Spt6 Antibody | Novus Biologicals NB100-2582 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

Spt6 Antibody

catalog :

NB100-2582

quantity :

0.1 ml

price :

449 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

104G4

reactivity :

human, mouse, chicken

application :

western blot, immunohistochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Novus Biologicals product webpage

citations: 32

Reference
Djakovic L, Hennig T, Reinisch K, Mili x107 A, Whisnant A, Wolf K, et al. The HSV-1 ICP22 protein selectively impairs histone repositioning upon Pol II transcription downstream of genes. Nat Commun. 2023;14:4591 pubmed publisher
Appel L, Franke V, Benedum J, Grishkovskaya I, Strobl X, Polyansky A, et al. The SPOC domain is a phosphoserine binding module that bridges transcription machinery with co- and post-transcriptional regulators. Nat Commun. 2023;14:166 pubmed publisher
Liu X, Guo Z, Han J, Peng B, Zhang B, Li H, et al. The PAF1 complex promotes 3' processing of pervasive transcripts. Cell Rep. 2022;38:110519 pubmed publisher
Arnold M, Bressin A, Jasnovidova O, Meierhofer D, Mayer A. A BRD4-mediated elongation control point primes transcribing RNA polymerase II for 3'-processing and termination. Mol Cell. 2021;81:3589-3603.e13 pubmed publisher
Narain A, Bhandare P, Adhikari B, Backes S, Eilers M, Dölken L, et al. Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination. Mol Cell. 2021;81:3110-3127.e14 pubmed publisher
Studniarek C, Tellier M, Martin P, Murphy S, Kiss T, Egloff S. The 7SK/P-TEFb snRNP controls ultraviolet radiation-induced transcriptional reprogramming. Cell Rep. 2021;35:108965 pubmed publisher
Obara E, Aguilar Morante D, Rasmussen R, Frias A, Vitting Serup K, Lim Y, et al. SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells. Nat Commun. 2020;11:4709 pubmed publisher
Lu H, Xie Y, Tran L, Lan J, Yang Y, Murugan N, et al. Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness. J Clin Invest. 2020;: pubmed publisher
Xue D, Tabib T, Morse C, Lafyatis R. Transcriptome landscape of myeloid cells in human skin reveals diversity, rare populations and putative DC progenitors. J Dermatol Sci. 2020;97:41-49 pubmed publisher
Chirackal Manavalan A, Pilarova K, Kluge M, Bartholomeeusen K, Rajecky M, Oppelt J, et al. CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes. EMBO Rep. 2019;20:e47592 pubmed publisher
Hou L, Wang Y, Liu Y, Zhang N, Shamovsky I, Nudler E, et al. Paf1C regulates RNA polymerase II progression by modulating elongation rate. Proc Natl Acad Sci U S A. 2019;116:14583-14592 pubmed publisher
Baluapuri A, Hofstetter J, Dudvarski Stankovic N, Endres T, Bhandare P, Vos S, et al. MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation. Mol Cell. 2019;74:674-687.e11 pubmed publisher
Nojima T, Tellier M, Foxwell J, Ribeiro de Almeida C, Tan Wong S, Dhir S, et al. Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence. Mol Cell. 2018;72:970-984.e7 pubmed publisher
Nojima T, Rebelo K, Gomes T, Grosso A, Proudfoot N, Carmo Fonseca M. RNA Polymerase II Phosphorylated on CTD Serine 5 Interacts with the Spliceosome during Co-transcriptional Splicing. Mol Cell. 2018;72:369-379.e4 pubmed publisher
Li S, Han X, Lyu N, Xie Q, Deng H, Mu L, et al. Mechanism and prognostic value of indoleamine 2,3-dioxygenase 1 expressed in hepatocellular carcinoma. Cancer Sci. 2018;109:3726-3736 pubmed publisher
Wang A, Juan A, Ko K, Tsai P, Zare H, Dell Orso S, et al. The Elongation Factor Spt6 Maintains ESC Pluripotency by Controlling Super-Enhancers and Counteracting Polycomb Proteins. Mol Cell. 2017;68:398-413.e6 pubmed publisher
Chang C, Lin C, Cheng A, Medeiros L, Chang K. Primary central nervous system diffuse large B-cell lymphoma has poorer immune cell infiltration and prognosis than its peripheral counterpart. Histopathology. 2015;67:625-35 pubmed publisher
Tseng W, Malu S, Zhang M, Chen J, Sim G, Wei W, et al. Analysis of the intratumoral adaptive immune response in well differentiated and dedifferentiated retroperitoneal liposarcoma. Sarcoma. 2015;2015:547460 pubmed publisher
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product information

master code :

NB100-2582

SKU :

NB100-2582

product name :

Spt6 Antibody

unit size :

0.1 ml

description :

The Spt6 Antibody from Novus is a rabbit polyclonal antibody to Spt6. This antibody reacts with avian - chicken,chicken,human,mouse. The Spt6 Antibody has been validated for the following applications: Chemotaxis,Immunoprecipitation,Western Blot,Knockdown Validated,Immunohistochemistry,Immunohistochemistry-Paraffin,Chromatin Immunoprecipitation (ChIP).

target :

Spt6

category :

Primary Antibodies

buffer :

TBS, 0.1% BSA

clonality :

Polyclonal

concentration :

0.2 mg/ml

conjugate :

Unconjugated

host :

Rabbit

immunogen :

The immunogen recognized by this antibody maps to a region between residue 425 and 475 of human Suppressor of Ty 6 Homolog using the numbering given in entry NP_003161.2 (GeneID 6830).

isotype :

IgG

purity :

Immunogen affinity purified

species :

Avian - Chicken,Chicken,Human,Mouse

gene symbol :

SUPT6H

Antibody validation :

Independent Anitbodies

accessionNumbers :

Q7KZ85

applications :

Chemotaxis,Immunoprecipitation,Western Blot,Knockdown Validated,Immunohistochemistry,Immunohistochemistry-Paraffin,Chromatin Immunoprecipitation (ChIP)

USD :

449 USD

alt names :

emb-5, hSPT6, KIAA0162MGC87943, SPT6HSPT6, suppressor of Ty (S.cerevisiae) 6 homolog, suppressor of Ty 6 homolog (S. cerevisiae), Tat-cotransactivator 2 protein, Tat-CT2 protein, transcription elongation factor SPT6

storage :

Store at 4C. Do not freeze.

more info or order :

Novus Biologicals product webpage