product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
ATM Antibody (2C1) - Azide and BSA Free
catalog :
NB100-309
quantity :
100 ul
price :
459 USD
clonality :
monoclonal
host :
mouse
conjugate :
DyLight680
clone name :
2C1
reactivity :
human, mouse, rat, rhesus macaque
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
citations: 129
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 3g, 3h
Wang S, Luke C, Pak S, Shi V, Chen L, Moore J, et al. SERPINB3 (SCCA1) inhibits cathepsin L and lysoptosis, protecting cervical cancer cells from chemoradiation. Commun Biol. 2022;5:46 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5a
Fu X, Zhang C, Meng H, Zhang K, Shi L, Cao C, et al. Oncoprotein Tudor-SN is a key determinant providing survival advantage under DNA damaging stress. Cell Death Differ. 2018;25:1625-1637 pubmed publisher
  • western blot; rhesus macaque; fig 2
Simões M, Martins C, Ferreira F. Early intranuclear replication of African swine fever virus genome modifies the landscape of the host cell nucleus. Virus Res. 2015;210:1-7 pubmed publisher
  • immunohistochemistry; human; 1:100
  • immunohistochemistry; rat; 1:100
Batenburg N, Thompson E, Hendrickson E, Zhu X. Cockayne syndrome group B protein regulates DNA double-strand break repair and checkpoint activation. EMBO J. 2015;34:1399-416 pubmed publisher
Maeda J, Haskins J, Kato T. XRCC8 mutation causes hypersensitivity to PARP inhibition without Homologous recombination repair deficiency. Mutat Res. 2023;826:111815 pubmed publisher
Osma García I, Capitan Sobrino D, Mouysset M, Aubert Y, Maloudi O, Turner M, et al. The splicing regulators TIA1 and TIAL1 are required for the expression of the DNA damage repair machinery during B cell lymphopoiesis. Cell Rep. 2022;41:111869 pubmed publisher
Cui W, Ye C, Wang K, Yang X, Zhu P, Hu K, et al. Momordica. charantia-Derived Extracellular Vesicles-Like Nanovesicles Protect Cardiomyocytes Against Radiation Injury via Attenuating DNA Damage and Mitochondria Dysfunction. Front Cardiovasc Med. 2022;9:864188 pubmed publisher
Fu X, Duan Z, Lu X, Zhu Y, Ren Y, Zhang W, et al. SND1 Promotes Radioresistance in Cervical Cancer Cells by Targeting the DNA Damage Response. Cancer Biother Radiopharm. 2022;: pubmed publisher
Yang Y, Lu H, Chen C, Lyu Y, Cole R, Semenza G. HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia. Nat Commun. 2022;13:316 pubmed publisher
Kirtay M, Sell J, Marx C, Haselmann H, Ceanga M, Zhou Z, et al. ATR regulates neuronal activity by modulating presynaptic firing. Nat Commun. 2021;12:4067 pubmed publisher
Blakemore D, Vilaplana Lopera N, Almaghrabi R, Gonzalez E, Moya M, Ward C, et al. MYBL2 and ATM suppress replication stress in pluripotent stem cells. EMBO Rep. 2021;22:e51120 pubmed publisher
Marx C, Schaarschmidt M, Kirkpatrick J, Marx Blümel L, Halilovic M, Westermann M, et al. Cooperative treatment effectiveness of ATR and HSP90 inhibition in Ewing's sarcoma cells. Cell Biosci. 2021;11:57 pubmed publisher
Affandi T, Ohm A, Gaillard D, Haas A, Reyland M. Tyrosine kinase inhibitors protect the salivary gland from radiation damage by increasing DNA double-strand break repair. J Biol Chem. 2021;296:100401 pubmed publisher
Bensimon A, Koch J, Francica P, Roth S, Riedo R, Glück A, et al. Deciphering MET-dependent modulation of global cellular responses to DNA damage by quantitative phosphoproteomics. Mol Oncol. 2020;14:1185-1206 pubmed publisher
El Hajjar J, Chatoo W, Hanna R, Nkanza P, Tétreault N, Tse Y, et al. Heterochromatic genome instability and neurodegeneration sharing similarities with Alzheimer's disease in old Bmi1+/- mice. Sci Rep. 2019;9:594 pubmed publisher
Belužić L, Grbesa I, Beluzić R, Park J, Kong H, Kopjar N, et al. Knock-down of AHCY and depletion of adenosine induces DNA damage and cell cycle arrest. Sci Rep. 2018;8:14012 pubmed publisher
Göder A, Emmerich C, Nikolova T, Kiweler N, Schreiber M, Kühl T, et al. HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130. Nat Commun. 2018;9:764 pubmed publisher
Park S, Kong H, Kim Y, Lee Y, Park J. Inhibition of S-adenosylhomocysteine hydrolase decreases cell mobility and cell proliferation through cell cycle arrest. Am J Cancer Res. 2015;5:2127-38 pubmed
Muraki K, Han L, Miller D, Murnane J. Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks. Nucleic Acids Res. 2015;43:7911-30 pubmed publisher
Vermezovic J, Adamowicz M, Santarpia L, Rustighi A, Forcato M, Lucano C, et al. Notch is a direct negative regulator of the DNA-damage response. Nat Struct Mol Biol. 2015;22:417-24 pubmed publisher
Palazzo L, Della Monica R, Visconti R, Costanzo V, Grieco D. ATM controls proper mitotic spindle structure. Cell Cycle. 2014;13:1091-100 pubmed publisher
Min W, Bruhn C, Grigaravicius P, Zhou Z, Li F, Krüger A, et al. Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation. Nat Commun. 2013;4:2993 pubmed publisher
Simões M, Martins C, Ferreira F. Host DNA damage response facilitates African swine fever virus infection. Vet Microbiol. 2013;165:140-7 pubmed publisher
Gutiérrez González A, Belda Iniesta C, Bargiela Iparraguirre J, Dominguez G, Garcia Alfonso P, Perona R, et al. Targeting Chk2 improves gastric cancer chemotherapy by impairing DNA damage repair. Apoptosis. 2013;18:347-60 pubmed publisher
Shi Y, Felley Bosco E, Marti T, Orlowski K, Pruschy M, Stahel R. Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin. BMC Cancer. 2012;12:571 pubmed publisher
Murad N, Cullen J, McKenzie M, Ryan M, Thorburn D, Gueven N, et al. Mitochondrial dysfunction in a novel form of autosomal recessive ataxia. Mitochondrion. 2013;13:235-45 pubmed publisher
Sakasai R, Sakai A, Iimori M, Kiyonari S, Matsuoka K, Kakeji Y, et al. CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication. Genes Cells. 2012;17:962-70 pubmed publisher
Shi Y, Felley Bosco E, Marti T, Stahel R. Differential effects of lovastatin on cisplatin responses in normal human mesothelial cells versus cancer cells: implication for therapy. PLoS ONE. 2012;7:e45354 pubmed publisher
Baritaud M, Cabon L, Delavallée L, Galán Malo P, Gilles M, Brunelle Navas M, et al. AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation. Cell Death Dis. 2012;3:e390 pubmed publisher
Hardee M, Marciscano A, Medina Ramirez C, Zagzag D, Narayana A, Lonning S, et al. Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-?. Cancer Res. 2012;72:4119-29 pubmed publisher
Mahajan K, Coppola D, Rawal B, Chen Y, Lawrence H, Engelman R, et al. Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer. J Biol Chem. 2012;287:22112-22 pubmed publisher
Hsu C, Lee Y, Yeh S, Chen C, Wu C, Wang T, et al. 58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway. J Biol Chem. 2012;287:22533-48 pubmed publisher
Dellago H, Khan A, Nussbacher M, Gstraunthaler A, Lämmermann I, Schosserer M, et al. ATM-dependent phosphorylation of SNEVhPrp19/hPso4 is involved in extending cellular life span and suppression of apoptosis. Aging (Albany NY). 2012;4:290-304 pubmed
Yan Y, Greer P, Cao P, Kolb R, Cowan K. RAC1 GTPase plays an important role in ?-irradiation induced G2/M checkpoint activation. Breast Cancer Res. 2012;14:R60 pubmed
Ai L, Skehan R, Saydi J, Lin T, Brown K. Ataxia-Telangiectasia, Mutated (ATM)/Nuclear Factor ? light chain enhancer of activated B cells (NF?B) signaling controls basal and DNA damage-induced transglutaminase 2 expression. J Biol Chem. 2012;287:18330-41 pubmed publisher
Zhang J, De Toledo S, Pandey B, Guo G, Pain D, Li H, et al. Role of the translationally controlled tumor protein in DNA damage sensing and repair. Proc Natl Acad Sci U S A. 2012;109:E926-33 pubmed publisher
Kang M, So E, Ouchi T. Deregulation of DNA damage response pathway by intercellular contact. J Biol Chem. 2012;287:16246-55 pubmed publisher
Hao Z, Duncan G, Su Y, Li W, Silvester J, Hong C, et al. The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis. J Exp Med. 2012;209:173-86 pubmed publisher
Xu Y, Parmar K, Du F, Price B, Sun Y. The radioprotective agent WR1065 protects cells from radiation damage by regulating the activity of the Tip60 acetyltransferase. Int J Biochem Mol Biol. 2011;2:295-302 pubmed
Assaily W, Rubinger D, Wheaton K, Lin Y, Ma W, Xuan W, et al. ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress. Mol Cell. 2011;44:491-501 pubmed publisher
Sugimoto N, Yugawa T, Iizuka M, Kiyono T, Fujita M. Chromatin remodeler sucrose nonfermenting 2 homolog (SNF2H) is recruited onto DNA replication origins through interaction with Cdc10 protein-dependent transcript 1 (Cdt1) and promotes pre-replication complex formation. J Biol Chem. 2011;286:39200-10 pubmed publisher
Brown J, Roberts T, Richards R, Woods R, Birrell G, Lim Y, et al. A novel role for hSMG-1 in stress granule formation. Mol Cell Biol. 2011;31:4417-29 pubmed publisher
Hada M, Huff J, Patel Z, Kawata T, Pluth J, George K, et al. AT cells are not radiosensitive for simple chromosomal exchanges at low dose. Mutat Res. 2011;716:76-83 pubmed publisher
Serrano D, Bleau A, Fernandez Garcia I, Fernandez Marcelo T, Iniesta P, Ortiz de Solorzano C, et al. Inhibition of telomerase activity preferentially targets aldehyde dehydrogenase-positive cancer stem-like cells in lung cancer. Mol Cancer. 2011;10:96 pubmed publisher
Luo K, Yuan J, Lou Z. Oligomerization of MDC1 protein is important for proper DNA damage response. J Biol Chem. 2011;286:28192-9 pubmed publisher
Bouquet F, Ousset M, Biard D, Fallone F, Dauvillier S, Frit P, et al. A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia. J Cell Sci. 2011;124:1943-51 pubmed publisher
Shouse G, Nobumori Y, Panowicz M, Liu X. ATM-mediated phosphorylation activates the tumor-suppressive function of B56?-PP2A. Oncogene. 2011;30:3755-65 pubmed publisher
Cherubini G, Naim V, Caruso P, Burla R, Bogliolo M, Cundari E, et al. The FANC pathway is activated by adenovirus infection and promotes viral replication-dependent recombination. Nucleic Acids Res. 2011;39:5459-73 pubmed publisher
Chen Y, Chen C, Riley D, Chen P. Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR. Cell Cycle. 2011;10:655-63 pubmed
Matsumoto Y, Miyamoto T, Sakamoto H, Izumi H, Nakazawa Y, Ogi T, et al. Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly. DNA Repair (Amst). 2011;10:314-21 pubmed publisher
Urquhart A, Gatei M, Richard D, Khanna K. ATM mediated phosphorylation of CHD4 contributes to genome maintenance. Genome Integr. 2011;2:1 pubmed publisher
Ruiz Z, Mihaylov I, Cotmore S, Tattersall P. Recruitment of DNA replication and damage response proteins to viral replication centers during infection with NS2 mutants of Minute Virus of Mice (MVM). Virology. 2011;410:375-84 pubmed publisher
Guo Z, Deshpande R, Paull T. ATM activation in the presence of oxidative stress. Cell Cycle. 2010;9:4805-11 pubmed
Kozlov S, Graham M, Jakob B, Tobias F, Kijas A, Tanuji M, et al. Autophosphorylation and ATM activation: additional sites add to the complexity. J Biol Chem. 2011;286:9107-19 pubmed publisher
Powell M, Manandhar G, Spate L, Sutovsky M, Zimmerman S, Sachdev S, et al. Discovery of putative oocyte quality markers by comparative ExacTag proteomics. Proteomics Clin Appl. 2010;4:337-51 pubmed publisher
Xu Y, Sun Y, Jiang X, Ayrapetov M, Moskwa P, Yang S, et al. The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair. J Cell Biol. 2010;191:31-43 pubmed publisher
Huang Q, Tomida S, Masuda Y, Arima C, Cao K, Kasahara T, et al. Regulation of DNA polymerase POLD4 influences genomic instability in lung cancer. Cancer Res. 2010;70:8407-16 pubmed publisher
Shanware N, Zhan L, Hutchinson J, Kim S, Williams L, Tibbetts R. Conserved and distinct modes of CREB/ATF transcription factor regulation by PP2A/B56gamma and genotoxic stress. PLoS ONE. 2010;5:e12173 pubmed publisher
Lee J, Choy M, Ngo L, Foster S, Marks P. Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair. Proc Natl Acad Sci U S A. 2010;107:14639-44 pubmed publisher
Fang Z, Kozlov S, McKay M, Woods R, Birrell G, Sprung C, et al. Low levels of ATM in breast cancer patients with clinical radiosensitivity. Genome Integr. 2010;1:9 pubmed publisher
Ousset M, Bouquet F, Fallone F, Biard D, Dray C, Valet P, et al. Loss of ATM positively regulates the expression of hypoxia inducible factor 1 (HIF-1) through oxidative stress: Role in the physiopathology of the disease. Cell Cycle. 2010;9:2814-22 pubmed
Storch K, Eke I, Borgmann K, Krause M, Richter C, Becker K, et al. Three-dimensional cell growth confers radioresistance by chromatin density modification. Cancer Res. 2010;70:3925-34 pubmed publisher
Bowen C, Gelmann E. NKX3.1 activates cellular response to DNA damage. Cancer Res. 2010;70:3089-97 pubmed publisher
Kongruttanachok N, Phuangphairoj C, Thongnak A, Ponyeam W, Rattanatanyong P, Pornthanakasem W, et al. Replication independent DNA double-strand break retention may prevent genomic instability. Mol Cancer. 2010;9:70 pubmed publisher
Sakasai R, Teraoka H, Takagi M, Tibbetts R. Transcription-dependent activation of ataxia telangiectasia mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison. J Biol Chem. 2010;285:15201-8 pubmed publisher
Wilhelm M, Rufini A, Wetzel M, Tsuchihara K, Inoue S, Tomasini R, et al. Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway. Genes Dev. 2010;24:549-60 pubmed publisher
Kodama M, Otsubo C, Hirota T, Yokota J, Enari M, Taya Y. Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences. Mol Cell Biol. 2010;30:1620-33 pubmed publisher
Hu H, Du L, Nagabayashi G, Seeger R, Gatti R. ATM is down-regulated by N-Myc-regulated microRNA-421. Proc Natl Acad Sci U S A. 2010;107:1506-11 pubmed publisher
Yoshida K, Sugimoto N, Iwahori S, Yugawa T, Narisawa Saito M, Kiyono T, et al. CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells. J Cell Sci. 2010;123:225-35 pubmed publisher
So S, Davis A, Chen D. Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites. J Cell Biol. 2009;187:977-90 pubmed publisher
Bolderson E, Tomimatsu N, Richard D, Boucher D, Kumar R, Pandita T, et al. Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks. Nucleic Acids Res. 2010;38:1821-31 pubmed publisher
Sakasai R, Teraoka H, Tibbetts R. Proteasome inhibition suppresses DNA-dependent protein kinase activation caused by camptothecin. DNA Repair (Amst). 2010;9:76-82 pubmed publisher
Britton S, Frit P, Biard D, Salles B, Calsou P. ARTEMIS nuclease facilitates apoptotic chromatin cleavage. Cancer Res. 2009;69:8120-6 pubmed publisher
Papp L, Lu J, Bolderson E, Boucher D, Singh R, Holmgren A, et al. SECIS-binding protein 2 promotes cell survival by protecting against oxidative stress. Antioxid Redox Signal. 2010;12:797-808 pubmed publisher
Sun Y, Jiang X, Xu Y, Ayrapetov M, Moreau L, Whetstine J, et al. Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60. Nat Cell Biol. 2009;11:1376-82 pubmed publisher
Sugimoto N, Yoshida K, Tatsumi Y, Yugawa T, Narisawa Saito M, Waga S, et al. Redundant and differential regulation of multiple licensing factors ensures prevention of re-replication in normal human cells. J Cell Sci. 2009;122:1184-91 pubmed publisher
Cui B, Johnson S, Bullock N, Ali Osman F, Bigner D, Friedman H. Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway. Mol Pharmacol. 2009;75:1356-63 pubmed publisher
Heffernan T, Kawasumi M, Blasina A, Anderes K, Conney A, Nghiem P. ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine. J Invest Dermatol. 2009;129:1805-15 pubmed publisher
Nahas S, Butch A, Du L, Gatti R. Rapid flow cytometry-based structural maintenance of chromosomes 1 (SMC1) phosphorylation assay for identification of ataxia-telangiectasia homozygotes and heterozygotes. Clin Chem. 2009;55:463-72 pubmed publisher
Chou W, Wang H, Wong F, Ding S, Wu P, Shieh S, et al. Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair. EMBO J. 2008;27:3140-50 pubmed publisher
Hein J, Boichuk S, Wu J, Cheng Y, Freire R, Jat P, et al. Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding. J Virol. 2009;83:117-27 pubmed publisher
Meulle A, Salles B, Daviaud D, Valet P, Muller C. Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: the example of adipogenesis. PLoS ONE. 2008;3:e3345 pubmed publisher
Martin L, Liu Z, Pipino J, Chestnut B, Landek M. Molecular regulation of DNA damage-induced apoptosis in neurons of cerebral cortex. Cereb Cortex. 2009;19:1273-93 pubmed publisher
Ariumi Y, Kuroki M, Dansako H, Abe K, Ikeda M, Wakita T, et al. The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication. J Virol. 2008;82:9639-46 pubmed publisher
Stohr B, Blackburn E. ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells. Cancer Res. 2008;68:5309-17 pubmed publisher
Yalcin S, Zhang X, Luciano J, Mungamuri S, Marinkovic D, Vercherat C, et al. Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells. J Biol Chem. 2008;283:25692-705 pubmed publisher
Rimkus S, Katzenberger R, Trinh A, Dodson G, Tibbetts R, Wassarman D. Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia. Genes Dev. 2008;22:1205-20 pubmed publisher
Wei G, Defeo K, Hayes C, Woster P, Mandik Nayak L, Gilmour S. Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes. Cancer Res. 2008;68:2214-22 pubmed publisher
Sakasai R, Tibbetts R. RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage. J Biol Chem. 2008;283:13549-55 pubmed publisher
Sugimoto N, Kitabayashi I, Osano S, Tatsumi Y, Yugawa T, Narisawa Saito M, et al. Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1. Mol Biol Cell. 2008;19:1007-21 pubmed
Wood J, Singh N, Mer G, Chen J. MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage. J Biol Chem. 2007;282:35416-23 pubmed
Sun Y, Xu Y, Roy K, Price B. DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity. Mol Cell Biol. 2007;27:8502-9 pubmed
Iwahori S, Shirata N, Kawaguchi Y, Weller S, Sato Y, Kudoh A, et al. Enhanced phosphorylation of transcription factor sp1 in response to herpes simplex virus type 1 infection is dependent on the ataxia telangiectasia-mutated protein. J Virol. 2007;81:9653-64 pubmed
Fernandes N, Sun Y, Price B. Activation of the kinase activity of ATM by retinoic acid is required for CREB-dependent differentiation of neuroblastoma cells. J Biol Chem. 2007;282:16577-84 pubmed
Inoue Y, Kitagawa M, Taya Y. Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage. EMBO J. 2007;26:2083-93 pubmed
