product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Carbonic Anhydrase IX/CA9 Antibody - BSA Free
catalog :
NB100-417
quantity :
0.1 ml (also 0.025 ml)
price :
469 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
HRP
clone name :
OTI2B3
reactivity :
human, mouse, rat, Xenopus laevis
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, EMSA, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, proximity ligation assay
more info or order :
citations: 179
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; human; loading ...; fig 6d
Wang Y, Lyu Y, Tu K, Xu Q, Yang Y, Salman S, et al. Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization. Sci Adv. 2021;7: pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 3a
Steenbrugge J, Vander Elst N, Demeyere K, De Wever O, Sanders N, van den Broeck W, et al. OMO-1 reduces progression and enhances cisplatin efficacy in a 4T1-based non-c-MET addicted intraductal mouse model for triple-negative breast cancer. NPJ Breast Cancer. 2021;7:27 pubmed publisher
  • western blot; human; 1:5000; loading ...; fig 1f
Greenhough A, Bagley C, Heesom K, Gurevich D, Gay D, Bond M, et al. Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis. EMBO Mol Med. 2018;10: pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:250-1:500
Rickelt S, Hynes R. Antibodies and methods for immunohistochemistry of extracellular matrix proteins. Matrix Biol. 2018;71-72:10-27 pubmed publisher
  • western blot; human; fig 13
Ono M, Yamada K, Bensaddek D, Afzal V, Biddlestone J, Ortmann B, et al. Enhanced snoMEN Vectors Facilitate Establishment of GFP-HIF-1α Protein Replacement Human Cell Lines. PLoS ONE. 2016;11:e0154759 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:2000; fig 6
Scholz A, Harter P, Cremer S, Yalcin B, Gurnik S, Yamaji M, et al. Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatment-naive and bevacizumab-resistant glioblastoma. EMBO Mol Med. 2016;8:39-57 pubmed publisher
  • western blot; human; 1:1000; fig 4
Ortmann B, Bensaddek D, Carvalhal S, Moser S, Mudie S, Griffis E, et al. CDK-dependent phosphorylation of PHD1 on serine 130 alters its substrate preference in cells. J Cell Sci. 2016;129:191-205 pubmed publisher
  • immunocytochemistry; Xenopus laevis; 1:500; fig 5c
  • western blot; Xenopus laevis; 1:500; fig 1e
  • immunocytochemistry; human; 1:500; loading ...; fig 5a
Klier M, Jamali S, Ames S, Schneider H, Becker H, Deitmer J. Catalytic activity of human carbonic anhydrase isoform IX is displayed both extra- and intracellularly. FEBS J. 2016;283:191-200 pubmed publisher
Miklovicova S, Volpini L, Sanovec O, Monaco F, Vanova K, Novák J, et al. Mitochondrial respiratory complex II is altered in renal carcinoma. Biochim Biophys Acta Mol Basis Dis. 2025;1871:167556 pubmed publisher
Suzuki S, Yashiro M, Izumi N, Tsukioka T, Inoue H, Hara K, et al. Impact of CA9 expression in the diagnosis of lymph-node metastases in non-small cell lung cancer based on [18F]FDG PET/CT. PLoS ONE. 2024;19:e0312846 pubmed publisher
Roos Mattila M, Kallio P, Luck T, Polso M, Kumari R, Mikkonen P, et al. Distinct molecular profiles and shared drug vulnerabilities in pancreatic metastases of renal cell carcinoma. Commun Biol. 2024;7:1355 pubmed publisher
Ge Z, Wang J, He L, Zhao M, Si Y, Chang S, et al. Reconstruction of cancer marker analysis with holistic anatomical precision implicates heterogeneity development during breast tumor progression. Discov Oncol. 2024;15:564 pubmed publisher
Feodoroff M, Hamdan F, Antignani G, Feola S, Fusciello M, Russo S, et al. Enhancing T-cell recruitment in renal cell carcinoma with cytokine-armed adenoviruses. Oncoimmunology. 2024;13:2407532 pubmed publisher
Baek S, Ha H, Park J, Cho M, Kim H, Yu S, et al. Chip collection of hepatocellular carcinoma based on O2 heterogeneity from patient tissue. Nat Commun. 2024;15:5117 pubmed publisher
Santamans A, Cicu xe9 ndez B, Mora A, Villalba Orero M, Rajlic S, Crespo M, et al. MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension. Sci Adv. 2024;10:eadk6524 pubmed publisher
Li H, Song C, Zhang Y, Liu G, Mi H, Li Y, et al. Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation. Adv Sci (Weinh). 2023;:e2305620 pubmed publisher
Massenet Regad L, Poirot J, Jackson M, Hoffmann C, Amblard E, Onodi F, et al. Large-scale analysis of cell-cell communication reveals angiogenin-dependent tumor progression in clear cell renal cell carcinoma. iScience. 2023;26:108367 pubmed publisher
Fantin J, Toutain J, P xe9 r xe8 s E, Bernay B, Mehani S, Helaine C, et al. Assessment of hypoxia and oxidative-related changes in a lung-derived brain metastasis model by [64Cu][Cu(ATSM)] PET and proteomic studies. EJNMMI Res. 2023;13:102 pubmed publisher
Sun X, Sui W, Mu Z, Xie S, Deng J, Li S, et al. Mirabegron displays anticancer effects by globally browning adipose tissues. Nat Commun. 2023;14:7610 pubmed publisher
Rao H, Liu C, Wang A, Ma C, Xu Y, Ye T, et al. SETD2 deficiency accelerates sphingomyelin accumulation and promotes the development of renal cancer. Nat Commun. 2023;14:7572 pubmed publisher
Imanishi M, Inoue T, Fukushima K, Yamashita R, Nakayama R, Nojima M, et al. CA9 and PRELID2; hypoxia-responsive potential therapeutic targets for pancreatic ductal adenocarcinoma as per bioinformatics analyses. J Pharmacol Sci. 2023;153:232-242 pubmed publisher
Griesinger A, Riemondy K, Eswaran N, Donson A, Willard N, Prince E, et al. Multi-omic approach identifies hypoxic tumor-associated myeloid cells that drive immunobiology of high-risk pediatric ependymoma. iScience. 2023;26:107585 pubmed publisher
Pearsall S, Williamson S, Humphrey S, Hughes E, Morgan D, Garc xed a Marqu xe9 s F, et al. Lineage plasticity in SCLC generates non-neuroendocrine cells primed for vasculogenic mimicry. J Thorac Oncol. 2023;: pubmed publisher
Zwergel C, Aventaggiato M, Garbo S, Di Bello E, Fassari B, Noce B, et al. Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells. J Med Chem. 2023;66:9622-9641 pubmed publisher
Wu J, Jing X, Du Q, Sun X, Holgersson K, Gao J, et al. Disruption of the Clock Component Bmal1 in Mice Promotes Cancer Metastasis through the PAI-1-TGF-β-myoCAF-Dependent Mechanism. Adv Sci (Weinh). 2023;10:e2301505 pubmed publisher
Vinciguerra A, Bedarida V, Pronier C, El Zein S, Wassef M, Atallah S, et al. Expression, Prognostic Value and Correlation with HPV Status of Hypoxia-Induced Markers in Sinonasal Squamous Cell Carcinoma. J Pers Med. 2023;13: pubmed publisher
Aboouf M, Armbruster J, Guscetti F, Thiersch M, Boss A, G xf6 decke A, et al. Endogenous myoglobin expression in mouse models of mammary carcinoma reduces hypoxia and metastasis in PyMT mice. Sci Rep. 2023;13:7530 pubmed publisher
Aventaggiato M, Preziosi A, Cheraghi Bidsorkhi H, Schifano E, Vespa S, Mardente S, et al. ZnO Nanorods Create a Hypoxic State with Induction of HIF-1 and EPAS1, Autophagy, and Mitophagy in Cancer and Non-Cancer Cells. Int J Mol Sci. 2023;24: pubmed publisher
Odeh S, Samarska I, Matoso A, van de Pol J, Baldewijns M, Hulsbergen van de Kaa C, et al. Histologic re‑evaluation of a population‑based series of renal cell carcinomas from The Netherlands Cohort Study according to the 2022 ISUP/WHO classification. Oncol Lett. 2023;25:174 pubmed publisher
Glassman D, Kim M, Spradlin M, Badal S, Taki M, Bhattacharya P, et al. Exploiting metabolic vulnerabilities after anti-VEGF antibody therapy in ovarian cancer. iScience. 2023;26:106020 pubmed publisher
Park E, Li L, He C, Abbasi A, Ahmed T, Foltz W, et al. Brain-Penetrating and Disease Site-Targeting Manganese Dioxide-Polymer-Lipid Hybrid Nanoparticles Remodel Microenvironment of Alzheimer's Disease by Regulating Multiple Pathological Pathways. Adv Sci (Weinh). 2023;10:e2207238 pubmed publisher
Aubin R, Montelongo J, Hu R, Camara P. Clustering-independent estimation of cell abundances in bulk tissues using single-cell RNA-seq data. bioRxiv. 2023;: pubmed publisher
Eloranta K, Pihlajoki M, Liljestr xf6 m E, Nousiainen R, Soini T, Lohi J, et al. SLC-0111, an inhibitor of carbonic anhydrase IX, attenuates hepatoblastoma cell viability and migration. Front Oncol. 2023;13:1118268 pubmed publisher
Mardente S, Aventaggiato M, Splendiani E, Mari E, Zicari A, Catanzaro G, et al. Extra-Cellular Vesicles Derived from Thyroid Cancer Cells Promote the Epithelial to Mesenchymal Transition (EMT) and the Transfer of Malignant Phenotypes through Immune Mediated Mechanisms. Int J Mol Sci. 2023;24: pubmed publisher
Ito R, Yashiro M, Tsukioka T, Izumi N, Komatsu H, Inoue H, et al. Usefulness of pyruvate dehydrogenase-E1α expression to determine SUVmax cut-off value of [18F]FDG-PET for predicting lymph node metastasis in lung cancer. Sci Rep. 2023;13:1565 pubmed publisher
Li Y, Lih T, Dhanasekaran S, Mannan R, Chen L, Cieslik M, et al. Histopathologic and proteogenomic heterogeneity reveals features of clear cell renal cell carcinoma aggressiveness. Cancer Cell. 2023;41:139-163.e17 pubmed publisher
Aoki T, Kinoshita J, Munesue S, Hamabe Horiike T, Yamaguchi T, Nakamura Y, et al. Hypoxia-Induced CD36 Expression in Gastric Cancer Cells Promotes Peritoneal Metastasis via Fatty Acid Uptake. Ann Surg Oncol. 2023;30:3125-3136 pubmed publisher
Jing X, Wu J, Dong C, Gao J, Seki T, Kim C, et al. COVID-19 instigates adipose browning and atrophy through VEGF in small mammals. Nat Metab. 2022;4:1674-1683 pubmed publisher
Agudelo J, Upadhyay D, Zhang D, Zhao H, Nolley R, Sun J, et al. Multiparametric Magnetic Resonance Imaging and Metabolic Characterization of Patient-Derived Xenograft Models of Clear Cell Renal Cell Carcinoma. Metabolites. 2022;12: pubmed publisher
Stirling E, Terabe M, Wilson A, Kooshki M, Yamaleyeva L, Alexander Miller M, et al. Targeting the CD47/thrombospondin-1 signaling axis regulates immune cell bioenergetics in the tumor microenvironment to potentiate antitumor immune response. J Immunother Cancer. 2022;10: pubmed publisher
Gong Y, Shao H, Li Y, Brafford P, Stine Z, Sun J, et al. Na+/H+-exchanger 1 enhances antitumor activity of engineered NK-92 natural killer cells. Cancer Res Commun. 2022;2:842-856 pubmed publisher
De Filippis R, W xf6 lflein G, Um I, Caie P, Warren S, White A, et al. Use of High-Plex Data Reveals Novel Insights into the Tumour Microenvironment of Clear Cell Renal Cell Carcinoma. Cancers (Basel). 2022;14: pubmed publisher
de Koster E, van Engen van Grunsven A, Bussink J, Frielink C, de Geus Oei L, Kusters B, et al. [18F]FDG Uptake and Expression of Immunohistochemical Markers Related to Glycolysis, Hypoxia, and Proliferation in Indeterminate Thyroid Nodules. Mol Imaging Biol. 2022;: pubmed publisher
Liu Q, Stel W, Noord V, Leegwater H, Coban B, Elbertse K, et al. Hypoxia Triggers TAZ Phosphorylation in Basal A Triple Negative Breast Cancer Cells. Int J Mol Sci. 2022;23: pubmed publisher
Ye C, Li H, Li Y, Zhang Y, Liu G, Mi H, et al. Hypoxia-induced HMGB1 promotes glioma stem cells self-renewal and tumorigenicity via RAGE. iScience. 2022;25:104872 pubmed publisher
Simmler P, Cortijo C, Koch L, Galliker P, Angori S, Bolck H, et al. SF3B1 facilitates HIF1-signaling and promotes malignancy in pancreatic cancer. Cell Rep. 2022;40:111266 pubmed publisher
Seki T, Yang Y, Sun X, Lim S, Xie S, Guo Z, et al. Brown-fat-mediated tumour suppression by cold-altered global metabolism. Nature. 2022;608:421-428 pubmed publisher
Steenbrugge J, Bellemans J, Vander Elst N, Demeyere K, De Vliegher J, Perera T, et al. One cisplatin dose provides durable stimulation of anti-tumor immunity and alleviates anti-PD-1 resistance in an intraductal model for triple-negative breast cancer. Oncoimmunology. 2022;11:2103277 pubmed publisher
Bell H, Kumar Sinha C, Mannan R, Zakalik D, Zhang Y, Mehra R, et al. Pathogenic ATM and BAP1 germline mutations in a case of early-onset, familial sarcomatoid renal cancer. Cold Spring Harb Mol Case Stud. 2022;8: pubmed publisher
Kim J, Nam J, Kim A, Park M, Lee H, Park J, et al. 2-Methoxyestradiol Inhibits Radiation-Induced Skin Injuries. Int J Mol Sci. 2022;23: pubmed publisher
Zhang P, Liu G, Hu J, Chen S, Wang B, Peng P, et al. Tenascin-C can Serve as an Indicator for the Immunosuppressive Microenvironment of Diffuse Low-Grade Gliomas. Front Immunol. 2022;13:824586 pubmed publisher
Ryniawec J, Coope M, Loertscher E, Bageerathan V, De Oliveira Pessoa D, Warfel N, et al. GLUT3/SLC2A3 Is an Endogenous Marker of Hypoxia in Prostate Cancer Cell Lines and Patient-Derived Xenograft Tumors. Diagnostics (Basel). 2022;12: pubmed publisher
Brereton C, Yao L, Davies E, Zhou Y, Vukmirovic M, Bell J, et al. Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis. elife. 2022;11: pubmed publisher
Boizot J, Minville Walz M, Reinhardt D, Bouschbacher M, Sommer P, Sigaudo Roussel D, et al. FBN2 Silencing Recapitulates Hypoxic Conditions and Induces Elastic Fiber Impairment in Human Dermal Fibroblasts. Int J Mol Sci. 2022;23: pubmed publisher
Yelek C, Mignion L, Paquot A, Bouzin C, Corbet C, Muccioli G, et al. Tumor Metabolism Is Affected by Obesity in Preclinical Models of Triple-Negative Breast Cancer. Cancers (Basel). 2022;14: pubmed publisher
Xie Y, Sahin M, Sinha S, Wang Y, Nargund A, Lyu Y, et al. SETD2 loss perturbs the kidney cancer epigenetic landscape to promote metastasis and engenders actionable dependencies on histone chaperone complexes. Nat Cancer. 2022;3:188-202 pubmed publisher
Westbrook R, Bridges E, Roberts J, Escribano Gonzalez C, Eales K, Vettore L, et al. Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions. Cell Rep. 2022;38:110320 pubmed publisher
Wiechec E, Matic N, Ali A, Roberg K. Hypoxia induces radioresistance, epithelial‑mesenchymal transition, cancer stem cell‑like phenotype and changes in genes possessing multiple biological functions in head and neck squamous cell carcinoma. Oncol Rep. 2022;47: pubmed publisher
Wadsworth B, Lee C, Bennewith K. Transiently hypoxic tumour cell turnover and radiation sensitivity in human tumour xenografts. Br J Cancer. 2022;126:1616-1626 pubmed publisher
Infantino R, Schiano C, Luongo L, Paino S, Mansueto G, Boccella S, et al. MED1/BDNF/TrkB pathway is involved in thalamic hemorrhage-induced pain and depression by regulating microglia. Neurobiol Dis. 2022;164:105611 pubmed publisher
Chow E, Lau J, Wai T, Lam I. The anti-tumoral effects of the oxygen carrier YQ23 in a triple-negative breast cancer syngeneic model. Transl Cancer Res. 2021;10:656-668 pubmed publisher
Chen F, Licarete E, Wu X, Petrusca D, Maguire C, Jacobsen M, et al. Pharmacological inhibition of Carbonic Anhydrase IX and XII to enhance targeting of acute myeloid leukaemia cells under hypoxic conditions. J Cell Mol Med. 2021;25:11039-11052 pubmed publisher
Kim H, Kang Y, Lee J, Han S, Kim D, Ko H, et al. Biphasic Regulation of Mitogen-Activated Protein Kinase Phosphatase 3 in Hypoxic Colon Cancer Cells. Mol Cells. 2021;44:710-722 pubmed publisher
Pang L, Ng K, Liu J, Yeung W, Zhu J, Chiu T, et al. Plasmacytoid dendritic cells recruited by HIF-1α/eADO/ADORA1 signaling induce immunosuppression in hepatocellular carcinoma. Cancer Lett. 2021;522:80-92 pubmed publisher
Lin C, Lai S, Shen C, Chen C, Tsai C, Liu Y, et al. Fenofibrate inhibits hypoxia-inducible factor-1 alpha and carbonic anhydrase expression through activation of AMP-activated protein kinase/HO-1/Sirt1 pathway in glioblastoma cells. Environ Toxicol. 2021;36:2551-2561 pubmed publisher
Maurer G, Tichy J, Harter P, N xf6 th U, Weise L, Quick Weller J, et al. Matching Quantitative MRI Parameters with Histological Features of Treatment-Naïve IDH Wild-Type Glioma. Cancers (Basel). 2021;13: pubmed publisher
Udayakumar D, Zhang Z, Xi Y, Dwivedi D, Fulkerson M, Haldeman S, et al. Deciphering Intratumoral Molecular Heterogeneity in Clear Cell Renal Cell Carcinoma with a Radiogenomics Platform. Clin Cancer Res. 2021;27:4794-4806 pubmed publisher
Mehibel M, Xu Y, Li C, Moon E, Thakkar K, Diep A, et al. Eliminating hypoxic tumor cells improves response to PARP inhibitors in homologous recombination-deficient cancer models. J Clin Invest. 2021;131: pubmed publisher
Mikkelsen M, Marcussen N, Rabjerg M. Surgically induced ischemia has no impact on protein expression levels of HIF-1α and related biomarkers in renal cell carcinoma. APMIS. 2021;129:535-547 pubmed publisher
Riechelmann H, Steinbichler T, Sprung S, Santer M, Runge A, Ganswindt U, et al. The Epithelial-Mesenchymal Transcription Factor Slug Predicts Survival Benefit of Up-Front Surgery in Head and Neck Cancer. Cancers (Basel). 2021;13: pubmed publisher
Anemone A, Consolino L, Conti L, Irrera P, Hsu M, Villano D, et al. Tumour acidosis evaluated in vivo by MRI-CEST pH imaging reveals breast cancer metastatic potential. Br J Cancer. 2021;124:207-216 pubmed publisher
Simko V, Belvončíková P, Csaderova L, Labudova M, Grossmannova K, Zatovicova M, et al. PIMT Binding to C-Terminal Ala459 of CAIX Is Involved in Inside-Out Signaling Necessary for Its Catalytic Activity. Int J Mol Sci. 2020;21: pubmed publisher
Alberti D, Michelotti A, Lanfranco A, Protti N, Altieri S, Deagostino A, et al. In vitro and in vivo BNCT investigations using a carborane containing sulfonamide targeting CAIX epitopes on malignant pleural mesothelioma and breast cancer cells. Sci Rep. 2020;10:19274 pubmed publisher
Menga A, Serra M, Todisco S, Riera Domingo C, Ammarah U, Ehling M, et al. Glufosinate constrains synchronous and metachronous metastasis by promoting anti-tumor macrophages. EMBO Mol Med. 2020;12:e11210 pubmed publisher
Huang B, Liu Y, Lai S, Lin H, Shen C, Yang L, et al. CAIX Regulates GBM Motility and TAM Adhesion and Polarization through EGFR/STAT3 under Hypoxic Conditions. Int J Mol Sci. 2020;21: pubmed publisher
Gillen A, Riemondy K, Amani V, Griesinger A, Gilani A, Venkataraman S, et al. Single-Cell RNA Sequencing of Childhood Ependymoma Reveals Neoplastic Cell Subpopulations That Impact Molecular Classification and Etiology. Cell Rep. 2020;32:108023 pubmed publisher
Hosaka K, Yang Y, Seki T, Du Q, Jing X, He X, et al. Therapeutic paradigm of dual targeting VEGF and PDGF for effectively treating FGF-2 off-target tumors. Nat Commun. 2020;11:3704 pubmed publisher
Mehes G, Matolay O, Beke L, Czenke M, Porszasz R, Miko E, et al. Carbonic Anhydrase Inhibitor Acetazolamide Enhances CHOP Treatment Response and Stimulates Effector T-Cell Infiltration in A20/BalbC Murine B-Cell Lymphoma. Int J Mol Sci. 2020;21: pubmed publisher
Ghosh P, Guo Y, Ashrafi A, Chen J, Dey S, Zhong S, et al. Oxygen-Enhanced Optoacoustic Tomography Reveals the Effectiveness of Targeting Heme and Oxidative Phosphorylation at Normalizing Tumor Vascular Oxygenation. Cancer Res. 2020;80:3542-3555 pubmed publisher
Kikuchi H, Maishi N, Annan D, Alam M, Dawood R, Sato M, et al. Chemotherapy-Induced IL8 Upregulates MDR1/ABCB1 in Tumor Blood Vessels and Results in Unfavorable Outcome. Cancer Res. 2020;80:2996-3008 pubmed publisher
Lovisa S, Fletcher Sananikone E, Sugimoto H, Hensel J, Lahiri S, Hertig A, et al. Endothelial-to-mesenchymal transition compromises vascular integrity to induce Myc-mediated metabolic reprogramming in kidney fibrosis. Sci Signal. 2020;13: pubmed publisher
Becker L, O Connell J, Vo A, Cain M, Tampe D, Bizarro L, et al. Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer. Cell Rep. 2020;31:107701 pubmed publisher
Fu S, Wang C, Chen F, Yu C, Hong J, Chiang C. Sunitinib Treatment-elicited Distinct Tumor Microenvironment Dramatically Compensated the Reduction of Myeloid-derived Suppressor Cells. In Vivo. 2020;34:1141-1152 pubmed publisher
Chen S, Xing C, Huang D, Zhou C, Ding B, Guo Z, et al. Eradication of tumor growth by delivering novel photothermal selenium-coated tellurium nanoheterojunctions. Sci Adv. 2020;6:eaay6825 pubmed publisher
Kim M, Joo J, Lee S, Cho Y, Park C, Cho N. Comprehensive Immunoprofiles of Renal Cell Carcinoma Subtypes. Cancers (Basel). 2020;12: pubmed publisher
Kuthi L, Somorácz A, Micsik T, Jenei A, Hajdu A, Sejben I, et al. Clinicopathological Findings on 28 Cases with XP11.2 Renal Cell Carcinoma. Pathol Oncol Res. 2020;: pubmed publisher
Brown E, Rowan C, Strowitzki M, Fagundes R, Faber K, Güntsch A, et al. Mucosal inflammation downregulates PHD1 expression promoting a barrier-protective HIF-1α response in ulcerative colitis patients. FASEB J. 2020;34:3732-3742 pubmed publisher
Steenbrugge J, Vander Elst N, Demeyere K, De Wever O, Sanders N, van den Broeck W, et al. Comparative Profiling of Metastatic 4T1- vs. Non-metastatic Py230-Based Mammary Tumors in an Intraductal Model for Triple-Negative Breast Cancer. Front Immunol. 2019;10:2928 pubmed publisher
Abdulfatah E, Kennedy J, Hafez K, Davenport M, Xiao H, Weizer A, et al. Clinicopathological characterisation of renal cell carcinoma in young adults: a contemporary update and review of literature. Histopathology. 2020;76:875-887 pubmed publisher
Silagi E, Novais E, Bisetto S, Telonis A, Snuggs J, Le Maitre C, et al. Lactate Efflux From Intervertebral Disc Cells Is Required for Maintenance of Spine Health. J Bone Miner Res. 2019;: pubmed publisher
Xiao Y, Zhao H, Tian L, Nolley R, Diep A, Ernst A, et al. S100A10 Is a Critical Mediator of GAS6/AXL-Induced Angiogenesis in Renal Cell Carcinoma. Cancer Res. 2019;79:5758-5768 pubmed publisher
Recondo G, Mezquita L, Facchinetti F, Planchard D, Gazzah A, Bigot L, et al. Diverse Resistance Mechanisms to the Third-Generation ALK Inhibitor Lorlatinib in ALK-Rearranged Lung Cancer. Clin Cancer Res. 2020;26:242-255 pubmed publisher
Kennedy J, Wang X, Plouffe K, Dhanasekaran S, Hafez K, Palapattu G, et al. Clinical and morphologic review of 60 hereditary renal tumors from 30 hereditary renal cell carcinoma syndrome patients: lessons from a contemporary single institution series. Med Oncol. 2019;36:74 pubmed publisher
Matolay O, Beke L, Gyurkovics A, Francz M, Varjasi G, Rejto L, et al. Quantitative Analysis of Carbonic Anhydrase IX Uncovers Hypoxia-Related Functional Differences in Classical Hodgkin Lymphoma Subtypes. Int J Mol Sci. 2019;20: pubmed publisher
Kitson S, Maskell Z, Sivalingam V, Shaw J, Crosbie E. Optimization of Window Study Endpoints in Endometrial Cancer. Front Oncol. 2019;9:428 pubmed publisher
Ron A, Dean Ben X, Gottschalk S, Razansky D. Volumetric optoacoustic imaging unveils high-resolution patterns of acute and cyclic hypoxia in a murine model of breast cancer. Cancer Res. 2019;: pubmed publisher
Reijnen C, van Weelden W, Arts M, Peters J, Rijken P, Van De Vijver K, et al. Poor outcome in hypoxic endometrial carcinoma is related to vascular density. Br J Cancer. 2019;120:1037-1044 pubmed publisher
Azam S, Porrello A, Harrison E, Leslie P, Liu X, Waugh T, et al. Quaking orchestrates a post-transcriptional regulatory network of endothelial cell cycle progression critical to angiogenesis and metastasis. Oncogene. 2019;: pubmed publisher
Frost J, Ciulli A, Rocha S. RNA-seq analysis of PHD and VHL inhibitors reveals differences and similarities to the hypoxia response. Wellcome Open Res. 2019;4:17 pubmed publisher
Najjar Y, Menk A, Sander C, Rao U, Karunamurthy A, Bhatia R, et al. Tumor cell oxidative metabolism as a barrier to PD-1 blockade immunotherapy in melanoma. JCI Insight. 2019;4: pubmed publisher
Schuurman T, Witteveen P, van der Wall E, Passier J, Huitema A, Amant F, et al. Tamoxifen and pregnancy: an absolute contraindication?. Breast Cancer Res Treat. 2019;175:17-25 pubmed publisher
Guo H, Ci X, Ahmed M, Hua J, Soares F, Lin D, et al. ONECUT2 is a driver of neuroendocrine prostate cancer. Nat Commun. 2019;10:278 pubmed publisher
Mehes G, Matolay O, Beke L, Czenke M, Jona A, Miltenyi Z, et al. Hypoxia-related carbonic anhydrase IX expression is associated with unfavourable response to first-line therapy in classical Hodgkin's lymphoma. Histopathology. 2019;74:699-708 pubmed publisher
Neal J, Li X, Zhu J, Giangarrà V, Grzeskowiak C, Ju J, et al. Organoid Modeling of the Tumor Immune Microenvironment. Cell. 2018;175:1972-1988.e16 pubmed publisher
Kubo H, Hanaoka K, Kuriki Y, Komatsu T, Ueno T, Kojima R, et al. Rapid detection of metastatic lymph nodes of colorectal cancer with a gamma-glutamyl transpeptidase-activatable fluorescence probe. Sci Rep. 2018;8:17781 pubmed publisher
Young J, Coy H, Kim H, Douek M, Sisk A, Pantuck A, et al. Association of the Gross Appearance of Intratumoral Vascularity at MDCT With the Carbonic Anhydrase IX Score in Clear Cell Renal Cell Carcinoma. AJR Am J Roentgenol. 2018;211:1254-1258 pubmed publisher
Davis R, Kiss B, Trivedi D, Metzner T, Liao J, Gambhir S. Surface-Enhanced Raman Scattering Nanoparticles for Multiplexed Imaging of Bladder Cancer Tissue Permeability and Molecular Phenotype. ACS Nano. 2018;12:9669-9679 pubmed publisher
Burman A, Kropski J, Calvi C, Serezani A, Pascoalino B, Han W, et al. Localized hypoxia links ER stress to lung fibrosis through induction of C/EBP homologous protein. JCI Insight. 2018;3: pubmed publisher
Steenbrugge J, Breyne K, Demeyere K, De Wever O, Sanders N, van den Broeck W, et al. Anti-inflammatory signaling by mammary tumor cells mediates prometastatic macrophage polarization in an innovative intraductal mouse model for triple-negative breast cancer. J Exp Clin Cancer Res. 2018;37:191 pubmed publisher
Balasundaram G, Ding L, Li X, Attia A, Dean Ben X, Ho C, et al. Noninvasive Anatomical and Functional Imaging of Orthotopic Glioblastoma Development and Therapy using Multispectral Optoacoustic Tomography. Transl Oncol. 2018;11:1251-1258 pubmed publisher
Lambrechts D, Wauters E, Boeckx B, Aibar S, Nittner D, Burton O, et al. Phenotype molding of stromal cells in the lung tumor microenvironment. Nat Med. 2018;24:1277-1289 pubmed publisher
Ames S, Pastorekova S, Becker H. The proteoglycan-like domain of carbonic anhydrase IX mediates non-catalytic facilitation of lactate transport in cancer cells. Oncotarget. 2018;9:27940-27957 pubmed publisher
Toonen L, Overzier M, Evers M, Leon L, van der Zeeuw S, Mei H, et al. Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model. Mol Neurodegener. 2018;13:31 pubmed publisher
Iwamoto H, Abe M, Yang Y, Cui D, Seki T, Nakamura M, et al. Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance. Cell Metab. 2018;28:104-117.e5 pubmed publisher
Rosenberg T, Aaberg Jessen C, Petterson S, Kristensen B. Heterogenic expression of stem cell markers in patient-derived glioblastoma spheroid cultures exposed to long-term hypoxia. CNS Oncol. 2018;7:CNS15 pubmed publisher
Schreier B, Wolf A, Hammer S, Pohl S, Mildenberger S, Rabe S, et al. The selective mineralocorticoid receptor antagonist eplerenone prevents decompensation of the liver in cirrhosis. Br J Pharmacol. 2018;175:2956-2967 pubmed publisher
Dao M, Pécriaux A, Bessede T, Durrbach A, Mussini C, Guettier C, et al. BK virus-associated collecting duct carcinoma of the renal allograft in a kidney-pancreas allograft recipient. Oncotarget. 2018;9:15157-15163 pubmed publisher
Ferecatu I, Canal F, Fabbri L, Mazure N, Bouton C, Golinelli Cohen M. Dysfunction in the mitochondrial Fe-S assembly machinery leads to formation of the chemoresistant truncated VDAC1 isoform without HIF-1? activation. PLoS ONE. 2018;13:e0194782 pubmed publisher
Corbet C, Bastien E, Draoui N, Doix B, Mignion L, Jordan B, et al. Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects. Nat Commun. 2018;9:1208 pubmed publisher
Young J, Coy H, Kim H, Douek M, Sisk A, Belldegrun A, et al. Utility of multiphasic multidetector computed tomography in discriminating between clear cell renal cell carcinomas with high and low carbonic anhydrase-IX expression. Abdom Radiol (NY). 2018;43:2734-2742 pubmed publisher
Dreyer Andersen N, Almeida A, Jensen P, Kamand M, Okarmus J, Rosenberg T, et al. Intermittent, low dose carbon monoxide exposure enhances survival and dopaminergic differentiation of human neural stem cells. PLoS ONE. 2018;13:e0191207 pubmed publisher
Boyd N, Walker K, Fried J, Hackney J, McDonald P, Benavides G, et al. Addition of carbonic anhydrase 9 inhibitor SLC-0111 to temozolomide treatment delays glioblastoma growth in vivo. JCI Insight. 2017;2: pubmed publisher
Pinato D, Black J, Trousil S, Dina R, Trivedi P, Mauri F, et al. Programmed cell death ligands expression in phaeochromocytomas and paragangliomas: Relationship with the hypoxic response, immune evasion and malignant behavior. Oncoimmunology. 2017;6:e1358332 pubmed publisher
He L, Zhao C, Li Y, Du G, Liu K, Cui D, et al. Antiangiogenic effects of recombinant human endostatin in lung cancers. Mol Med Rep. 2018;17:79-86 pubmed publisher
Ou D, Garberis I, Adam J, Blanchard P, Nguyen F, Levy A, et al. Prognostic value of tissue necrosis, hypoxia-related markers and correlation with HPV status in head and neck cancer patients treated with bio- or chemo-radiotherapy. Radiother Oncol. 2018;126:116-124 pubmed publisher
Nakamura M, Zhang Y, Yang Y, Sonmez C, Zheng W, Huang G, et al. Off-tumor targets compromise antiangiogenic drug sensitivity by inducing kidney erythropoietin production. Proc Natl Acad Sci U S A. 2017;114:E9635-E9644 pubmed publisher
Wang D, Berglund A, Kenchappa R, Macaulay R, MULE J, Etame A. BIRC3 is a biomarker of mesenchymal habitat of glioblastoma, and a mediator of survival adaptation in hypoxia-driven glioblastoma habitats. Sci Rep. 2017;7:9350 pubmed publisher
Bucau M, Laurent Bellue A, Poté N, Hentic O, Cros J, Mikail N, et al. 18F-FDG Uptake in Well-Differentiated Neuroendocrine Tumors Correlates with Both Ki-67 and VHL Pathway Inactivation. Neuroendocrinology. 2018;106:274-282 pubmed publisher
Dong Y, Manley B, Becerra M, Redzematovic A, Casuscelli J, Tennenbaum D, et al. Tumor Xenografts of Human Clear Cell Renal Cell Carcinoma But Not Corresponding Cell Lines Recapitulate Clinical Response to Sunitinib: Feasibility of Using Biopsy Samples. Eur Urol Focus. 2017;3:590-598 pubmed publisher
Klameth L, Rath B, Hochmaier M, Moser D, Redl M, Mungenast F, et al. Small cell lung cancer: model of circulating tumor cell tumorospheres in chemoresistance. Sci Rep. 2017;7:5337 pubmed publisher
Zhang Y, Sun M, Huang G, Yin L, Lai Q, Yang Y, et al. Maintenance of antiangiogenic and antitumor effects by orally active low-dose capecitabine for long-term cancer therapy. Proc Natl Acad Sci U S A. 2017;114:E5226-E5235 pubmed publisher
Takenaka M, Suzuki N, Mori M, Hirayama T, Nagasawa H, Morishige K. Iron regulatory protein 2 in ovarian endometrial cysts. Biochem Biophys Res Commun. 2017;487:789-794 pubmed publisher
Bousquet G, El Bouchtaoui M, Sophie T, Leboeuf C, De Bazelaire C, Ratajczak P, et al. Targeting autophagic cancer stem-cells to reverse chemoresistance in human triple negative breast cancer. Oncotarget. 2017;8:35205-35221 pubmed publisher
Tudisco L, Orlandi A, Tarallo V, De Falco S. Hypoxia activates placental growth factor expression in lymphatic endothelial cells. Oncotarget. 2017;8:32873-32883 pubmed publisher
Lee D, Cheul Oh S, Giles A, Jung J, Gilbert M, Park D. Cardiac glycosides suppress the maintenance of stemness and malignancy via inhibiting HIF-1? in human glioma stem cells. Oncotarget. 2017;8:40233-40245 pubmed publisher
Himmels P, Paredes I, Adler H, Karakatsani A, Luck R, Marti H, et al. Motor neurons control blood vessel patterning in the developing spinal cord. Nat Commun. 2017;8:14583 pubmed publisher
Fraga A, Ribeiro R, Coelho A, Vizcaíno J, Coutinho H, Lopes J, et al. Genetic polymorphisms in key hypoxia-regulated downstream molecules and phenotypic correlation in prostate cancer. BMC Urol. 2017;17:12 pubmed publisher
Bulusu V, Tumanov S, Michalopoulou E, van den Broek N, Mackay G, Nixon C, et al. Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation. Cell Rep. 2017;18:647-658 pubmed publisher
Tsuji T, Kurokawa Y, Chiche J, Pouysségur J, Sato H, Fukuzawa H, et al. Dissecting the Process of Activation of Cancer-promoting Zinc-requiring Ectoenzymes by Zinc Metalation Mediated by ZNT Transporters. J Biol Chem. 2017;292:2159-2173 pubmed publisher
Oh E, Kim J, Kim J, Kim S, Lee J, Hong S, et al. NQO1 inhibits proteasome-mediated degradation of HIF-1α. Nat Commun. 2016;7:13593 pubmed publisher
Frost J, Galdeano C, Soares P, Gadd M, Grzes K, Ellis L, et al. Potent and selective chemical probe of hypoxic signalling downstream of HIF-? hydroxylation via VHL inhibition. Nat Commun. 2016;7:13312 pubmed publisher
Cauchy F, Mebarki M, Leporq B, Laouirem S, Albuquerque M, Lambert S, et al. Strong antineoplastic effects of metformin in preclinical models of liver carcinogenesis. Clin Sci (Lond). 2017;131:27-36 pubmed
Eikrem O, Strauss P, Beisland C, Scherer A, Landolt L, Flatberg A, et al. Development and confirmation of potential gene classifiers of human clear cell renal cell carcinoma using next-generation RNA sequencing. Scand J Urol. 2016;50:452-462 pubmed
Huang Y, Lichtenberger L, Taylor M, Bottsford Miller J, Haemmerle M, Wagner M, et al. Antitumor and Antiangiogenic Effects of Aspirin-PC in Ovarian Cancer. Mol Cancer Ther. 2016;15:2894-2904 pubmed
Knudsen E, Balaji U, Freinkman E, McCue P, Witkiewicz A. Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential. Oncotarget. 2016;7:78396-78411 pubmed publisher
Kim E, Kim G, Kim J, Park I, Shin J, Chai Y, et al. A Pyloric Gland-Phenotype Ovarian Mucinous Tumor Resembling Lobular Endocervical Glandular Hyperplasia in a Patient with Peutz-Jeghers Syndrome. J Pathol Transl Med. 2017;51:159-164 pubmed publisher
van Kuijk S, Gieling R, Niemans R, Lieuwes N, Biemans R, Telfer B, et al. The Sulfamate Small Molecule CAIX Inhibitor S4 Modulates Doxorubicin Efficacy. PLoS ONE. 2016;11:e0161040 pubmed publisher
Hirakawa T, Yashiro M, Doi Y, Kinoshita H, Morisaki T, Fukuoka T, et al. Pancreatic Fibroblasts Stimulate the Motility of Pancreatic Cancer Cells through IGF1/IGF1R Signaling under Hypoxia. PLoS ONE. 2016;11:e0159912 pubmed publisher
Yoon C, Chang K, Lee J, Tap W, Hart C, Simon M, et al. Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1? inhibition, and hypoxia-activated chemotherapy. Oncotarget. 2016;7:42844-42858 pubmed publisher
Leek R, Grimes D, Harris A, McIntyre A. Methods: Using Three-Dimensional Culture (Spheroids) as an In Vitro Model of Tumour Hypoxia. Adv Exp Med Biol. 2016;899:167-96 pubmed publisher
He H, Yang Y, Xiang Z, Yu L, Chouitar J, Yu J, et al. A Sensitive IHC Method for Monitoring Autophagy-Specific Markers in Human Tumor Xenografts. J Biomark. 2016;2016:1274603 pubmed publisher
Hecht J, Zsengellér Z, Spiel M, Karumanchi S, Rosen S. Revisiting decidual vasculopathy. Placenta. 2016;42:37-43 pubmed publisher
Xu W, Ghosh S, Comhair S, Asosingh K, Janocha A, Mavrakis D, et al. Increased mitochondrial arginine metabolism supports bioenergetics in asthma. J Clin Invest. 2016;126:2465-81 pubmed publisher
Badar T, Handisides D, Benito J, Richie M, Borthakur G, Jabbour E, et al. Phase I study of evofosfamide, an investigational hypoxia-activated prodrug, in patients with advanced leukemia. Am J Hematol. 2016;91:800-5 pubmed publisher
Faes S, Planche A, Uldry E, Santoro T, Pythoud C, Stehle J, et al. Targeting carbonic anhydrase IX improves the anti-cancer efficacy of mTOR inhibitors. Oncotarget. 2016;7:36666-36680 pubmed publisher
Eikrem O, Beisland C, Hjelle K, Flatberg A, Scherer A, Landolt L, et al. Transcriptome Sequencing (RNAseq) Enables Utilization of Formalin-Fixed, Paraffin-Embedded Biopsies with Clear Cell Renal Cell Carcinoma for Exploration of Disease Biology and Biomarker Development. PLoS ONE. 2016;11:e0149743 pubmed publisher
Radoul M, Chaumeil M, Eriksson P, Wang A, Phillips J, Ronen S. MR Studies of Glioblastoma Models Treated with Dual PI3K/mTOR Inhibitor and Temozolomide:Metabolic Changes Are Associated with Enhanced Survival. Mol Cancer Ther. 2016;15:1113-22 pubmed publisher
Mitsuhashi A, Goto H, Saijo A, Trung V, Aono Y, Ogino H, et al. Fibrocyte-like cells mediate acquired resistance to anti-angiogenic therapy with bevacizumab. Nat Commun. 2015;6:8792 pubmed publisher
André H, Tunik S, Aronsson M, Kvanta A. Hypoxia-Inducible Factor-1α Is Associated With Sprouting Angiogenesis in the Murine Laser-Induced Choroidal Neovascularization Model. Invest Ophthalmol Vis Sci. 2015;56:6591-604 pubmed publisher
Islam S, Mokhtari R, Akbari P, Hatina J, Yeger H, Farhat W. Simultaneous Targeting of Bladder Tumor Growth, Survival, and Epithelial-to-Mesenchymal Transition with a Novel Therapeutic Combination of Acetazolamide (AZ) and Sulforaphane (SFN). Target Oncol. 2016;11:209-27 pubmed publisher
Kinoshita H, Yashiro M, Fukuoka T, Hasegawa T, Morisaki T, Kasashima H, et al. Diffuse-type gastric cancer cells switch their driver pathways from FGFR2 signaling to SDF1/CXCR4 axis in hypoxic tumor microenvironments. Carcinogenesis. 2015;36:1511-20 pubmed publisher
Jamali S, Klier M, Ames S, Barros L, McKenna R, Deitmer J, et al. Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function. Sci Rep. 2015;5:13605 pubmed publisher
Baine M, Turcu G, Zito C, Adeniran A, Camp R, Chen L, et al. Characterization of tumor infiltrating lymphocytes in paired primary and metastatic renal cell carcinoma specimens. Oncotarget. 2015;6:24990-5002 pubmed publisher
Song C, Lee Y, Griffin R, Park I, Koonce N, Hui S, et al. Indirect Tumor Cell Death After High-Dose Hypofractionated Irradiation: Implications for Stereotactic Body Radiation Therapy and Stereotactic Radiation Surgery. Int J Radiat Oncol Biol Phys. 2015;93:166-72 pubmed publisher
Ward C, Meehan J, Mullen P, Supuran C, Dixon J, Thomas J, et al. Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models. Oncotarget. 2015;6:24856-70 pubmed publisher
Kasashima H, Yashiro M, Kinoshita H, Fukuoka T, Morisaki T, Masuda G, et al. Lysyl oxidase is associated with the epithelial-mesenchymal transition of gastric cancer cells in hypoxia. Gastric Cancer. 2016;19:431-442 pubmed publisher
Yoon C, Lee H, Park D, Lee Y, Tap W, Eisinger Mathason T, et al. Hypoxia-activated chemotherapeutic TH-302 enhances the effects of VEGF-A inhibition and radiation on sarcomas. Br J Cancer. 2015;113:46-56 pubmed publisher
Brossa A, Grange C, Mancuso L, Annaratone L, Satolli M, Mazzone M, et al. Sunitinib but not VEGF blockade inhibits cancer stem cell endothelial differentiation. Oncotarget. 2015;6:11295-309 pubmed
Dulloo I, Phang B, Othman R, Tan S, Vijayaraghavan A, Goh L, et al. Hypoxia-inducible TAp73 supports tumorigenesis by regulating the angiogenic transcriptome. Nat Cell Biol. 2015;17:511-23 pubmed publisher
Cotroneo E, Ashek A, Wang L, Wharton J, Dubois O, Bozorgi S, et al. Iron homeostasis and pulmonary hypertension: iron deficiency leads to pulmonary vascular remodeling in the rat. Circ Res. 2015;116:1680-90 pubmed publisher
Kang H, Kim I, Sung C, Shim J, Yu E. Expression of carbonic anhydrase 9 is a novel prognostic marker in resectable hepatocellular carcinoma. Virchows Arch. 2015;466:403-13 pubmed publisher
Lee H, Yoon C, Park D, Kim Y, Schmidt B, Lee Y, et al. Inhibition of vascular endothelial growth factor A and hypoxia-inducible factor 1α maximizes the effects of radiation in sarcoma mouse models through destruction of tumor vasculature. Int J Radiat Oncol Biol Phys. 2015;91:621-30 pubmed publisher
Janmohamed S, Brinkhuizen T, Den Hollander J, Madern G, de Laat P, van Steensel M, et al. Support for the hypoxia theory in the pathogenesis of infantile haemangioma. Clin Exp Dermatol. 2015;40:431-7 pubmed publisher
Lin X, Zhang H, Tang N, Zhang X, Zhang W, Wang E, et al. Expression and diagnostic implications of carbonic anhydrase IX in several tumours with predominantly clear cell morphology. Histopathology. 2015;66:685-94 pubmed publisher
Dos Santos C, Tijeras Raballand A, Serova M, Sebbagh S, Slimane K, Faivre S, et al. Effects of preset sequential administrations of sunitinib and everolimus on tumour differentiation in Caki-1 renal cell carcinoma. Br J Cancer. 2015;112:86-94 pubmed publisher
Hwa J, Kwon O, Park J, Woo S, Kim J, Ko G, et al. The prognostic value of immunohistochemical markers for oral tongue squamous cell carcinoma. Eur Arch Otorhinolaryngol. 2015;272:2953-9 pubmed publisher
Chen L, Howison C, Spier C, Stopeck A, Malm S, Pagel M, et al. Assessment of carbonic anhydrase IX expression and extracellular pH in B-cell lymphoma cell line models. Leuk Lymphoma. 2015;56:1432-9 pubmed publisher
Sadlecki P, Bodnar M, Grabiec M, Marszalek A, Walentowicz P, Sokup A, et al. The role of Hypoxia-inducible factor-1 ? , glucose transporter-1, (GLUT-1) and carbon anhydrase IX in endometrial cancer patients. Biomed Res Int. 2014;2014:616850 pubmed publisher
Kwon O, Park J, Ko G, Seo J, Jeong B, Kang K, et al. HIF-1α and CA-IX as predictors of locoregional control for determining the optimal treatment modality for early-stage laryngeal carcinoma. Head Neck. 2015;37:505-10 pubmed publisher
product information
master code :
NB100-417
SKU :
NB100-417
product name :
Carbonic Anhydrase IX/CA9 Antibody - BSA Free
unit size :
0.1 ml (also 0.025 ml)
description :
The Carbonic Anhydrase IX/CA9 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to Carbonic Anhydrase IX/CA9. This antibody reacts with human,mouse,plant,rat. The Carbonic Anhydrase IX/CA9 Antibody - BSA Free has been validated for the following applications: Immunohistochemistry-Paraffin,Immunohistochemistry,Western Blot,Immunocytochemistry/ Immunofluorescence,Westen Blot,Chemotaxis,EMSA,IF/ICC,IF/IHC,ELISA,Immunohistochemistry-Frozen,Proximity Ligation Assay,Microarray,Immunofluorescence,Flow Cytometry,Immunoprecipitation,Immunoblotting,Gel Super Shift Assays,Simple Western,Chromatin Immunoprecipitation (ChIP),Dual RNAscope ISH-IHC.
target :
Carbonic Anhydrase IX/CA9
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
This Carbonic Anhydrase IX/CA9 Antibody was made from a synthetic peptide from the C-terminal sequence of human Carbonic Anhydrase IX (within residues 400-459) [UniProt# Q16790].
isotype :
IgG
purity :
Immunogen affinity purified
species :
Human,Mouse,Plant,Rat
theoretical molecular weight :
55 kDa
gene symbol :
CA9
Antibody validation :
Biological Validation
applications :
Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunocytochemistry/ Immunofluorescence,Westen Blot,Chemotaxis,EMSA,IF/ICC,IF/IHC,ELISA,Immunohistochemistry-Frozen,Proximity Ligation Assay,Microarray,Immunofluorescence,Flow Cytometry,Immunoprecipitation,Immunoblotting,Gel Super Shift Assays,Simple Western,Chromatin Immunoprecipitation (ChIP),Dual RNAscope ISH-IHC
USD :
469 USD
alt names :
CAIX, CA-IX, Carbonate dehydratase IX, carbonic anhydrase 9, carbonic anhydrase IX, carbonic dehydratase, EC 4.2.1.1, G250, Membrane antigen MN, MN, P54/58N, PMW1, RCC-associated antigen G250, RCC-associated protein G250, Renal cell carcinoma-associated antigen G250
storage :
Store at -20C. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.