RNase L Antibody (2E9) - BSA Free | Novus Biologicals NB100-351 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

RNase L Antibody (2E9) - BSA Free

catalog :

NB100-351

quantity :

0.1 ml (also 0.025 ml)

price :

409 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2.00E+09

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

Novus Biologicals product webpage

citations: 19

Published Application/Species/Sample/Dilution	Reference
western blot; human	Al Haj L, Blackshear P, Khabar K. Regulation of p21/CIP1/WAF-1 mediated cell-cycle arrest by RNase L and tristetraprolin, and involvement of AU-rich elements. Nucleic Acids Res. 2012;40:7739-52 pubmed publisher
western blot; mouse	Fabre O, Salehzada T, Lambert K, Boo Seok Y, Zhou A, Mercier J, et al. RNase L controls terminal adipocyte differentiation, lipids storage and insulin sensitivity via CHOP10 mRNA regulation. Cell Death Differ. 2012;19:1470-81 pubmed publisher
western blot; human	Dong B, Silverman R. A bipartite model of 2-5A-dependent RNase L. J Biol Chem. 1997;272:22236-42 pubmed
	Burke J, Ripin N, Ferretti M, St Clair L, Worden Sapper E, Salgado F, et al. RNase L activation in the cytoplasm induces aberrant processing of mRNAs in the nucleus. PLoS Pathog. 2022;18:e1010930 pubmed publisher
	Decker C, Burke J, Mulvaney P, Parker R. RNA is required for the integrity of multiple nuclear and cytoplasmic membrane-less RNP granules. EMBO J. 2022;41:e110137 pubmed publisher
	Jung S, von Thülen T, Yang I, Laukemper V, Rupf B, Janga H, et al. A ribosomal RNA fragment with 2',3'-cyclic phosphate and GTP-binding activity acts as RIG-I ligand. Nucleic Acids Res. 2020;48:10397-10412 pubmed publisher
	Burke J, Lester E, Tauber D, Parker R. RNase L promotes the formation of unique ribonucleoprotein granules distinct from stress granules. J Biol Chem. 2020;295:1426-1438 pubmed publisher
	Burke J, Moon S, Matheny T, Parker R. RNase L Reprograms Translation by Widespread mRNA Turnover Escaped by Antiviral mRNAs. Mol Cell. 2019;75:1203-1217.e5 pubmed publisher
	Lei Y, Hu Q, Gu J. Expressions of Carbohydrate Response Element Binding Protein and Glucose Transporters in Liver Cancer and Clinical Significance. Pathol Oncol Res. 2019;: pubmed publisher
	Nakagawa K, Fujiwara K, Nishimura A, Murakami C, Kawamoto K, Ichinose C, et al. UBIAD1 Plays an Essential Role in the Survival of Pancreatic Acinar Cells. Int J Mol Sci. 2019;20: pubmed publisher
	Du J, Hu C, Bai J, Peng M, Wang Q, Zhao N, et al. Intestinal Glucose Absorption Was Reduced by Vertical Sleeve Gastrectomy via Decreased Gastric Leptin Secretion. Obes Surg. 2018;28:3851-3861 pubmed publisher
	Hassani Nezhad Gashti F, Rysa J, Kummu O, Näpänkangas J, Buler M, Karpale M, et al. Activation of nuclear receptor PXR impairs glucose tolerance and dysregulates GLUT2 expression and subcellular localization in liver. Biochem Pharmacol. 2018;148:253-264 pubmed publisher
	Kim D, Song L, Wang J, Wu H, Gu G, Sugi Y, et al. GRP94 Is an Essential Regulator of Pancreatic β-Cell Development, Mass, and Function in Male Mice. Endocrinology. 2018;159:1062-1073 pubmed publisher
	Lin R, Yu H, Chang B, Tang W, Liao C, Lin Y. Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection. J Immunol. 2009;183:8035-43 pubmed publisher
	Al Ahmadi W, Al Ghamdi M, Al Haj L, Al Saif M, Khabar K. Alternative polyadenylation variants of the RNA binding protein, HuR: abundance, role of AU-rich elements and auto-Regulation. Nucleic Acids Res. 2009;37:3612-24 pubmed publisher
	Han J, Townsend H, Jha B, Paranjape J, Silverman R, Barton D. A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L. J Virol. 2007;81:5561-72 pubmed
	Carpten J, Nupponen N, Isaacs S, Sood R, Robbins C, Xu J, et al. Germline mutations in the ribonuclease L gene in families showing linkage with HPC1. Nat Genet. 2002;30:181-4 pubmed
	Wang L, Zhou A, Vasavada S, Dong B, Nie H, Church J, et al. Elevated levels of 2',5'-linked oligoadenylate-dependent ribonuclease L occur as an early event in colorectal tumorigenesis. Clin Cancer Res. 1995;1:1421-8 pubmed
	Dong B, Silverman R. 2-5A-dependent RNase molecules dimerize during activation by 2-5A. J Biol Chem. 1995;270:4133-7 pubmed

product information

master code :

NB100-351

SKU :

NB100-351

product name :

RNase L Antibody (2E9) - BSA Free

unit size :

0.1 ml (also 0.025 ml)

description :

The RNase L Antibody (2E9) - BSA Free from Novus is a mouse monoclonal antibody to RNase L. This antibody reacts with hamster,human,mouse (negative),primate,rat (negative). The RNase L Antibody (2E9) - BSA Free has been validated for the following applications: Western Blot,ELISA,Immunohistochemistry,Immunohistochemistry-Paraffin,Knockout Validated.

target :

RNase L

category :

Primary Antibodies

buffer :

PBS

clonality :

Monoclonal

clone :

2.00E+09

concentration :

1.0 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

Purified full-length recombinant human RNaseL produced in insect cells. [UniProt# Q05823]

isotype :

IgG1 Kappa

purity :

Protein G purified

species :

Hamster,Human,Mouse (Negative),Primate,Rat (Negative)

theoretical molecular weight :

83 kDa

gene symbol :

RNASEL

Antibody validation :

Knockout/Knockdown

applications :

Western Blot,ELISA,Immunohistochemistry,Immunohistochemistry-Paraffin,Knockout Validated

USD :

409 USD

alt names :

2-5A-dependent ribonuclease, 2-5A-dependent RNase, 2'-5'-oligoisoadenylate synthetase-dependent, EC 3.1.26.-, HPC1, interferon-induced 2-5A-dependent RNase, MGC104972, MGC133329, PRCA1, prostate cancer 1, Ribonuclease 4, Ribonuclease L, ribonuclease L (2'-5'-oligoisoadenylate synthetase-dependent), RNase L, RNS4DKFZp781D08126

storage :

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage