product summary
request information :
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Rabbit Polyclonal Ceramide Kinase Antibody
catalog :
NB100-2911F
quantity :
0.1 ml
price :
309.00 USD
clonality :
polyclonal
host :
rabbit
conjugate :
FITC
reactivity :
human, mouse
application :
western blot
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NB100-2911F
Product Name :
Rabbit Polyclonal Ceramide Kinase Antibody
List Price :
309.00 USD
Product Type :
Primary Antibodies
Package Size :
0.1 ml
AltNames :
ceramide kinase, dA59H18.2, DKFZp434E0211, EC 2.7.1.138, FLJ21430, FLJ23239, hCERKLipid kinase 4, KIAA1646dA59H18.3, lipid kinase LK4, LK4Acylsphingosine kinase, MGC131878
Background :
Ceramide kinase (CERK) belongs to diacylglycerol kinase family of lipid kinases and it catalyzes specifically the phosphorylation of ceramide to generate ceramide 1-phosphate (C1P). CERK acts primarily on natural as well as analog ceramides such as C6, C8, C16 ceramides, and C8-dihydroceramide, to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids including sphingosines. Localized in the cytoplasm and membrane as peripheral membrane protein, CERK is the only enzyme known to produce C1P, a signaling molecule which shows positive effect on cell proliferation or survival and also regulates cytosolic phospholipase A2 (cPLA2) activity . CERK/C1P signaling is implicated in mast cell activation, eicosanoid signaling, apoptosis, cellular immune response/inflammation, emotional behavior, angiogenesis, phagolysosome formation etc.
Buffer :
50mM sodium borate
Clonality :
Polyclonal
Conjugate :
FITC
Application Summary :
Western Blot
Host :
Rabbit
Immunogen :
A synthetic peptide made to an internal portion of human Ceramide Kinase (between residues 50-150). [Swiss-Prot Q8TCT0]
Localization :
Cytoplasmic and membraneous, cytoplasmic vesicles
Preservative :
No Preservative
Purity :
Immunogen affinity purified
CrossReactivity :
Human. Immunogen has 86% homology to mouse.
Storage :
Store at 4C in the dark.
Swissprot Human :
Q8TCT0
TMW :
65 kDa
Uses :
This Ceramide Kinase antibody is useful for Western Blot and Immunocytochemistry/Immunofluorescence. In Western blot a band is seen at ~65 kDa representing the Ceramide Kinase protein, and in Immunocytochemistry/Immunofluorescence vesicular cytoplasmic staining was observed in A431 cells.
Research Area :
Apoptosis, Cell Biology, Lipid and Metabolism
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: USA
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.