product summary
request information :
company name :
Novus Biologicals
product type :
antibody
product name :
Mouse Monoclonal Rad21 Antibody
catalog :
NB100-386C
quantity :
0.1 ml
price :
379.00 USD
clonality :
monoclonal
host :
mouse
reactivity :
human, mouse
application :
western blot
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NB100-386C
Product Name :
Mouse Monoclonal Rad21 Antibody
List Price :
379.00 USD
Product Type :
Primary Antibodies
Package Size :
0.1 ml
AltNames :
double-strand-break repair protein rad21 homolog, hHR21FLJ25655, HR21, KIAA0078RAD21 (S. pombe) homolog, MCD1, Nuclear matrix protein 1, NXP-1, NXP1HRAD21, protein involved in DNA double-strand break repair, RAD21 homolog (S. pombe), SCC1 homolog, SCC1FLJ40596
Background :
The cohesin complex plays an important role in tethering sister chromatids during the prophase through anaphase stages of mitosis, making certain that genomic information is replicated accurately. As the cellular division process continues, separase destroys the cohesin complex by means of cleavaging its Scc1 subunit (Mcd1/Scc1/hRad21), allowing the chromatids to separate and divide with the cell. During apoptosis the C-terminal portion of hRad21 is cleaved and translocated to the cytoplasm. This cleavage and translocation may act as a nuclear signal that promotes and accelerates subsequent events of apoptosis (2).
Buffer :
50mM sodium borate
Clonality :
Monoclonal
Clone :
CM110-2C10
Concentration :
1.0 mg/ml
Conjugate :
DyLight 650
Application Summary :
Western Blot
Host :
Mouse
Immunogen :
An N-terminal fusion protein of the C-terminal fragment of Scc1 subunit human cohesin (amino acids 544-631 of hRad21).
Isotype :
IgG1 Kappa
Localization :
Nuclear and cytoplasm
Preservative :
No Preservative
Purity :
Protein G purified
CrossReactivity :
Human and mouse.
Specificity :
NB100-386 is specific for both the nuclear hRad21 protein and the cleaved cytoplasmic hRad21 protein.
Storage :
Store at 4C in the dark.
Swissprot Human :
O60216
Uses :
This Rad21 (CM110-2C10) antibody can be used in Western blot, where two bands are seen. The full-length Rad21 is seen around 130 kDa, while the cleaved Rad21 is seen around 70 kDa.
Research Area :
Apoptosis, Cancer, Cell Biology, Cell Cycle and Replication, Chromatin Research, DNA Repair
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: usa
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.