ATR Antibody (2B5) - Azide and BSA Free | Novus Biologicals NB100-308 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

ATR Antibody (2B5) - Azide and BSA Free

catalog :

NB100-308

quantity :

0.1 ml

price :

479 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2B5

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation

more info or order :

Novus Biologicals product webpage

citations: 28

Reference
Uchida C, Niida H, Sakai S, Iijima K, Kitagawa K, Ohhata T, et al. p130RB2 positively contributes to ATR activation in response to replication stress via the RPA32-ETAA1 axis. Biochim Biophys Acta Mol Cell Res. 2023;1870:119484 pubmed publisher
Zeng F, Parker K, Zhan Y, Miller M, Zhu M. Upregulated DNA Damage-Linked Biomarkers in Parkinson's Disease Model Mice. ASN Neuro. 2023;15:17590914231152099 pubmed publisher
Chakraborty P, Hiom K. DHX9-dependent recruitment of BRCA1 to RNA promotes DNA end resection in homologous recombination. Nat Commun. 2021;12:4126 pubmed publisher
Harasim Symbor E, Polak Iwaniuk A, Konstantynowicz Nowicka K, Bielawiec P, Malinowska B, Kasacka I, et al. Experimental Activation of Endocannabinoid System Reveals Antilipotoxic Effects on Cardiac Myocytes. Molecules. 2020;25: pubmed publisher
Kim W, Zhao F, Wu R, Qin S, Nowsheen S, Huang J, et al. ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex. Nat Commun. 2019;10:5304 pubmed publisher
Larsen S, Vigelsø A, Dandanell S, Prats C, Dela F, Helge J. Simvastatin-Induced Insulin Resistance May Be Linked to Decreased Lipid Uptake and Lipid Synthesis in Human Skeletal Muscle: the LIFESTAT Study. J Diabetes Res. 2018;2018:9257874 pubmed publisher
Van Pelt D, Guth L, Wang A, Horowitz J. Factors regulating subcutaneous adipose tissue storage, fibrosis, and inflammation may underlie low fatty acid mobilization in insulin-sensitive obese adults. Am J Physiol Endocrinol Metab. 2017;313:E429-E439 pubmed publisher
Cubizolle A, Guillou L, Mollereau B, Hamel C, Brabet P. Fatty acid transport protein 1 regulates retinoid metabolism and photoreceptor development in mouse retina. PLoS ONE. 2017;12:e0180148 pubmed publisher
Newsom S, Everett A, Park S, Van Pelt D, Hinko A, Horowitz J. Lipid mixtures containing a very high proportion of saturated fatty acids only modestly impair insulin signaling in cultured muscle cells. PLoS ONE. 2015;10:e0120871 pubmed publisher
Choi Y, Lee C, Lee K, Jung S, Lee B. Increased hepatic Fatty Acid uptake and esterification contribute to tetracycline-induced steatosis in mice. Toxicol Sci. 2015;145:273-82 pubmed publisher
Larsen S, Danielsen J, Søndergård S, Søgaard D, Vigelsoe A, Dybboe R, et al. The effect of high-intensity training on mitochondrial fat oxidation in skeletal muscle and subcutaneous adipose tissue. Scand J Med Sci Sports. 2015;25:e59-69 pubmed publisher
Haro K, Sheth A, Scheinberg D. Dysregulation of IRP1-mediated iron metabolism causes gamma ray-specific radioresistance in leukemia cells. PLoS ONE. 2012;7:e48841 pubmed publisher
Oku T, Nakano M, Kaneko Y, Ando Y, Kenmotsu H, Itoh S, et al. Constitutive turnover of phosphorylation at Thr-412 of human p57/coronin-1 regulates the interaction with actin. J Biol Chem. 2012;287:42910-20 pubmed publisher
Ha K, Fiskus W, Rao R, Balusu R, Venkannagari S, Nalabothula N, et al. Hsp90 inhibitor-mediated disruption of chaperone association of ATR with hsp90 sensitizes cancer cells to DNA damage. Mol Cancer Ther. 2011;10:1194-206 pubmed publisher
Chen Y, Chen C, Riley D, Chen P. Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR. Cell Cycle. 2011;10:655-63 pubmed
Zuco V, Benedetti V, Zunino F. ATM- and ATR-mediated response to DNA damage induced by a novel camptothecin, ST1968. Cancer Lett. 2010;292:186-96 pubmed publisher
Cui B, Johnson S, Bullock N, Ali Osman F, Bigner D, Friedman H. Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway. Mol Pharmacol. 2009;75:1356-63 pubmed publisher
Katsuki Y, Nakada S, Yokoyama T, Imoto I, Inazawa J, Nagasawa M, et al. Caffeine yields aneuploidy through asymmetrical cell division caused by misalignment of chromosomes. Cancer Sci. 2008;99:1539-45 pubmed publisher
Kulkarni A, Das K. Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation. Am J Physiol Lung Cell Mol Physiol. 2008;294:L998-L1006 pubmed publisher
Liu X, Matsuda A, Plunkett W. Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine. Mol Cancer Ther. 2008;7:133-42 pubmed publisher
Manthey K, Opiyo S, Glanzer J, Dimitrova D, Elliott J, Oakley G. NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse. J Cell Sci. 2007;120:4221-9 pubmed
Liu Y, Rusinol A, Sinensky M, Wang Y, Zou Y. DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A. J Cell Sci. 2006;119:4644-9 pubmed
Wu X, Shell S, Liu Y, Zou Y. ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation. Oncogene. 2007;26:757-64 pubmed
Tyagi A, Singh R, Agarwal C, Agarwal R. Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2. Carcinogenesis. 2006;27:2269-80 pubmed
Wu X, Shell S, Yang Z, Zou Y. Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation. Cancer Res. 2006;66:2997-3005 pubmed
Gibson S, Bindra R, Glazer P. Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner. Cancer Res. 2005;65:10734-41 pubmed
Horton J, Stefanick D, Naron J, Kedar P, Wilson S. Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest after DNA methylating agent exposure. J Biol Chem. 2005;280:15773-85 pubmed
Li J, Stern D. Regulation of CHK2 by DNA-dependent protein kinase. J Biol Chem. 2005;280:12041-50 pubmed

