7190 pubmed publisher
Nakashima R, Goto Y, Koyasu S, Kobayashi M, Morinibu A, Yoshimura M, et al. UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization. Sci Rep. 2017;7:6879 pubmed publisher
Braverman J, Stanley S. Nitric Oxide Modulates Macrophage Responses to Mycobacterium tuberculosis Infection through Activation of HIF-1? and Repression of NF-?B. J Immunol. 2017;199:1805-1816 pubmed publisher
Cosin Roger J, Simmen S, Melhem H, Atrott K, Frey Wagner I, Hausmann M, et al. Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation. Nat Commun. 2017;8:98 pubmed publisher
Casciello F, Al Ejeh F, Kelly G, Brennan D, Ngiow S, Young A, et al. G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis. Proc Natl Acad Sci U S A. 2017;114:7077-7082 pubmed publisher
Zheng X, Narayanan S, Zheng X, Luecke Johansson S, Gradin K, Catrina S, et al. A Notch-independent mechanism contributes to the induction of Hes1 gene expression in response to hypoxia in P19 cells. Exp Cell Res. 2017;358:129-139 pubmed publisher
Licarete E, Sesarman A, Rauca V, Lupuţ L, Pătraş L, Banciu M. HIF-1α acts as a molecular target for simvastatin cytotoxicity in B16.F10 melanoma cells cultured under chemically induced hypoxia. Oncol Lett. 2017;13:3942-3950 pubmed publisher
Kiriakidis S, Hoer S, Burrows N, Biddlecome G, Khan M, Thinnes C, et al. Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor. Kidney Int. 2017;92:900-908 pubmed publisher
Jackson C, Durandt C, Janse van Rensburg I, Praloran V, Brunet de la Grange P, Pepper M. Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion. Stem Cell Res. 2017;21:124-131 pubmed publisher
Lin Y, Shyu W, Chang C, Wang C, Wu C, Lee H, et al. Tumor Hypoxia Regulates Forkhead Box C1 to Promote Lung Cancer Progression. Theranostics. 2017;7:1177-1191 pubmed publisher
Tokumoto Y, Tamaki S, Kabe Y, Takubo K, Suematsu M. Quiescence of adult oligodendrocyte precursor cells requires thyroid hormone and hypoxia to activate Runx1. Sci Rep. 2017;7:1019 pubmed publisher
Duan C, Pérez Torres C, Yuan L, Engelbach J, Beeman S, Tsien C, et al. Can anti-vascular endothelial growth factor antibody reverse radiation necrosis? A preclinical investigation. J Neurooncol. 2017;133:9-16 pubmed publisher
Schuoler C, Haider T, Leuenberger C, Vogel J, Ostergaard L, Kwapiszewska G, et al. Aquaporin 1 controls the functional phenotype of pulmonary smooth muscle cells in hypoxia-induced pulmonary hypertension. Basic Res Cardiol. 2017;112:30 pubmed publisher
Hum J, Clinkenbeard E, Ip C, Cass T, Allen M, White K. The metabolic bone disease associated with the Hyp mutation is independent of osteoblastic HIF1α expression. Bone Rep. 2017;6:38-43 pubmed publisher
Sato Y, Tsuyama T, Sato C, Karim M, Yoshizawa T, Inoue M, et al. Hypoxia reduces HNF4α/MODY1 protein expression in pancreatic β-cells by activating AMP-activated protein kinase. J Biol Chem. 2017;292:8716-8728 pubmed publisher
Soni S, Padwad Y. HIF-1 in cancer therapy: two decade long story of a transcription factor. Acta Oncol. 2017;56:503-515 pubmed publisher
Landfried B, Samardzija M, Barben M, Schori C, Klee K, Storti F, et al. Digoxin-induced retinal degeneration depends on rhodopsin. Cell Death Dis. 2017;8:e2670 pubmed publisher
Wang S, Zeng H, Chen S, Zhou L, Xie X, He X, et al. Ablation of endothelial prolyl hydroxylase domain protein-2 promotes renal vascular remodelling and fibrosis in mice. J Cell Mol Med. 2017;21:1967-1978 pubmed publisher
Maturu P, Jones D, Ruteshouser E, Hu Q, Reynolds J, Hicks J, et al. Role of Cyclooxygenase-2 Pathway in Creating an Immunosuppressive Microenvironment and in Initiation and Progression of Wilms' Tumor. Neoplasia. 2017;19:237-249 pubmed publisher
