product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
EGLN3/PHD3 Antibody - BSA Free
catalog :
NB100-303
quantity :
0.1 ml (also 0.025 ml)
price :
399 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
DyLight 405
clone name :
6C5cc
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
Novus Biologicals product webpage
citations: 21
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; fig 1
Shin J, Nunomiya A, Kitajima Y, Dan T, Miyata T, Nagatomi R. Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber-type transition via a calcineurin/NFATc1-dependent pathway. Skelet Muscle. 2016;6:5 pubmed publisher
  • western blot; human; fig 1f
Heir P, Srikumar T, Bikopoulos G, Bunda S, Poon B, Lee J, et al. Oxygen-dependent Regulation of Erythropoietin Receptor Turnover and Signaling. J Biol Chem. 2016;291:7357-72 pubmed publisher
Ting K, Yu P, Dow R, Ibrahim H, Karim S, Polenz C, et al. Cholesterol accumulation impairs HIF-1α-dependent immunometabolic reprogramming of LPS-stimulated macrophages by upregulating the NRF2 pathway. Sci Rep. 2024;14:11162 pubmed publisher
Wong N, Solly E, Le R, Nankivell V, Mulangala J, Psaltis P, et al. TRIM2 Selectively Regulates Inflammation-Driven Pathological Angiogenesis without Affecting Physiological Hypoxia-Mediated Angiogenesis. Int J Mol Sci. 2024;25: pubmed publisher
Noonan M, Ni P, Solis E, Marambio Y, Agoro R, Chu X, et al. Osteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23. Bone Res. 2023;11:7 pubmed publisher
Woods P, Kimmig L, Sun K, Meliton A, Shamaa O, Tian Y, et al. HIF-1α induces glycolytic reprograming in tissue-resident alveolar macrophages to promote cell survival during acute lung injury. elife. 2022;11: pubmed publisher
Angelini A, Saha P, Jain A, Jung S, Mynatt R, Pi X, et al. PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes. Cell Rep. 2021;37:109767 pubmed publisher
Soni C, Perez O, Voss W, Pucella J, Serpas L, Mehl J, et al. Plasmacytoid Dendritic Cells and Type I Interferon Promote Extrafollicular B Cell Responses to Extracellular Self-DNA. Immunity. 2020;52:1022-1038.e7 pubmed publisher
Xu Y, Gao Q, Zhang J, Lu Y, Xing D, Qin Y, et al. Prolyl hydroxylase 3 controls the intestine goblet cell generation through stabilizing ATOH1. Cell Death Differ. 2020;27:2131-2142 pubmed publisher
Xu Y, Gao Q, Xue Y, Li X, Xu L, Li C, et al. Prolyl hydroxylase 3 stabilizes the p53 tumor suppressor by inhibiting the p53-MDM2 interaction in a hydroxylase-independent manner. J Biol Chem. 2019;294:9949-9958 pubmed publisher
Egners A, Rezaei M, Kuzmanov A, Poitz D, Streichert D, MULLER REICHERT T, et al. PHD3 Acts as Tumor Suppressor in Mouse Osteosarcoma and Influences Tumor Vascularization via PDGF-C Signaling. Cancers (Basel). 2018;10: pubmed publisher
Chowdhury A, Aich A, Jain G, Wozny K, Lüchtenborg C, Hartmann M, et al. Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia. Cell Rep. 2018;25:561-570.e6 pubmed publisher
Yano H, Sakai M, Matsukawa T, Yagi T, Naganuma T, Mitsushima M, et al. PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeogenesis and insulin signalling in hepatocytes. Sci Rep. 2018;8:14290 pubmed publisher
Sim J, Cowburn A, Palazon A, Madhu B, Tyrakis P, Macías D, et al. The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia. Cell Metab. 2018;27:898-913.e7 pubmed publisher
Bialešová L, Xu L, Gustafsson J, Haldosén L, Zhao C, Dahlman Wright K. Estrogen receptor ?2 induces proliferation and invasiveness of triple negative breast cancer cells: association with regulation of PHD3 and HIF-1?. Oncotarget. 2017;8:76622-76633 pubmed publisher
Casciello F, Al Ejeh F, Kelly G, Brennan D, Ngiow S, Young A, et al. G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis. Proc Natl Acad Sci U S A. 2017;114:7077-7082 pubmed publisher
Gibier J, Hemon B, Fanchon M, Gaudelot K, Pottier N, Ringot B, et al. Dual role of MUC1 mucin in kidney ischemia-reperfusion injury: Nephroprotector in early phase, but pro-fibrotic in late phase. Biochim Biophys Acta Mol Basis Dis. 2017;1863:1336-1349 pubmed publisher
Chen T, Zhou Q, Tang H, Bozkanat M, Yuan J, Raj J, et al. miR-17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia-Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation. J Am Heart Assoc. 2016;5: pubmed
Tan J, Prosser H, Dunn L, Vanags L, Ridiandries A, Tsatralis T, et al. High-Density Lipoproteins Rescue Diabetes-Impaired Angiogenesis via Scavenger Receptor Class B Type I. Diabetes. 2016;65:3091-103 pubmed publisher
Zieseniss A, Hesse A, Jatho A, Krull S, Hölscher M, Vogel S, et al. Cardiomyocyte-Specific Transgenic Expression of Prolyl-4-Hydroxylase Domain 3 Impairs the Myocardial Response to Ischemia. Cell Physiol Biochem. 2015;36:843-51 pubmed publisher
Pastor Soler N, Sutton T, Mang H, Kinlough C, Gendler S, Madsen C, et al. Muc1 is protective during kidney ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2015;308:F1452-62 pubmed publisher
product information
master code :
NB100-303
SKU :
NB100-303
product name :
EGLN3/PHD3 Antibody - BSA Free
unit size :
0.1 ml (also 0.025 ml)
description :
The EGLN3/PHD3 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to EGLN3/PHD3. This antibody reacts with human,mouse,primate,rat. The EGLN3/PHD3 Antibody - BSA Free has been validated for the following applications: Immunoprecipitation,Western Blot,Chemotaxis,Immunohistochemistry-Paraffin,Immunoblotting,Immunocytochemistry/ Immunofluorescence,Chromatin Immunoprecipitation,Immunohistochemistry,Simple Western,Chromatin Immunoprecipitation (ChIP).
target :
EGLN3/PHD3
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
A synthetic peptide made to the C-terminus of humanPHD3/HIF Prolyl Hydroxylase 3. [LocusLink ID 112399]
isotype :
IgG
purity :
Immunogen affinity purified
species :
Human,Mouse,Primate,Rat
theoretical molecular weight :
27 kDa
gene symbol :
EGLN3
applications :
Western Blot,Chemotaxis,Immunoprecipitation,Immunohistochemistry-Paraffin,Immunoblotting,Immunocytochemistry/ Immunofluorescence,Chromatin Immunoprecipitation,Immunohistochemistry,Simple Western,Chromatin Immunoprecipitation (ChIP)
USD :
399 USD
alt names :
EC 1.14.11, EC 1.14.11.-, EGL nine (C.elegans) homolog 3, egl nine homolog 3, egl nine homolog 3 (C. elegans), egl nine-like protein 3 isoform, FLJ21620, HIF prolyl hydroxylase 3, HIF-PH3, HIFPH3 MGC125998, HIF-prolyl hydroxylase 3, HPH-1, HPH-3, Hypoxia-inducible factor prolyl hydroxylase 3, MGC125999, pdh3, PHD3, Prolyl hydroxylase domain-containing protein 3
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.