product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Polyoma Virus, Medium T Antigen Antibody (PyMT) - BSA Free
catalog :
NB100-2749
quantity :
0.1 ml (also 0.025 ml)
price :
409 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
PyMT
reactivity :
mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
Novus Biologicals product webpage
citations: 29
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:2500; loading ...; fig s1d
Bueno M, Jimenez Renard V, Samino S, Capellades J, Junza A, López Rodríguez M, et al. Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells. Nat Commun. 2019;10:5011 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 3b
Mao S, Park M, Cabrera R, Christin J, Karagiannis G, Oktay M, et al. Loss of amphiregulin reduces myoepithelial cell coverage of mammary ducts and alters breast tumor growth. Breast Cancer Res. 2018;20:131 pubmed publisher
Passarelli M, Pinzaru A, Asgharian H, Liberti M, Heissel S, Molina H, et al. Leucyl-tRNA synthetase is a tumour suppressor in breast cancer and regulates codon-dependent translation dynamics. Nat Cell Biol. 2022;24:307-315 pubmed publisher
Borriello L, Coste A, Traub B, Sharma V, Karagiannis G, Lin Y, et al. Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells. Nat Commun. 2022;13:626 pubmed publisher
Park M, Zhang L, Min K, Cho J, Yeh C, Moon H, et al. NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis. Cell Metab. 2021;33:2380-2397.e9 pubmed publisher
Williams M, Christenson J, O Neill K, Hafeez S, Ihle C, Spoelstra N, et al. MicroRNA-200c restoration reveals a cytokine profile to enhance M1 macrophage polarization in breast cancer. NPJ Breast Cancer. 2021;7:64 pubmed publisher
Tavora B, Mederer T, Wessel K, Ruffing S, Sadjadi M, Missmahl M, et al. Tumoural activation of TLR3-SLIT2 axis in endothelium drives metastasis. Nature. 2020;586:299-304 pubmed publisher
Hughes S, Hemenway E, Guo F, Yi K, Yu Z, Hawley R. The E3 ubiquitin ligase Sina regulates the assembly and disassembly of the synaptonemal complex in Drosophila females. PLoS Genet. 2019;15:e1008161 pubmed publisher
Ma B, Cheng H, Mu C, Geng G, Zhao T, Luo Q, et al. The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression. Nat Commun. 2019;10:1034 pubmed publisher
Jing Y, Nguyen M, Wang D, Pascal L, Guo W, Xu Y, et al. DHX15 promotes prostate cancer progression by stimulating Siah2-mediated ubiquitination of androgen receptor. Oncogene. 2017;: pubmed publisher
Joshi S, Yang J, Wang Q, Li P, Wang H, Zhang Q, et al. 14-3-3ζ loss impedes oncogene-induced mammary tumorigenesis and metastasis by attenuating oncogenic signaling. Am J Cancer Res. 2017;7:1654-1664 pubmed
Christenson J, Butterfield K, Spoelstra N, Norris J, Josan J, Pollock J, et al. MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression. Horm Cancer. 2017;8:69-77 pubmed publisher
van Reesema L, Zheleva V, Winston J, Jansen R, O Connor C, Isbell A, et al. SIAH and EGFR, Two RAS Pathway Biomarkers, are Highly Prognostic in Locally Advanced and Metastatic Breast Cancer. EBioMedicine. 2016;11:183-198 pubmed publisher
van der Willik K, Timmermans M, van Deurzen C, Look M, Reijm E, van Zundert W, et al. SIAH2 protein expression in breast cancer is inversely related with ER status and outcome to tamoxifen therapy. Am J Cancer Res. 2016;6:270-84 pubmed
Ma B, Cheng H, Gao R, Mu C, Chen L, Wu S, et al. Zyxin-Siah2-Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways. Nat Commun. 2016;7:11123 pubmed publisher
Moreno P, Lara Chica M, Soler Torronteras R, Caro T, Medina M, Alvarez A, et al. The Expression of the Ubiquitin Ligase SIAH2 (Seven In Absentia Homolog 2) Is Increased in Human Lung Cancer. PLoS ONE. 2015;10:e0143376 pubmed publisher
Wong C, Chen A, Liu M, Parker B, Möller A. Loss of Siah2 does not impact angiogenic potential of murine endothelial cells. Microvasc Res. 2015;102:38-45 pubmed publisher
Qin R, Smyrk T, Reed N, Schmidt R, Schnelldorfer T, Chari S, et al. Combining clinicopathological predictors and molecular biomarkers in the oncogenic K-RAS/Ki67/HIF-1α pathway to predict survival in resectable pancreatic cancer. Br J Cancer. 2015;112:514-22 pubmed publisher
Tanaka T, Li T, Urata Y, Goto S, Ono Y, Kawakatsu M, et al. Increased expression of PHD3 represses the HIF-1 signaling pathway and contributes to poor neovascularization in pancreatic ductal adenocarcinoma. J Gastroenterol. 2015;50:975-83 pubmed publisher
Chen A, Wong C, Liu M, House C, Sceneay J, Bowtell D, et al. The ubiquitin ligase Siah is a novel regulator of Zeb1 in breast cancer. Oncotarget. 2015;6:862-73 pubmed
Ma B, Chen Y, Chen L, Cheng H, Mu C, Li J, et al. Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase. Nat Cell Biol. 2015;17:95-103 pubmed publisher
Christenson J, Kane S. Darpp-32 and t-Darpp are differentially expressed in normal and malignant mouse mammary tissue. Mol Cancer. 2014;13:192 pubmed publisher
Rizzardi A, Rosener N, Koopmeiners J, Isaksson Vogel R, Metzger G, Forster C, et al. Evaluation of protein biomarkers of prostate cancer aggressiveness. BMC Cancer. 2014;14:244 pubmed publisher
Qi J, Tripathi M, Mishra R, Sahgal N, Fazli L, Fazil L, et al. The E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity. Cancer Cell. 2013;23:332-46 pubmed publisher
Gao D, Joshi N, Choi H, Ryu S, Hahn M, Catena R, et al. Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition. Cancer Res. 2012;72:1384-94 pubmed publisher
Chan P, Möller A, Liu M, Sceneay J, Wong C, Waddell N, et al. The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression. Breast Cancer Res. 2011;13:R19 pubmed publisher
Guest I, Ilic Z, Ma J, Grant D, Glinsky G, Sell S. Direct and indirect contribution of bone marrow-derived cells to cancer. Int J Cancer. 2010;126:2308-18 pubmed publisher
Ahmed A, Schmidt R, Park C, Reed N, Hesse S, Thomas C, et al. Effect of disrupting seven-in-absentia homolog 2 function on lung cancer cell growth. J Natl Cancer Inst. 2008;100:1606-29 pubmed publisher
Schmidt R, Park C, Ahmed A, Gundelach J, Reed N, Cheng S, et al. Inhibition of RAS-mediated transformation and tumorigenesis by targeting the downstream E3 ubiquitin ligase seven in absentia homologue. Cancer Res. 2007;67:11798-810 pubmed
product information
master code :
NB100-2749
SKU :
NB100-2749
product name :
Polyoma Virus, Medium T Antigen Antibody (PyMT) - BSA Free
unit size :
0.1 ml (also 0.025 ml)
description :
The Polyoma Virus, Medium T Antigen Antibody (PyMT) - BSA Free from Novus is a rat monoclonal antibody to Polyoma Virus, Medium T Antigen. This antibody reacts with mouse,virus. The Polyoma Virus, Medium T Antigen Antibody (PyMT) - BSA Free has been validated for the following applications: IF/IHC,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Dual RNAscope ISH-IHC,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry.
target :
Polyoma Virus, Medium T Antigen
category :
Primary Antibodies
buffer :
PBS
clonality :
Monoclonal
clone :
PyMT
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Rat
immunogen :
Polyoma Virus-transformed Wistar rat fibroblast cell line Py REWA5/T1A1.
isotype :
IgG2b
purity :
Protein G purified
species :
Mouse,Virus
applications :
IF/IHC,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Dual RNAscope ISH-IHC,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry
USD :
409 USD
alt names :
Middle t antigen, MPyVgp2, Polyoma virus middle T antigen, Polyomavirus medium t antigen, Polyomavirus middle t antigen
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.