product information

master code :

NB100-308

SKU :

NB100-308

product name :

ATR Antibody (2B5) - Azide and BSA Free

unit size :

0.1 ml

description :

The ATR Antibody (2B5) - Azide and BSA Free from Novus is a mouse monoclonal antibody to ATR. This antibody reacts with human,mouse. The ATR Antibody (2B5) - Azide and BSA Free has been validated for the following applications: Immunoprecipitation,Functional Assay,Western Blot,Knockout Validated,Functional,In vitro assay,Immunocytochemistry/ Immunofluorescence.

target :

ATR

category :

Primary Antibodies

buffer :

PBS

clonality :

Monoclonal

clone :

2B5

conjugate :

Unconjugated

host :

Mouse

immunogen :

Recombinant fragment, corresponding to amino acids 710-1100 of Human ATR.

isotype :

IgG1

purity :

Protein G purified

species :

Human,Mouse

theoretical molecular weight :

317 kDa

gene symbol :

ATR

Antibody validation :

Orthogonal Validation

accessionNumbers :

Q13535

applications :

Western Blot,Immunoprecipitation,Knockout Validated,Functional Assay,Functional,In vitro assay,Immunocytochemistry/ Immunofluorescence

USD :

479 USD

alt names :

ataxia telangiectasia and Rad3 related, Ataxia telangiectasia and Rad3-related protein, EC 2.7.11.1, FRAP-related protein 1, FRP1FRAP-related protein-1, MEC1, protein kinase ATR, Rad3 related protein, SCKL1, SCKLMEC1, mitosis entry checkpoint 1, homolog, serine/threonine-protein kinase ATR

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage