product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
FIH-1/HIF-1AN Antibody - BSA Free
catalog :
NB100-428
quantity :
0.1 ml (also 0.025 ml)
price :
409 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 41
Reference
E G, Sun B, Liu B, Xu G, He S, Wang Y, et al. Enhanced BPGM/2,3-DPG pathway activity suppresses glycolysis in hypoxic astrocytes via FIH-1 and TET2. Brain Res Bull. 2023;192:36-46 pubmed publisher
Sch xfc tzhold V, Gravemeyer J, Bicker A, Hager T, Padberg C, Sch xe4 fer J, et al. Knockout of Factor-Inhibiting HIF (Hif1an) in Colon Epithelium Attenuates Chronic Colitis but Does Not Reduce Colorectal Cancer in Mice. J Immunol. 2022;208:1280-1291 pubmed publisher
Li Z, Wang B, Lv L, Tang T, Wen Y, Cao J, et al. FIH-1-modulated HIF-1α C-TAD promotes acute kidney injury to chronic kidney disease progression via regulating KLF5 signaling. Acta Pharmacol Sin. 2021;: pubmed publisher
Chung Y, Saitoh Y, Hayashi T, Fukui Y, Terada N, Seiki M, et al. Mint3 is dispensable for pancreatic and kidney functions in mice. Biochem Biophys Rep. 2020;24:100872 pubmed publisher
Williams A, Khadka V, Anagaran M, Lee K, Avelar A, Deng Y, et al. miR-125 family regulates XIRP1 and FIH in response to myocardial infarction. Physiol Genomics. 2020;52:358-368 pubmed publisher
Che L, Alavattam K, Stambrook P, Namekawa S, Du C. BRUCE preserves genomic stability in the male germline of mice. Cell Death Differ. 2020;: pubmed publisher
Pan H, Jiang N, Sun S, Jiang H, Xu J, Jiang X, et al. UHRF1-repressed 5'-hydroxymethylcytosine is essential for the male meiotic prophase I. Cell Death Dis. 2020;11:142 pubmed publisher
Guioli S, Zhao D, Nandi S, Clinton M, Lovell Badge R. Oestrogen in the chick embryo can induce chromosomally male ZZ left gonad epithelial cells to form an ovarian cortex that can support oogenesis. Development. 2020;147: pubmed publisher
Mader J, Huber J, Bonn F, Dötsch V, Rogov V, Bremm A. Oxygen-dependent asparagine hydroxylation of the ubiquitin-associated (UBA) domain in Cezanne regulates ubiquitin binding. J Biol Chem. 2020;295:2160-2174 pubmed publisher
Abe H, Alavattam K, Hu Y, Pang Q, Andreassen P, Hegde R, et al. The Initiation of Meiotic Sex Chromosome Inactivation Sequesters DNA Damage Signaling from Autosomes in Mouse Spermatogenesis. Curr Biol. 2019;: pubmed publisher
Harpelunde Poulsen K, Nielsen J, Frederiksen H, Melau C, Juul Hare K, Langhoff Thuesen L, et al. Dysregulation of FGFR signalling by a selective inhibitor reduces germ cell survival in human fetal gonads of both sexes and alters the somatic niche in fetal testes. Hum Reprod. 2019;34:2228-2243 pubmed publisher
Ugidos N, Mena J, Baquero S, Alloza I, Azkargorta M, Elortza F, et al. Interactome of the Autoimmune Risk Protein ANKRD55. Front Immunol. 2019;10:2067 pubmed publisher
Xie Y, Khan R, Wahab F, Hussain H, Ali A, Ma H, et al. The testis-specifically expressed Dpep3 is not essential for male fertility in mice. Gene. 2019;: pubmed publisher
Docherty C, Nilsen M, MacLean M. Influence of 2-Methoxyestradiol and Sex on Hypoxia-Induced Pulmonary Hypertension and Hypoxia-Inducible Factor-1-α. J Am Heart Assoc. 2019;8:e011628 pubmed publisher
Pillai M, Mihi B, Ishiwata K, Nakamura K, Sakuragi N, Finkelstein D, et al. Myc-induced nuclear antigen constrains a latent intestinal epithelial cell-intrinsic anthelmintic pathway. PLoS ONE. 2019;14:e0211244 pubmed publisher
Gorence G, Pulcastro H, Lawson C, Gerona R, Friesen M, Horan T, et al. Chemical Contaminants from Plastics in the Animal Environment. J Am Assoc Lab Anim Sci. 2019;58:190-196 pubmed publisher
Jørgensen A, Macdonald J, Nielsen J, Kilcoyne K, Perlman S, Lundvall L, et al. Nodal Signaling Regulates Germ Cell Development and Establishment of Seminiferous Cords in the Human Fetal Testis. Cell Rep. 2018;25:1924-1937.e4 pubmed publisher
Mu X, Wen J, Chen Q, Wang Z, Wang Y, Guo M, et al. Retinoic acid-induced CYP51 nuclear translocation promotes meiosis prophase I process and is correlated to the expression of REC8 and STAG3 in mice. Biol Open. 2018;7: pubmed publisher
Mary N, Villagómez D, Revay T, Rezaei S, Donaldson B, Pinton A, et al. Meiotic Synapsis and Gene Expression Altered by a Balanced Y-Autosome Reciprocal Translocation in an Azoospermic Pig. Sex Dev. 2018;12: pubmed publisher
Zhai Q, Ge W, Wang J, Sun X, Ma J, Liu J, et al. Exposure to Zinc oxide nanoparticles during pregnancy induces oocyte DNA damage and affects ovarian reserve of mouse offspring. Aging (Albany NY). 2018;10:2170-2189 pubmed publisher
Cheng S, Qin X, Han Z, Sun X, Feng Y, Yang F, et al. Nicotine exposure impairs germ cell development in human fetal ovaries cultured in vitro. Aging (Albany NY). 2018;10:1556-1574 pubmed publisher
Fouquet B, Pawlikowska P, Caburet S, Guigon C, Mäkinen M, Tanner L, et al. A homozygous FANCM mutation underlies a familial case of non-syndromic primary ovarian insufficiency. elife. 2017;6: pubmed publisher
Cheng P, Wu H, Li C, Chen C, Cheng H. Characterization of the testicular regeneration potential in premature cockerels. J Reprod Dev. 2017;63:563-570 pubmed publisher
Pang J, Zhou Q, Sun X, Li L, Zhou B, Zeng F, et al. Effect of low-dose zearalenone exposure on reproductive capacity of male mice. Toxicol Appl Pharmacol. 2017;333:60-67 pubmed publisher
Liu J, Lai F, Li L, Sun X, Cheng S, Ge W, et al. Di (2-ethylhexyl) phthalate exposure impairs meiotic progression and DNA damage repair in fetal mouse oocytes in vitro. Cell Death Dis. 2017;8:e2966 pubmed publisher
Jung D, Xiong J, Ye M, Qin X, Li L, Cheng S, et al. In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells. Nat Commun. 2017;8:15680 pubmed publisher
Liu K, Sun X, Feng Y, Cheng S, Li B, Li Y, et al. The impact of Zearalenone on the meiotic progression and primordial follicle assembly during early oogenesis. Toxicol Appl Pharmacol. 2017;329:9-17 pubmed publisher
Vallot C, Patrat C, Collier A, Huret C, Casanova M, Liyakat Ali T, et al. XACT Noncoding RNA Competes with XIST in the Control of X Chromosome Activity during Human Early Development. Cell Stem Cell. 2017;20:102-111 pubmed publisher
Zhuang X, Tang W, Feng X, Liu C, Zhu J, Yan J, et al. Trim27 interacts with Slx2, is associated with meiotic processes during spermatogenesis. Cell Cycle. 2016;15:2576-2584 pubmed
Tang X, Xu S, Li R, Zhang H, Chen Q, Wu W, et al. Polycomb repressive complex 1 (PRC1) regulates meiotic initiation of ovarian germ cells in chick embryos. Mol Cell Endocrinol. 2016;437:171-182 pubmed publisher
Bullen J, Tchernyshyov I, Holewinski R, Devine L, Wu F, Venkatraman V, et al. Protein kinase A-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1. Sci Signal. 2016;9:ra56 pubmed publisher
Hanna R, Moffett D, Forster F, Trudgett A, Brennan G, Fairweather I. Fasciola hepatica: a light and electron microscope study of the ovary and of the development of oocytes within eggs in the uterus provides an insight into reproductive strategy. Vet Parasitol. 2016;221:93-103 pubmed publisher
Nakaoka H, Hara T, Yoshino S, Kanamori A, Matsui Y, Shimamura T, et al. NECAB3 Promotes Activation of Hypoxia-inducible factor-1 during Normoxia and Enhances Tumourigenicity of Cancer Cells. Sci Rep. 2016;6:22784 pubmed publisher
Heeren A, He N, de Souza A, Goercharn Ramlal A, van Iperen L, Roost M, et al. On the development of extragonadal and gonadal human germ cells. Biol Open. 2016;5:185-94 pubmed publisher
Lambeth L, Morris K, Ayers K, Wise T, O Neil T, Wilson S, et al. Overexpression of Anti-Müllerian Hormone Disrupts Gonadal Sex Differentiation, Blocks Sex Hormone Synthesis, and Supports Cell Autonomous Sex Development in the Chicken. Endocrinology. 2016;157:1258-75 pubmed publisher
Ge W, Ma H, Cheng S, Sun Y, Sun L, Sun X, et al. Differentiation of early germ cells from human skin-derived stem cells without exogenous gene integration. Sci Rep. 2015;5:13822 pubmed publisher
Cadalbert L, Ghaffar F, Stevenson D, Bryson S, Vaz F, Gottlieb E, et al. Mouse Tafazzin Is Required for Male Germ Cell Meiosis and Spermatogenesis. PLoS ONE. 2015;10:e0131066 pubmed publisher
De Melo Bernardo A, Heeren A, van Iperen L, Fernandes M, He N, Anjie S, et al. Meiotic wave adds extra asymmetry to the development of female chicken gonads. Mol Reprod Dev. 2015;82:774-86 pubmed publisher
Liang G, Zhang X, Wang J, Sun Y, Sun X, Cheng S, et al. Activin A accelerates the progression of fetal oocytes throughout meiosis and early oogenesis in the mouse. Stem Cells Dev. 2015;24:2455-65 pubmed publisher
Kiriakidis S, Henze A, Kruszynska Ziaja I, Skobridis K, Theodorou V, Paleolog E, et al. Factor-inhibiting HIF-1 (FIH-1) is required for human vascular endothelial cell survival. FASEB J. 2015;29:2814-27 pubmed publisher
Karttunen S, Duffield M, Scrimgeour N, Squires L, Lim W, Dallas M, et al. Oxygen-dependent hydroxylation by FIH regulates the TRPV3 ion channel. J Cell Sci. 2015;128:225-31 pubmed publisher
product information
master code :
NB100-428
SKU :
NB100-428
product name :
FIH-1/HIF-1AN Antibody - BSA Free
unit size :
0.1 ml (also 0.025 ml)
description :
The FIH-1/HIF-1AN Antibody - BSA Free from Novus is a rabbit polyclonal antibody to FIH-1/HIF-1AN. This antibody reacts with human,mouse,rat. The FIH-1/HIF-1AN Antibody - BSA Free has been validated for the following applications: Western Blot,Immunohistochemistry-Paraffin,Electron Microscopy,Immunocytochemistry/ Immunofluorescence,Immunoprecipitation,Knockout Validated,Immunohistochemistry,Immunohistochemistry-Frozen,Knockdown Validated.
target :
FIH-1/HIF-1AN
category :
Primary Antibodies
buffer :
Tris-Citrate/Phosphate (pH 7.0 - 8.0)
clonality :
Polyclonal
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
A synthetic peptide made to the C-terminal region of human Factor Inhibiting HIF-1 (between residues 300 and the C-terminus). [UniProt# Q9NWT6]
isotype :
IgG
purity :
Immunogen affinity purified
species :
Human,Mouse,Rat
theoretical molecular weight :
40.3 kDa
gene symbol :
HIF1AN
Antibody validation :
Biological Validation
accessionNumbers :
Q9NWT6
applications :
Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Electron Microscopy,Knockout Validated,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,Immunohistochemistry-Frozen,Knockdown Validated
USD :
409 USD
alt names :
DKFZp762F1811, EC 1.14.11.16, factor inhibiting HIF1, Factor inhibiting HIF-1, FIH1FIH-1, FLJ20615, FLJ22027, hypoxia inducible factor 1, alpha subunit inhibitor, hypoxia-inducible factor 1-alpha inhibitor, Hypoxia-inducible factor asparagine hydroxylase, peptide-aspartate beta-dioxygenase
storage :
Store at 4C. Do not freeze.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.