Asai Y, Yamada T, Tsukita S, Takahashi K, Maekawa M, Honma M, et al. Activation of the Hypoxia Inducible Factor 1α Subunit Pathway in Steatotic Liver Contributes to Formation of Cholesterol Gallstones. Gastroenterology. 2017;152:1521-1535.e8 pubmed publisher
Brock M, Schuoler C, Leuenberger C, Bühlmann C, Haider T, Vogel J, et al. Analysis of hypoxia-induced noncoding RNAs reveals metastasis-associated lung adenocarcinoma transcript 1 as an important regulator of vascular smooth muscle cell proliferation. Exp Biol Med (Maywood). 2017;242:487-496 pubmed publisher
Razafinjatovo C, Stiehl D, Deininger E, Rechsteiner M, Moch H, Schraml P. VHL missense mutations in the p53 binding domain show different effects on p53 signaling and HIFα degradation in clear cell renal cell carcinoma. Oncotarget. 2017;8:10199-10212 pubmed publisher
Negrette Guzmán M, Huerta Yepez S, Vega M, León Contreras J, Hernandez Pando R, Medina Campos O, et al. Sulforaphane induces differential modulation of mitochondrial biogenesis and dynamics in normal cells and tumor cells. Food Chem Toxicol. 2017;100:90-102 pubmed publisher
Morita M, Sato Y, Iwasaki R, Kobayashi T, Watanabe R, Oike T, et al. Selective Estrogen Receptor Modulators Suppress Hif1? Protein Accumulation in Mouse Osteoclasts. PLoS ONE. 2016;11:e0165922 pubmed publisher
Hoogewijs D, Vogler M, Zwenger E, Krull S, Zieseniss A. Oxygen-dependent regulation of aquaporin-3 expression. Hypoxia (Auckl). 2016;4:91-97 pubmed
Guentsch A, Beneke A, Swain L, Farhat K, Nagarajan S, Wielockx B, et al. PHD2 Is a Regulator for Glycolytic Reprogramming in Macrophages. Mol Cell Biol. 2017;37: pubmed publisher
Tian X, Nguyen M, Foote H, Caster J, Roche K, Peters C, et al. CRLX101, a Nanoparticle-Drug Conjugate Containing Camptothecin, Improves Rectal Cancer Chemoradiotherapy by Inhibiting DNA Repair and HIF1α. Cancer Res. 2017;77:112-122 pubmed publisher
Sousa L, Silva R, Fonseca V, Leandro R, Di Vincenzo T, Alves Wagner A, et al. Is the canine corpus luteum an insulin-sensitive tissue?. J Endocrinol. 2016;231:223-233 pubmed
Clever D, Roychoudhuri R, Constantinides M, Askenase M, Sukumar M, Klebanoff C, et al. Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche. Cell. 2016;166:1117-1131.e14 pubmed publisher
Koivunen P, Fell S, Lu W, Rabinowitz J, Kung A, Schlisio S. The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth. Hypoxia (Auckl). 2016;4:15-27 pubmed
Pandya P, Fisher A, Mickler E, Temm C, Lipking K, Gracon A, et al. Hypoxia-Inducible Factor-1α Regulates CD55 in Airway Epithelium. Am J Respir Cell Mol Biol. 2016;55:889-898 pubmed
Jung G, Jeon J, Choi Y, Jang S, Park S, Kim S, et al. Pyruvate dehydrogenase kinase regulates hepatitis C virus replication. Sci Rep. 2016;6:30846 pubmed publisher
Leinonen H, Rossi M, Salo A, Tiainen P, Hyvärinen J, Pitkänen M, et al. Lack of P4H-TM in mice results in age-related retinal and renal alterations. Hum Mol Genet. 2016;25:3810-3823 pubmed publisher
Xue H, Chen D, Zhong Y, Zhou Z, Fang S, Li M, et al. Deferoxamine ameliorates hepatosteatosis via several mechanisms in ob/ob mice. Ann N Y Acad Sci. 2016;1375:52-65 pubmed publisher
Aarup A, Pedersen T, Junker N, Christoffersen C, Bartels E, Madsen M, et al. Hypoxia-Inducible Factor-1? Expression in Macrophages Promotes Development of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2016;36:1782-90 pubmed publisher
Braverman J, Sogi K, Benjamin D, Nomura D, Stanley S. HIF-1? Is an Essential Mediator of IFN-?-Dependent Immunity to Mycobacterium tuberculosis. J Immunol. 2016;197:1287-97 pubmed publisher
Robl B, Botter S, Pellegrini G, Neklyudova O, Fuchs B. Evaluation of intraarterial and intravenous cisplatin chemotherapy in the treatment of metastatic osteosarcoma using an orthotopic xenograft mouse model. J Exp Clin Cancer Res. 2016;35:113 pubmed publisher
Luo B, Wang J, Liu Z, Shen Z, Shi R, Liu Y, et al. Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution. Nat Commun. 2016;7:12177 pubmed publisher
Nunomiya A, Shin J, Kitajima Y, Dan T, Miyata T, Nagatomi R. Activation of the hypoxia-inducible factor pathway induced by prolyl hydroxylase domain 2 deficiency enhances the effect of running training in mice. Acta Physiol (Oxf). 2017;220:99-112 pubmed publisher
Diaz Trelles R, Scimia M, Bushway P, Tran D, Monosov A, Monosov E, et al. Notch-independent RBPJ controls angiogenesis in the adult heart. Nat Commun. 2016;7:12088 pubmed publisher
Muiños López E, Ripalda Cemboráin P, López Martínez T, González Gil A, Lamo Espinosa J, Valenti A, et al. Hypoxia and Reactive Oxygen Species Homeostasis in Mesenchymal Progenitor Cells Define a Molecular Mechanism for Fracture Nonunion. Stem Cells. 2016;34:2342-53 pubmed publisher
Bullen J, Tchernyshyov I, Holewinski R, Devine L, Wu F, Venkatraman V, et al. Protein kinase A-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1. Sci Signal. 2016;9:ra56 pubmed publisher
Halt K, Pärssinen H, Junttila S, Saarela U, Sims Lucas S, Koivunen P, et al. CD146(+) cells are essential for kidney vasculature development. Kidney Int. 2016;90:311-324 pubmed publisher
Christinat Y, Pawłowski R, Krek W. jSplice: a high-performance method for accurate prediction of alternative splicing events and its application to large-scale renal cancer transcriptome data. Bioinformatics. 2016;32:2111-9 pubmed publisher
Ruffenach G, Chabot S, Tanguay V, Courboulin A, Boucherat O, Potus F, et al. Role for Runt-related Transcription Factor 2 in Proliferative and Calcified Vascular Lesions in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2016;194:1273-1285 pubmed
Takahashi N, Davy P, Gardner L, Mathews J, Yamazaki Y, Allsopp R. Hypoxia Inducible Factor 1 Alpha Is Expressed in Germ Cells throughout the Murine Life Cycle. PLoS ONE. 2016;11:e0154309 pubmed publisher
Msaki A, Pastò A, Curtarello M, Arigoni M, Barutello G, Calogero R, et al. A hypoxic signature marks tumors formed by disseminated tumor cells in the BALB-neuT mammary cancer model. Oncotarget. 2016;7:33081-95 pubmed publisher
Trinh N, Yamashita T, Ohneda K, Kimura K, Salazar G, Sato F, et al. Increased Expression of EGR-1 in Diabetic Human Adipose Tissue-Derived Mesenchymal Stem Cells Reduces Their Wound Healing Capacity. Stem Cells Dev. 2016;25:760-73 pubmed publisher
Shin J, Nunomiya A, Kitajima Y, Dan T, Miyata T, Nagatomi R. Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber-type transition via a calcineurin/NFATc1-dependent pathway. Skelet Muscle. 2016;6:5 pubmed publisher
Rahtu Korpela L, Määttä J, Dimova E, Hörkkö S, Gylling H, Walkinshaw G, et al. Hypoxia-Inducible Factor Prolyl 4-Hydroxylase-2 Inhibition Protects Against Development of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2016;36:608-17 pubmed publisher
Lee S, Kim W, Jeong J, Park J, Kim J. AK-1, a SIRT2 inhibitor, destabilizes HIF-1α and diminishes its transcriptional activity during hypoxia. Cancer Lett. 2016;373:138-145 pubmed publisher
Qian F, He M, Duan W, Mao L, Li Q, Yu Z, et al. Cross regulation between hypoxia-inducible transcription factor-1α (HIF-1α) and transforming growth factor (TGF)-ß1 mediates nickel oxide nanoparticles (NiONPs)-induced pulmonary fibrosis. Am J Transl Res. 2015;7:2364-78 pubmed
Tando T, Sato Y, Miyamoto K, Morita M, Kobayashi T, Funayama A, et al. Hif1α is required for osteoclast activation and bone loss in male osteoporosis. Biochem Biophys Res Commun. 2016;470:391-396 pubmed publisher
Kinoshita T, Fujii H, Hayashi Y, Kamiyama I, Ohtsuka T, Asamura H. Prognostic significance of hypoxic PET using (18)F-FAZA and (62)Cu-ATSM in non-small-cell lung cancer. Lung Cancer. 2016;91:56-66 pubmed publisher
Laukka T, Mariani C, Ihantola T, Cao J, Hokkanen J, Kaelin W, et al. Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes. J Biol Chem. 2016;291:4256-65 pubmed publisher
Zhang J, Wang C, Chen X, Takada M, Fan C, Zheng X, et al. EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer. EMBO J. 2015;34:2953-70 pubmed publisher
Karsikas S, Myllymäki M, Heikkilä M, Sormunen R, Kivirikko K, Myllyharju J, et al. HIF-P4H-2 deficiency protects against skeletal muscle ischemia-reperfusion injury. J Mol Med (Berl). 2016;94:301-10 pubmed publisher
Saini Y, Proper S, Dornbos P, Greenwood K, Kopec A, Lynn S, et al. Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice. PLoS ONE. 2015;10:e0139270 pubmed publisher
Bustamante Marin X, Cook M, Gooding J, Newgard C, Capel B. Left-Biased Spermatogenic Failure in 129/SvJ Dnd1Ter/+ Mice Correlates with Differences in Vascular Architecture, Oxygen Availability, and Metabolites. Biol Reprod. 2015;93:78 pubmed publisher
Zeng Z, Huang W, Gao Q, Su M, Yang Y, Liu Z, et al. Arnebin-1 promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway. Int J Mol Med. 2015;36:685-97 pubmed publisher
Chen X, Liu J, He B, Li Y, Liu S, Wu B, et al. Vascular endothelial growth factor (VEGF) regulation by hypoxia inducible factor-1 alpha (HIF1A) starts and peaks during endometrial breakdown, not repair, in a mouse menstrual-like model. Hum Reprod. 2015;30:2160-70 pubmed publisher
Liu J, You P, Chen G, Fu X, Zeng X, Wang C, et al. Hyperactivated FRS2α-mediated signaling in prostate cancer cells promotes tumor angiogenesis and predicts poor clinical outcome of patients. Oncogene. 2016;35:1750-9 pubmed publisher
Mirtschink P, Krishnan J, Grimm F, Sarre A, Hörl M, Kayikci M, et al. HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease. Nature. 2015;522:444-449 pubmed publisher
Guo C, Zhang Y, Wang T, Zhong M, Yang Z, Hao L, et al. Intranasal deferoxamine attenuates synapse loss via up-regulating the P38/HIF-1α pathway on the brain of APP/PS1 transgenic mice. Front Aging Neurosci. 2015;7:104 pubmed publisher
Zhao H, Wu Y, Chen Y, Liu H. Clinical significance of hypoxia-inducible factor 1 and VEGF-A in osteosarcoma. Int J Clin Oncol. 2015;20:1233-43 pubmed publisher
Xie L, Pi X, Townley Tilson W, Li N, Wehrens X, Entman M, et al. PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban. J Clin Invest. 2015;125:2759-71 pubmed publisher
Yorulmaz H, Ozkok E, Erguven M, Ates G, Aydın I, Tamer S. Effect of simvastatin on mitochondrial enzyme activities, ghrelin, hypoxia-inducible factor 1α in hepatic tissue during early phase of sepsis. Int J Clin Exp Med. 2015;8:3640-50 pubmed
Zieseniss A, Hesse A, Jatho A, Krull S, Hölscher M, Vogel S, et al. Cardiomyocyte-Specific Transgenic Expression of Prolyl-4-Hydroxylase Domain 3 Impairs the Myocardial Response to Ischemia. Cell Physiol Biochem. 2015;36:843-51 pubmed publisher
Hwang H, Lynn S, Vengellur A, Saini Y, Grier E, Ferguson Miller S, et al. Hypoxia Inducible Factors Modulate Mitochondrial Oxygen Consumption and Transcriptional Regulation of Nuclear-Encoded Electron Transport Chain Genes. Biochemistry. 2015;54:3739-48 pubmed publisher
Conley S, Baker T, Burnett J, Theisen R, Lazarus D, Peters C, et al. CRLX101, an investigational camptothecin-containing nanoparticle-drug conjugate, targets cancer stem cells and impedes resistance to antiangiogenic therapy in mouse models of breast cancer. Breast Cancer Res Treat. 2015;150:559-67 pubmed publisher
Tan S, Gomes R, Yeoh K, Perbellini F, Malandraki Miller S, Ambrose L, et al. Preconditioning of Cardiosphere-Derived Cells With Hypoxia or Prolyl-4-Hydroxylase Inhibitors Increases Stemness and Decreases Reliance on Oxidative Metabolism. Cell Transplant. 2016;25:35-53 pubmed publisher
Albers J, Danzer C, Rechsteiner M, Lehmann H, Brandt L, Hejhal T, et al. A versatile modular vector system for rapid combinatorial mammalian genetics. J Clin Invest. 2015;125:1603-19 pubmed publisher
Lee M, Choi S, Kang B, Yoo H, Song S, Seong I, et al. Differential microscopic finding and glucose transporter 3 expression in terminal chorionic villi among birth weight-discordant twin placentas. Histol Histopathol. 2015;30:955-62 pubmed publisher
Qiao N, Xu C, Zhu Y, Cao Y, Liu D, Han X. Ets-1 as an early response gene against hypoxia-induced apoptosis in pancreatic β-cells. Cell Death Dis. 2015;6:e1650 pubmed publisher
Stantic M, Sakil H, Zirath H, Fang T, Sanz G, Fernandez Woodbridge A, et al. TAp73 suppresses tumor angiogenesis through repression of proangiogenic cytokines and HIF-1α activity. Proc Natl Acad Sci U S A. 2015;112:220-5 pubmed publisher
Fine J, Renner D, Forsberg A, Cameron R, Galick B, Le C, et al. Intranasal deferoxamine engages multiple pathways to decrease memory loss in the APP/PS1 model of amyloid accumulation. Neurosci Lett. 2015;584:362-7 pubmed publisher
Lam G, Sefton M. Tuning graft- and host-derived vascularization in modular tissue constructs: a potential role of HIF1 activation. Tissue Eng Part A. 2015;21:803-16 pubmed publisher
Takahashi H, Inoue A, Kawabe Y, Hosokawa Y, Iwata S, Sugimoto K, et al. Oct-3/4 promotes tumor angiogenesis through VEGF production in glioblastoma. Brain Tumor Pathol. 2015;32:31-40 pubmed publisher
product information
master code :
NB100-479
SKU :
NB100-479
product name :
HIF-1 alpha Antibody - BSA Free
unit size :
0.1 ml (also 0.025 ml)
description :
The HIF-1 alpha Antibody - BSA Free from Novus is a rabbit polyclonal antibody to HIF-1 alpha. This antibody reacts with canine,fish,goat,hamster,human,moth - trichoplusia ni (cabbage looper),mouse,porcine,primate,rabbit,rat,zebrafish,fish - danio rerio (zebrafish). The HIF-1 alpha Antibody - BSA Free has been validated for the following applications: Western Blot,Immunohistochemistry,Immunocytochemistry/ Immunofluorescence,Chromatin Immunoprecipitation,Immunoprecipitation,Knockdown Validated,Chemotaxis,CyTof,EA,IF/IHC,Flow Cytometry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunoblotting,Immunohistochemistry Free-Floating,Immunohistochemistry Whole-Mount,Chromatin Immunoprecipitation (ChIP),Knockout Validated,Simple Western.
target :
HIF-1 alpha
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
This HIF-1 alpha antibody was developed against a fusion protein including amino acids 530 - 825 of the mouse HIF-1 alpha protein [Uniprot# Q61221].
isotype :
IgG
purity :
Immunogen affinity purified
species :
Canine,Fish,Goat,Hamster,Human,Moth - Trichoplusia ni (Cabbage Looper),Mouse,Porcine,Primate,Rabbit,Rat,Zebrafish,Fish - Danio rerio (Zebrafish)
theoretical molecular weight :
93 kDa
gene symbol :
HIF1A
Antibody validation :
Biological Validation
accessionNumbers :
Q61221
applications :
Immunohistochemistry,Western Blot,Immunocytochemistry/ Immunofluorescence,Chromatin Immunoprecipitation,Immunoprecipitation,Knockdown Validated,Chemotaxis,CyTof,EA,IF/IHC,Flow Cytometry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunoblotting,Immunohistochemistry Free-Floating,Immunohistochemistry Whole-Mount,Chromatin Immunoprecipitation (ChIP),Knockout Validated,Simple Western
USD :
459 USD
alt names :
AINT, anti-HIF-1 alpha, anti-HIF1A, ARNT interacting protein, ARNT-interacting protein, Basic-helix-loop-helix-PAS protein MOP1, BHLHE78, Class E basic helix-loop-helix protein 78, HIF1, HIF-1 alpha, HIF1A, HIF-1A, HIF-1alpha, HIF-1-alpha, HIF1-alpha, hypoxia inducible factor 1 alpha subunit, hypoxia inducible factor 1 subunit alpha, hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor), hypoxia-inducible factor 1-alpha, Member of PAS protein 1, member of PAS superfamily 1, MOP1, PAS domain-containing protein 8, PASD8
storage :
Store at -20C.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.