product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
53BP1 Antibody - BSA Free
catalog :
NB100-305
quantity :
0.1 mg (also 0.025 mg)
price :
489 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
Alexa Fluor 532
reactivity :
human, mouse, rat, dogs, bovine
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 96
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; mouse; fig 4d
Parisotto M, Grelet E, El Bizri R, Dai Y, Terzic J, Eckert D, et al. PTEN deletion in luminal cells of mature prostate induces replication stress and senescence in vivo. J Exp Med. 2018;215:1749-1763 pubmed publisher
  • immunocytochemistry; human; 1:1200; loading ...; fig 6b
Takaki T, Montagner M, Serres M, Le Berre M, Russell M, Collinson L, et al. Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability. Nat Commun. 2017;8:16013 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 2b
Vancevska A, Douglass K, Pfeiffer V, Manley S, Lingner J. The telomeric DNA damage response occurs in the absence of chromatin decompaction. Genes Dev. 2017;31:567-577 pubmed publisher
  • immunocytochemistry; mouse; 1:500; loading ...; fig s7a
Kanakkanthara A, Jeganathan K, Limzerwala J, Baker D, Hamada M, Nam H, et al. Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation. Science. 2016;353:1549-1552 pubmed
  • immunocytochemistry; human; loading ...; fig 1e
  • western blot; human; loading ...; fig 4a
Bakr A, Köcher S, Volquardsen J, Petersen C, Borgmann K, Dikomey E, et al. Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1. Oncotarget. 2016;7:57679-57693 pubmed publisher
  • chromatin immunoprecipitation; human; fig 7
Morales J, Richard P, Patidar P, Motea E, Dang T, Manley J, et al. XRN2 Links Transcription Termination to DNA Damage and Replication Stress. PLoS Genet. 2016;12:e1006107 pubmed publisher
  • immunocytochemistry; human; 1:500; fig 5
Penterling C, Drexler G, Böhland C, Stamp R, Wilke C, Braselmann H, et al. Depletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair. PLoS ONE. 2016;11:e0156599 pubmed publisher
  • immunocytochemistry; human; 1:500; fig 4
Mutschelknaus L, Peters C, Winkler K, Yentrapalli R, Heider T, Atkinson M, et al. Exosomes Derived from Squamous Head and Neck Cancer Promote Cell Survival after Ionizing Radiation. PLoS ONE. 2016;11:e0152213 pubmed publisher
  • immunocytochemistry; human; 1:500; fig s11
Weyemi U, Redon C, Choudhuri R, Aziz T, Maeda D, Boufraqech M, et al. The histone variant H2A.X is a regulator of the epithelial-mesenchymal transition. Nat Commun. 2016;7:10711 pubmed publisher
  • western blot; mouse; fig 4a
Kibe T, Zimmermann M, de Lange T. TPP1 Blocks an ATR-Mediated Resection Mechanism at Telomeres. Mol Cell. 2016;61:236-46 pubmed publisher
  • immunocytochemistry; human; fig 1
Cristini A, Park J, Capranico G, Legube G, Favre G, Sordet O. DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions. Nucleic Acids Res. 2016;44:1161-78 pubmed publisher
Kochman R, Ba I, Yates M, Pirabakaran V, Gourmelon F, Churikov D, et al. Heterozygous RPA2 variant as a novel genetic cause of telomere biology disorders. Genes Dev. 2024;38:755-771 pubmed publisher
MacDonald K, Khan S, Lin B, Hurren R, Schimmer A, Kislinger T, et al. The proteomic landscape of genotoxic stress-induced micronuclei. Mol Cell. 2024;84:1377-1391.e6 pubmed publisher
Schwarz B, Matejka N, Rudigkeit S, Sammer M, Reindl J. Chromatin Organization after High-LET Irradiation Revealed by Super-Resolution STED Microscopy. Int J Mol Sci. 2024;25: pubmed publisher
Krais J, Glass D, Chudoba I, Wang Y, Feng W, Simpson D, et al. Genetic separation of Brca1 functions reveal mutation-dependent Polθ vulnerabilities. Nat Commun. 2023;14:7714 pubmed publisher
Arnould C, Rocher V, Saur F, Bader A, Muzzopappa F, Collins S, et al. Chromatin compartmentalization regulates the response to DNA damage. Nature. 2023;623:183-192 pubmed publisher
Sharma A, Ramlee M, Kosmin J, Higgs M, Wolstenholme A, Ronson G, et al. C16orf72/HAPSTR1/TAPR1 functions with BRCA1/Senataxin to modulate replication-associated R-loops and confer resistance to PARP disruption. Nat Commun. 2023;14:5003 pubmed publisher
Jin B, Zhu J, Pan T, Yang Y, Liang L, Zhou Y, et al. MEN1 is a regulator of alternative splicing and prevents R-loop-induced genome instability through suppression of RNA polymerase II elongation. Nucleic Acids Res. 2023;51:7951-7971 pubmed publisher
Jacome Burbano M, Robin J, Bauwens S, Martin M, Donati E, Mart xed nez L, et al. Non-canonical telomere protection role of FOXO3a of human skeletal muscle cells regulated by the TRF2-redox axis. Commun Biol. 2023;6:561 pubmed publisher
Oetting A, Christiansen S, Gatzemeier F, K xf6 cher S, Bu xdf mann L, B xf6 ttcher A, et al. Impaired DNA double-strand break repair and effective radiosensitization of HPV-negative HNSCC cell lines through combined inhibition of PARP and Wee1. Clin Transl Radiat Oncol. 2023;41:100630 pubmed publisher
Komar Z, van Gent D, Chakrabarty S. Establishing a Microfluidic Tumor Slice Culture Platform to Study Drug Response. Curr Protoc. 2023;3:e693 pubmed publisher
Capala M, Pachler K, Lauwers I, de Korte M, Verkaik N, Mast H, et al. Ex Vivo Functional Assay for Evaluating Treatment Response in Tumor Tissue of Head and Neck Squamous Cell Carcinoma. Cancers (Basel). 2023;15: pubmed publisher
Storchova R, Palek M, Palkova N, Veverka P, Brom T, Hofr C, et al. Phosphorylation of TRF2 promotes its interaction with TIN2 and regulates DNA damage response at telomeres. Nucleic Acids Res. 2023;51:1154-1172 pubmed publisher
Jung Garcia Y, Maiques O, Monger J, Rodriguez Hernandez I, Fanshawe B, Domart M, et al. LAP1 supports nuclear adaptability during constrained melanoma cell migration and invasion. Nat Cell Biol. 2023;: pubmed publisher
Meador J, Morris R, Balajee A. Ionizing Radiation-Induced DNA Damage Response in Primary Melanocytes and Keratinocytes of Human Skin. Cytogenet Genome Res. 2022;162:188-200 pubmed publisher
Jacobs K, Doerdelmann C, Krietsch J, Gonz xe1 lez Acosta D, Mathis N, Kushinsky S, et al. Stress-triggered hematopoietic stem cell proliferation relies on PrimPol-mediated repriming. Mol Cell. 2022;82:4176-4188.e8 pubmed publisher
Mendez Bermudez A, Lototska L, Pousse M, Tessier F, Croce O, Latrick C, et al. Selective pericentromeric heterochromatin dismantling caused by TP53 activation during senescence. Nucleic Acids Res. 2022;50:7493-7510 pubmed publisher
Subtil F, Gr xf6 bner C, Recknagel N, Parplys A, Kohl S, Arenz A, et al. Dual PI3K/mTOR Inhibitor NVP-BEZ235 Leads to a Synergistic Enhancement of Cisplatin and Radiation in Both HPV-Negative and -Positive HNSCC Cell Lines. Cancers (Basel). 2022;14: pubmed publisher
Meador J, Balajee A. Analysis of ionizing radiation induced DNA damage response in human adult stem cells and differentiated neurons. Mutat Res Genet Toxicol Environ Mutagen. 2022;878:503486 pubmed publisher
Abu Zhayia E, Bishara L, Machour F, Barisaac A, Ben Oz B, Ayoub N. CDYL1-dependent decrease in lysine crotonylation at DNA double-strand break sites functionally uncouples transcriptional silencing and repair. Mol Cell. 2022;82:1940-1955.e7 pubmed publisher
Magni M, Paolizzi C, Monfrini C, Vella C, Corradini P, Carniti C. Targeting the DNA Damage Response to Increase Anthracycline-Based Chemotherapy Cytotoxicity in T-Cell Lymphoma. Int J Mol Sci. 2022;23: pubmed publisher
Thomsen A, Aldrian C, Luka B, Hornhardt S, Gomolka M, Moertl S, et al. Biopsy-derived oral keratinocytes - A model to potentially test for oral mucosa radiation sensitivity. Clin Transl Radiat Oncol. 2022;34:51-56 pubmed publisher
Pelicci S, Furia L, Scanarini M, Pelicci P, Lanzano L, Faretta M. Novel Tools to Measure Single Molecules Colocalization in Fluorescence Nanoscopy by Image Cross Correlation Spectroscopy. Nanomaterials (Basel). 2022;12: pubmed publisher
Reindl J, Kundrát P, Girst S, Sammer M, Schwarz B, Dollinger G. Dosimetry of heavy ion exposure to human cells using nanoscopic imaging of double strand break repair protein clusters. Sci Rep. 2022;12:1305 pubmed publisher
Jack A, Kim Y, Strom A, Lee D, Williams B, Schaub J, et al. Compartmentalization of telomeres through DNA-scaffolded phase separation. Dev Cell. 2022;57:277-290.e9 pubmed publisher
Sturmlechner I, Zhang C, Sine C, van Deursen E, Jeganathan K, Hamada N, et al. p21 produces a bioactive secretome that places stressed cells under immunosurveillance. Science. 2021;374:eabb3420 pubmed publisher
Paiano J, Zolnerowich N, Wu W, Pavani R, Wang C, Li H, et al. Role of 53BP1 in end protection and DNA synthesis at DNA breaks. Genes Dev. 2021;35:1356-1367 pubmed publisher
Chen B, Wang Y, Tubbs A, Zong D, Fowler F, Zolnerowich N, et al. LIN37-DREAM prevents DNA end resection and homologous recombination at DNA double-strand breaks in quiescent cells. elife. 2021;10: pubmed publisher
Krais J, Wang Y, Patel P, Basu J, Bernhardy A, Johnson N. RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage. Nat Commun. 2021;12:5016 pubmed publisher
Gatta A, Olmos Y, Stoten C, Chen Q, Rosenthal P, Carlton J. CDK1 controls CHMP7-dependent nuclear envelope reformation. elife. 2021;10: pubmed publisher
Mehibel M, Xu Y, Li C, Moon E, Thakkar K, Diep A, et al. Eliminating hypoxic tumor cells improves response to PARP inhibitors in homologous recombination-deficient cancer models. J Clin Invest. 2021;131: pubmed publisher
Shinoda K, Zong D, Callen E, Wu W, Dumitrache L, Belinky F, et al. The dystonia gene THAP1 controls DNA double-strand break repair choice. Mol Cell. 2021;81:2611-2624.e10 pubmed publisher
Wu W, Hill S, Nathan W, Paiano J, Callen E, Wang D, et al. Neuronal enhancers are hotspots for DNA single-strand break repair. Nature. 2021;593:440-444 pubmed publisher
Levone B, Lenzken S, Antonaci M, Maiser A, Rapp A, Conte F, et al. FUS-dependent liquid-liquid phase separation is important for DNA repair initiation. J Cell Biol. 2021;220: pubmed publisher
Zou R, Liu Y, Wu B, Ha T. Cas9 deactivation with photocleavable guide RNAs. Mol Cell. 2021;81:1553-1565.e8 pubmed publisher
Nomura D, Abe R, Tsukimoto M. Involvement of TRPM8 Channel in Radiation-Induced DNA Damage Repair Mechanism Contributing to Radioresistance of B16 Melanoma. Biol Pharm Bull. 2021;44:642-652 pubmed publisher
Augereau A, Mariotti M, Pousse M, Filipponi D, Libert F, Beck B, et al. Naked mole rat TRF1 safeguards glycolytic capacity and telomere replication under low oxygen. Sci Adv. 2021;7: pubmed publisher
Affandi T, Ohm A, Gaillard D, Haas A, Reyland M. Tyrosine kinase inhibitors protect the salivary gland from radiation damage by increasing DNA double-strand break repair. J Biol Chem. 2021;296:100401 pubmed publisher
Oizumi T, Ohno R, Yamabe S, Funayama T, Nakamura A. Repair Kinetics of DNA Double Strand Breaks Induced by Simulated Space Radiation. Life (Basel). 2020;10: pubmed publisher
Elsesy M, Oh Hohenhorst S, Löser A, Oing C, Mutiara S, Köcher S, et al. Second-Generation Antiandrogen Therapy Radiosensitizes Prostate Cancer Regardless of Castration State through Inhibition of DNA Double Strand Break Repair. Cancers (Basel). 2020;12: pubmed publisher
Bucher M, Duchrow L, Endesfelder D, Roessler U, Gomolka M. Comparison of inexperienced operators and experts in γH2A.X and 53BP1 foci assay for high-throughput biodosimetry approaches in a mass casualty incident. Int J Radiat Biol. 2020;96:1263-1273 pubmed publisher
Gerakopoulos V, Ngo P, Tsiokas L. Loss of polycystins suppresses deciliation via the activation of the centrosomal integrity pathway. Life Sci Alliance. 2020;3: pubmed publisher
Malaquin N, Vancayseele A, Gilbert S, Antenor Habazac L, Olivier M, Ait Ali Brahem Z, et al. DNA Damage- But Not Enzalutamide-Induced Senescence in Prostate Cancer Promotes Senolytic Bcl-xL Inhibitor Sensitivity. Cells. 2020;9: pubmed publisher
de Krijger I, van der Torre J, Peuscher M, Eder M, Jacobs J. H3K36 dimethylation by MMSET promotes classical non-homologous end-joining at unprotected telomeres. Oncogene. 2020;39:4814-4827 pubmed publisher
Nacson J, Di Marcantonio D, Wang Y, Bernhardy A, Clausen E, Hua X, et al. BRCA1 Mutational Complementation Induces Synthetic Viability. Mol Cell. 2020;78:951-959.e6 pubmed publisher
Prajapati B, Fatima M, Fatma M, Maddhesiya P, Arora H, Naskar T, et al. Temporal transcriptome analysis of neuronal commitment reveals the preeminent role of the divergent lncRNA biotype and a critical candidate gene during differentiation. Cell Death Discov. 2020;6:28 pubmed publisher
Bao X, Wang J, Zhou G, Aszodi A, Schönitzer V, Scherthan H, et al. Extended in vitro culture of primary human mesenchymal stem cells downregulates Brca1-related genes and impairs DNA double-strand break recognition. FEBS Open Bio. 2020;: pubmed publisher
Elbasani E, Gramolelli S, Gunther T, Gabaev I, Grundhoff A, Ojala P. Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication Is Independent of Anaphase-Promoting Complex Activity. J Virol. 2020;94: pubmed publisher
Lototska L, Yue J, Li J, Giraud Panis M, Songyang Z, Royle N, et al. Human RAP1 specifically protects telomeres of senescent cells from DNA damage. EMBO Rep. 2020;21:e49076 pubmed publisher
Ercilla A, Benada J, Amitash S, Zonderland G, Baldi G, Somyajit K, et al. Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication. Cell Rep. 2020;30:2416-2429.e7 pubmed publisher
Göttgens E, van den Heuvel C, de Jong M, Kaanders J, Leenders W, Ansems M, et al. ACLY (ATP Citrate Lyase) Mediates Radioresistance in Head and Neck Squamous Cell Carcinomas and is a Novel Predictive Radiotherapy Biomarker. Cancers (Basel). 2019;11: pubmed publisher
Dulev S, Lin S, Liu Q, Cetintas V, Batada N. SET8 localization to chromatin flanking DNA damage is dependent on RNF168 ubiquitin ligase. Cell Cycle. 2020;19:15-23 pubmed publisher
Sieben C, Jeganathan K, Nelson G, Sturmlechner I, Zhang C, van Deursen W, et al. BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome. J Clin Invest. 2020;130:171-188 pubmed publisher
Callen E, Zong D, Wu W, Wong N, Stanlie A, Ishikawa M, et al. 53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination. Mol Cell. 2019;: pubmed publisher
Ochs F, Karemore G, Miron E, Brown J, Sedlackova H, Rask M, et al. Stabilization of chromatin topology safeguards genome integrity. Nature. 2019;574:571-574 pubmed publisher
Hladik D, Höfig I, Oestreicher U, Beckers J, Matjanovski M, Bao X, et al. Long-term culture of mesenchymal stem cells impairs ATM-dependent recognition of DNA breaks and increases genetic instability. Stem Cell Res Ther. 2019;10:218 pubmed publisher
Hwang S, Kang M, Baik C, Lee Y, Hang N, Kim B, et al. CTCF cooperates with CtIP to drive homologous recombination repair of double-strand breaks. Nucleic Acids Res. 2019;47:9160-9179 pubmed publisher
Göttgens E, Bussink J, Leszczynska K, Peters H, Span P, Hammond E. Inhibition of CD4/CDK6 enhances radiosensitivity of HPV negative head and neck squamous cell carcinomas. Int J Radiat Oncol Biol Phys. 2019;: pubmed publisher
Spies J, Lukas C, Somyajit K, Rask M, Lukas J, Neelsen K. 53BP1 nuclear bodies enforce replication timing at under-replicated DNA to limit heritable DNA damage. Nat Cell Biol. 2019;21:487-497 pubmed publisher
Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, et al. Length-independent telomere damage drives post-mitotic cardiomyocyte senescence. EMBO J. 2019;38: pubmed publisher
Zong D, Adam S, Wang Y, Sasanuma H, Callen E, Murga M, et al. BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation. Mol Cell. 2019;73:1267-1281.e7 pubmed publisher
Benkafadar N, François F, Affortit C, Casas F, Ceccato J, Menardo J, et al. ROS-Induced Activation of DNA Damage Responses Drives Senescence-Like State in Postmitotic Cochlear Cells: Implication for Hearing Preservation. Mol Neurobiol. 2019;: pubmed publisher
Boscolo Sesillo F, Fox D, Sacco A. Muscle Stem Cells Give Rise to Rhabdomyosarcomas in a Severe Mouse Model of Duchenne Muscular Dystrophy. Cell Rep. 2019;26:689-701.e6 pubmed publisher
Köcher S, Beyer B, Lange T, Nordquist L, Volquardsen J, Burdak Rothkamm S, et al. A functional ex vivo assay to detect PARP1-EJ repair and radiosensitization by PARP-inhibitor in prostate cancer. Int J Cancer. 2019;144:1685-1696 pubmed publisher
Clouaire T, Rocher V, Lashgari A, Arnould C, Aguirrebengoa M, Biernacka A, et al. Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures. Mol Cell. 2018;72:250-262.e6 pubmed publisher
Zhang Y, Chang J, Sun J, Chen L, Yang X, Tang H, et al. Histone H3K27 methylation modulates the dynamics of FANCD2 on chromatin to facilitate NHEJ and genome stability. J Cell Sci. 2018;131: pubmed publisher
Mendez Bermudez A, Lototska L, Bauwens S, Giraud Panis M, Croce O, Jamet K, et al. Genome-wide Control of Heterochromatin Replication by the Telomere Capping Protein TRF2. Mol Cell. 2018;70:449-461.e5 pubmed publisher
Ohsaki A, Miyano Y, Tanaka R, Tanuma S, Kojima S, Tsukimoto M. A Novel Mechanism of γ-Irradiation-Induced IL-6 Production Mediated by P2Y11 Receptor in Epidermal Keratinocytes. Biol Pharm Bull. 2018;41:925-936 pubmed publisher
Chen N, Partridge A, Tuzer F, Cohen J, Nacarelli T, Navas Martin S, et al. Induction of a Senescence-Like Phenotype in Cultured Human Fetal Microglia During HIV-1 Infection. J Gerontol A Biol Sci Med Sci. 2018;73:1187-1196 pubmed publisher
Michelini F, Pitchiaya S, Vitelli V, Sharma S, Gioia U, Pessina F, et al. Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks. Nat Cell Biol. 2017;19:1400-1411 pubmed publisher
Santaguida S, Richardson A, Iyer D, M Saad O, Zasadil L, Knouse K, et al. Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System. Dev Cell. 2017;41:638-651.e5 pubmed publisher
Reindl J, Girst S, Walsh D, Greubel C, Schwarz B, Siebenwirth C, et al. Chromatin organization revealed by nanostructure of irradiation induced γH2AX, 53BP1 and Rad51 foci. Sci Rep. 2017;7:40616 pubmed publisher
Benkafadar N, Menardo J, Bourien J, Nouvian R, François F, Decaudin D, et al. Reversible p53 inhibition prevents cisplatin ototoxicity without blocking chemotherapeutic efficacy. EMBO Mol Med. 2017;9:7-26 pubmed publisher
Croco E, Marchionni S, Bocchini M, Angeloni C, STAMATO T, Stefanelli C, et al. DNA Damage Detection by 53BP1: Relationship to Species Longevity. J Gerontol A Biol Sci Med Sci. 2017;72:763-770 pubmed publisher
. Inhibition of DNA damage repair by the CDK4/6 inhibitor palbociclib delays irradiated intracranial atypical teratoid rhabdoid tumor and glioblastoma xenograft regrowth. Neuro Oncol. 2016;18:1519-1528 pubmed
Ochs F, Somyajit K, Altmeyer M, Rask M, Lukas J, Lukas C. 53BP1 fosters fidelity of homology-directed DNA repair. Nat Struct Mol Biol. 2016;23:714-21 pubmed publisher
van Ree J, Nam H, Jeganathan K, Kanakkanthara A, van Deursen J. Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes. Nat Cell Biol. 2016;18:814-21 pubmed publisher
Szczepanski S, Hussain M, Sur I, Altmüller J, Thiele H, Abdullah U, et al. A novel homozygous splicing mutation of CASC5 causes primary microcephaly in a large Pakistani family. Hum Genet. 2016;135:157-70 pubmed publisher
Bakr A, Köcher S, Volquardsen J, Reimer R, Borgmann K, Dikomey E, et al. Functional crosstalk between DNA damage response proteins 53BP1 and BRCA1 regulates double strand break repair choice. Radiother Oncol. 2016;119:276-81 pubmed publisher
Reindl J, Drexler G, Girst S, Greubel C, Siebenwirth C, Drexler S, et al. Nanoscopic exclusion between Rad51 and 53BP1 after ion irradiation in human HeLa cells. Phys Biol. 2015;12:066005 pubmed publisher
Belin B, Lee T, Mullins R. DNA damage induces nuclear actin filament assembly by Formin -2 and Spire-½ that promotes efficient DNA repair. [corrected]. elife. 2015;4:e07735 pubmed publisher
Yi Y, Park J, Kwak S, Seong Y. Co-treatment with BEZ235 Enhances Sensitivity of BRCA1-negative Breast Cancer Cells to Olaparib. Anticancer Res. 2015;35:3829-38 pubmed
Mathieu A, Verronèse E, Rice G, Fouyssac F, Bertrand Y, Picard C, et al. PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator-dependent autoimmunity. J Allergy Clin Immunol. 2015;135:1578-88.e5 pubmed publisher
Boersma V, Moatti N, Segura Bayona S, Peuscher M, van der Torre J, Wevers B, et al. MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end resection. Nature. 2015;521:537-540 pubmed publisher
Walter D, Lier A, Geiselhart A, Thalheimer F, Huntscha S, Sobotta M, et al. Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells. Nature. 2015;520:549-52 pubmed publisher
Chen L, Zhu X, Zou Y, Xing J, Gilson E, Lu Y, et al. The topoisomerase II catalytic inhibitor ICRF-193 preferentially targets telomeres that are capped by TRF2. Am J Physiol Cell Physiol. 2015;308:C372-7 pubmed publisher
product information
master code :
NB100-305
SKU :
NB100-305
product name :
53BP1 Antibody - BSA Free
unit size :
0.1 mg (also 0.025 mg)
description :
The 53BP1 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to 53BP1. This antibody reacts with bat,bovine,canine,human,insect - drosophila melanogaster,mouse,naked mole-rat,rat. The 53BP1 Antibody - BSA Free has been validated for the following applications: Western Blot,Immunocytochemistry/ Immunofluorescence,Chemotaxis,IF/IHC,Flow Cytometry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,In Situ Hybridization,Chromatin Immunoprecipitation,Immunohistochemistry,Chromatin Immunoprecipitation (ChIP),Knockdown Validated.
target :
53BP1
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
The epitope recognized by 53BP1 Antibody maps to a region between residues 1925 and the C-terminus (residue 1972) of human 53BP1 (NP_005648.1).
isotype :
IgG
purity :
Immunogen affinity purified
species :
Bat,Bovine,Canine,Human,Insect - Drosophila melanogaster,Mouse,Naked mole-rat,Rat
gene symbol :
TP53BP1
Antibody validation :
Biological Validation
applications :
Western Blot,Immunocytochemistry/ Immunofluorescence,Chemotaxis,IF/IHC,Flow Cytometry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,In Situ Hybridization,Chromatin Immunoprecipitation,Immunohistochemistry,Chromatin Immunoprecipitation (ChIP),Knockdown Validated
USD :
489 USD
alt names :
53BP1, p202, p53-binding protein 1, p53bp1, TDRD30, TP53-Binding Protein 1, tumor protein 53-binding protein, 1, tumor protein p53 binding protein 1, tumor protein p53-binding protein, 1, tumor suppressor p53-binding protein 1
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.