Published Application/Species/Sample/Dilution | Reference |
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- western blot; human; 1:1000; loading ...; fig 3g, 3h
| Wang S, Luke C, Pak S, Shi V, Chen L, Moore J, et al. SERPINB3 (SCCA1) inhibits cathepsin L and lysoptosis, protecting cervical cancer cells from chemoradiation. Commun Biol. 2022;5:46 pubmed publisher
|
- western blot; mouse; 1:1000; loading ...; fig 5a
| Fu X, Zhang C, Meng H, Zhang K, Shi L, Cao C, et al. Oncoprotein Tudor-SN is a key determinant providing survival advantage under DNA damaging stress. Cell Death Differ. 2018;25:1625-1637 pubmed publisher
|
- western blot; rhesus macaque; fig 2
| Simões M, Martins C, Ferreira F. Early intranuclear replication of African swine fever virus genome modifies the landscape of the host cell nucleus. Virus Res. 2015;210:1-7 pubmed publisher
|
- immunohistochemistry; human; 1:100
- immunohistochemistry; rat; 1:100
| Batenburg N, Thompson E, Hendrickson E, Zhu X. Cockayne syndrome group B protein regulates DNA double-strand break repair and checkpoint activation. EMBO J. 2015;34:1399-416 pubmed publisher
|
| Maeda J, Haskins J, Kato T. XRCC8 mutation causes hypersensitivity to PARP inhibition without Homologous recombination repair deficiency. Mutat Res. 2023;826:111815 pubmed publisher
|
| Osma García I, Capitan Sobrino D, Mouysset M, Aubert Y, Maloudi O, Turner M, et al. The splicing regulators TIA1 and TIAL1 are required for the expression of the DNA damage repair machinery during B cell lymphopoiesis. Cell Rep. 2022;41:111869 pubmed publisher
|
| Cui W, Ye C, Wang K, Yang X, Zhu P, Hu K, et al. Momordica. charantia-Derived Extracellular Vesicles-Like Nanovesicles Protect Cardiomyocytes Against Radiation Injury via Attenuating DNA Damage and Mitochondria Dysfunction. Front Cardiovasc Med. 2022;9:864188 pubmed publisher
|
| Fu X, Duan Z, Lu X, Zhu Y, Ren Y, Zhang W, et al. SND1 Promotes Radioresistance in Cervical Cancer Cells by Targeting the DNA Damage Response. Cancer Biother Radiopharm. 2022;: pubmed publisher
|
| Yang Y, Lu H, Chen C, Lyu Y, Cole R, Semenza G. HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia. Nat Commun. 2022;13:316 pubmed publisher
|
| Kirtay M, Sell J, Marx C, Haselmann H, Ceanga M, Zhou Z, et al. ATR regulates neuronal activity by modulating presynaptic firing. Nat Commun. 2021;12:4067 pubmed publisher
|
| Blakemore D, Vilaplana Lopera N, Almaghrabi R, Gonzalez E, Moya M, Ward C, et al. MYBL2 and ATM suppress replication stress in pluripotent stem cells. EMBO Rep. 2021;22:e51120 pubmed publisher
|
| Marx C, Schaarschmidt M, Kirkpatrick J, Marx Blümel L, Halilovic M, Westermann M, et al. Cooperative treatment effectiveness of ATR and HSP90 inhibition in Ewing's sarcoma cells. Cell Biosci. 2021;11:57 pubmed publisher
|
| Affandi T, Ohm A, Gaillard D, Haas A, Reyland M. Tyrosine kinase inhibitors protect the salivary gland from radiation damage by increasing DNA double-strand break repair. J Biol Chem. 2021;296:100401 pubmed publisher
|
| Bensimon A, Koch J, Francica P, Roth S, Riedo R, Glück A, et al. Deciphering MET-dependent modulation of global cellular responses to DNA damage by quantitative phosphoproteomics. Mol Oncol. 2020;14:1185-1206 pubmed publisher
|
| El Hajjar J, Chatoo W, Hanna R, Nkanza P, Tétreault N, Tse Y, et al. Heterochromatic genome instability and neurodegeneration sharing similarities with Alzheimer's disease in old Bmi1+/- mice. Sci Rep. 2019;9:594 pubmed publisher
|
| Belužić L, Grbesa I, Beluzić R, Park J, Kong H, Kopjar N, et al. Knock-down of AHCY and depletion of adenosine induces DNA damage and cell cycle arrest. Sci Rep. 2018;8:14012 pubmed publisher
|
| Göder A, Emmerich C, Nikolova T, Kiweler N, Schreiber M, Kühl T, et al. HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130. Nat Commun. 2018;9:764 pubmed publisher
|
| Park S, Kong H, Kim Y, Lee Y, Park J. Inhibition of S-adenosylhomocysteine hydrolase decreases cell mobility and cell proliferation through cell cycle arrest. Am J Cancer Res. 2015;5:2127-38 pubmed
|
| Muraki K, Han L, Miller D, Murnane J. Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks. Nucleic Acids Res. 2015;43:7911-30 pubmed publisher
|
| Vermezovic J, Adamowicz M, Santarpia L, Rustighi A, Forcato M, Lucano C, et al. Notch is a direct negative regulator of the DNA-damage response. Nat Struct Mol Biol. 2015;22:417-24 pubmed publisher
|
| Palazzo L, Della Monica R, Visconti R, Costanzo V, Grieco D. ATM controls proper mitotic spindle structure. Cell Cycle. 2014;13:1091-100 pubmed publisher
|
| Min W, Bruhn C, Grigaravicius P, Zhou Z, Li F, Krüger A, et al. Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation. Nat Commun. 2013;4:2993 pubmed publisher
|
| Simões M, Martins C, Ferreira F. Host DNA damage response facilitates African swine fever virus infection. Vet Microbiol. 2013;165:140-7 pubmed publisher
|
| Gutiérrez González A, Belda Iniesta C, Bargiela Iparraguirre J, Dominguez G, Garcia Alfonso P, Perona R, et al. Targeting Chk2 improves gastric cancer chemotherapy by impairing DNA damage repair. Apoptosis. 2013;18:347-60 pubmed publisher
|
| Shi Y, Felley Bosco E, Marti T, Orlowski K, Pruschy M, Stahel R. Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin. BMC Cancer. 2012;12:571 pubmed publisher
|
| Murad N, Cullen J, McKenzie M, Ryan M, Thorburn D, Gueven N, et al. Mitochondrial dysfunction in a novel form of autosomal recessive ataxia. Mitochondrion. 2013;13:235-45 pubmed publisher
|
| Sakasai R, Sakai A, Iimori M, Kiyonari S, Matsuoka K, Kakeji Y, et al. CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication. Genes Cells. 2012;17:962-70 pubmed publisher
|
| Shi Y, Felley Bosco E, Marti T, Stahel R. Differential effects of lovastatin on cisplatin responses in normal human mesothelial cells versus cancer cells: implication for therapy. PLoS ONE. 2012;7:e45354 pubmed publisher
|
| Baritaud M, Cabon L, Delavallée L, Galán Malo P, Gilles M, Brunelle Navas M, et al. AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation. Cell Death Dis. 2012;3:e390 pubmed publisher
|
| Hardee M, Marciscano A, Medina Ramirez C, Zagzag D, Narayana A, Lonning S, et al. Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-?. Cancer Res. 2012;72:4119-29 pubmed publisher
|
| Mahajan K, Coppola D, Rawal B, Chen Y, Lawrence H, Engelman R, et al. Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer. J Biol Chem. 2012;287:22112-22 pubmed publisher
|
| Hsu C, Lee Y, Yeh S, Chen C, Wu C, Wang T, et al. 58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway. J Biol Chem. 2012;287:22533-48 pubmed publisher
|
| Dellago H, Khan A, Nussbacher M, Gstraunthaler A, Lämmermann I, Schosserer M, et al. ATM-dependent phosphorylation of SNEVhPrp19/hPso4 is involved in extending cellular life span and suppression of apoptosis. Aging (Albany NY). 2012;4:290-304 pubmed