Stauffer D, Chang B, Huang J, Dunn A, Thayer M. p300/CREB-binding protein interacts with ATR and is required for the DNA replication checkpoint. J Biol Chem. 2007;282:9678-87 pubmed
Shi Y, Dodson G, Mukhopadhyay P, Shanware N, Trinh A, Tibbetts R. Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phosphospecific antibodies. J Biol Chem. 2007;282:9236-43 pubmed
Geng L, Zhang X, Zheng S, Legerski R. Artemis links ATM to G2/M checkpoint recovery via regulation of Cdk1-cyclin B. Mol Cell Biol. 2007;27:2625-35 pubmed
Ahmed K, Dong S, Fan M, Li J. Nuclear factor-kappaB p65 inhibits mitogen-activated protein kinase signaling pathway in radioresistant breast cancer cells. Mol Cancer Res. 2006;4:945-55 pubmed
Shreeram S, Hee W, Demidov O, Kek C, Yamaguchi H, Fornace A, et al. Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase. J Exp Med. 2006;203:2793-9 pubmed
Kirshner J, Jobling M, Pajares M, Ravani S, Glick A, Lavin M, et al. Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress. Cancer Res. 2006;66:10861-9 pubmed
Henderson M, Munoz M, Saunders D, Clancy J, Russell A, Williams B, et al. EDD mediates DNA damage-induced activation of CHK2. J Biol Chem. 2006;281:39990-40000 pubmed
Liu Y, Rusinol A, Sinensky M, Wang Y, Zou Y. DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A. J Cell Sci. 2006;119:4644-9 pubmed
Shreeram S, Demidov O, Hee W, Yamaguchi H, Onishi N, Kek C, et al. Wip1 phosphatase modulates ATM-dependent signaling pathways. Mol Cell. 2006;23:757-64 pubmed
Wu X, Shell S, Liu Y, Zou Y. ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation. Oncogene. 2007;26:757-64 pubmed
Kozlov S, Graham M, Peng C, Chen P, Robinson P, Lavin M. Involvement of novel autophosphorylation sites in ATM activation. EMBO J. 2006;25:3504-14 pubmed
Tatsumi Y, Sugimoto N, Yugawa T, Narisawa Saito M, Kiyono T, Fujita M. Deregulation of Cdt1 induces chromosomal damage without rereplication and leads to chromosomal instability. J Cell Sci. 2006;119:3128-40 pubmed
Jiang X, Sun Y, Chen S, Roy K, Price B. The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM. J Biol Chem. 2006;281:15741-6 pubmed
Gueven N, Becherel O, Birrell G, Chen P, DelSal G, Carney J, et al. Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype. Cancer Res. 2006;66:2907-12 pubmed
Shiotani B, Kobayashi M, Watanabe M, Yamamoto K, Sugimura T, Wakabayashi K. Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1. Mol Cancer Res. 2006;4:125-33 pubmed
Freiberg R, Hammond E, Dorie M, Welford S, Giaccia A. DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response. Mol Cell Biol. 2006;26:1598-609 pubmed
Aglipay J, Martin S, Tawara H, Lee S, Ouchi T. ATM activation by ionizing radiation requires BRCA1-associated BAAT1. J Biol Chem. 2006;281:9710-8 pubmed
Wang H, Chou W, Shieh S, Shen C. Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining. Cancer Res. 2006;66:1391-400 pubmed
Pusapati R, Rounbehler R, Hong S, Powers J, Yan M, Kiguchi K, et al. ATM promotes apoptosis and suppresses tumorigenesis in response to Myc. Proc Natl Acad Sci U S A. 2006;103:1446-51 pubmed
Gibson S, Bindra R, Glazer P. Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner. Cancer Res. 2005;65:10734-41 pubmed
Shi Y, Dodson G, Shaikh S, Rundell K, Tibbetts R. Ataxia-telangiectasia-mutated (ATM) is a T-antigen kinase that controls SV40 viral replication in vivo. J Biol Chem. 2005;280:40195-200 pubmed
Sun Y, Jiang X, Chen S, Fernandes N, Price B. A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. Proc Natl Acad Sci U S A. 2005;102:13182-7 pubmed
