product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
53BP1 Antibody - BSA Free
catalog :
NB100-304
quantity :
0.1 mg (also 0.025 mg)
price :
499 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
OTI2B3
reactivity :
hamsters, human, mouse, rat, dogs, bovine
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, proximity ligation assay
more info or order :
citations: 573
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; 1:5000; loading ...; fig s3b
Groelly F, Porru M, Zimmer J, Benainous H, De Visser Y, Kosova A, et al. Anti-tumoural activity of the G-quadruplex ligand pyridostatin against BRCA1/2-deficient tumours. EMBO Mol Med. 2022;14:e14501 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 1h
Pal S, Nixon B, Glennon M, Shridhar P, Satterfield S, Su Y, et al. Replication Stress Response Modifies Sarcomeric Cardiomyopathy Remodeling. J Am Heart Assoc. 2021;10:e021768 pubmed publisher
  • immunocytochemistry; mouse; fig 4d
Tichy E, Ma N, Sidibe D, Loro E, Kocan J, Chen D, et al. Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shortening. Cell Rep. 2021;35:109098 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 1g
Hanna R, Flamier A, Barabino A, Bernier G. G-quadruplexes originating from evolutionary conserved L1 elements interfere with neuronal gene expression in Alzheimer's disease. Nat Commun. 2021;12:1828 pubmed publisher
  • immunocytochemistry; human; 1:400; loading ...; fig 5a
Nouws J, Wan F, Finnemore E, Roque W, Kim S, Bazan I, et al. MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease. JCI Insight. 2021;6: pubmed publisher
  • immunocytochemistry; human; loading ...; fig 2c
Wang H, Nakamura M, Abbott T, Zhao D, Luo K, Yu C, et al. CRISPR-mediated live imaging of genome editing and transcription. Science. 2019;: pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig s2b
  • western blot; mouse; loading ...; fig 1e
Sundaravinayagam D, Rahjouei A, Andreani M, Tupiņa D, Balasubramanian S, Saha T, et al. 53BP1 Supports Immunoglobulin Class Switch Recombination Independently of Its DNA Double-Strand Break End Protection Function. Cell Rep. 2019;28:1389-1399.e6 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 7c
Wen H, Gao S, Wang Y, Ray M, Magnuson M, Wright C, et al. Myeloid cell-derived HB-EGF Drives Tissue Recovery After Pancreatitis. Cell Mol Gastroenterol Hepatol. 2019;: pubmed publisher
  • immunocytochemistry; human; loading ...; fig s10a
Zhang M, Wang B, Li T, Liu R, Xiao Y, Geng X, et al. Mammalian CST averts replication failure by preventing G-quadruplex accumulation. Nucleic Acids Res. 2019;47:5243-5259 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:5000; loading ...; fig s2d
López Erauskin J, Tadokoro T, Baughn M, Myers B, McAlonis Downes M, Chillon Marinas C, et al. ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS. Neuron. 2018;100:816-830.e7 pubmed publisher
  • immunocytochemistry; human; 1:250; loading ...; fig s5d
Schrank B, Aparicio T, Li Y, Chang W, Chait B, Gundersen G, et al. Nuclear ARP2/3 drives DNA break clustering for homology-directed repair. Nature. 2018;559:61-66 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 6
Cottineau J, Kottemann M, Lach F, Kang Y, Vély F, Deenick E, et al. Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency. J Clin Invest. 2017;127:1991-2006 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 2b
Vancevska A, Douglass K, Pfeiffer V, Manley S, Lingner J. The telomeric DNA damage response occurs in the absence of chromatin decompaction. Genes Dev. 2017;31:567-577 pubmed publisher
  • western blot; human; loading ...; fig 4d
Liu Y, Cussiol J, Dibitetto D, Sims J, Twayana S, Weiss R, et al. TOPBP1Dpb11 plays a conserved role in homologous recombination DNA repair through the coordinated recruitment of 53BP1Rad9. J Cell Biol. 2017;216:623-639 pubmed publisher
  • immunocytochemistry; human; loading ...
Li J, Miralles Fusté J, Simavorian T, Bartocci C, Tsai J, Karlseder J, et al. TZAP: A telomere-associated protein involved in telomere length control. Science. 2017;355:638-641 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 3d
Mytych J, Wos I, Solek P, Koziorowski M. Protective role of klotho protein on epithelial cells upon co-culture with activated or senescent monocytes. Exp Cell Res. 2017;350:358-367 pubmed publisher
  • immunocytochemistry; human; 1:500; loading ...; fig 2a
Tumini E, Barroso S, Calero C, Aguilera A. Roles of human POLD1 and POLD3 in genome stability. Sci Rep. 2016;6:38873 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 2c
Bezine E, Malaisé Y, Loeuillet A, Chevalier M, Boutet Robinet E, Salles B, et al. Cell resistance to the Cytolethal Distending Toxin involves an association of DNA repair mechanisms. Sci Rep. 2016;6:36022 pubmed publisher
  • immunocytochemistry; rat; 1:500; loading ...; fig 4c
Piechota M, Sunderland P, Wysocka A, Nalberczak M, Sliwinska M, Radwanska K, et al. Is senescence-associated β-galactosidase a marker of neuronal senescence?. Oncotarget. 2016;7:81099-81109 pubmed publisher
  • immunocytochemistry; mouse; 1:600; fig 2
Lescale C, Lenden Hasse H, Blackford A, Balmus G, Bianchi J, Yu W, et al. Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination. Cell Rep. 2016;16:2967-2979 pubmed publisher
  • immunocytochemistry; human; fig s2d
Schmidt J, Zaug A, Cech T. Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres. Cell. 2016;166:1188-1197.e9 pubmed publisher
  • immunocytochemistry; human; 1:2000; fig 1
Mao P, Liu J, Zhang Z, Zhang H, Liu H, Gao S, et al. Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells. Nat Commun. 2016;7:12154 pubmed publisher
  • immunocytochemistry; human; 1:3000; fig 5
Jullien D, Vignard J, Fedor Y, Bery N, Olichon A, Crozatier M, et al. Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells. J Cell Sci. 2016;129:2673-83 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 2
Ho T, Guilbaud G, Blow J, Sale J, Watson C. The KRAB Zinc Finger Protein Roma/Zfp157 Is a Critical Regulator of Cell-Cycle Progression and Genomic Stability. Cell Rep. 2016;15:724-734 pubmed publisher
  • immunocytochemistry; human; fig 4
  • western blot; human; fig 4
Chiang T, le Sage C, Larrieu D, Demir M, Jackson S. CRISPR-Cas9(D10A) nickase-based genotypic and phenotypic screening to enhance genome editing. Sci Rep. 2016;6:24356 pubmed publisher
  • immunocytochemistry; human; fig 3a
Medves S, Auchter M, Chambeau L, Gazzo S, Poncet D, Grangier B, et al. A high rate of telomeric sister chromatid exchange occurs in chronic lymphocytic leukaemia B-cells. Br J Haematol. 2016;174:57-70 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 1d
O Hagan Wong K, Nadeau S, Carrier Leclerc A, Apablaza F, Hamdy R, Shum Tim D, et al. Increased IL-6 secretion by aged human mesenchymal stromal cells disrupts hematopoietic stem and progenitor cells' homeostasis. Oncotarget. 2016;7:13285-96 pubmed publisher
  • immunocytochemistry; human; 1:1000; fig 2
  • western blot; human; fig s3
Francia S, Cabrini M, Matti V, Oldani A, d Adda di Fagagna F. DICER, DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors. J Cell Sci. 2016;129:1468-76 pubmed publisher
  • western blot; human; fig 5
Cekan P, Hasegawa K, Pan Y, Tubman E, Odde D, Chen J, et al. RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage-induced cell senescence. Mol Biol Cell. 2016;27:1346-57 pubmed publisher
  • immunocytochemistry; human; fig s7
Nagy Z, Kalousi A, Furst A, Koch M, Fischer B, Soutoglou E. Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs. PLoS Genet. 2016;12:e1005791 pubmed publisher
  • western blot; human; 1:1000; fig 4
Zhang H, Liu H, Chen Y, Yang X, Wang P, Liu T, et al. A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice. Nat Commun. 2016;7:10201 pubmed publisher
  • immunocytochemistry; hamsters; 1:1000; fig 8
Chatalic K, Konijnenberg M, Nonnekens J, De Blois E, Hoeben S, de Ridder C, et al. In Vivo Stabilization of a Gastrin-Releasing Peptide Receptor Antagonist Enhances PET Imaging and Radionuclide Therapy of Prostate Cancer in Preclinical Studies. Theranostics. 2016;6:104-17 pubmed publisher
  • western blot; human; fig 5
Obermeier K, Sachsenweger J, Friedl T, Pospiech H, Winqvist R, Wiesmüller L. Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients. Oncogene. 2016;35:3796-806 pubmed publisher
  • immunocytochemistry; human; 1:2000; loading ...; fig 5a
Kubben N, Brimacombe K, Donegan M, Li Z, Misteli T. A high-content imaging-based screening pipeline for the systematic identification of anti-progeroid compounds. Methods. 2016;96:46-58 pubmed publisher
  • immunocytochemistry; mouse; fig 6c
Petroni M, Sardina F, Heil C, Sahún Roncero M, Colicchia V, Veschi V, et al. The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress. Cell Death Differ. 2016;23:197-206 pubmed publisher
Herrera Moyano E, Porreca R, Ranjha L, Skourti E, Gonzalez Franco R, Stylianakis E, et al. Human SKI component SKIV2L regulates telomeric DNA-RNA hybrids and prevents telomere fragility. iScience. 2024;27:111096 pubmed publisher
Chen J, Merrick K, Kong Y, Izrael Tomasevic A, Eng G, Handly E, et al. An RNA damage response network mediates the lethality of 5-FU in colorectal cancer. Cell Rep Med. 2024;5:101778 pubmed publisher
McDonald J, Kim J, Farmerie L, Johnson M, Trovão N, Arif S, et al. Space radiation damage rescued by inhibition of key spaceflight associated miRNAs. Nat Commun. 2024;15:4825 pubmed publisher
Sanese P, De Marco K, Lepore Signorile M, La Rocca F, Forte G, Latrofa M, et al. The novel SMYD3 inhibitor EM127 impairs DNA repair response to chemotherapy-induced DNA damage and reverses cancer chemoresistance. J Exp Clin Cancer Res. 2024;43:151 pubmed publisher
Li Y, Li L, Wang X, Zhao F, Yang Y, Zhou Y, et al. USP25 Elevates SHLD2-Mediated DNA Double-Strand Break Repair and Regulates Chemoresponse in Cancer. Adv Sci (Weinh). 2024;11:e2403485 pubmed publisher
Siametis A, Stratigi K, Giamaki D, Chatzinikolaou G, Akalestou Clocher A, Goulielmaki E, et al. Transcription stress at telomeres leads to cytosolic DNA release and paracrine senescence. Nat Commun. 2024;15:4061 pubmed publisher
Garc xed a Rodr xed guez N, Dom xed nguez Garc xed a I, Dom xed nguez P xe9 rez M, Huertas P. EXO1 and DNA2-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cells. Nucleic Acids Res. 2024;52:6376-6391 pubmed publisher
Wang Y, Liu X, Zuo X, Wang C, Zhang Z, Zhang H, et al. NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors. Cell Genom. 2024;4:100550 pubmed publisher
Dunne V, Wright T, Liberal F, O Sullivan J, Prise K. Synergistic Activity of DNA Damage Response Inhibitors in Combination with Radium-223 in Prostate Cancer. Cancers (Basel). 2024;16: pubmed publisher
Campos D xed az A, Morej xf3 n Garc xed a P, Monte Serrano E, Ros Pardo D, Marcos Alcalde I, G xf3 mez Puertas P, et al. Pathogenic effects of Leu200Pro and Arg387His VRK1 protein variants on phosphorylation targets and H4K16 acetylation in distal hereditary motor neuropathy. J Mol Med (Berl). 2024;102:801-817 pubmed publisher
Petropoulos M, Karamichali A, Rossetti G, Freudenmann A, Iacovino L, Dionellis V, et al. Transcription-replication conflicts underlie sensitivity to PARP inhibitors. Nature. 2024;628:433-441 pubmed publisher
Foo M, Ong P, Yap Z, Maric M, Bong C, Dr xf6 ge P, et al. Genetic and pharmacological modulation of lamin A farnesylation determines its function and turnover. Aging Cell. 2024;23:e14105 pubmed publisher
Escoubas C, Dorman L, Nguyen P, Lagares Linares C, Nakajo H, Anderson S, et al. Type-I-interferon-responsive microglia shape cortical development and behavior. Cell. 2024;187:1936-1954.e24 pubmed publisher
Jonkhout M, Vanhessche T, Ferreira M, Verbinnen I, Withof F, Van der Hoeven G, et al. Embryonic NIPP1 Depletion in Keratinocytes Triggers a Cell Cycle Arrest and Premature Senescence in Adult Mice. J Invest Dermatol. 2024;144:2162-2175.e12 pubmed publisher
Ascen xe7 xe3 o C, Sims J, Dziubek A, Comstock W, Fogarty E, Badar J, et al. A TOPBP1 allele causing male infertility uncouples XY silencing dynamics from sex body formation. elife. 2024;12: pubmed publisher
Duran I, Pombo J, Sun B, Gallage S, Kudo H, McHugh D, et al. Detection of senescence using machine learning algorithms based on nuclear features. Nat Commun. 2024;15:1041 pubmed publisher
Sanchez Lopez I, Orantos Aguilera Y, Pozo Guisado E, Alvarez Barrientos A, Lilla S, Zanivan S, et al. STIM1 translocation to the nucleus protects cells from DNA damage. Nucleic Acids Res. 2024;52:2389-2415 pubmed publisher
Kurtenbach S, Sanchez M, Kuznetsoff J, Rodriguez D, Weich N, Dollar J, et al. PRAME induces genomic instability in uveal melanoma. Oncogene. 2024;43:555-565 pubmed publisher
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Sutcu H, Rassinoux P, Donnio L, Neuillet D, Vianna F, Gabillot O, et al. Decline of DNA damage response along with myogenic differentiation. Life Sci Alliance. 2024;7: pubmed publisher
Liu X, Lu R, Yang Q, He J, Huang C, Cao Y, et al. USP7 reduces the level of nuclear DICER, impairing DNA damage response and promoting cancer progression. Mol Oncol. 2024;18:170-189 pubmed publisher
Guerra Liberal F, Parsons J, McMahon S. Most DNA repair defects do not modify the relationship between relative biological effectiveness and linear energy transfer in CRISPR-edited cells. Med Phys. 2024;51:591-600 pubmed publisher
Ma B, Mart xed nez P, S xe1 nchez V xe1 zquez R, Blasco M. Telomere dynamics in human pluripotent stem cells. Cell Cycle. 2023;22:2505-2521 pubmed publisher
Smoczer C, Park Y, Herrington J, Askar M, Plecha S, KRUKONIS E, et al. A Potential Intracanal Medicament, 2-Hydroxyisocaproic Acid (HICA): Cytotoxicity, Genotoxicity, and Its Effect on SCAP Differentiation. Dent J (Basel). 2023;11: pubmed publisher
Braun H, Xu Z, Chang F, Viceconte N, Rane G, Levin M, et al. ZNF524 directly interacts with telomeric DNA and supports telomere integrity. Nat Commun. 2023;14:8252 pubmed publisher
Stroik S, Carvajal Garcia J, Gupta D, Edwards A, Luthman A, Wyatt D, et al. Stepwise requirements for polymerases δ and θ in theta-mediated end joining. Nature. 2023;623:836-841 pubmed publisher
Chatzinikolaou G, Stratigi K, Siametis A, Goulielmaki E, Akalestou Clocher A, Tsamardinos I, et al. XPF interacts with TOP2B for R-loop processing and DNA looping on actively transcribed genes. Sci Adv. 2023;9:eadi2095 pubmed publisher
Wang Y, Zhu W, Jang Y, Sommers J, Yi G, Puligilla C, et al. The RNA-binding motif protein 14 regulates telomere integrity at the interface of TERRA and telomeric R-loops. Nucleic Acids Res. 2023;51:12242-12260 pubmed publisher
Emori C, Boucher Z, Bolcun Filas E. CHEK2 signaling is the key regulator of oocyte survival after chemotherapy. Sci Adv. 2023;9:eadg0898 pubmed publisher
Ma T, Worth K, Maher C, Ng N, Begh xe8 C, Gromak N, et al. Hypoxia-induced transcriptional stress is mediated by ROS-induced R-loops. Nucleic Acids Res. 2023;51:11584-11599 pubmed publisher
Qiu C, Shen X, Lu H, Chen Y, Xu C, Zheng P, et al. Combination therapy with HSP90 inhibitors and piperlongumine promotes ROS-mediated ER stress in colon cancer cells. Cell Death Discov. 2023;9:375 pubmed publisher
ElGhazaly M, Collins M, Ibler A, Humphreys D. Typhoid toxin hijacks Wnt5a to establish host senescence and Salmonella infection. Cell Rep. 2023;42:113181 pubmed publisher
Bloom S, Tucker J, Machin D, Abdeahad H, Adeyemo A, Thomas T, et al. Reduction of double-strand DNA break repair exacerbates vascular aging. Aging (Albany NY). 2023;15:9913-9947 pubmed publisher
Handwerk L, Schreier H, Kraft D, Shreder K, Hemmersbach R, Hauslage J, et al. Simulating Space Conditions Evokes Different DNA Damage Responses in Immature and Mature Cells of the Human Hematopoietic System. Int J Mol Sci. 2023;24: pubmed publisher
Liu J, Zheng T, Chen D, Huang J, Zhao Y, Ma W, et al. RBMX involves in telomere stability maintenance by regulating TERRA expression. PLoS Genet. 2023;19:e1010937 pubmed publisher
Hu Q, Valle Inclan J, Dahiya R, Guyer A, Mazzagatti A, Maurais E, et al. Non-homologous end joining shapes the genomic rearrangement landscape of chromothripsis from mitotic errors. bioRxiv. 2023;: pubmed publisher
Bona N, Crossan G. Fanconi anemia DNA crosslink repair factors protect against LINE-1 retrotransposition during mouse development. Nat Struct Mol Biol. 2023;30:1434-1445 pubmed publisher
Nie L, Wang C, Huang M, Liu X, Feng X, Tang M, et al. DePARylation is critical for S phase progression and cell survival. bioRxiv. 2023;: pubmed publisher
Qiu L, Xu W, Lu X, Chen F, Chen Y, Tian Y, et al. The HDAC6-RNF168 axis regulates H2A/H2A.X ubiquitination to enable double-strand break repair. Nucleic Acids Res. 2023;: pubmed publisher
Sung S, Kim E, Niida H, Kim C, Lee J. Distinct characteristics of two types of alternative lengthening of telomeres in mouse embryonic stem cells. Nucleic Acids Res. 2023;51:9122-9143 pubmed publisher
Lee S, Kelliher J, Song W, Tengler K, Sarkar A, Dray E, et al. UBA80 and UBA52 fine-tune RNF168-dependent histone ubiquitination and DNA repair. J Biol Chem. 2023;:105043 pubmed publisher
Guerra Liberal F, Thompson S, Prise K, McMahon S. High-LET radiation induces large amounts of rapidly-repaired sublethal damage. Sci Rep. 2023;13:11198 pubmed publisher
Min J, Zhao J, Zagelbaum J, Lee J, Takahashi S, Cummings P, et al. Mechanisms of insertions at a DNA double-strand break. Mol Cell. 2023;83:2434-2448.e7 pubmed publisher
Oropeza E, Seker S, Carrel S, Mazumder A, Lozano D, Jimenez A, et al. Molecular portraits of cell cycle checkpoint kinases in cancer evolution, progression, and treatment responsiveness. Sci Adv. 2023;9:eadf2860 pubmed publisher
G xf6 der A, Quinlan A, Rainey M, Bennett D, Shamavu D, Corso J, et al. PTBP1 enforces ATR-CHK1 signaling determining the potency of CDC7 inhibitors. iScience. 2023;26:106951 pubmed publisher
Heyza J, Mikhova M, Bahl A, Broadbent D, Schmidt J. Systematic analysis of the molecular and biophysical properties of key DNA damage response factors. elife. 2023;12: pubmed publisher
Chen B, Ge T, Jian M, Chen L, Fang Z, He Z, et al. Transmembrane nuclease NUMEN/ENDOD1 regulates DNA repair pathway choice at the nuclear periphery. Nat Cell Biol. 2023;25:1004-1016 pubmed publisher
Zhang X, Duan J, Li Y, Jin X, Wu C, Yang X, et al. NKAP acts with HDAC3 to prevent R-loop associated genome instability. Cell Death Differ. 2023;30:1811-1828 pubmed publisher
Choi Y, Kim M, Rhoades J, Johnson N, Berry C, Root S, et al. Patient-Induced Pluripotent Stem Cell-Derived Hepatostellate Organoids Establish a Basis for Liver Pathologies in Telomeropathies. Cell Mol Gastroenterol Hepatol. 2023;16:451-472 pubmed publisher
Bloom S, Liu Y, Tucker J, Islam M, Machin D, Abdeahad H, et al. Endothelial cell telomere dysfunction induces senescence and results in vascular and metabolic impairments. Aging Cell. 2023;22:e13875 pubmed publisher
Sachsenweger J, Jansche R, Merk T, Heitmeir B, Deniz M, Faust U, et al. ABRAXAS1 orchestrates BRCA1 activities to counter genome destabilizing repair pathways-lessons from breast cancer patients. Cell Death Dis. 2023;14:328 pubmed publisher
Liberal F, McMahon S. Characterization of Intrinsic Radiation Sensitivity in a Diverse Panel of Normal, Cancerous and CRISPR-Modified Cell Lines. Int J Mol Sci. 2023;24: pubmed publisher
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Barreto Galvez A, Niljikar M, Gagliardi J, Zhang R, Kumar V, Juruwala A, et al. Acetyl transferase EP300 deficiency leads to chronic replication stress mediated by defective fork protection at stalled replication forks. bioRxiv. 2023;: pubmed publisher
Harbour J, Kurtenbach S, Sanchez M, Kuznetsoff J, Rodriguez D, Weich N, et al. PRAME induces genomic instability in uveal melanoma. Res Sq. 2023;: pubmed publisher
Li Z, Jiao X, Robertson A, Di Sante G, Ashton A, DiRocco A, et al. The DACH1 gene is frequently deleted in prostate cancer, restrains prostatic intraepithelial neoplasia, decreases DNA damage repair, and predicts therapy responses. Oncogene. 2023;42:1857-1873 pubmed publisher
De Rosa M, Barnes R, Nyalapatla P, Wipf P, Opresko P. OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced cellular senescence. bioRxiv. 2023;: pubmed publisher
Bao G, Zhou H, Zou S, Chen L, Zhang B, Wang Z, et al. Inhibition of Poly(ADP-ribose) Polymerase Sensitizes [177Lu]Lu-DOTAGA.(SA.FAPi)2-Mediated Radiotherapy in Triple-Negative Breast Cancer. Mol Pharm. 2023;20:2443-2451 pubmed publisher
Jaworski D, Gzil A, Antosik P, Zar x119 bska I, Dominiak J, Neska D x142 ugosz I, et al. Expression differences between proteins responsible for DNA damage repair according to the Gleason grade as a new heterogeneity marker in prostate cancer. Arch Med Sci. 2023;19:499-506 pubmed publisher
Bery A, Etienne O, Mouton L, Mokrani S, Granotier Beckers C, Gauthier L, et al. XLF/Cernunnos loss impairs mouse brain development by altering symmetric proliferative divisions of neural progenitors. Cell Rep. 2023;42:112342 pubmed publisher
Velázquez C, Orhan E, Tabet I, Fenou L, Orsetti B, Ad xe9 la xef de J, et al. BRCA1-methylated triple negative breast cancers previously exposed to neoadjuvant chemotherapy form RAD51 foci and respond poorly to olaparib. Front Oncol. 2023;13:1125021 pubmed publisher
Brambati A, Sacco O, Porcella S, Heyza J, Kareh M, Schmidt J, et al. RHINO restricts MMEJ activity to mitosis. bioRxiv. 2023;: pubmed publisher
Debaugnies M, Rodr xed guez Acebes S, Blondeau J, Parent M, Zocco M, Song Y, et al. RHOJ controls EMT-associated resistance to chemotherapy. Nature. 2023;616:168-175 pubmed publisher
Refaat A, Nakata M, Husain A, Kosako H, Honjo T, Begum N. HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression. Cell Rep. 2023;42:112284 pubmed publisher
Gioia U, Tavella S, Mart xed nez Orellana P, Cicio G, Colliva A, Ceccon M, et al. SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence. Nat Cell Biol. 2023;25:550-564 pubmed publisher
Huang J, Wu C, Kloeber J, Gao H, Gao M, Zhu Q, et al. SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology. Mol Cell. 2023;83:1043-1060.e10 pubmed publisher
Sreekumar S, Zhou D, Mpoy C, Schenk E, Scott J, Arbeit J, et al. Preclinical Efficacy of a PARP-1 Targeted Auger-Emitting Radionuclide in Prostate Cancer. Int J Mol Sci. 2023;24: pubmed publisher
Stock A, Ayyar S, Kashyap A, Wang Y, Yanai H, Starost M, et al. Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo. GeroScience. 2023;: pubmed publisher
Alagia A, Ketley R, Gullerova M. Detecting RNA-protein proximity at DNA double-strand breaks using combined fluorescence in situ hybridization with proximity ligation assay. STAR Protoc. 2023;4:102096 pubmed publisher
Han Z, Andr x161 M, Madhavan B, Kaymak S, Sulaj A, Kender Z, et al. The importance of nuclear RAGE-Mcm2 axis in diabetes or cancer-associated replication stress. Nucleic Acids Res. 2023;51:2298-2318 pubmed publisher
Su B, Lim D, Qi C, Zhang Z, Wang J, Zhang F, et al. VPA mediates bidirectional regulation of cell cycle progression through the PPP2R2A-Chk1 signaling axis in response to HU. Cell Death Dis. 2023;14:114 pubmed publisher
Benitez A, Sebald M, Kanagaraj R, Rodrigo Brenni M, Chan Y, Liang C, et al. GEN1 promotes common fragile site expression. Cell Rep. 2023;42:112062 pubmed publisher
Udden S, Baek G, Pandey K, Vidal C, Liu Y, Rahimi A, et al. Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy. NPJ Precis Oncol. 2023;7:11 pubmed publisher
Zeng F, Parker K, Zhan Y, Miller M, Zhu M. Upregulated DNA Damage-Linked Biomarkers in Parkinson's Disease Model Mice. ASN Neuro. 2023;15:17590914231152099 pubmed publisher
Tham C, Poon L, Yan T, Koh J, Ramlee M, Teoh V, et al. High-throughput telomere length measurement at nucleotide resolution using the PacBio high fidelity sequencing platform. Nat Commun. 2023;14:281 pubmed publisher
Zhao S, Huang C, Yang Y, Xu W, Yu Y, Wen C, et al. DNA repair protein FANCD2 has both ubiquitination-dependent and ubiquitination-independent functions during germ cell development. J Biol Chem. 2023;299:102905 pubmed publisher
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product information
master code :
NB100-304
SKU :
NB100-304
product name :
53BP1 Antibody - BSA Free
unit size :
0.1 mg (also 0.025 mg)
description :
The 53BP1 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to 53BP1. This antibody reacts with avian,bat,bovine,canine,fish,goat,human,insect - drosophila melanogaster,mouse,naked mole-rat,porcine,primate,rabbit,rat,reptile. The 53BP1 Antibody - BSA Free has been validated for the following applications: Immunoprecipitation,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence,Chromatin Immunoprecipitation,Chemotaxis,FISH,IF/ICC,IF-FISH,IF/IHC,Flow Cytometry,Immunoblotting,Proximity Ligation Assay,Immunofluorescence,Chromatin Immunoprecipitation (ChIP),Knockout Validated,Knockdown Validated,In Situ Hybridization,In-situ Hybridization,Flow (Intracellular).
target :
53BP1
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
Partial synthetic peptide made to an internal portion of human 53BP1 (between amino acids 350-400) [NP_005648.1].
isotype :
IgG
purity :
Immunogen affinity purified
species :
Avian,Bat,Bovine,Canine,Fish,Goat,Human,Insect - Drosophila melanogaster,Mouse,Naked mole-rat,Porcine,Primate,Rabbit,Rat,Reptile
theoretical molecular weight :
214 kDa
gene symbol :
TP53BP1
Antibody validation :
Biological Validation
applications :
Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence,Chromatin Immunoprecipitation,Chemotaxis,FISH,IF/ICC,IF-FISH,IF/IHC,Flow Cytometry,Immunoprecipitation,Immunoblotting,Proximity Ligation Assay,Immunofluorescence,Chromatin Immunoprecipitation (ChIP),Knockout Validated,Knockdown Validated,In Situ Hybridization,In-situ Hybridization,Flow (Intracellular)
USD :
499 USD
alt names :
53BP1, p202, p53-binding protein 1, p53bp1, TDRD30, TP53-Binding Protein 1, tumor protein 53-binding protein, 1, tumor protein p53 binding protein 1, tumor protein p53-binding protein, 1, tumor suppressor p53-binding protein 1
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.