|
| Yan Y, Greer P, Cao P, Kolb R, Cowan K. RAC1 GTPase plays an important role in ?-irradiation induced G2/M checkpoint activation. Breast Cancer Res. 2012;14:R60 pubmed
|
| Ai L, Skehan R, Saydi J, Lin T, Brown K. Ataxia-Telangiectasia, Mutated (ATM)/Nuclear Factor ? light chain enhancer of activated B cells (NF?B) signaling controls basal and DNA damage-induced transglutaminase 2 expression. J Biol Chem. 2012;287:18330-41 pubmed publisher
|
| Zhang J, De Toledo S, Pandey B, Guo G, Pain D, Li H, et al. Role of the translationally controlled tumor protein in DNA damage sensing and repair. Proc Natl Acad Sci U S A. 2012;109:E926-33 pubmed publisher
|
| Kang M, So E, Ouchi T. Deregulation of DNA damage response pathway by intercellular contact. J Biol Chem. 2012;287:16246-55 pubmed publisher
|
| Hao Z, Duncan G, Su Y, Li W, Silvester J, Hong C, et al. The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis. J Exp Med. 2012;209:173-86 pubmed publisher
|
| Xu Y, Parmar K, Du F, Price B, Sun Y. The radioprotective agent WR1065 protects cells from radiation damage by regulating the activity of the Tip60 acetyltransferase. Int J Biochem Mol Biol. 2011;2:295-302 pubmed
|
| Assaily W, Rubinger D, Wheaton K, Lin Y, Ma W, Xuan W, et al. ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress. Mol Cell. 2011;44:491-501 pubmed publisher
|
| Sugimoto N, Yugawa T, Iizuka M, Kiyono T, Fujita M. Chromatin remodeler sucrose nonfermenting 2 homolog (SNF2H) is recruited onto DNA replication origins through interaction with Cdc10 protein-dependent transcript 1 (Cdt1) and promotes pre-replication complex formation. J Biol Chem. 2011;286:39200-10 pubmed publisher
|
| Brown J, Roberts T, Richards R, Woods R, Birrell G, Lim Y, et al. A novel role for hSMG-1 in stress granule formation. Mol Cell Biol. 2011;31:4417-29 pubmed publisher
|
| Hada M, Huff J, Patel Z, Kawata T, Pluth J, George K, et al. AT cells are not radiosensitive for simple chromosomal exchanges at low dose. Mutat Res. 2011;716:76-83 pubmed publisher
|
| Serrano D, Bleau A, Fernandez Garcia I, Fernandez Marcelo T, Iniesta P, Ortiz de Solorzano C, et al. Inhibition of telomerase activity preferentially targets aldehyde dehydrogenase-positive cancer stem-like cells in lung cancer. Mol Cancer. 2011;10:96 pubmed publisher
|
| Luo K, Yuan J, Lou Z. Oligomerization of MDC1 protein is important for proper DNA damage response. J Biol Chem. 2011;286:28192-9 pubmed publisher
|
| Bouquet F, Ousset M, Biard D, Fallone F, Dauvillier S, Frit P, et al. A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia. J Cell Sci. 2011;124:1943-51 pubmed publisher
|
| Shouse G, Nobumori Y, Panowicz M, Liu X. ATM-mediated phosphorylation activates the tumor-suppressive function of B56?-PP2A. Oncogene. 2011;30:3755-65 pubmed publisher
|
| Cherubini G, Naim V, Caruso P, Burla R, Bogliolo M, Cundari E, et al. The FANC pathway is activated by adenovirus infection and promotes viral replication-dependent recombination. Nucleic Acids Res. 2011;39:5459-73 pubmed publisher
|
| Chen Y, Chen C, Riley D, Chen P. Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR. Cell Cycle. 2011;10:655-63 pubmed
|
| Matsumoto Y, Miyamoto T, Sakamoto H, Izumi H, Nakazawa Y, Ogi T, et al. Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly. DNA Repair (Amst). 2011;10:314-21 pubmed publisher
|
| Urquhart A, Gatei M, Richard D, Khanna K. ATM mediated phosphorylation of CHD4 contributes to genome maintenance. Genome Integr. 2011;2:1 pubmed publisher
|
| Ruiz Z, Mihaylov I, Cotmore S, Tattersall P. Recruitment of DNA replication and damage response proteins to viral replication centers during infection with NS2 mutants of Minute Virus of Mice (MVM). Virology. 2011;410:375-84 pubmed publisher
|
| Guo Z, Deshpande R, Paull T. ATM activation in the presence of oxidative stress. Cell Cycle. 2010;9:4805-11 pubmed
|
| Kozlov S, Graham M, Jakob B, Tobias F, Kijas A, Tanuji M, et al. Autophosphorylation and ATM activation: additional sites add to the complexity. J Biol Chem. 2011;286:9107-19 pubmed publisher
|
| Powell M, Manandhar G, Spate L, Sutovsky M, Zimmerman S, Sachdev S, et al. Discovery of putative oocyte quality markers by comparative ExacTag proteomics. Proteomics Clin Appl. 2010;4:337-51 pubmed publisher
|
| Xu Y, Sun Y, Jiang X, Ayrapetov M, Moskwa P, Yang S, et al. The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair. J Cell Biol. 2010;191:31-43 pubmed publisher
|
| Huang Q, Tomida S, Masuda Y, Arima C, Cao K, Kasahara T, et al. Regulation of DNA polymerase POLD4 influences genomic instability in lung cancer. Cancer Res. 2010;70:8407-16 pubmed publisher
|
| Shanware N, Zhan L, Hutchinson J, Kim S, Williams L, Tibbetts R. Conserved and distinct modes of CREB/ATF transcription factor regulation by PP2A/B56gamma and genotoxic stress. PLoS ONE. 2010;5:e12173 pubmed publisher
|
| Lee J, Choy M, Ngo L, Foster S, Marks P. Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair. Proc Natl Acad Sci U S A. 2010;107:14639-44 pubmed publisher
|
| Fang Z, Kozlov S, McKay M, Woods R, Birrell G, Sprung C, et al. Low levels of ATM in breast cancer patients with clinical radiosensitivity. Genome Integr. 2010;1:9 pubmed publisher
|
| Ousset M, Bouquet F, Fallone F, Biard D, Dray C, Valet P, et al. Loss of ATM positively regulates the expression of hypoxia inducible factor 1 (HIF-1) through oxidative stress: Role in the physiopathology of the disease. Cell Cycle. 2010;9:2814-22 pubmed
|
| Storch K, Eke I, Borgmann K, Krause M, Richter C, Becker K, et al. Three-dimensional cell growth confers radioresistance by chromatin density modification. Cancer Res. 2010;70:3925-34 pubmed publisher
|
| Bowen C, Gelmann E. NKX3.1 activates cellular response to DNA damage. Cancer Res. 2010;70:3089-97 pubmed publisher
|
| Kongruttanachok N, Phuangphairoj C, Thongnak A, Ponyeam W, Rattanatanyong P, Pornthanakasem W, et al. Replication independent DNA double-strand break retention may prevent genomic instability. Mol Cancer. 2010;9:70 pubmed publisher
|
| Sakasai R, Teraoka H, Takagi M, Tibbetts R. Transcription-dependent activation of ataxia telangiectasia mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison. J Biol Chem. 2010;285:15201-8 pubmed publisher
|
| Wilhelm M, Rufini A, Wetzel M, Tsuchihara K, Inoue S, Tomasini R, et al. Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway. Genes Dev. 2010;24:549-60 pubmed publisher
|
| Kodama M, Otsubo C, Hirota T, Yokota J, Enari M, Taya Y. Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences. Mol Cell Biol. 2010;30:1620-33 pubmed publisher
|
| Hu H, Du L, Nagabayashi G, Seeger R, Gatti R. ATM is down-regulated by N-Myc-regulated microRNA-421. Proc Natl Acad Sci U S A. 2010;107:1506-11 pubmed publisher
|
| Yoshida K, Sugimoto N, Iwahori S, Yugawa T, Narisawa Saito M, Kiyono T, et al. CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells. J Cell Sci. 2010;123:225-35 pubmed publisher
|
| So S, Davis A, Chen D. Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites. J Cell Biol. 2009;187:977-90 pubmed publisher
|
| Bolderson E, Tomimatsu N, Richard D, Boucher D, Kumar R, Pandita T, et al. Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks. Nucleic Acids Res. 2010;38:1821-31 pubmed publisher
|
| Sakasai R, Teraoka H, Tibbetts R. Proteasome inhibition suppresses DNA-dependent protein kinase activation caused by camptothecin. DNA Repair (Amst). 2010;9:76-82 pubmed publisher
|
| Britton S, Frit P, Biard D, Salles B, Calsou P. ARTEMIS nuclease facilitates apoptotic chromatin cleavage. Cancer Res. 2009;69:8120-6 pubmed publisher
|
| Papp L, Lu J, Bolderson E, Boucher D, Singh R, Holmgren A, et al. SECIS-binding protein 2 promotes cell survival by protecting against oxidative stress. Antioxid Redox Signal. 2010;12:797-808 pubmed publisher
|
| Sun Y, Jiang X, Xu Y, Ayrapetov M, Moreau L, Whetstine J, et al. Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60. Nat Cell Biol. 2009;11:1376-82 pubmed publisher
|
| Sugimoto N, Yoshida K, Tatsumi Y, Yugawa T, Narisawa Saito M, Waga S, et al. Redundant and differential regulation of multiple licensing factors ensures prevention of re-replication in normal human cells. J Cell Sci. 2009;122:1184-91 pubmed publisher
|
| Cui B, Johnson S, Bullock N, Ali Osman F, Bigner D, Friedman H. Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway. Mol Pharmacol. 2009;75:1356-63 pubmed publisher
|
| Heffernan T, Kawasumi M, Blasina A, Anderes K, Conney A, Nghiem P. ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine. J Invest Dermatol. 2009;129:1805-15 pubmed publisher
|
| Nahas S, Butch A, Du L, Gatti R. Rapid flow cytometry-based structural maintenance of chromosomes 1 (SMC1) phosphorylation assay for identification of ataxia-telangiectasia homozygotes and heterozygotes. Clin Chem. 2009;55:463-72 pubmed publisher
|
| Chou W, Wang H, Wong F, Ding S, Wu P, Shieh S, et al. Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair. EMBO J. 2008;27:3140-50 pubmed publisher
|
| Hein J, Boichuk S, Wu J, Cheng Y, Freire R, Jat P, et al. Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding. J Virol. 2009;83:117-27 pubmed publisher
|
| Meulle A, Salles B, Daviaud D, Valet P, Muller C. Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: the example of adipogenesis. PLoS ONE. 2008;3:e3345 pubmed publisher
|
| Martin L, Liu Z, Pipino J, Chestnut B, Landek M. Molecular regulation of DNA damage-induced apoptosis in neurons of cerebral cortex. Cereb Cortex. 2009;19:1273-93 pubmed publisher
|
| Ariumi Y, Kuroki M, Dansako H, Abe K, Ikeda M, Wakita T, et al. The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication. J Virol. 2008;82:9639-46 pubmed publisher
|
| Stohr B, Blackburn E. ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells. Cancer Res. 2008;68:5309-17 pubmed publisher
|
| Yalcin S, Zhang X, Luciano J, Mungamuri S, Marinkovic D, Vercherat C, et al. Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells. J Biol Chem. 2008;283:25692-705 pubmed publisher
|
| Rimkus S, Katzenberger R, Trinh A, Dodson G, Tibbetts R, Wassarman D. Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia. Genes Dev. 2008;22:1205-20 pubmed publisher
|
| Wei G, Defeo K, Hayes C, Woster P, Mandik Nayak L, Gilmour S. Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes. Cancer Res. 2008;68:2214-22 pubmed publisher
|
| Sakasai R, Tibbetts R. RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage. J Biol Chem. 2008;283:13549-55 pubmed publisher
|
| Sugimoto N, Kitabayashi I, Osano S, Tatsumi Y, Yugawa T, Narisawa Saito M, et al. Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1. Mol Biol Cell. 2008;19:1007-21 pubmed
|
| Wood J, Singh N, Mer G, Chen J. MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage. J Biol Chem. 2007;282:35416-23 pubmed
|
| Sun Y, Xu Y, Roy K, Price B. DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity. Mol Cell Biol. 2007;27:8502-9 pubmed
|
| Iwahori S, Shirata N, Kawaguchi Y, Weller S, Sato Y, Kudoh A, et al. Enhanced phosphorylation of transcription factor sp1 in response to herpes simplex virus type 1 infection is dependent on the ataxia telangiectasia-mutated protein. J Virol. 2007;81:9653-64 pubmed
|
| Fernandes N, Sun Y, Price B. Activation of the kinase activity of ATM by retinoic acid is required for CREB-dependent differentiation of neuroblastoma cells. J Biol Chem. 2007;282:16577-84 pubmed
|
| Inoue Y, Kitagawa M, Taya Y. Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage. EMBO J. 2007;26:2083-93 pubmed
|
| Stauffer D, Chang B, Huang J, Dunn A, Thayer M. p300/CREB-binding protein interacts with ATR and is required for the DNA replication checkpoint. J Biol Chem. 2007;282:9678-87 pubmed
|
| Shi Y, Dodson G, Mukhopadhyay P, Shanware N, Trinh A, Tibbetts R. Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phosphospecific antibodies. J Biol Chem. 2007;282:9236-43 pubmed
|
| Geng L, Zhang X, Zheng S, Legerski R. Artemis links ATM to G2/M checkpoint recovery via regulation of Cdk1-cyclin B. Mol Cell Biol. 2007;27:2625-35 pubmed
|
| Ahmed K, Dong S, Fan M, Li J. Nuclear factor-kappaB p65 inhibits mitogen-activated protein kinase signaling pathway in radioresistant breast cancer cells. Mol Cancer Res. 2006;4:945-55 pubmed
|
| Shreeram S, Hee W, Demidov O, Kek C, Yamaguchi H, Fornace A, et al. Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase. J Exp Med. 2006;203:2793-9 pubmed
|
| Kirshner J, Jobling M, Pajares M, Ravani S, Glick A, Lavin M, et al. Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress. Cancer Res. 2006;66:10861-9 pubmed
|
| Henderson M, Munoz M, Saunders D, Clancy J, Russell A, Williams B, et al. EDD mediates DNA damage-induced activation of CHK2. J Biol Chem. 2006;281:39990-40000 pubmed
|
| Liu Y, Rusinol A, Sinensky M, Wang Y, Zou Y. DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A. J Cell Sci. 2006;119:4644-9 pubmed
|
| Shreeram S, Demidov O, Hee W, Yamaguchi H, Onishi N, Kek C, et al. Wip1 phosphatase modulates ATM-dependent signaling pathways. Mol Cell. 2006;23:757-64 pubmed
|
| Wu X, Shell S, Liu Y, Zou Y. ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation. Oncogene. 2007;26:757-64 pubmed
|
| Kozlov S, Graham M, Peng C, Chen P, Robinson P, Lavin M. Involvement of novel autophosphorylation sites in ATM activation. EMBO J. 2006;25:3504-14 pubmed
|
| Tatsumi Y, Sugimoto N, Yugawa T, Narisawa Saito M, Kiyono T, Fujita M. Deregulation of Cdt1 induces chromosomal damage without rereplication and leads to chromosomal instability. J Cell Sci. 2006;119:3128-40 pubmed
|
| Jiang X, Sun Y, Chen S, Roy K, Price B. The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM. J Biol Chem. 2006;281:15741-6 pubmed
|
| Gueven N, Becherel O, Birrell G, Chen P, DelSal G, Carney J, et al. Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype. Cancer Res. 2006;66:2907-12 pubmed
|
| Shiotani B, Kobayashi M, Watanabe M, Yamamoto K, Sugimura T, Wakabayashi K. Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1. Mol Cancer Res. 2006;4:125-33 pubmed
|
| Freiberg R, Hammond E, Dorie M, Welford S, Giaccia A. DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response. Mol Cell Biol. 2006;26:1598-609 pubmed
|
| Aglipay J, Martin S, Tawara H, Lee S, Ouchi T. ATM activation by ionizing radiation requires BRCA1-associated BAAT1. J Biol Chem. 2006;281:9710-8 pubmed
|
| Wang H, Chou W, Shieh S, Shen C. Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining. Cancer Res. 2006;66:1391-400 pubmed
|
| Pusapati R, Rounbehler R, Hong S, Powers J, Yan M, Kiguchi K, et al. ATM promotes apoptosis and suppresses tumorigenesis in response to Myc. Proc Natl Acad Sci U S A. 2006;103:1446-51 pubmed
|
| Gibson S, Bindra R, Glazer P. Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner. Cancer Res. 2005;65:10734-41 pubmed
|
| Shi Y, Dodson G, Shaikh S, Rundell K, Tibbetts R. Ataxia-telangiectasia-mutated (ATM) is a T-antigen kinase that controls SV40 viral replication in vivo. J Biol Chem. 2005;280:40195-200 pubmed
|
| Sun Y, Jiang X, Chen S, Fernandes N, Price B. A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. Proc Natl Acad Sci U S A. 2005;102:13182-7 pubmed
|
| Kim J, Krasieva T, Kurumizaka H, Chen D, Taylor A, Yokomori K. Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells. J Cell Biol. 2005;170:341-7 pubmed
|
| Young D, Jonnalagadda J, Gatei M, Jans D, Meyn S, Khanna K. Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association. J Biol Chem. 2005;280:27587-94 pubmed
|
| Wang J, Pluth J, Cooper P, Cowan M, Chen D, Yannone S. Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression. DNA Repair (Amst). 2005;4:556-70 pubmed
|
| Peng Y, Woods R, Beamish H, Ye R, Lees Miller S, Lavin M, et al. Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM. Cancer Res. 2005;65:1670-7 pubmed
|
| Li J, Stern D. Regulation of CHK2 by DNA-dependent protein kinase. J Biol Chem. 2005;280:12041-50 pubmed
|
| Kudoh A, Fujita M, Zhang L, Shirata N, Daikoku T, Sugaya Y, et al. Epstein-Barr virus lytic replication elicits ATM checkpoint signal transduction while providing an S-phase-like cellular environment. J Biol Chem. 2005;280:8156-63 pubmed
|
| Xu X, Lee J, Stern D. Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. J Biol Chem. 2004;279:34091-4 pubmed
|
| Dodson G, Shi Y, Tibbetts R. DNA replication defects, spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells. J Biol Chem. 2004;279:34010-4 pubmed
|
| Dork T, Bendix Waltes R, Wegner R, Stumm M. Slow progression of ataxia-telangiectasia with double missense and in frame splice mutations. Am J Med Genet A. 2004;126A:272-7 pubmed
|
| Naka K, Tachibana A, Ikeda K, Motoyama N. Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts. J Biol Chem. 2004;279:2030-7 pubmed
|
| Vemuri M, Schiller E, Naegele J. Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant mice. Cell Death Differ. 2001;8:245-55 pubmed
|
| Scherthan H, Jerratsch M, Dhar S, Wang Y, Goff S, Pandita T. Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm- and Atm-p53-deficient mice. Mol Cell Biol. 2000;20:7773-83 pubmed
|