BRCA1 Antibody (6B4) - Azide and BSA Free | Novus Biologicals NB100-404 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

BRCA1 Antibody (6B4) - Azide and BSA Free

catalog :

NB100-404

quantity :

100 ul

price :

479 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6B4

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Novus Biologicals product webpage

citations: 11

Reference
Yu L, Wu D. SMARCA2 and SMARCA4 Participate in DNA Damage Repair. Front Biosci (Landmark Ed). 2024;29:262 pubmed publisher
Di Agostino S, Canu V, Donzelli S, Pulito C, Sacconi A, Ganci F, et al. HSF-1/miR-145-5p transcriptional axis enhances hyperthermic intraperitoneal chemotherapy efficacy on peritoneal ovarian carcinosis. Cell Death Dis. 2023;14:535 pubmed publisher
Wei Y, Chen Y, Li W, Yang Y, Lin S, Wu C, et al. Antioxidant Nanoparticles Restore Cisplatin-Induced Male Fertility Defects by Promoting MDC1-53bp1-Associated Non-Homologous DNA Repair Mechanism and Sperm Intracellular Calcium Influx. Int J Nanomedicine. 2023;18:4313-4327 pubmed publisher
Swift M, Azizkhan Clifford J. DNA damage-induced sumoylation of Sp1 induces its interaction with RNF4 and degradation in S phase to remove 53BP1 from DSBs and permit HR. DNA Repair (Amst). 2022;111:103289 pubmed publisher
Swift M, Beishline K, Flashner S, Azizkhan Clifford J. DSB repair pathway choice is regulated by recruitment of 53BP1 through cell cycle-dependent regulation of Sp1. Cell Rep. 2021;34:108840 pubmed publisher
Zhai B, Li Y, Kotapalli S, Bacha J, Brown D, Steinø A, et al. Dianhydrogalactitol synergizes with topoisomerase poisons to overcome DNA repair activity in tumor cells. Cell Death Dis. 2020;11:577 pubmed publisher
Mori S, Honda H, Ishii T, Yoshimura M, Sasagasako N, Suzuki S, et al. Expanded polyglutamine impairs normal nuclear distribution of fused in sarcoma and poly (rC)-binding protein 1 in Huntington's disease. Neuropathology. 2019;39:358-367 pubmed publisher
Zhai B, Steinø A, Bacha J, Brown D, Daugaard M. Dianhydrogalactitol induces replication-dependent DNA damage in tumor cells preferentially resolved by homologous recombination. Cell Death Dis. 2018;9:1016 pubmed publisher
Berger A, Cortese G, Amodeo K, Weihofen A, Letai A, LaVoie M. Parkin selectively alters the intrinsic threshold for mitochondrial cytochrome c release. Hum Mol Genet. 2009;18:4317-28 pubmed publisher
Bernard Gallon D, Dechelotte P, Le Corre L, Chalabi N, Vissac Sabatier C, Bignon Y. Differential expressions of BRCA1 and BRCA2 in infantile gynecomastia. Anticancer Res. 2004;24:321-4 pubmed
Li S, Ting N, Zheng L, Chen P, Ziv Y, Shiloh Y, et al. Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Nature. 2000;406:210-5 pubmed

product information

master code :

NB100-404

SKU :

NB100-404

product name :

BRCA1 Antibody (6B4) - Azide and BSA Free

unit size :

100 ul

description :

The BRCA1 Antibody (6B4) - Azide and BSA Free from Novus is a mouse monoclonal antibody to BRCA1. This antibody reacts with human. The BRCA1 Antibody (6B4) - Azide and BSA Free has been validated for the following applications: Immunohistochemistry,Chemotaxis,IF/IHC,Western Blot,Immunocytochemistry/ Immunofluorescence,Immunoprecipitation,Immunohistochemistry-Paraffin,Chromatin Immunoprecipitation (ChIP),Knockout Validated,Knockdown Validated.

target :

BRCA1

category :

Primary Antibodies

buffer :

PBS

clonality :

Monoclonal

clone :

6B4

conjugate :

Unconjugated

host :

Mouse

immunogen :

BRCA1 protein fragment expressed in E. coli corresponding to amino acids 341-748.

isotype :

IgG1

purity :

Protein G purified

species :

Human

specificity :

This recognizes BRCA1, a 220-kDa nuclear phosphoprotein, and does not recognize the exon 11 splice variant

theoretical molecular weight :

220 kDa

gene symbol :

BRCA1

Antibody validation :

Biological Validation

applications :

Chemotaxis,IF/IHC,Immunohistochemistry,Western Blot,Immunocytochemistry/ Immunofluorescence,Immunoprecipitation,Immunohistochemistry-Paraffin,Chromatin Immunoprecipitation (ChIP),Knockout Validated,Knockdown Validated

USD :

479 USD

alt names :

BRCAI, breast and ovarian cancer susceptibility protein 1, breast and ovarian cancer sususceptibility protein, breast cancer 1, early onset, breast cancer type 1 susceptibility protein, EC 6.3.2, EC 6.3.2.-, IRIS, PNCA4, PSCP, subunit 1

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage