Mre11 Antibody (12D7) - Azide and BSA Free | Novus Biologicals NB100-473 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

Mre11 Antibody (12D7) - Azide and BSA Free

catalog :

NB100-473

quantity :

100 ul

price :

459 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

12D7

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, proximity ligation assay

more info or order :

Novus Biologicals product webpage

citations: 29

Reference
Schuhwerk H, Kleemann J, Gupta P, van Roey R, Armstark I, Kreileder M, et al. The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response. Cell Rep. 2022;41:111819 pubmed publisher
Xiao H, Li F, Mladenov E, Soni A, Mladenova V, Pan B, et al. Increased Resection at DSBs in G2-Phase Is a Unique Phenotype Associated with DNA-PKcs Defects That Is Not Shared by Other Factors of c-NHEJ. Cells. 2022;11: pubmed publisher
Kusi M, Zand M, Lin L, Chen M, Lopez A, Lin C, et al. 2-Hydroxyglutarate destabilizes chromatin regulatory landscape and lineage fidelity to promote cellular heterogeneity. Cell Rep. 2022;38:110220 pubmed publisher
Chansel Da Cruz M, Hohl M, Ceppi I, Kermasson L, Maggiorella L, Modesti M, et al. A Disease-Causing Single Amino Acid Deletion in the Coiled-Coil Domain of RAD50 Impairs MRE11 Complex Functions in Yeast and Humans. Cell Rep. 2020;33:108559 pubmed publisher
de Vries M, Parma L, Peters H, Schepers A, Hamming J, Jukema J, et al. Blockade of vascular endothelial growth factor receptor 2 inhibits intraplaque haemorrhage by normalization of plaque neovessels. J Intern Med. 2019;285:59-74 pubmed publisher
Wei Z, Yoshihara E, He N, Hah N, Fan W, Pinto A, et al. Vitamin D Switches BAF Complexes to Protect β Cells. Cell. 2018;173:1135-1149.e15 pubmed publisher
Sweeney L, Bikoff J, Gabitto M, Brenner Morton S, Baek M, Yang J, et al. Origin and Segmental Diversity of Spinal Inhibitory Interneurons. Neuron. 2018;97:341-355.e3 pubmed publisher
Akai R, Hosoda A, Yoshino M, Iwawaki T. Constitutive role of GADD34 and CReP in cancellation of phospho-eIF2α-dependent translational attenuation and insulin biosynthesis in pancreatic β cells. Genes Cells. 2015;20:871-86 pubmed publisher
Blanchet E, Van de Velde S, Matsumura S, Hao E, LeLay J, KAESTNER K, et al. Feedback inhibition of CREB signaling promotes beta cell dysfunction in insulin resistance. Cell Rep. 2015;10:1149-57 pubmed publisher
Soares D, Battistella A, Rocca C, Matuo R, Henriques J, Larsen A, et al. Ataxia telangiectasia mutated- and Rad3-related kinase drives both the early and the late DNA-damage response to the monofunctional antitumour alkylator S23906. Biochem J. 2011;437:63-73 pubmed publisher
Yamasaki S, Miura Y, Brown E, Davydova J, Yamamoto M. Development of a method for effective amplification of human adenovirus 40. Arch Virol. 2010;155:1059-68 pubmed publisher
Zheng L, Kanagaraj R, Mihaljevic B, Schwendener S, Sartori A, Gerrits B, et al. MRE11 complex links RECQ5 helicase to sites of DNA damage. Nucleic Acids Res. 2009;37:2645-57 pubmed publisher
Helmink B, Bredemeyer A, Lee B, Huang C, Sharma G, Walker L, et al. MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks. J Exp Med. 2009;206:669-79 pubmed publisher
Ottini L, Falchetti M, Saieva C, De Marco M, Masala G, Zanna I, et al. MRE11 expression is impaired in gastric cancer with microsatellite instability. Carcinogenesis. 2004;25:2337-43 pubmed
Giannini G, Rinaldi C, Ristori E, Ambrosini M, Cerignoli F, Viel A, et al. Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability. Oncogene. 2004;23:2640-7 pubmed
Uziel T, Lerenthal Y, Moyal L, Andegeko Y, Mittelman L, Shiloh Y. Requirement of the MRN complex for ATM activation by DNA damage. EMBO J. 2003;22:5612-21 pubmed
Xu X, Stern D. NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors. FASEB J. 2003;17:1842-8 pubmed
Lee J, Xu B, Lee C, Ahn J, Song M, Lee H, et al. Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage. Mol Cancer Res. 2003;1:674-81 pubmed
Celeste A, Fernandez Capetillo O, Kruhlak M, Pilch D, Staudt D, Lee A, et al. Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nat Cell Biol. 2003;5:675-9 pubmed
Stewart G, Wang B, Bignell C, Taylor A, Elledge S. MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature. 2003;421:961-6 pubmed
Lukas C, Falck J, Bartkova J, Bartek J, Lukas J. Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nat Cell Biol. 2003;5:255-60 pubmed
Xu X, Stern D. NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways. J Biol Chem. 2003;278:8795-803 pubmed
Nakanishi K, Taniguchi T, Ranganathan V, New H, Moreau L, Stotsky M, et al. Interaction of FANCD2 and NBS1 in the DNA damage response. Nat Cell Biol. 2002;4:913-20 pubmed
Stracker T, Carson C, Weitzman M. Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex. Nature. 2002;418:348-52 pubmed
Limoli C, Giedzinski E, Bonner W, Cleaver J. UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization. Proc Natl Acad Sci U S A. 2002;99:233-8 pubmed
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product information

master code :

NB100-473

SKU :

NB100-473

product name :

Mre11 Antibody (12D7) - Azide and BSA Free

unit size :

100 ul

description :

The Mre11 Antibody (12D7) - Azide and BSA Free from Novus is a mouse monoclonal antibody to Mre11. This antibody reacts with human,mouse,rat. The Mre11 Antibody (12D7) - Azide and BSA Free has been validated for the following applications: IF/IHC,Western Blot,Immunocytochemistry/ Immunofluorescence,ELISA,Immunohistochemistry,Immunoprecipitation,Immunohistochemistry-Paraffin,Functional,Proximity Ligation Assay,Knockdown Validated.

target :

Mre11

category :

Primary Antibodies

buffer :

PBS

clonality :

Monoclonal

clone :

12D7

conjugate :

Unconjugated

host :

Mouse

immunogen :

Amino acids 182-582 of Mre11 expressed in E. coli.

isotype :

IgG1

purity :

Protein G purified

species :

Human,Mouse,Rat

theoretical molecular weight :

80 kDa

gene symbol :

MRE11

Antibody validation :

Knockout/Knockdown

accessionNumbers :

P49959

applications :

IF/IHC,Western Blot,Immunocytochemistry/ Immunofluorescence,ELISA,Immunohistochemistry,Immunoprecipitation,Immunohistochemistry-Paraffin,Functional,Proximity Ligation Assay,Knockdown Validated

USD :

459 USD

alt names :

ATLDmeiotic recombination (S. cerevisiae) 11 homolog A, AT-like disease, DNA recombination and repair protein, double-strand break repair protein MRE11A, endo/exonuclease Mre11, HNGS1, Meiotic recombination 11 homolog 1, Meiotic recombination 11 homolog A, MRE11 homolog 1, MRE11 homolog A, MRE11 meiotic recombination 11 homolog A (S. cerevisiae), MRE11B

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage