WRN Antibody - BSA Free | Novus Biologicals NB100-472 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

WRN Antibody - BSA Free

catalog :

NB100-472

quantity :

100 ul

price :

479 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

32.1

reactivity :

human, mouse

application :

western blot, immunoprecipitation, western blot knockout validation

more info or order :

Novus Biologicals product webpage

citations: 15

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; human; 1:1000; loading ...; fig 4a, e3a	Chan E, Shibue T, McFarland J, Gaeta B, Ghandi M, Dumont N, et al. WRN helicase is a synthetic lethal target in microsatellite unstable cancers. Nature. 2019;568:551-556 pubmed publisher
	Emam A, Wu X, Xu S, Wang L, Liu S, Wang B. Stalled replication fork protection limits cGAS-STING and P-body-dependent innate immune signalling. Nat Cell Biol. 2022;24:1154-1164 pubmed publisher
	Barroso Gonz xe1 lez J, Garc xed a Exp xf3 sito L, Galaviz P, Lynskey M, Allen J, Hoang S, et al. Anti-recombination function of MutSα restricts telomere extension by ALT-associated homology-directed repair. Cell Rep. 2021;37:110088 pubmed publisher
	van Wietmarschen N, Sridharan S, Nathan W, Tubbs A, Chan E, Callen E, et al. Repeat expansions confer WRN dependence in microsatellite-unstable cancers. Nature. 2020;586:292-298 pubmed publisher
	Wu X, Li Y, Liu X, Chen C, Harrington S, Cao S, et al. Targeting B7-H1 (PD-L1) sensitizes cancer cells to chemotherapy. Heliyon. 2018;4:e01039 pubmed publisher
	Meunier M, Scandolera A, Chapuis E, Lambert C, Jarrin C, Robe P, et al. From stem cells protection to skin microbiota balance: Orobanche rapum extract, a new natural strategy. J Cosmet Dermatol. 2019;18:1140-1154 pubmed publisher
	Hori M, Miki T, Okamoto M, Yazama F, Konishi H, Kaneko H, et al. The detergent-soluble cytoplasmic pool of survivin suppresses anoikis and its expression is associated with metastatic disease of human colon cancer. PLoS ONE. 2013;8:e55710 pubmed publisher
	Güvenç H, Pavlyukov M, Joshi K, Kurt H, Banasavadi Siddegowda Y, Mao P, et al. Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex. Clin Cancer Res. 2013;19:631-42 pubmed publisher
	Lechler P, Schaumburger J, Köck F, Balakrishnan S, Doukas S, Prantl L, et al. The oncofetal gene survivin promotes cell proliferation and survival in primary human osteoblastic cells. Calcif Tissue Int. 2011;89:211-20 pubmed publisher
	Lechler P, Renkawitz T, Campean V, Balakrishnan S, Tingart M, Grifka J, et al. The antiapoptotic gene survivin is highly expressed in human chondrosarcoma and promotes drug resistance in chondrosarcoma cells in vitro. BMC Cancer. 2011;11:120 pubmed publisher
	Qi G, Tuncel H, Aoki E, Tanaka S, Oka S, Kaneko I, et al. Intracellular localization of survivin determines biological behavior in colorectal cancer. Oncol Rep. 2009;22:557-62 pubmed
	Lechler P, Wu X, Bernhardt W, Campean V, Gastiger S, Hackenbeck T, et al. The tumor gene survivin is highly expressed in adult renal tubular cells: implications for a pathophysiological role in the kidney. Am J Pathol. 2007;171:1483-98 pubmed
	Ding Y, Prieto V, Zhang P, Rosenthal S, Smith K, Skelton H, et al. Nuclear expression of the antiapoptotic protein survivin in malignant melanoma. Cancer. 2006;106:1123-9 pubmed
	Giodini A, Kallio M, Wall N, Gorbsky G, Tognin S, Marchisio P, et al. Regulation of microtubule stability and mitotic progression by survivin. Cancer Res. 2002;62:2462-7 pubmed
	Fortugno P, Wall N, Giodini A, O Connor D, Plescia J, Padgett K, et al. Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function. J Cell Sci. 2002;115:575-85 pubmed

product information

master code :

NB100-472

SKU :

NB100-472

product name :

WRN Antibody - BSA Free

unit size :

100 ul

description :

The WRN Antibody - BSA Free from Novus is a rabbit polyclonal antibody to WRN. This antibody reacts with human,mouse. The WRN Antibody - BSA Free has been validated for the following applications: Western Blot,Knockout Validated,Immunoprecipitation.

target :

WRN

category :

Primary Antibodies

buffer :

Tris-Citrate/Phosphate (pH 7.0 - 8.0)

clonality :

Polyclonal

concentration :

1.0 mg/ml

conjugate :

Unconjugated

host :

Rabbit

immunogen :

The immunogen recognized by this antibody maps to a region between residues 1400 and the C-terminus (residue 1432) of human Werner Syndrome Helicase using the numbering given in SwissProt entry Q14191 (GeneID 7486).

isotype :

IgG

purity :

Immunogen affinity purified

species :

Human,Mouse

theoretical molecular weight :

162 kDa

gene symbol :

WRN

Antibody validation :

Independent Anitbodies

accessionNumbers :

Q14191

applications :

Western Blot,Knockout Validated,Immunoprecipitation

USD :

479 USD

alt names :

DKFZp686C2056, DNA helicase, RecQ-like type 3, EC 3.1, EC 3.6.1, EC 3.6.4.12, Exonuclease WRN, RecQ protein-like 2, RecQ3, RECQ3RECQL3, RECQL2Werner syndrome ATP-dependent helicase, Werner syndrome, Werner syndrome, RecQ helicase-like

storage :

Store at 4C. Do not freeze.

more info or order :

Novus Biologicals product webpage