Kim J, Krasieva T, Kurumizaka H, Chen D, Taylor A, Yokomori K. Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells. J Cell Biol. 2005;170:341-7 pubmed
Young D, Jonnalagadda J, Gatei M, Jans D, Meyn S, Khanna K. Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association. J Biol Chem. 2005;280:27587-94 pubmed
Wang J, Pluth J, Cooper P, Cowan M, Chen D, Yannone S. Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression. DNA Repair (Amst). 2005;4:556-70 pubmed
Peng Y, Woods R, Beamish H, Ye R, Lees Miller S, Lavin M, et al. Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM. Cancer Res. 2005;65:1670-7 pubmed
Li J, Stern D. Regulation of CHK2 by DNA-dependent protein kinase. J Biol Chem. 2005;280:12041-50 pubmed
Kudoh A, Fujita M, Zhang L, Shirata N, Daikoku T, Sugaya Y, et al. Epstein-Barr virus lytic replication elicits ATM checkpoint signal transduction while providing an S-phase-like cellular environment. J Biol Chem. 2005;280:8156-63 pubmed
Xu X, Lee J, Stern D. Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. J Biol Chem. 2004;279:34091-4 pubmed
Dodson G, Shi Y, Tibbetts R. DNA replication defects, spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells. J Biol Chem. 2004;279:34010-4 pubmed
Dork T, Bendix Waltes R, Wegner R, Stumm M. Slow progression of ataxia-telangiectasia with double missense and in frame splice mutations. Am J Med Genet A. 2004;126A:272-7 pubmed
Naka K, Tachibana A, Ikeda K, Motoyama N. Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts. J Biol Chem. 2004;279:2030-7 pubmed
Vemuri M, Schiller E, Naegele J. Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant mice. Cell Death Differ. 2001;8:245-55 pubmed
Scherthan H, Jerratsch M, Dhar S, Wang Y, Goff S, Pandita T. Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm- and Atm-p53-deficient mice. Mol Cell Biol. 2000;20:7773-83 pubmed
product information
master code :
NB100-309
SKU :
NB100-309
product name :
ATM Antibody (2C1) - Azide and BSA Free
unit size :
100 ul
description :
The ATM Antibody (2C1) - Azide and BSA Free from Novus is a mouse monoclonal antibody to ATM. This antibody reacts with human,monkey,mouse,rat,hamster - cricetulus (chinese hamster). The ATM Antibody (2C1) - Azide and BSA Free has been validated for the following applications: Immunocytochemistry/ Immunofluorescence,Western Blot,ELISA,SDS-Page,Flow Cytometry,Immunoprecipitation,Immunohistochemistry-Paraffin,Immunohistochemistry,Chromatin Immunoprecipitation (ChIP),Single Cell Western,Knockdown Validated.
target :
ATM
category :
Primary Antibodies
buffer :
PBS
clonality :
Monoclonal
clone :
2C1
conjugate :
Unconjugated
host :
Mouse
immunogen :
Recombinant protein expressed in E. coli corresponding to amino acids 2577-3056.
isotype :
IgG1
purity :
Antigen Affinity-purified
species :
Human,Monkey,Mouse,Rat,Hamster - Cricetulus (Chinese Hamster)
specificity :
ATM Antibody (2C1) recognizes full-length ATM, a 350-kDa nuclear phosphoprotein
theoretical molecular weight :
351 kDa
gene symbol :
ATM
Antibody validation :
Biological Validation
accessionNumbers :
Q13315
applications :
Western Blot,ELISA,SDS-Page,Flow Cytometry,Immunoprecipitation,Immunohistochemistry-Paraffin,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,Chromatin Immunoprecipitation (ChIP),Single Cell Western,Knockdown Validated
USD :
459 USD
alt names :
AT mutated, A-T mutated, AT1, ATA, ataxia telangiectasia mutated, ataxia telangiectasia mutated (includes complementation groups A, C and D), ATC, ATD, ATDC, ATE, ATM serine/threonine kinase, DKFZp781A0353, EC 2.7.11.1, MGC74674, serine-protein kinase ATM, TEL1, TEL1, telomere maintenance 1, homolog, TELO1
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.